7KOP
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![BU of 7kop by Molmil](/molmil-images/mine/7kop) | The crystal structure of the 2009/H1N1/California PA endonuclease I38T mutant in complex with SJ000988539 | Descriptor: | 2-(2-fluorophenyl)-5-hydroxy-N-[2-(2-methoxypyridin-4-yl)ethyl]-6-oxo-1,6-dihydropyrimidine-4-carboxamide, Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, ... | Authors: | Cuypers, M.G, Slavish, P.J, Seetharaman, J, White, S.W. | Deposit date: | 2020-11-09 | Release date: | 2021-11-10 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.33 Å) | Cite: | The crystal structure of the 2009/H1N1/California PA endonuclease I38T mutant in complex with SJ000988539 To Be Published
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3C5G
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![BU of 3c5g by Molmil](/molmil-images/mine/3c5g) | Structure of a ternary complex of the R517K Pol lambda mutant | Descriptor: | 1,2-ETHANEDIOL, 2',3'-DIDEOXY-THYMIDINE-5'-TRIPHOSPHATE, DNA (5'-D(*DCP*DAP*DGP*DTP*DAP*(2DT))-3'), ... | Authors: | Garcia-Diaz, M, Bebenek, K, Foley, M.C, Pedersen, L.C, Schlick, T, Kunkel, T.A. | Deposit date: | 2008-01-31 | Release date: | 2008-07-29 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Substrate-induced DNA strand misalignment during catalytic cycling by DNA polymerase lambda. Embo Rep., 9, 2008
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7QH5
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8B67
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![BU of 8b67 by Molmil](/molmil-images/mine/8b67) | |
8B6K
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![BU of 8b6k by Molmil](/molmil-images/mine/8b6k) | |
8B76
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![BU of 8b76 by Molmil](/molmil-images/mine/8b76) | |
4H62
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![BU of 4h62 by Molmil](/molmil-images/mine/4h62) | Structure of the Saccharomyces cerevisiae Mediator subcomplex Med17C/Med11C/Med22C | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Mediator of RNA polymerase II transcription subunit 11, Mediator of RNA polymerase II transcription subunit 17, ... | Authors: | Lariviere, L, Plaschka, C, Seizl, M, Wenzeck, L, Kurth, F, Cramer, P. | Deposit date: | 2012-09-19 | Release date: | 2012-10-31 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structure of the Mediator head module. Nature, 492, 2012
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2HZM
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![BU of 2hzm by Molmil](/molmil-images/mine/2hzm) | Structure of the Mediator head subcomplex Med18/20 | Descriptor: | PHOSPHATE ION, RNA polymerase II mediator complex subunit 18, RNA polymerase II mediator complex subunit 20 | Authors: | Lariviere, L, Geiger, S, Hoeppner, S, Rother, S, Straesser, K, Cramer, P. | Deposit date: | 2006-08-09 | Release date: | 2006-09-12 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure and TBP binding of the Mediator head subcomplex Med8-Med18-Med20. Nat.Struct.Mol.Biol., 13, 2006
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3RJ1
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![BU of 3rj1 by Molmil](/molmil-images/mine/3rj1) | Architecture of the Mediator Head module | Descriptor: | Mediator of RNA polymerase II transcription subunit 11, Mediator of RNA polymerase II transcription subunit 17, Mediator of RNA polymerase II transcription subunit 18, ... | Authors: | Imasaki, T, Calero, G, Cai, G, Tsai, K.L, Yamada, K, Cardelli, F, Erdjument-Bromage, H, Tempst, P, Berger, I, Kornberg, G.L, Asturias, F.J, Kornberg, R.D, Takagi, Y. | Deposit date: | 2011-04-14 | Release date: | 2011-07-27 | Last modified: | 2017-08-02 | Method: | X-RAY DIFFRACTION (4.3 Å) | Cite: | Architecture of the Mediator head module. Nature, 475, 2011
