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6AZK
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BU of 6azk by Molmil
Structure of cetuximab with aminoheptanoic acid-linked N-(3-hydroxypropyl)-L-arginine meditope variant
Descriptor: SULFATE ION, cetuximab Fab heavy chain, cetuximab Fab light chain, ...
Authors:Bzymek, K.P, Williams, J.C.
Deposit date:2017-09-11
Release date:2017-12-13
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.477 Å)
Cite:Meditope-Fab interaction: threading the hole.
Acta Crystallogr F Struct Biol Commun, 73, 2017
7JRA
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BU of 7jra by Molmil
HUMAN TNF-ALPHA IN COMPLEX WITH 2-[5-(3-chloro-4-{[(1R)-1-(2-fluorophenyl)ethyl]amino}quinolin-6-yl)pyrimidin-2-yl]propan-2-ol
Descriptor: 2-[5-(3-chloro-4-{[(1R)-1-(2-fluorophenyl)ethyl]amino}quinolin-6-yl)pyrimidin-2-yl]propan-2-ol, GLYCEROL, Tumor necrosis factor
Authors:Sheriff, S.
Deposit date:2020-08-11
Release date:2020-12-09
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Biologic-like In Vivo Efficacy with Small Molecule Inhibitors of TNF alpha Identified Using Scaffold Hopping and Structure-Based Drug Design Approaches.
J.Med.Chem., 63, 2020
7K7A
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BU of 7k7a by Molmil
Transmembrane structure of TNFR1
Descriptor: Tumor necrosis factor receptor superfamily member 1A
Authors:Zhao, L, Chou, J.
Deposit date:2020-09-22
Release date:2020-09-30
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:The Diversity and Similarity of Transmembrane Trimerization of TNF Receptors.
Front Cell Dev Biol, 8, 2020
7KNE
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BU of 7kne by Molmil
Cryo-EM structure of single ACE2-bound SARS-CoV-2 trimer spike at pH 5.5
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ...
Authors:Gorman, J, Rapp, M, Kwong, P.D, Shapiro, L.
Deposit date:2020-11-04
Release date:2020-12-16
Last modified:2021-12-15
Method:ELECTRON MICROSCOPY (3.85 Å)
Cite:Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains.
Cell Host Microbe, 28, 2020
7KNI
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BU of 7kni by Molmil
Cryo-EM structure of Triple ACE2-bound SARS-CoV-2 Trimer Spike at pH 5.5
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ...
Authors:Gorman, J, Rapp, M, Kwong, P.D, Shapiro, L.
Deposit date:2020-11-04
Release date:2020-12-16
Last modified:2021-12-15
Method:ELECTRON MICROSCOPY (3.91 Å)
Cite:Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains.
Cell Host Microbe, 28, 2020
7JWY
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BU of 7jwy by Molmil
Structure of SARS-CoV-2 spike at pH 4.5
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:Zhou, T, Tsybovsky, Y, Kwong, P.D.
Deposit date:2020-08-26
Release date:2020-11-25
Last modified:2021-12-15
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains.
Cell Host Microbe, 28, 2020
7KNB
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BU of 7knb by Molmil
Cryo-EM structure of single ACE2-bound SARS-CoV-2 trimer spike at pH 7.4
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ...
Authors:Gorman, J, Kwong, P.D, Shapiro, L.
Deposit date:2020-11-04
Release date:2020-12-09
Last modified:2021-12-15
Method:ELECTRON MICROSCOPY (3.93 Å)
Cite:Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains.
Cell Host Microbe, 28, 2020
7KMB
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BU of 7kmb by Molmil
ACE2-RBD Focused Refinement Using Symmetry Expansion of Applied C3 for Triple ACE2-bound SARS-CoV-2 Trimer Spike at pH 7.4
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ...
Authors:Gorman, J, Kwong, P.D, Shapiro, L.
Deposit date:2020-11-02
Release date:2020-12-09
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (3.39 Å)
Cite:Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains.
Cell Host Microbe, 28, 2020
7KNH
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BU of 7knh by Molmil
Cryo-EM Structure of Double ACE2-Bound SARS-CoV-2 Trimer Spike at pH 5.5
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ...
Authors:Gorman, J, Rapp, M, Kwong, P.D, Shapiro, L.
