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8QTG
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BU of 8qtg by Molmil
Crystal structure of CBL-b in complex with an allosteric inhibitor (compound 9)
Descriptor: 3-[3-[3-methyl-1-(4-methyl-1,2,4-triazol-3-yl)cyclobutyl]phenyl]-5-(trifluoromethyl)-1~{H}-pyridin-2-one, E3 ubiquitin-protein ligase CBL-B, SODIUM ION, ...
Authors:Schimpl, M.
Deposit date:2023-10-12
Release date:2024-01-10
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.419 Å)
Cite:Discovery, Optimization, and Biological Evaluation of Arylpyridones as Cbl-b Inhibitors.
J.Med.Chem., 67, 2024
8QTH
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BU of 8qth by Molmil
Crystal structure of CBL-b in complex with an allosteric inhibitor (compound 8)
Descriptor: 1-methyl-5-[3-[3-methyl-1-(4-methyl-1,2,4-triazol-3-yl)cyclobutyl]phenyl]-3-(trifluoromethyl)-7H-pyrrolo[2,3-b]pyridin-6-one, E3 ubiquitin-protein ligase CBL-B, SODIUM ION, ...
Authors:Schimpl, M.
Deposit date:2023-10-12
Release date:2024-01-10
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.198 Å)
Cite:Discovery, Optimization, and Biological Evaluation of Arylpyridones as Cbl-b Inhibitors.
J.Med.Chem., 67, 2024
8QTJ
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BU of 8qtj by Molmil
Crystal structure of Cbl-b in complex with an allosteric inhibitor (compound 30)
Descriptor: 3-[3-[3-methyl-1-(4-methyl-1,2,4-triazol-3-yl)cyclobutyl]phenyl]-1-[(1~{R})-1-(1-methylpyrazol-4-yl)ethyl]-5-(trifluoromethyl)pyridin-2-one, E3 ubiquitin-protein ligase CBL-B, SODIUM ION, ...
Authors:Schimpl, M.
Deposit date:2023-10-12
Release date:2024-01-10
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.523 Å)
Cite:Discovery, Optimization, and Biological Evaluation of Arylpyridones as Cbl-b Inhibitors.
J.Med.Chem., 67, 2024
8QTK
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BU of 8qtk by Molmil
Crystal structure of CBL-b in complex with an allosteric inhibitor (compound 31)
Descriptor: 3-[3-[3-methyl-1-(4-methyl-1,2,4-triazol-3-yl)cyclobutyl]phenyl]-1-[(1S)-1-(1-methylpyrazol-4-yl)ethyl]-5-(trifluoromethyl)pyridin-2-one, E3 ubiquitin-protein ligase CBL-B, SODIUM ION, ...
Authors:Schimpl, M.
Deposit date:2023-10-12
Release date:2024-01-24
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.873 Å)
Cite:Discovery, Optimization, and Biological Evaluation of Arylpyridones as Cbl-b Inhibitors.
J.Med.Chem., 67, 2024
7BJD
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BU of 7bjd by Molmil
Crystal structure of CHK1-10pt-mutant complex with compound 3
Descriptor: 2-methyl-2-(3-methyl-4-{[4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}-1H-pyrazol-1-yl)propanenitrile, CHLORIDE ION, Serine/threonine-protein kinase Chk1
Authors:Dokurno, P, Surgenor, A.E, Williamson, D.S.
Deposit date:2021-01-14
Release date:2021-07-07
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2 Å)
Cite:Design and Synthesis of Pyrrolo[2,3- d ]pyrimidine-Derived Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Checkpoint Kinase 1 (CHK1)-Derived Crystallographic Surrogate.
J.Med.Chem., 64, 2021
7BJH
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BU of 7bjh by Molmil
Crystal structure of CHK1-10pt-mutant complex with compound 8
Descriptor: CHLORIDE ION, N,N-dimethyl-7H-purin-6-amine, Serine/threonine-protein kinase Chk1
Authors:Dokurno, P, Surgenor, A.E, Williamson, D.S.
Deposit date:2021-01-14
Release date:2021-07-07
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Design and Synthesis of Pyrrolo[2,3- d ]pyrimidine-Derived Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Checkpoint Kinase 1 (CHK1)-Derived Crystallographic Surrogate.
