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3V51
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BU of 3v51 by Molmil
Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor RM-1-176
Descriptor: 3-{6-[(3-chlorobenzyl)oxy]naphthalen-2-yl}-1-(propan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Calmodulin-domain protein kinase 1
Authors:Merritt, E.A, Larson, E.T.
Deposit date:2011-12-15
Release date:2012-03-14
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Multiple Determinants for Selective Inhibition of Apicomplexan Calcium-Dependent Protein Kinase CDPK1.
J.Med.Chem., 55, 2012
3V5P
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BU of 3v5p by Molmil
Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1288
Descriptor: 3-(4-methoxy-3-methylphenyl)-1-(piperidin-4-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Calmodulin-domain protein kinase 1
Authors:Merritt, E.A, Larson, E.T.
Deposit date:2011-12-16
Release date:2012-03-14
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Multiple Determinants for Selective Inhibition of Apicomplexan Calcium-Dependent Protein Kinase CDPK1.
J.Med.Chem., 55, 2012
3V5T
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BU of 3v5t by Molmil
Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1299
Descriptor: 1-[(2S)-2-(dimethylamino)-3-methylbutyl]-3-(6-ethoxynaphthalen-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Calmodulin-domain protein kinase 1
Authors:Merritt, E.A, Larson, E.T.
Deposit date:2011-12-16
Release date:2012-03-14
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:Multiple Determinants for Selective Inhibition of Apicomplexan Calcium-Dependent Protein Kinase CDPK1.
J.Med.Chem., 55, 2012
6DMU
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BU of 6dmu by Molmil
PI(4,5)P2 bound full-length rbTRPV5
Descriptor: Transient receptor potential cation channel subfamily V member 5, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate
Authors:Hughes, T.E.T, Pumroy, R.A, Moiseenkova-Bell, V.Y.
Deposit date:2018-06-05
Release date:2018-10-24
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Structural insights on TRPV5 gating by endogenous modulators.
Nat Commun, 9, 2018
3UPZ
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BU of 3upz by Molmil
Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with bumpless BKI analog UW1243
Descriptor: 1-(piperidin-4-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Calmodulin-domain protein kinase 1
Authors:Merritt, E.A, Larson, E.T.
Deposit date:2011-11-18
Release date:2012-03-14
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Multiple Determinants for Selective Inhibition of Apicomplexan Calcium-Dependent Protein Kinase CDPK1.
J.Med.Chem., 55, 2012
3HKO
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BU of 3hko by Molmil
Crystal structure of a cdpk kinase domain from cryptosporidium Parvum, cgd7_40
Descriptor: Calcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands, GLYCEROL, MAGNESIUM ION, ...
Authors:Wernimont, A.K, Hutchinson, A, Wasney, G, Vedadi, M, MacKenzie, F, Kozieradzki, I, Cossar, D, Weigelt, J, Edwards, A.M, Arrowsmith, C.H, Bountra, C, Botchkarev, A, Hui, R, Artz, J.D, Amani, M, Structural Genomics Consortium (SGC)
Deposit date:2009-05-25
Release date:2009-06-02
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of a cdpk kinase domain from cryptosporidium Parvum, cgd7_40
To be Published
7URW
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BU of 7urw by Molmil
Tetradecameric hub domain of CaMKII beta
Descriptor: Calcium/calmodulin-dependent protein kinase type II subunit beta
Authors:Ozden, C, Samkutty, A, Stratton, M.M, Garman, S.C.
Deposit date:2022-04-22
Release date:2022-05-11
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.11 Å)
Cite:Tetradecameric hub domain of CaMKII beta
To Be Published
7URZ
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BU of 7urz by Molmil
Hexadecameric hub domain of CaMKII beta
Descriptor: Calcium/calmodulin-dependent protein kinase type II subunit beta
Authors:Ozden, C, Samkutty, A, Stratton, M.M, Garman, S.C.
Deposit date:2022-04-22
Release date:2022-05-11
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.45 Å)
Cite:Hexadecameric hub domain of CaMKII beta
To Be Published
8J07
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BU of 8j07 by Molmil
96nm repeat of human respiratory doublet microtubule and associated axonemal complexes
Descriptor: ACTA2, Axonemal dynein light intermediate polypeptide 1, Calaxin, ...
Authors:Gui, M, Brown, A.
Deposit date:2023-04-09
Release date:2023-07-26
Last modified:2023-08-02
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Axonemal structures reveal mechanoregulatory and disease mechanisms.
Nature, 618, 2023
7TZC
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BU of 7tzc by Molmil
A drug and ATP binding site in type 1 ryanodine receptor
Descriptor: (2S)-3-(octadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 4-[(7-methoxy-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)methyl]benzoic acid, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Melville, Z, Dridi, H, Yuan, Q, Reiken, S, Anetta, W, Liu, Y, Clarke, O.B, Marks, A.R.
