2MNE
 
 | | Recognition complex of DNA d(CGACTAGTCG)2 with thiazotropsin analogue AIK-18/51 | | Descriptor: | 5'-D(*CP*GP*AP*CP*TP*AP*GP*TP*CP*G)-3', AIK-18/51 | | Authors: | Alniss, H.Y, Salvia, M.-V, Sadikov, M, Golovchenko, I, Anthony, N.G, Khalaf, A.I, Mackay, S.P, Suckling, C.J, Parkinson, J.A. | | Deposit date: | 2014-04-03 | | Release date: | 2014-07-30 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | Recognition of the DNA minor groove by thiazotropsin analogues.
Chembiochem, 15, 2014
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3EY3
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4MB9
 | | Structure of Streptococcus pneumonia ParE in complex with AZ13102335 | | Descriptor: | 1-ethyl-3-{6-(pyrimidin-5-yl)-5-[(3R)-tetrahydrofuran-3-ylmethoxy][1,3]thiazolo[5,4-b]pyridin-2-yl}urea, DNA topoisomerase IV, B subunit, ... | | Authors: | Ogg, D, Tucker, J. | | Deposit date: | 2013-08-19 | | Release date: | 2013-10-16 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Thiazolopyridine Ureas as Novel Antitubercular Agents Acting through Inhibition of DNA Gyrase B.
J.Med.Chem., 56, 2013
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4MBC
 | | Structure of Streptococcus pneumonia ParE in complex with AZ13053807 | | Descriptor: | 1-{5-[2-(morpholin-4-yl)ethoxy]-6-(pyridin-3-yl)[1,3]thiazolo[5,4-b]pyridin-2-yl}-3-prop-2-en-1-ylurea, DNA topoisomerase IV, B subunit | | Authors: | Ogg, D, Tucker, J. | | Deposit date: | 2013-08-19 | | Release date: | 2013-10-16 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Thiazolopyridine Ureas as Novel Antitubercular Agents Acting through Inhibition of DNA Gyrase B.
J.Med.Chem., 56, 2013
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308D
 | | BINDING OF DAUNOMYCIN TO B-D-GLUCOSYLATED DNA FOUND IN PROTOZOA TRYPANOSOMA BRUCEI STUDIED BY X-RAY CRYSTALLOGRAPH | | Descriptor: | DAUNOMYCIN, DNA (5'-D(*CP*GP*TP*AP*CP*G)-3'), MAGNESIUM ION, ... | | Authors: | Gao, Y.-G, Robinson, H, Wijsman, E.R, Van Der Marel, G.A, Van Boom, J.H, Wang, A.H.-J. | | Deposit date: | 1997-01-15 | | Release date: | 1997-01-21 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Binding of Daunomycin to beta-D-Glucosylated DNA Found in Protozoa Trypanosoma brucei Studied by X-Ray Crystallography
J.Am.Chem.Soc., 119, 1997
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2HMY
 | | BINARY COMPLEX OF HHAI METHYLTRANSFERASE WITH ADOMET FORMED IN THE PRESENCE OF A SHORT NONPSECIFIC DNA OLIGONUCLEOTIDE | | Descriptor: | PROTEIN (CYTOSINE-SPECIFIC METHYLTRANSFERASE HHAI), S-ADENOSYLMETHIONINE | | Authors: | O'Gara, M, Zhang, X, Roberts, R.J, Cheng, X. | | Deposit date: | 1999-02-08 | | Release date: | 1999-03-19 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.61 Å) | | Cite: | Structure of a binary complex of HhaI methyltransferase with S-adenosyl-L-methionine formed in the presence of a short non-specific DNA oligonucleotide.