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6IN7
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![BU of 6in7 by Molmil](/molmil-images/mine/6in7) | Crystal structure of AlgU in complex with MucA(cyto) | Descriptor: | NICOTINAMIDE, RNA polymerase sigma-H factor, Sigma factor AlgU negative regulatory protein | Authors: | Li, S, Zhang, Q, Bartlam, M. | Deposit date: | 2018-10-24 | Release date: | 2019-07-24 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.96 Å) | Cite: | Structural basis for the recognition of MucA by MucB and AlgU in Pseudomonas aeruginosa. Febs J., 286, 2019
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4G8X
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![BU of 4g8x by Molmil](/molmil-images/mine/4g8x) | G1 ORF67 / Staphyloccus aureus sigmaA domain 4 complex | Descriptor: | ORF067, RNA polymerase sigma factor rpoD | Authors: | Darst, S.A, Osmundson, J.S, Montero-Diaz, C.M, Hochschild, A. | Deposit date: | 2012-07-23 | Release date: | 2013-08-07 | Method: | X-RAY DIFFRACTION (3.001 Å) | Cite: | Promoter-specific transcription inhibition in Staphylococcus aureus by a phage protein. Cell(Cambridge,Mass.), 151, 2012
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4G6D
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4G94
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![BU of 4g94 by Molmil](/molmil-images/mine/4g94) | G1 ORF67 / Staphyloccus aureus sigmaA domain 4 complex | Descriptor: | ORF067, RNA polymerase sigma factor rpoD | Authors: | Darst, S.A, Osmundson, J.S, Montero-Diaz, C.M, Hochschild, A. | Deposit date: | 2012-07-23 | Release date: | 2013-01-23 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.9971 Å) | Cite: | Promoter-specific transcription inhibition in Staphylococcus aureus by a phage protein. Cell(Cambridge,Mass.), 151, 2012
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5YIX
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![BU of 5yix by Molmil](/molmil-images/mine/5yix) | Caulobacter crescentus GcrA sigma-interacting domain (SID) in complex with domain 2 of sigma 70 | Descriptor: | (R,R)-2,3-BUTANEDIOL, Cell cycle regulatory protein GcrA, RNA polymerase sigma factor RpoD, ... | Authors: | Wu, X, Zhang, Y. | Deposit date: | 2017-10-06 | Release date: | 2018-03-21 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.302 Å) | Cite: | Structural insights into the unique mechanism of transcription activation by Caulobacter crescentus GcrA. Nucleic Acids Res., 46, 2018
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4BDP
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![BU of 4bdp by Molmil](/molmil-images/mine/4bdp) | CRYSTAL STRUCTURE OF BACILLUS DNA POLYMERASE I FRAGMENT COMPLEXED TO 11 BASE PAIRS OF DUPLEX DNA AFTER ADDITION OF TWO DATP RESIDUES | Descriptor: | DNA (5'-D(*GP*CP*AP*TP*CP*AP*TP*GP*CP*AP*A)-3'), DNA (5'-D(*TP*AP*TP*TP*GP*CP*AP*TP*GP*AP*TP*GP*C)-3'), MAGNESIUM ION, ... | Authors: | Kiefer, J.R, Mao, C, Beese, L.S. | Deposit date: | 1997-11-17 | Release date: | 1999-01-13 | Last modified: | 2023-08-02 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Visualizing DNA replication in a catalytically active Bacillus DNA polymerase crystal. Nature, 391, 1998
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4JVQ
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![BU of 4jvq by Molmil](/molmil-images/mine/4jvq) | Crystal structure of hcv ns5b polymerase in complex with compound 9 | Descriptor: | 5-{4-[(4-methoxybenzoyl)amino]phenoxy}-2-{[(trans-4-methylcyclohexyl)carbonyl](propan-2-yl)amino}benzoic acid, GLYCEROL, Genome polyprotein, ... | Authors: | Coulombe, R. | Deposit date: | 2013-03-26 | Release date: | 2014-02-05 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Enantiomeric Atropisomers Inhibit HCV Polymerase and/or HIV Matrix: Characterizing Hindered Bond Rotations and Target Selectivity. J.Med.Chem., 57, 2014
