1EGU
 
 | | CRYSTAL STRUCTURE OF STREPTOCOCCUS PNEUMONIAE HYALURONATE LYASE AT 1.56 A RESOLUTION | | Descriptor: | HYALURONATE LYASE, SULFATE ION | | Authors: | Li, S, Kelly, S.J, Lamani, E, Ferraroni, M, Jedrzejas, M.J. | | Deposit date: | 2000-02-16 | | Release date: | 2001-02-16 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.56 Å) | | Cite: | Structural basis of hyaluronan degradation by Streptococcus pneumoniae hyaluronate lyase.
EMBO J., 19, 2000
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1EFR
 | | BOVINE MITOCHONDRIAL F1-ATPASE COMPLEXED WITH THE PEPTIDE ANTIBIOTIC EFRAPEPTIN | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BOVINE MITOCHONDRIAL F1-ATPASE SUBUNIT ALPHA, BOVINE MITOCHONDRIAL F1-ATPASE SUBUNIT BETA, ... | | Authors: | Abrahams, J.P, Buchanan, S.K, Van Raaij, M.J, Fearnley, I.M, Leslie, A.G.W, Walker, J.E. | | Deposit date: | 1996-05-24 | | Release date: | 1997-02-12 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | The Structure of Bovine F1-ATPase Complexed with the Peptide Antibiotic Efrapeptin.
Proc.Natl.Acad.Sci.USA, 93, 1996
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4WUV
 | | Crystal Structure of a putative D-Mannonate oxidoreductase from Haemophilus influenza (Avi_5165, TARGET EFI-513796) with bound NAD | | Descriptor: | 1,2-ETHANEDIOL, 2-hydroxycyclohexanecarboxyl-CoA dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | Authors: | Yadava, U, Vetting, M.W, Al Obaidi, N.F, Toro, R, Morisco, L.L, Benach, J, Wasserman, S.R, Attonito, J.D, Scott Glenn, A, Chamala, S, Chowdhury, S, Lafleur, J, Love, J, Seidel, R.D, Whalen, K.L, Gerlt, J.A, Almo, S.C. | | Deposit date: | 2014-11-03 | | Release date: | 2014-11-26 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (1.551 Å) | | Cite: | Crystal structure of a putative D-Mannonate oxidoreductase from Haemophilus influenza (Avi_5165, TARGET EFI-513796) with bound NAD
To be published
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9UMA
 | | CryoEM structure of T.thermophilus transcription initiation complex bound to Gp4A-C, -1 dA in the template DNA strand | | Descriptor: | CHAPSO, CYTIDINE-5'-MONOPHOSPHATE, DNA-directed RNA polymerase subunit alpha, ... | | Authors: | Duan, W, Kaushik, A, Serganov, A. | | Deposit date: | 2025-04-21 | | Release date: | 2025-10-22 | | Last modified: | 2025-10-29 | | Method: | ELECTRON MICROSCOPY (2.77 Å) | | Cite: | Molecular basis for noncanonical transcription initiation from Np 4 A alarmones.
Nat.Chem.Biol., 2025
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9YIC
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9WBT
 | | Crystal Structure of Escherichia coli GroEL with Magnesium Ions and a Phosphorylated Serine Residue-3.2A | | Descriptor: | BETA-MERCAPTOETHANOL, Chaperonin GroEL, HEXANE-1,6-DIOL, ... | | Authors: | Guo, Y, Zhang, L, Zheng, H, Li, J, Han, Q. | | Deposit date: | 2025-08-15 | | Release date: | 2025-09-03 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Crystal Structure of Escherichia coli GroEL with Magnesium Ions and a Phosphorylated Serine Residue
To Be Published
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1EJN
 | | UROKINASE PLASMINOGEN ACTIVATOR B-CHAIN INHIBITOR COMPLEX | | Descriptor: | N-(1-ADAMANTYL)-N'-(4-GUANIDINOBENZYL)UREA, SULFATE ION, UROKINASE-TYPE PLASMINOGEN ACTIVATOR | | Authors: | Sperl, S, Jacob, U, Arroyo de Prada, N, Stuerzebecher, J, Wilhelm, O.G, Bode, W, Magdolen, V, Huber, R, Moroder, L. | | Deposit date: | 2000-04-22 | | Release date: | 2000-05-17 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | (4-aminomethyl)phenylguanidine derivatives as nonpeptidic highly selective inhibitors of human urokinase.
