PDB: 8697 resultsInfo pagesStatus searchChemie searchBIRD

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4Y2C	M300V 3D polymerase mutant of EMCV Descriptor: GLYCEROL, Genome polyprotein Authors: Verdaguer, N, Ferrer-Orta, C, Vives-Adrian, L. Deposit date: 2015-02-09 Release date: 2015-04-01 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.2 Å) Cite: The RNA Template Channel of the RNA-Dependent RNA Polymerase as a Target for Development of Antiviral Therapy of Multiple Genera within a Virus Family. Plos Pathog., 11, 2015
6KOP	Mycobacterium tuberculosis initial transcription complex comprising sigma H and 5'-OH RNA of 9 nt Descriptor: DNA (5'-D(*TP*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*GP*TP*G)-3'), DNA (5'-D(*TP*TP*GP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*A)-3'), DNA-directed RNA polymerase subunit alpha, ... Authors: Li, L, Zhang, Y. Deposit date: 2019-08-12 Release date: 2020-03-11 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (3.303 Å) Cite: RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription. Proc.Natl.Acad.Sci.USA, 117, 2020
6KOQ	Mycobacterium tuberculosis initial transcription complex comprising sigma H and 5'-OH RNA of 10 nt Descriptor: DNA (5'-D(*TP*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*GP*TP*G)-3'), DNA (5'-D(*TP*TP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*A)-3'), DNA-directed RNA polymerase subunit alpha, ... Authors: Li, L, Zhang, Y. Deposit date: 2019-08-12 Release date: 2020-03-11 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (3.353 Å) Cite: RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription. Proc.Natl.Acad.Sci.USA, 117, 2020
6KQH	Thermus thermophilus initial transcription complex comprising sigma A and 5'-OH RNA of 7 nt Descriptor: DNA (5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*G)-3'), DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G*)-3'), DNA-directed RNA polymerase subunit alpha, ... Authors: Zhang, Y, Li, L, Ebright, R.H. Deposit date: 2019-08-17 Release date: 2020-03-11 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (3.18 Å) Cite: RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription. Proc.Natl.Acad.Sci.USA, 117, 2020
6KOO	Mycobacterium tuberculosis initial transcription complex comprising sigma H and 5'-OH RNA of 7 nt Descriptor: DNA (5'-D(*TP*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*GP*TP*G)-3'), DNA (5'-D(*TP*TP*GP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*A)-3'), DNA-directed RNA polymerase subunit alpha, ... Authors: Li, L, Zhang, Y. Deposit date: 2019-08-12 Release date: 2020-03-11 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.8 Å) Cite: RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription. Proc.Natl.Acad.Sci.USA, 117, 2020
6KQG	Thermus thermophilus initial transcription complex comprising sigma A and 5'-OH RNA of 6 nt Descriptor: DNA (5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*G)-3'), DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G*)-3'), DNA-directed RNA polymerase subunit alpha, ... Authors: Zhang, Y, Li, L, Ebright, R.H. Deposit date: 2019-08-17 Release date: 2020-03-11 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.783 Å) Cite: RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription. Proc.Natl.Acad.Sci.USA, 117, 2020
6KQN	Thermus thermophilus initial transcription complex comprising sigma A and 5'-triphosphate RNA of 6 nt Descriptor: DNA (5'-D(*CP*CP*TP*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*G)-3'), DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G*)-3'), DNA-directed RNA polymerase subunit alpha, ... Authors: Zhang, Y, Li, L, Ebright, R.H. Deposit date: 2019-08-18 Release date: 2020-03-11 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (3.489 Å) Cite: RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription. Proc.Natl.Acad.Sci.USA, 117, 2020
6KON	Mycobacterium tuberculosis initial transcription complex comprising sigma H and 5'-OH RNA of 5 nt Descriptor: DNA (5'-D(P*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*GP*TP*G)-3'), DNA (5'-D(P*GP*TP*TP*GP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*C)-3'), DNA-directed RNA polymerase subunit alpha, ... Authors: Li, L, Zhang, Y. Deposit date: 2019-08-12 Release date: 2020-03-11 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (3 Å) Cite: RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription. Proc.Natl.Acad.Sci.USA, 117, 2020