J.Med.Chem., 64, 2021
7BJM
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BU of 7bjm by Molmil
Crystal structure of CHK1-10pt-mutant complex with compound 10
Descriptor: 4-amino-6-{[(2-fluorophenyl)methyl]amino}-7-methyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile, Serine/threonine-protein kinase Chk1
Authors:Dokurno, P, Surgenor, A.E, Williamson, D.S.
Deposit date:2021-01-14
Release date:2021-07-07
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Design and Synthesis of Pyrrolo[2,3- d ]pyrimidine-Derived Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Checkpoint Kinase 1 (CHK1)-Derived Crystallographic Surrogate.
J.Med.Chem., 64, 2021
7BK3
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BU of 7bk3 by Molmil
Crystal structure of CHK1-10pt-mutant complex with compound 45
Descriptor: 4-amino-7-methyl-2-({5-methyl-1-[(3S)-oxolan-3-yl]-1H-pyrazol-4-yl}amino)-6-[(2R)-2-methylpyrrolidin-1-yl]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile, CHLORIDE ION, Serine/threonine-protein kinase Chk1
Authors:Dokurno, P, Surgenor, A.E, Williamson, D.S.
Deposit date:2021-01-15
Release date:2021-07-07
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2 Å)
Cite:Design and Synthesis of Pyrrolo[2,3- d ]pyrimidine-Derived Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Checkpoint Kinase 1 (CHK1)-Derived Crystallographic Surrogate.
J.Med.Chem., 64, 2021
7BJR
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BU of 7bjr by Molmil
Crystal structure of CHK1-10pt-mutant complex with compound 18
Descriptor: 4-amino-7-methyl-6-[(2R)-2-methylpyrrolidin-1-yl]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile, Serine/threonine-protein kinase Chk1
Authors:Dokurno, P, Surgenor, A.E, Williamson, D.S.
Deposit date:2021-01-14
Release date:2021-07-07
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Design and Synthesis of Pyrrolo[2,3- d ]pyrimidine-Derived Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Checkpoint Kinase 1 (CHK1)-Derived Crystallographic Surrogate.
J.Med.Chem., 64, 2021
7BKO
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BU of 7bko by Molmil
Crystal structure of CHK1 complex with compound 9
Descriptor: 1H-pyrazolo[3,4-d]pyrimidin-4-amine, Serine/threonine-protein kinase Chk1
Authors:Baker, L.M, Surgenor, A.E, Williamson, D.S.
Deposit date:2021-01-16
Release date:2021-07-07
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Design and Synthesis of Pyrrolo[2,3- d ]pyrimidine-Derived Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Checkpoint Kinase 1 (CHK1)-Derived Crystallographic Surrogate.
J.Med.Chem., 64, 2021
7BJX
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BU of 7bjx by Molmil
Crystal structure of CHK1-10pt-mutant complex with compound 26
Descriptor: 4-amino-7-methyl-2-[(1-methyl-1H-pyrazol-4-yl)amino]-6-[(2R)-2-methylpyrrolidin-1-yl]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile, Serine/threonine-protein kinase Chk1
Authors:Dokurno, P, Surgenor, A.E, Williamson, D.S.
Deposit date:2021-01-14
Release date:2021-07-07
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Design and Synthesis of Pyrrolo[2,3- d ]pyrimidine-Derived Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Checkpoint Kinase 1 (CHK1)-Derived Crystallographic Surrogate.
J.Med.Chem., 64, 2021
7BJJ
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BU of 7bjj by Molmil
Crystal structure of CHK1-10pt-mutant complex with compound 9
Descriptor: 1H-pyrazolo[3,4-d]pyrimidin-4-amine, CHLORIDE ION, Serine/threonine-protein kinase Chk1
Authors:Dokurno, P, Surgenor, A.E, Williamson, D.S.
Deposit date:2021-01-14
Release date:2021-07-07
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Design and Synthesis of Pyrrolo[2,3- d ]pyrimidine-Derived Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Checkpoint Kinase 1 (CHK1)-Derived Crystallographic Surrogate.
J.Med.Chem., 64, 2021
7BJO
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BU of 7bjo by Molmil
Crystal structure of CHK1-10pt-mutant complex with compound 13
Descriptor: 4-amino-6-(2,3-difluorophenyl)-7-methyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile, Serine/threonine-protein kinase Chk1
Authors:Dokurno, P, Surgenor, A.E, Williamson, D.S.
Deposit date:2021-01-14
Release date:2021-07-07
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Design and Synthesis of Pyrrolo[2,3- d ]pyrimidine-Derived Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Checkpoint Kinase 1 (CHK1)-Derived Crystallographic Surrogate.