J.Mol.Biol., 287, 1999
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2KDA
 | | Solution Structure of DNA Containing Alpha-OH-PdG: the Mutagenic Adduct Produced by Acrolein | | Descriptor: | 5'-D(*CP*GP*TP*AP*CP*(63H)P*CP*AP*TP*GP*C)-3', 5'-D(*GP*CP*AP*TP*GP*CP*GP*TP*AP*CP*G)-3' | | Authors: | de los Santos, C, Zaliznyak, T, Johnson, F, Bonala, R, Attaluri, S. | | Deposit date: | 2009-01-05 | | Release date: | 2009-04-21 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Solution structure of DNA containing alpha-OH-PdG: the mutagenic adduct produced by acrolein.
Nucleic Acids Res., 37, 2009
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426D
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2KD9
 | | Solution Structure of DNA Containing Alpha-OH-PdG: the Mutagenic Adduct Produced by Acrolein | | Descriptor: | 5'-D(*CP*GP*TP*AP*CP*(63G)P*CP*AP*TP*GP*C)-3', 5'-D(*GP*CP*AP*TP*GP*CP*GP*TP*AP*CP*G)-3' | | Authors: | de los Santos, C, Zaliznyak, T, Johnson, F, Bonala, R, Attaluri, S. | | Deposit date: | 2009-01-05 | | Release date: | 2009-04-21 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Solution structure of DNA containing alpha-OH-PdG: the mutagenic adduct produced by acrolein.
Nucleic Acids Res., 37, 2009
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4HXZ
 | | Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity. | | Descriptor: | 6-ethyl-4-methoxy-2-(pyridin-3-ylsulfanyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbaldehyde, Topoisomerase IV, subunit B | | Authors: | Bensen, D.C, Creighton, C.J, Kwan, B, Tari, L.W. | | Deposit date: | 2012-11-12 | | Release date: | 2013-02-13 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.
Bioorg.Med.Chem.Lett., 23, 2013
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3WI3
 | | Crystal Structure of the Sld3/Treslin domain from yeast Sld3 | | Descriptor: | 1,2-ETHANEDIOL, DNA replication regulator SLD3, SULFATE ION | | Authors: | Itou, H, Araki, H, Shirakihara, Y. | | Deposit date: | 2013-09-05 | | Release date: | 2014-08-20 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Crystal structure of the homology domain of the eukaryotic DNA replication proteins sld3/treslin.
Structure, 22, 2014
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4HY1
 | | Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity. | | Descriptor: | 6-({4-[(3R)-3-aminopyrrolidin-1-yl]-5-chloro-6-ethyl-7H-pyrrolo[2,3-d]pyrimidin-2-yl}sulfanyl)-1H-isoindol-1-one, Topoisomerase IV, subunit B | | Authors: | Bensen, D.C, Creighton, C.J, Kwan, B, Tari, L.W. | | Deposit date: | 2012-11-12 | | Release date: | 2013-02-13 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.
Bioorg.Med.Chem.Lett., 23, 2013
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2KVY
 | | NMR solution structure of the 4:1 complex between an uncharged distamycin A analogue and [d(TGGGGT)]4 | | Descriptor: | 4-amino-1-methyl-N-{1-methyl-5-[(1-methyl-5-{[3-(methylamino)-3-oxopropyl]carbamoyl}-1H-pyrrol-3-yl)carbamoyl]-1H-pyrrol-3-yl}-1H-pyrrole-2-carboxamide, DNA (5'-D(*TP*GP*GP*GP*GP*T)-3') | | Authors: | Cosconati, S, Marinelli, L, Trotta, R, Virno, A, De Tito, S, Romagnoli, R, Pagano, B, Limongelli, V, Giancola, C, Baraldi, P, Mayol, L, Novellino, E, Randazzo, A. | | Deposit date: | 2010-03-29 | | Release date: | 2010-05-26 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Structural and conformational requisites in DNA quadruplex groove binding: another piece to the puzzle.