6KQF	Thermus thermophilus initial transcription complex comprising sigma A and 5'-OH RNA of 5 nt Descriptor: DNA (5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*G)-3'), DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G*)-3'), DNA-directed RNA polymerase subunit alpha, ... Authors: Zhang, Y, Li, L, Ebright, R.H. Deposit date: 2019-08-17 Release date: 2020-03-11 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.45 Å) Cite: RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription. Proc.Natl.Acad.Sci.USA, 117, 2020
6KQE	Thermus thermophilus initial transcription complex comprising sigma A and 5'-OH RNA of 4 nt Descriptor: DNA (5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*G)-3'), DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G*)-3'), DNA-directed RNA polymerase subunit alpha, ... Authors: Zhang, Y, Li, L, Ebright, R.H. Deposit date: 2019-08-17 Release date: 2020-03-11 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (3.3 Å) Cite: RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription. Proc.Natl.Acad.Sci.USA, 117, 2020
6KQM	Thermus thermophilus initial transcription complex comprising sigma A and 5'-triphosphate RNA of 5 nt Descriptor: DNA (5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*G)-3'), DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G*)-3'), DNA-directed RNA polymerase subunit alpha, ... Authors: Zhang, Y, Li, L, Ebright, R.H. Deposit date: 2019-08-18 Release date: 2020-03-11 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (3.197 Å) Cite: RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription. Proc.Natl.Acad.Sci.USA, 117, 2020
7RKP	The crystal structure of I38T mutant PA endonuclease (2009/H1N1/CALIFORNIA) in complex with cyclic compound SJ001034733 Descriptor: (5R)-5-hydroxy-16,21-dioxa-3,8,28-triazatetracyclo[20.3.1.1~2,6~.1~11,15~]octacosa-1(26),2,6(28),11(27),12,14,22,24-octaene-4,7-dione, Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, ... Authors: Cuypers, M.G, Slavish, J.P, Rankovic, Z, White, S.W. Deposit date: 2021-07-22 Release date: 2022-07-27 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.36 Å) Cite: Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential. Eur.J.Med.Chem., 247, 2023
6KQD	Thermus thermophilus initial transcription complex comprising sigma A and 5'-OH RNA of 3 nt Descriptor: 2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE, DNA (5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*CP*AP*GP*GP*G)-3'), DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G*)-3'), ... Authors: Zhang, Y, Li, L, Ebright, R.H. Deposit date: 2019-08-17 Release date: 2020-03-11 Last modified: 2024-05-29 Method: X-RAY DIFFRACTION (3.3 Å) Cite: RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription. Proc.Natl.Acad.Sci.USA, 117, 2020
6KQL	Thermus thermophilus initial transcription complex comprising sigma A and 5'-triphosphate RNA of 4 nt Descriptor: DNA (5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*G)-3'), DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*G*)-3'), DNA-directed RNA polymerase subunit alpha, ... Authors: Zhang, Y, Li, L, Ebright, R.H. Deposit date: 2019-08-18 Release date: 2020-03-11 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.89 Å) Cite: RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription. Proc.Natl.Acad.Sci.USA, 117, 2020
3BSO	Norwalk Virus polymerase bound to cytidine 5'-triphosphate and primer-template RNA Descriptor: CYTIDINE-5'-TRIPHOSPHATE, GLYCEROL, MANGANESE (II) ION, ... Authors: Zamyatkin, D.F, Ng, K.K.S. Deposit date: 2007-12-26 Release date: 2008-01-08 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.74 Å) Cite: Structural insights into mechanisms of catalysis and inhibition in norwalk virus polymerase. J.Biol.Chem., 283, 2008
3BSN	Norwalk Virus polymerase bound to 5-nitrocytidine triphosphate and primer-template RNA Descriptor: 5-nitrocytidine 5'-(tetrahydrogen triphosphate), GLYCEROL, MANGANESE (II) ION, ... Authors: Zamyatkin, D.F, Ng, K.K.S. Deposit date: 2007-12-26 Release date: 2008-01-08 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structural insights into mechanisms of catalysis and inhibition in norwalk virus polymerase. J.Biol.Chem., 283, 2008