Proc.Natl.Acad.Sci.USA, 97, 2000
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9VH0
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9OUC
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9OWG
 | | Crystal Structure of the Immunity Protein (52 domain-containing protein) from Pseudomonas aeruginosa PAO1. | | Descriptor: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CARBONATE ION, ... | | Authors: | Minasov, G, Wawrzak, Z, Skarina, T, Stogios, P.J, Savchenko, A, Satchell, K.F, Center for Structural Biology of Infectious Diseases (CSBID) | | Deposit date: | 2025-06-02 | | Release date: | 2025-06-18 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Crystal Structure of the Immunity Protein (52 domain-containing protein) from Pseudomonas aeruginosa PAO1.
To Be Published
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9RLM
 | | HUMAN CYCLOPHILIN D IN COMPLEX WITH INHIBITOR | | Descriptor: | Peptidyl-prolyl cis-trans isomerase F, mitochondrial, SULFATE ION, ... | | Authors: | Graedler, U. | | Deposit date: | 2025-06-17 | | Release date: | 2025-07-02 | | Method: | X-RAY DIFFRACTION (1.25 Å) | | Cite: | HUMAN CYCLOPHILIN D IN COMPLEX WITH INHIBITOR
To Be Published
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9UPT
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9PEC
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9PEB
 | | Cryo-EM structure of Arabidopsis thaliana Met1 | | Descriptor: | DNA (cytosine-5)-methyltransferase 1, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION | | Authors: | Lu, J, Chen, X, Song, J. | | Deposit date: | 2025-07-01 | | Release date: | 2025-10-22 | | Method: | ELECTRON MICROSCOPY (3.13 Å) | | Cite: | Structure and autoinhibitory regulation of MET1 in the maintenance of plant CG methylation.
Plant Cell, 2025
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9UKU
 | | CryoEM structure of the T.thermophilus transcription initiation complex bound to Gp4A-C, -1 dC in the template DNA strand | | Descriptor: | CHAPSO, CYTIDINE-5'-MONOPHOSPHATE, DNA-directed RNA polymerase subunit alpha, ... | | Authors: | Duan, W, Kaushik, A, Serganov, A. | | Deposit date: | 2025-04-18 | | Release date: | 2025-10-22 | | Last modified: | 2025-10-29 | | Method: | ELECTRON MICROSCOPY (2.73 Å) | | Cite: | Molecular basis for noncanonical transcription initiation from Np 4 A alarmones.
Nat.Chem.Biol., 2025
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9YON
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9QQX
 | | Crystal Structure of 54k bound to CK2a | | Descriptor: | 5-[2-[4-[[3-aminocarbonyl-5-(trifluoromethyloxy)phenyl]methylamino]butoxy]ethylamino]benzo[c][2,6]naphthyridine-8-carboxamide, ACETATE ION, Casein kinase II subunit alpha | | Authors: | Brear, P, Glossop, P, Pandey, S, Hyvonen, M, Spring, D, Butt, R, Cawkill, D. | | Deposit date: | 2025-04-02 | | Release date: | 2025-10-22 | | Last modified: | 2025-11-05 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Exploiting the Cryptic alpha D Pocket of Casein Kinase 2 alpha (CK2 alpha ) to Deliver Highly Potent and Selective Type 1 Inhibitors.