J.Am.Chem.Soc., 132, 2010
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1D9R
 | | CRYSTAL STRUCTURE OF DNA SHEARED TANDEM G-A BASE PAIRS | | Descriptor: | 5'-D(*CP*CP*GP*AP*AP*(BRU)P*GP*AP*GP*G)-3', COBALT HEXAMMINE(III) | | Authors: | Gao, Y.-G, Robinson, H, Sanishvili, R, Joachimiak, A, Wang, A.H.-J. | | Deposit date: | 1999-10-29 | | Release date: | 1999-11-05 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Structure and recognition of sheared tandem G x A base pairs associated with human centromere DNA sequence at atomic resolution.
Biochemistry, 38, 1999
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3GSJ
 | | A Bulky Rhodium Complex Bound to an Adenosine-Adenosine DNA Mismatch | | Descriptor: | 5'-D(*CP*GP*GP*AP*AP*AP*TP*TP*AP*CP*CP*G)-3', CHLORIDE ION, SODIUM ION, ... | | Authors: | Zeglis, B.M, Pierre, V.C, Kaiser, J.T, Barton, J.K. | | Deposit date: | 2009-03-27 | | Release date: | 2009-05-19 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | A bulky rhodium complex bound to an adenosine-adenosine DNA mismatch: general architecture of the metalloinsertion binding mode
Biochemistry, 48, 2009
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3GSK
 | | A Bulky Rhodium Complex Bound to an Adenosine-Adenosine DNA Mismatch | | Descriptor: | 5'-D(*CP*GP*GP*AP*AP*AP*TP*TP*AP*CP*CP*G)-3', CACODYLATE ION, bis(2,2'-bipyridine-kappa~2~N~1~,N~1'~)[chrysene-5,6-diiminato(2-)-kappa~2~N,N']rhodium(4+) | | Authors: | Zeglis, B.M, Pierre, V.C, Kaiser, J.T, Barton, J.K. | | Deposit date: | 2009-03-27 | | Release date: | 2009-05-19 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | A bulky rhodium complex bound to an adenosine-adenosine DNA mismatch: general architecture of the metalloinsertion binding mode
Biochemistry, 48, 2009
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1DK9
 | | SOLUTION STRUCTURE ANALYSIS OF THE DNA DUPLEX D(CATGAGTAC)D(GTACTCATG) | | Descriptor: | 5'-D(CP*AP*TP*GP*AP*GP*TP*AP*CP*)-3', 5'-D(GP*TP*AP*CP*TP*CP*AP*TP*GP*)-3' | | Authors: | Klewer, D.A, Hoskins, A, Davisson, V.J, Bergstrom, D.E, LiWang, A.C. | | Deposit date: | 1999-12-06 | | Release date: | 1999-12-16 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | NMR structure of a DNA duplex containing nucleoside analog 1-(2'-deoxy-beta-D-ribofuranosyl)-3-nitropyrrole and the structure of the unmodified control.
Nucleic Acids Res., 28, 2000
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1X3E
 | | Crystal structure of the single-stranded DNA-binding protein from Mycobacterium smegmatis | | Descriptor: | CADMIUM ION, Single-strand binding protein | | Authors: | Saikrishnan, K, Manjunath, G.P, Singh, P, Jeyakanthan, J, Dauter, Z, Sekar, K, Muniyappa, K, Vijayan, M. | | Deposit date: | 2005-05-04 | | Release date: | 2005-08-15 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Structure of Mycobacterium smegmatis single-stranded DNA-binding protein and a comparative study involving homologus SSBs: biological implications of structural plasticity and variability in quaternary association.
Acta Crystallogr.,Sect.D, 61, 2005
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1X3G
 | | Crystal structure of the single-stranded DNA-binding protein from Mycobacterium SMEGMATIS | | Descriptor: | CADMIUM ION, Single-strand binding protein | | Authors: | Saikrishnan, K, Manjunath, G.P, Singh, P, Jeyakanthan, J, Dauter, Z, Sekar, K, Muniyappa, K, Vijayan, M. | | Deposit date: | 2005-05-05 | | Release date: | 2005-08-15 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Structure of Mycobacterium smegmatis single-stranded DNA-binding protein and a comparative study involving homologus SSBs: biological implications of structural plasticity and variability in quaternary association.