Deposit date:2022-02-15
Release date:2022-05-18
Last modified:2022-07-20
Method:ELECTRON MICROSCOPY (2.45 Å)
Cite:A drug and ATP binding site in type 1 ryanodine receptor.
Structure, 30, 2022
5C1V
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BU of 5c1v by Molmil
CRYSTAL STRUCTURE ANALYSIS OF CATALYTIC SUBUNIT OF HUMAN CALCINEURIN
Descriptor: FE (III) ION, PHOSPHATE ION, Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform, ...
Authors:Guasch, A, Fita, I, Perez-Luque, R, Aparicio, D, Aranguren-Ibanez, A, Perez-Riba, M.
Deposit date:2015-06-15
Release date:2016-02-03
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.35 Å)
Cite:Calcineurin Undergoes a Conformational Switch Evoked via Peptidyl-Prolyl Isomerization.
Plos One, 10, 2015
2YAA
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BU of 2yaa by Molmil
Crystal structure of the autoinhibited form of mouse DAPK2 in complex with ATP
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, DEATH-ASSOCIATED PROTEIN KINASE 2, ...
Authors:Patel, A.K, Kursula, P.
Deposit date:2011-02-18
Release date:2011-04-13
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of the Dimeric Autoinhibited Conformation of Dapk2, a Pro-Apoptotic Protein Kinase.
J.Mol.Biol., 409, 2011
2YA9
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BU of 2ya9 by Molmil
Crystal structure of the autoinhibited form of mouse DAPK2
Descriptor: (4S,5S)-1,2-DITHIANE-4,5-DIOL, CALCIUM ION, DEATH-ASSOCIATED PROTEIN KINASE 2
Authors:Patel, A.K, Kursula, P.
Deposit date:2011-02-18
Release date:2011-04-13
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of the Dimeric Autoinhibited Conformation of Dapk2, a Pro-Apoptotic Protein Kinase.
J.Mol.Biol., 409, 2011
2XUU
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BU of 2xuu by Molmil
Crystal structure of a DAP-kinase 1 mutant
Descriptor: ADENOSINE-5'-DIPHOSPHATE, DEATH-ASSOCIATED PROTEIN KINASE 1, MAGNESIUM ION, ...
Authors:de Diego, I, Kuper, J, Lehmann, F, Wilmanns, M.
Deposit date:2010-10-21
Release date:2011-11-02
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A Pef/Y Substrate Recognition and Signature Motif Plays a Critical Role in Dapk-Related Kinase Activity.
Chem.Biol., 21, 2014
2YAB
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BU of 2yab by Molmil
Crystal structure of the autoinhibited form of mouse DAPK2 in complex with AMP
Descriptor: ADENOSINE MONOPHOSPHATE, CALCIUM ION, DEATH-ASSOCIATED PROTEIN KINASE 2, ...
Authors:Patel, A.K, Kursula, P.
Deposit date:2011-02-18
Release date:2011-04-13
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of the Dimeric Autoinhibited Conformation of Dapk2, a Pro-Apoptotic Protein Kinase.
J.Mol.Biol., 409, 2011
1QX2
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BU of 1qx2 by Molmil
X-ray Structure of Calcium-loaded Calbindomodulin (A Calbindin D9k Re-engineered to Undergo a Conformational Opening) at 1.44 A Resolution
Descriptor: CALCIUM ION, Vitamin D-dependent calcium-binding protein, intestinal, ...
Authors:Bunick, C.G, Nelson, M.R, Mangahas, S, Mizoue, L.S, Bunick, G.J, Chazin, W.J.
Deposit date:2003-09-04
Release date:2004-05-25
Last modified:2021-10-27
Method:X-RAY DIFFRACTION (1.44 Å)
Cite:Designing Sequence to Control Protein Function in an EF-Hand Protein
J.Am.Chem.Soc., 126, 2004
1SJJ
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BU of 1sjj by Molmil
Cryo-EM Structure of Chicken Gizzard Smooth Muscle alpha-Actinin
Descriptor: actinin
Authors:Liu, J, Taylor, D.W, Taylor, K.A.
Deposit date:2004-03-03
Release date:2004-03-23
Last modified:2024-02-14
Method:ELECTRON CRYSTALLOGRAPHY (20 Å)
Cite:A 3-D Reconstruction of Smooth Muscle alpha-Actinin by CryoEm Reveals Two Different Conformations at the Actin-binding Region.