Deposit date:2020-11-04
Release date:2020-12-16
Last modified:2021-12-15
Method:ELECTRON MICROSCOPY (3.74 Å)
Cite:Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains.
Cell Host Microbe, 28, 2020
6AZL
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BU of 6azl by Molmil
Structure of cetuximab with aminoheptanoic acid-linked N-carboxyethylarginine meditope variant
Descriptor: SULFATE ION, cetuximab Fab heavy chain, cetuximab Fab light chain, ...
Authors:Bzymek, K.P, Williams, J.C.
Deposit date:2017-09-11
Release date:2017-12-13
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.482 Å)
Cite:Meditope-Fab interaction: threading the hole.
Acta Crystallogr F Struct Biol Commun, 73, 2017
7KMS
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BU of 7kms by Molmil
Cryo-EM structure of triple ACE2-bound SARS-CoV-2 trimer spike at pH 7.4
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ...
Authors:Gorman, J, Kwong, P.D, Shapiro, L.
Deposit date:2020-11-03
Release date:2020-12-09
Last modified:2021-12-15
Method:ELECTRON MICROSCOPY (3.64 Å)
Cite:Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains.
Cell Host Microbe, 28, 2020
7KMZ
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BU of 7kmz by Molmil
Cryo-EM structure of double ACE2-bound SARS-CoV-2 trimer Spike at pH 7.4
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ...
Authors:Gorman, J, Kwong, P.D, Shapiro, L.
Deposit date:2020-11-03
Release date:2020-12-09
Last modified:2021-12-15
Method:ELECTRON MICROSCOPY (3.62 Å)
Cite:Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains.
Cell Host Microbe, 28, 2020
5W62
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BU of 5w62 by Molmil
Crystal structure of mouse BAX monomer
Descriptor: Apoptosis regulator BAX, SULFATE ION
Authors:Robin, A.Y, Colman, P.M, Czabotar, P.E, Luo, C.S.
Deposit date:2017-06-16
Release date:2018-06-27
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.196 Å)
Cite:Ensemble Properties of Bax Determine Its Function.
Structure, 26, 2018
5WTH
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BU of 5wth by Molmil
Cryo-EM structure for Hepatitis A virus complexed with FAB
Descriptor: FAB Heavy Chain, FAB Light Chain, Polyprotein, ...
Authors:Wang, X, Zhu, L, Dang, M, Hu, Z, Gao, Q, Yuan, S, Sun, Y, Zhang, B, Ren, J, Walter, T.S, Wang, J, Fry, E.E, Stuart, D.I, Rao, Z.
Deposit date:2016-12-12
Release date:2017-01-25
Last modified:2019-11-06
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Potent neutralization of hepatitis A virus reveals a receptor mimic mechanism and the receptor recognition site
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5WTF
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BU of 5wtf by Molmil
Cryo-EM structure for Hepatitis A virus empty particle
Descriptor: VP0, VP1, VP3
Authors:Wang, X, Zhu, L, Dang, M, Hu, Z, Gao, Q, Yuan, S, Sun, Y, Zhang, B, Ren, J, Walter, T.S, Wang, J, Fry, E.E, Stuart, D.I, Rao, Z.
Deposit date:2016-12-11
Release date:2017-01-25
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Potent neutralization of hepatitis A virus reveals a receptor mimic mechanism and the receptor recognition site
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
7RPV
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BU of 7rpv by Molmil
Crystal structure of affinity-enhancing and catalytically inactive ACE2 in complex with SARS-CoV-2 RBD
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, Spike protein S1, ...
Authors:Chen, Y, Tolbert, D.W, Pazgier, M.
Deposit date:2021-08-04
Release date:2021-12-15
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.54 Å)
Cite:Engineered ACE2-Fc counters murine lethal SARS-CoV-2 infection through direct neutralization and Fc-effector activities.
Biorxiv, 2021
5W60
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BU of 5w60 by Molmil
Crystal structure of BAXP168G monomer cryo-protected with ethylene glycol
Descriptor: Apoptosis regulator BAX, SULFATE ION
Authors:Robin, A.Y, Colman, P.M, Czabotar, P.E.
Deposit date:2017-06-16
Release date:2018-06-27
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.803 Å)
Cite:Ensemble Properties of Bax Determine Its Function.