Acta Crystallogr.,Sect.D, 61, 2005
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1X3F
 | | Crystal structure of the single-stranded DNA-binding protein from Mycobacterium SMEGMATIS | | Descriptor: | CADMIUM ION, Single-strand binding protein | | Authors: | Saikrishnan, K, Manjunath, G.P, Singh, P, Jeyakanthan, J, Dauter, Z, Sekar, K, Muniyappa, K, Vijayan, M. | | Deposit date: | 2005-05-05 | | Release date: | 2005-08-15 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structure of Mycobacterium smegmatis single-stranded DNA-binding protein and a comparative study involving homologus SSBs: biological implications of structural plasticity and variability in quaternary association.
Acta Crystallogr.,Sect.D, 61, 2005
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2N6C
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1FZX
 | | NMR SOLUTION STRUCTURE OF THE DNA DODECAMER GGCAAAAAACGG | | Descriptor: | 5'-D(*CP*CP*GP*TP*TP*TP*TP*TP*TP*GP*CP*C)-3', 5'-D(*GP*GP*CP*AP*AP*AP*AP*AP*AP*CP*GP*G)-3' | | Authors: | MacDonald, D, Herbert, K, Zhang, X, Pologruto, T, Lu, P. | | Deposit date: | 2000-10-04 | | Release date: | 2001-03-14 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Solution structure of an A-tract DNA bend.
J.Mol.Biol., 306, 2001
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2HSL
 | | NMR structure of 13mer duplex DNA containing an abasic site, averaged structure (alpha anomer) | | Descriptor: | 5'-D(*CP*CP*AP*AP*AP*GP*(D1P)P*AP*CP*CP*GP*GP*G)-3', 5'-D(*CP*CP*CP*GP*GP*TP*AP*CP*TP*TP*TP*GP*G)-3' | | Authors: | Chen, J, Dupradeau, F.Y, Case, D.A, Turner, C.J, Stubbe, J. | | Deposit date: | 2006-07-22 | | Release date: | 2007-05-29 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | Nuclear magnetic resonance structural studies and molecular modeling of duplex DNA containing normal and 4'-oxidized abasic sites.
Biochemistry, 46, 2007
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2HSS
 | | 13mer duplex DNA containg an abasic site with beta anomer, averaged structure | | Descriptor: | 5'-D(*CP*CP*AP*AP*AP*GP*(AAB)P*AP*CP*CP*GP*GP*G)-3', 5'-D(*CP*CP*CP*GP*GP*TP*AP*CP*TP*TP*TP*GP*G)-3' | | Authors: | Chen, J, Dupradeau, F.Y, Case, D.A, Turner, C.J, Stubbe, J. | | Deposit date: | 2006-07-22 | | Release date: | 2007-05-29 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | Nuclear magnetic resonance structural studies and molecular modeling of duplex DNA containing normal and 4'-oxidized abasic sites.
Biochemistry, 46, 2007
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2K1Y
 | | Solution Structure of Duplex DNA Containing the Mutagenic Lesion: 1,N2-Etheno-2'-deoxyguanine | | Descriptor: | 5'-D(*DCP*DGP*DTP*DAP*DCP*(GNE)P*DCP*DAP*DTP*DGP*DC)-3', 5'-D(*DGP*DCP*DAP*DTP*DGP*DCP*DGP*DTP*DAP*DCP*DG)-3' | | Authors: | Zaliznyak, T, Lukin, M, Johnson, F, de los Santos, C. | | Deposit date: | 2008-03-18 | | Release date: | 2009-02-03 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Solution structure of duplex DNA containing the mutagenic lesion 1,N(2)-etheno-2'-deoxyguanine.
Biochemistry, 47, 2008
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