J.Mol.Biol., 338, 2004
3F3Z
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BU of 3f3z by Molmil
Crystal structure of Cryptosporidium parvum calcium dependent protein kinase cgd7_1840 in presence of indirubin E804
Descriptor: 3-({[(3S)-3,4-dihydroxybutyl]oxy}amino)-1H,2'H-2,3'-biindol-2'-one, Calcium/calmodulin-dependent protein kinase with a kinase domain and 4 calmodulin like EF hands, GLYCEROL
Authors:Wernimont, A.K, Lew, J, Wasney, G, Kozieradzki, I, Cossar, D, Vedadi, M, Bochkarev, A, Arrowsmith, C.H, Sundstrom, M, Weigelt, J, Edwards, A.M, Hui, R, Artz, J.D, Amani, M, Structural Genomics Consortium (SGC)
Deposit date:2008-10-31
Release date:2008-12-23
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Crystal structure of Cryptosporidium parvum calcium dependent protein kinase cgd7_1840 in presence of indirubin E804
To be Published
5JQA
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BU of 5jqa by Molmil
CaM:RM20 complex
Descriptor: CALCIUM ION, Calmodulin, Myosin light chain kinase, ...
Authors:Tokars, V.L, Minasov, G, Anderson, W.F, Watterson, D.M.
Deposit date:2016-05-04
Release date:2017-10-11
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:CaM:RM20 complex
To be Published
6NID
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BU of 6nid by Molmil
Crystal structure of a human calcium/calmodulin dependent serine protein kinase (CASK) PDZ domain in complex with Neurexin-1 peptide
Descriptor: 1,2-ETHANEDIOL, Neurexin-1, Peripheral plasma membrane protein CASK
Authors:Sun, Y.J, Gakhar, L, Fuentes, E.J.
Deposit date:2018-12-27
Release date:2020-01-01
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:CASK PDZ domain specificity
To be published
7SQC
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BU of 7sqc by Molmil
Ciliary C1 central pair apparatus isolated from Chlamydomonas reinhardtii
Descriptor: ADENOSINE-5'-DIPHOSPHATE, CPC1, Calmodulin, ...
Authors:Gui, M, Wang, X, Dutcher, S.K, Brown, A, Zhang, R.
Deposit date:2021-11-05
Release date:2022-04-13
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Ciliary central apparatus structure reveals mechanisms of microtubule patterning.
Nat.Struct.Mol.Biol., 29, 2022
6NH9
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BU of 6nh9 by Molmil
Crystal structure of a human calcium/calmodulin dependent serine protein kinase (CASK) PDZ domain
Descriptor: Peripheral plasma membrane protein CASK
Authors:Sun, Y.J, Gakhar, L, Fuentes, E.J.
Deposit date:2018-12-21
Release date:2019-12-25
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:CASK PDZ domain specificity
To be published
6C1D
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BU of 6c1d by Molmil
High-Resolution Cryo-EM Structures of Actin-bound Myosin States Reveal the Mechanism of Myosin Force Sensing
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ...
Authors:Mentes, A, Huehn, A, Liu, X, Zwolak, A, Dominguez, R, Shuman, H, Ostap, E.M, Sindelar, C.V.
Deposit date:2018-01-04
Release date:2018-01-31
Last modified:2020-01-08
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:High-resolution cryo-EM structures of actin-bound myosin states reveal the mechanism of myosin force sensing.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
3LIJ
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BU of 3lij by Molmil
Crystal structure of full length CpCDPK3 (cgd5_820) in complex with Ca2+ and AMPPNP
Descriptor: CALCIUM ION, Calcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands, MAGNESIUM ION, ...
Authors:Qiu, W, Hutchinson, A, Wernimont, A, Walker, J.R, Sullivan, H, Lin, Y.-H, Mackenzie, F, Kozieradzki, I, Cossar, D, Schapira, M, Senisterra, G, Vedadi, M, Arrowsmith, C.H, Bountra, C, Weigelt, J, Edwards, A.M, Bochkarev, A, Hui, R, Amani, M, Structural Genomics Consortium (SGC)
Deposit date:2010-01-25
Release date:2010-02-02
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of full length CpCDPK3 (cgd5_820) in complex with Ca2+ and AMPPNP
To be Published
4PJJ
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BU of 4pjj by Molmil
MYOSIN VI (MD-INSERT2-CAM, DELTA-INSERT1) post-rigor state - long soaking with PO4
Descriptor: ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, Calmodulin, ...
Authors:Isabet, T, Benisty, H, Llinas, P, Sweeney, H.L, Houdusse, A.
Deposit date:2014-05-12
Release date:2015-04-29
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:How actin initiates the motor activity of Myosin.
Dev.Cell, 33, 2015

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數據於2024-07-24公開中

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