J.Med.Chem., 64, 2021
7BJE
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BU of 7bje by Molmil
Crystal structure of CHK1-10pt-mutant complex with adenine
Descriptor: ADENINE, CHLORIDE ION, Serine/threonine-protein kinase Chk1
Authors:Dokurno, P, Surgenor, A.E, Williamson, D.S.
Deposit date:2021-01-14
Release date:2021-07-07
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Design and Synthesis of Pyrrolo[2,3- d ]pyrimidine-Derived Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Checkpoint Kinase 1 (CHK1)-Derived Crystallographic Surrogate.
J.Med.Chem., 64, 2021
7BK1
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BU of 7bk1 by Molmil
Crystal structure of CHK1-10pt-mutant complex with compound 32
Descriptor: 4-amino-2-[(1,3-dimethyl-1H-pyrazol-4-yl)amino]-7-methyl-6-[(2R)-2-methylpyrrolidin-1-yl]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile, CHLORIDE ION, Serine/threonine-protein kinase Chk1
Authors:Dokurno, P, Surgenor, A.E, Williamson, D.S.
Deposit date:2021-01-15
Release date:2021-07-07
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2 Å)
Cite:Design and Synthesis of Pyrrolo[2,3- d ]pyrimidine-Derived Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Checkpoint Kinase 1 (CHK1)-Derived Crystallographic Surrogate.
J.Med.Chem., 64, 2021
7BKN
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BU of 7bkn by Molmil
Crystal structure of CHK1 complex with adenine
Descriptor: ADENINE, SULFATE ION, Serine/threonine-protein kinase Chk1
Authors:Baker, L.M, Surgenor, A.E, Williamson, D.S.
Deposit date:2021-01-16
Release date:2021-07-07
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.74 Å)
Cite:Design and Synthesis of Pyrrolo[2,3- d ]pyrimidine-Derived Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Checkpoint Kinase 1 (CHK1)-Derived Crystallographic Surrogate.
J.Med.Chem., 64, 2021
7BK2
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BU of 7bk2 by Molmil
Crystal structure of CHK1-10pt-mutant complex with compound 44
Descriptor: 4-amino-7-methyl-2-({5-methyl-1-[(3R)-oxolan-3-yl]-1H-pyrazol-4-yl}amino)-6-[(2R)-2-methylpyrrolidin-1-yl]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile, CHLORIDE ION, Serine/threonine-protein kinase Chk1
Authors:Dokurno, P, Surgenor, A.E, Williamson, D.S.
Deposit date:2021-01-15
Release date:2021-07-07
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2 Å)
Cite:Design and Synthesis of Pyrrolo[2,3- d ]pyrimidine-Derived Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Checkpoint Kinase 1 (CHK1)-Derived Crystallographic Surrogate.
J.Med.Chem., 64, 2021
8AAK
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BU of 8aak by Molmil
Crystal structure of the PDZ tandem of syntenin in complex with compound 29
Descriptor: (2~{S})-2-[[(2~{S})-2-(3-oxidanylidene-1~{H}-isoindol-2-yl)-3-phenyl-propanoyl]amino]propanoic acid, GLYCEROL, Syntenin-1
Authors:Feracci, M, Barral, K.
Deposit date:2022-07-01
Release date:2023-04-26
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.554 Å)
Cite:Discovery of a PDZ Domain Inhibitor Targeting the Syndecan/Syntenin Protein-Protein Interaction: A Semi-Automated "Hit Identification-to-Optimization" Approach.
J.Med.Chem., 66, 2023
8AAP
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BU of 8aap by Molmil
Crystal structure of the PDZ tandem of syntenin in complex with compound SYNTi
Descriptor: (2S)-2-[[(2S)-2-(6-bromanyl-3-oxidanylidene-1H-isoindol-2-yl)-3-[4-(5-ethanoyl-2-fluoranyl-phenyl)phenyl]propanoyl]amino]propanoic acid, Syntenin-1
Authors:Feracci, M, Barral, K.
Deposit date:2022-07-01
Release date:2023-04-26
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.174 Å)
Cite:Discovery of a PDZ Domain Inhibitor Targeting the Syndecan/Syntenin Protein-Protein Interaction: A Semi-Automated "Hit Identification-to-Optimization" Approach.