6EOJ	PolyA polymerase module of the cleavage and polyadenylation factor (CPF) from Saccharomyces cerevisiae Descriptor: Polyadenylation factor subunit 2,Polyadenylation factor subunit 2, Protein CFT1, ZINC ION, ... Authors: Casanal, A, Kumar, A, Hill, C.H, Emsley, P, Passmore, L.A. Deposit date: 2017-10-09 Release date: 2017-11-15 Last modified: 2024-05-15 Method: ELECTRON MICROSCOPY (3.55 Å) Cite: Architecture of eukaryotic mRNA 3'-end processing machinery. Science, 358, 2017
7THM	SARS-CoV-2 nsp12/7/8 complex with a native N-terminus nsp9 Descriptor: MANGANESE (II) ION, Non-structural protein 7, Non-structural protein 8, ... Authors: Osinski, A, Tagliabracci, V.S, Chen, Z, Li, Y. Deposit date: 2022-01-11 Release date: 2022-03-16 Last modified: 2024-01-17 Method: ELECTRON MICROSCOPY (3.18 Å) Cite: The mechanism of RNA capping by SARS-CoV-2. Nature, 609, 2022
5X21	Crystal structure of Thermus thermophilus transcription initiation complex with GpA and pseudouridimycin (PUM) Descriptor: (1S)-1,4-anhydro-5-[(N-carbamimidoylglycyl-N~2~-hydroxy-L-glutaminyl)amino]-5-deoxy-1-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-D-ribitol, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Zhang, Y, Ebright, R. Deposit date: 2017-01-29 Release date: 2017-07-05 Last modified: 2022-10-12 Method: X-RAY DIFFRACTION (3.323 Å) Cite: Antibacterial Nucleoside-Analog Inhibitor of Bacterial RNA Polymerase. Cell, 169, 2017
5X22	Crystal structure of Thermus thermophilus transcription initiation complex with GpA and CMPcPP Descriptor: 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]cytidine, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Zhang, Y, Ebright, R. Deposit date: 2017-01-29 Release date: 2017-07-05 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (3.35 Å) Cite: Antibacterial Nucleoside-Analog Inhibitor of Bacterial RNA Polymerase. Cell, 169, 2017
7UUH	The crystal structure of wild type PA endonuclease (2009/H1N1/CALIFORNIA) in complex with compound SJ001034732-2 (cis-form) Descriptor: (1P,18Z)-5-hydroxy-16,21-dioxa-3,8,28-triazatetracyclo[20.3.1.1~2,6~.1~11,15~]octacosa-1(26),2(28),5,11(27),12,14,18,22,24-nonaene-4,7-dione, Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, ... Authors: Cuypers, M.G, Slavish, J.P, Rankovic, Z, White, S.W. Deposit date: 2022-04-28 Release date: 2022-11-02 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.89 Å) Cite: Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential. Eur.J.Med.Chem., 247, 2023
3RTX	Crystal structure of mammalian capping enzyme (Mce1) and Pol II CTD complex Descriptor: GUANINE, RNA Polymerase II C-terminal domain, mRNA-capping enzyme Authors: Ghosh, A, Lima, C.D. Deposit date: 2011-05-04 Release date: 2011-06-29 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.81 Å) Cite: Structural insights to how mammalian capping enzyme reads the CTD code. Mol.Cell, 43, 2011
7UMR	The crystal structure of wild type PA endonuclease (2009/H1N1/CALIFORNIA) in complex with compound SJ001034732-1 (trans-form) Descriptor: (1P,18Z)-5-hydroxy-16,21-dioxa-3,8,28-triazatetracyclo[20.3.1.1~2,6~.1~11,15~]octacosa-1(26),2(28),5,11(27),12,14,18,22,24-nonaene-4,7-dione, Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, ... Authors: Cuypers, M.G, Slavish, J.P, Rankovic, Z, White, S.W. Deposit date: 2022-04-07 Release date: 2022-10-12 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.53 Å) Cite: Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential. Eur.J.Med.Chem., 247, 2023
3AQN	Complex structure of bacterial protein (apo form II) Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Poly(A) polymerase Authors: Toh, Y, Takeshita, D, Tomita , K. Deposit date: 2010-11-09 Release date: 2011-02-09 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (3.3 Å) Cite: Mechanism for the alteration of the substrate specificities of template-independent RNA polymerases Structure, 19, 2011
3AQL	Structure of bacterial protein (apo form II) Descriptor: GLYCEROL, MAGNESIUM ION, Poly(A) polymerase Authors: Toh, Y, Takeshita, D, Tomita , K. Deposit date: 2010-11-09 Release date: 2011-02-09 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (3 Å) Cite: Mechanism for the alteration of the substrate specificities of template-independent RNA polymerases Structure, 19, 2011

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