Structure, 26, 2018
5W61
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BU of 5w61 by Molmil
Crystal structure of BAXP168G monomer co-crystallized with glycerol
Descriptor: Apoptosis regulator BAX
Authors:Robin, A.Y, Colman, P.M, Czabotar, P.E.
Deposit date:2017-06-16
Release date:2018-06-27
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Ensemble Properties of Bax Determine Its Function.
Structure, 26, 2018
5W63
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BU of 5w63 by Molmil
Crystal structure of channel catfish BAX
Descriptor: 1,2-ETHANEDIOL, Apoptosis regulator bax, SULFATE ION
Authors:Robin, A.Y, Colman, P.M, Czabotar, P.E, Luo, C.S.
Deposit date:2017-06-16
Release date:2018-06-27
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.436 Å)
Cite:Ensemble Properties of Bax Determine Its Function.
Structure, 26, 2018
5XJM
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BU of 5xjm by Molmil
Complex structure of angiotensin II type 2 receptor with Fab
Descriptor: FabH, FabL, Sar1, ...
Authors:Asada, H, Horita, S, Shimamura, T, Iwata, S.
Deposit date:2017-05-02
Release date:2018-07-11
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structure of the human angiotensin II type 2 receptor bound to an angiotensin II analog
Nat. Struct. Mol. Biol., 25, 2018
5WTE
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BU of 5wte by Molmil
Cryo-EM structure for Hepatitis A virus full particle
Descriptor: VP1, VP2, VP3
Authors:Wang, X, Zhu, L, Dang, M, Hu, Z, Gao, Q, Yuan, S, Sun, Y, Zhang, B, Ren, J, Walter, T.S, Wang, J, Fry, E.E, Stuart, D.I, Rao, Z.
Deposit date:2016-12-11
Release date:2017-01-25
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Potent neutralization of hepatitis A virus reveals a receptor mimic mechanism and the receptor recognition site
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
7RDB
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BU of 7rdb by Molmil
Crystal structure of Tspan15 large extracellular loop (Tspan15 LEL)
Descriptor: Tetraspanin-15
Authors:Lipper, C.H, Gabriel, K.H, Seegar, T.C.M, Durr, K.L, Tomlinson, M.G, Blacklow, S.C.
Deposit date:2021-07-09
Release date:2021-11-03
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:Crystal structure of the Tspan15 LEL domain reveals a conserved ADAM10 binding site.
Structure, 30, 2022
7RD5
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BU of 7rd5 by Molmil
Crystal structure of Tspan15 large extracellular loop (Tspan15 LEL) in complex with 1C12 Fab
Descriptor: 1C12 Fab Heavy Chain, 1C12 Fab Light Chain, Tetraspanin-15
Authors:Lipper, C.H, Gabriel, K.H, Seegar, T.C.M, Durr, K.L, Tomlinson, M.G, Blacklow, S.C.
Deposit date:2021-07-09
Release date:2021-11-03
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Crystal structure of the Tspan15 LEL domain reveals a conserved ADAM10 binding site.
Structure, 30, 2022
4RSO
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BU of 4rso by Molmil
The structure of the neurotropic AAVrh.8 viral vector
Descriptor: 2'-DEOXYADENOSINE-5'-MONOPHOSPHATE, CHLORIDE ION, Capsid protein VP1, ...
Authors:Halder, S, Van Vliet, K, Smith, J.K, McKenna, R, Wilson, J.M, Agbandje-McKenna, M.
Deposit date:2014-11-10
Release date:2016-04-13
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structure of neurotropic adeno-associated virus AAVrh.8.
J.Struct.Biol., 192, 2015
8SGT
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BU of 8sgt by Molmil
Cryo-EM structure of human NCX1 in Ca2+ bound, activated state (group II in the presence of 0.5 mM Ca2+)
Descriptor: CALCIUM ION, Fab heavy chain, Fab light chain, ...
Authors:Xue, J, Jiang, Y.
Deposit date:2023-04-13
Release date:2023-10-11
Last modified:2023-11-01
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structural mechanisms of the human cardiac sodium-calcium exchanger NCX1.
Nat Commun, 14, 2023

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數據於2024-07-24公開中

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