J.Med.Chem., 66, 2023
8AAO
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BU of 8aao by Molmil
Crystal structure of the PDZ tandem of syntenin in complex with compound 95
Descriptor: (2~{S})-2-[[(2~{S})-3-[4-(5-ethanoyl-2-fluoranyl-phenyl)phenyl]-2-(3-oxidanylidene-1~{H}-isoindol-2-yl)propanoyl]amino]propanoic acid, Syntenin-1
Authors:Feracci, M, Barral, K.
Deposit date:2022-07-01
Release date:2023-04-26
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.469 Å)
Cite:Discovery of a PDZ Domain Inhibitor Targeting the Syndecan/Syntenin Protein-Protein Interaction: A Semi-Automated "Hit Identification-to-Optimization" Approach.
J.Med.Chem., 66, 2023
8AAI
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BU of 8aai by Molmil
Crystal structure of the PDZ tandem of syntenin in complex with fragment E5
Descriptor: (2~{S})-2-[[(2~{S})-3-methyl-2-(3-oxidanylidene-1~{H}-isoindol-2-yl)butanoyl]amino]propanoic acid, Syntenin-1
Authors:Feracci, M, Barral, K.
Deposit date:2022-07-01
Release date:2023-04-26
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.76 Å)
Cite:Discovery of a PDZ Domain Inhibitor Targeting the Syndecan/Syntenin Protein-Protein Interaction: A Semi-Automated "Hit Identification-to-Optimization" Approach.
J.Med.Chem., 66, 2023
7P58
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BU of 7p58 by Molmil
Pyrazole Carboxylic Acid Inhibitors of KEAP1:NRF2 interaction
Descriptor: 1-[6-(3-propan-2-yloxyphenyl)pyridin-2-yl]-5-(trifluoromethyl)pyrazole-4-carboxylic acid, CHLORIDE ION, DIMETHYL SULFOXIDE, ...
Authors:Davies, T.G.
Deposit date:2021-07-14
Release date:2021-11-17
Last modified:2024-06-19
Method:X-RAY DIFFRACTION (1.886 Å)
Cite:Fragment-Guided Discovery of Pyrazole Carboxylic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2 Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction.
J.Med.Chem., 64, 2021
7P5E
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BU of 7p5e by Molmil
Pyrazole Carboxylic Acid Inhibitors of KEAP1:NRF2 interaction
Descriptor: 1-[6-[3-(dimethylcarbamoyl)phenyl]pyridin-2-yl]-5-(trifluoromethyl)pyrazole-4-carboxylic acid, CHLORIDE ION, DIMETHYL SULFOXIDE, ...
Authors:Davies, T.G, Cleasby, A.
Deposit date:2021-07-14
Release date:2021-11-17
Last modified:2024-06-19
Method:X-RAY DIFFRACTION (1.874 Å)
Cite:Fragment-Guided Discovery of Pyrazole Carboxylic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2 Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction.
J.Med.Chem., 64, 2021
7P5P
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BU of 7p5p by Molmil
Pyrazole Carboxylic Acid Inhibitors of KEAP1:NRF2 interaction
Descriptor: 5-[(1~{R},2~{R})-2-(1-methyl-1,2,3-triazol-4-yl)cyclopropyl]-1-[3-[3-[(2~{R})-2-propylpiperidin-1-yl]carbonylphenyl]phenyl]pyrazole-4-carboxylic acid, CHLORIDE ION, Kelch-like ECH-associated protein 1, ...
Authors:Davies, T.G.
Deposit date:2021-07-14
Release date:2021-11-17
Last modified:2024-06-19
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Fragment-Guided Discovery of Pyrazole Carboxylic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2 Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction.
J.Med.Chem., 64, 2021
7P5I
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BU of 7p5i by Molmil
Pyrazole Carboxylic Acid Inhibitors of KEAP1:NRF2 interaction
Descriptor: 1-[3-[3-(dimethylcarbamoyl)phenyl]phenyl]-5-[(1~{R},2~{R})-2-(1-methyl-1,2,3-triazol-4-yl)cyclopropyl]pyrazole-4-carboxylic acid, CHLORIDE ION, Kelch-like ECH-associated protein 1, ...
Authors:Davies, T.G, Cleasby, A.
Deposit date:2021-07-14
Release date:2021-11-17
Last modified:2024-06-19
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Fragment-Guided Discovery of Pyrazole Carboxylic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2 Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction.
J.Med.Chem., 64, 2021

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數據於2024-07-17公開中

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