J.Med.Chem., 68, 2025
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9SA2
 | | The RING domain of IDOL | | Descriptor: | 1,2-ETHANEDIOL, E3 ubiquitin-protein ligase MYLIP, ZINC ION | | Authors: | Bradshaw, W.J, He, L, Guenther, F, Murphy, E.J. | | Deposit date: | 2025-08-07 | | Release date: | 2025-09-10 | | Method: | X-RAY DIFFRACTION (1.1 Å) | | Cite: | The RING domain of IDOL
To Be Published
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9V4J
 | | Prenyltransferase Ord1 Wild type-FSPP | | Descriptor: | 1,2-ETHANEDIOL, MAGNESIUM ION, S-[(2E,6E)-3,7,11-TRIMETHYLDODECA-2,6,10-TRIENYL] TRIHYDROGEN THIODIPHOSPHATE, ... | | Authors: | Oshiro, T, Uehara, S, Ito, T, Tanaka, Y, Kodera, Y, Matsui, T. | | Deposit date: | 2025-05-23 | | Release date: | 2025-10-01 | | Last modified: | 2025-10-22 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structure-Activity Relationship of an All-alpha-helical Prenyltransferase Reveals the Mechanism of Indole Prenylation.
Biochemistry, 64, 2025
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9R9J
 | | IRAK4 in complex with inhibitor | | Descriptor: | Interleukin-1 receptor-associated kinase 4, ~{N}-[2-(3-methyl-3-oxidanyl-butyl)-6-(2-oxidanylpropan-2-yl)indazol-5-yl]-1-(2-methylpyridin-4-yl)pyrazole-3-carboxamide | | Authors: | Xue, Y, Terstiege, I, Aagaard, A. | | Deposit date: | 2025-05-20 | | Release date: | 2025-10-01 | | Method: | X-RAY DIFFRACTION (2.39 Å) | | Cite: | Generation of a potent & selective series of IRAK4 inhibitors based on a structure based, hybridization approach.
Bioorg.Med.Chem., 131, 2025
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9RS2
 | | Sesterterpene Synthase from Kitasatospora viridis in complex with the surrogate GFSPP | | Descriptor: | 1,2-ETHANEDIOL, GLYCEROL, MAGNESIUM ION, ... | | Authors: | Li, H, Troycke, P, Yin, Z, Groll, M, Dickschat, J.S. | | Deposit date: | 2025-06-30 | | Release date: | 2025-09-24 | | Last modified: | 2025-10-08 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structure-Guided Engineering of a Bacterial Sesterterpene Synthase for Sesterviridene Diversification.
J.Am.Chem.Soc., 147, 2025
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9RFE
 | | Human ADP-ribosylhydrolase 3 (ARH3) in complex with an inhibitor | | Descriptor: | 2-[(2~{E})-2-[1-(4-aminophenyl)ethylidene]hydrazinyl]-6-methyl-1~{H}-pyrimidin-4-one, ACETIC ACID, ADP-ribosylhydrolase ARH3, ... | | Authors: | Paakkonen, J, Lehtio, L. | | Deposit date: | 2025-06-04 | | Release date: | 2025-09-24 | | Last modified: | 2025-10-29 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Discovery and Structural Optimization of 2-Hydrazinopyrimidin-4-one Analogs Inhibiting Human ADP-Ribosylhydrolase ARH3.
Acs Chem.Biol., 20, 2025
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9QY7
 | | Crystal Structure of 54e bound to CK2a | | Descriptor: | 5-[2-[4-[[3-chloranyl-4-(trifluoromethyloxy)phenyl]methylamino]butoxy]ethylamino]benzo[c][2,6]naphthyridine-8-carboxamide, ACETATE ION, Casein kinase II subunit alpha | | Authors: | Brear, P, Glossop, P, Pandey, S, Hyvonen, M, Spring, D, Butt, R, Cawkill, D. | | Deposit date: | 2025-04-17 | | Release date: | 2025-10-22 | | Last modified: | 2025-11-05 | | Method: | X-RAY DIFFRACTION (1.39 Å) | | Cite: | Exploiting the Cryptic alpha D Pocket of Casein Kinase 2 alpha (CK2 alpha ) to Deliver Highly Potent and Selective Type 1 Inhibitors.
J.Med.Chem., 68, 2025
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9RV5
 | | Crystal structure of SPSB2 SPRY domain in complex with linear TAT peptide | | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, SPRY domain-containing SOCS box protein 2, ... | | Authors: | Lenz, C, Knapp, S, Kraemer, A, Structural Genomics Consortium (SGC) | | Deposit date: | 2025-07-07 | | Release date: | 2025-08-06 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Crystal structure of SPSB2 SPRY domain in complex with linear TAT peptide
To Be Published
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9R73
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