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2C2R
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![BU of 2c2r by Molmil](/molmil-images/mine/2c2r) | Efficient and High Fidelity Incorporation of dCTP Opposite 7,8- Dihydro-8-oxodeoxyguanosine by Sulfolobus solfataricus DNA Polymerase Dpo4 | Descriptor: | 2',3'-DIDEOXYCYTIDINE 5'-TRIPHOSPHATE, 5'-D(*GP*GP*GP*GP*GP*AP*AP*GP*GP*AP *TP*TP*C)-3', 5'-D(*TP*CP*AP*C 8OGP*GP*AP*AP*TP*CP*CP *TP*TP*CP*CP*CP*CP*C)-3', ... | Authors: | Irimia, A, Loukachevitch, L.V, Egli, M. | Deposit date: | 2005-09-29 | Release date: | 2005-11-29 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Efficient and High Fidelity Incorporation of Dctp Opposite 7,8-Dihydro-8-Oxodeoxyguanosine by Sulfolobus Solfataricus DNA Polymerase Dpo4 J.Biol.Chem., 281, 2006
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3BDP
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![BU of 3bdp by Molmil](/molmil-images/mine/3bdp) | DNA POLYMERASE I/DNA COMPLEX | Descriptor: | DNA (5'-D(*AP*GP*CP*AP*TP*CP*AP*TP*GP*C)-3'), DNA (5'-D(*GP*CP*AP*TP*GP*AP*TP*GP*CP*2DT)-3'), PROTEIN (DNA POLYMERASE I), ... | Authors: | Kiefer, J.R, Mao, C, Beese, L.S. | Deposit date: | 1997-11-17 | Release date: | 1999-01-13 | Last modified: | 2023-08-02 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Visualizing DNA replication in a catalytically active Bacillus DNA polymerase crystal. Nature, 391, 1998
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1D9D
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![BU of 1d9d by Molmil](/molmil-images/mine/1d9d) | CRYSTALL STRUCTURE OF THE COMPLEX OF DNA POLYMERASE I KLENOW FRAGMENT WITH SHORT DNA FRAGMENT CARRYING 2'-0-AMINOPROPYL-RNA MODIFICATIONS 5'-D(TCG)-AP(AUC)-3' | Descriptor: | 5'-D(*TP*CP*GP)-R(AP*(U31)P*(C31))-3', DNA POLYMERASE I, MAGNESIUM ION, ... | Authors: | Teplova, M, Wallace, S.T, Tereshko, V, Minasov, G, Simons, A.M, Cook, P.D, Manoharan, M, Egli, M. | Deposit date: | 1999-10-27 | Release date: | 1999-12-02 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.18 Å) | Cite: | Structural origins of the exonuclease resistance of a zwitterionic RNA. Proc.Natl.Acad.Sci.USA, 96, 1999
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6BJY
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![BU of 6bjy by Molmil](/molmil-images/mine/6bjy) | VSV Nucleocapsid with Polyamide Bound | Descriptor: | 4-{[4-(acetylamino)-1-methyl-1H-pyrrole-2-carbonyl]amino}-1-methyl-N-{4-[(1-methyl-1H-pyrrol-3-yl)amino]-4-oxobutyl}-1H-imidazole-2-carboxamide, Nucleoprotein, RNA (45-MER), ... | Authors: | Gumpper, R.H, Luo, M. | Deposit date: | 2017-11-07 | Release date: | 2018-02-28 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.46 Å) | Cite: | A Polyamide Inhibits Replication of Vesicular Stomatitis Virus by Targeting RNA in the Nucleocapsid. J. Virol., 92, 2018
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4H5P
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1D8Y
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![BU of 1d8y by Molmil](/molmil-images/mine/1d8y) | CRYSTAL STRUCTURE OF THE COMPLEX OF DNA POLYMERASE I KLENOW FRAGMENT WITH DNA | Descriptor: | D(T)19 OLIGOMER, DNA POLYMERASE I, SULFATE ION, ... | Authors: | Teplova, M, Wallace, S.T, Tereshko, V, Minasov, G, Simons, A.M, Cook, P.D, Manoharan, M, Egli, M. | Deposit date: | 1999-10-26 | Release date: | 1999-12-02 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.08 Å) | Cite: | Structural origins of the exonuclease resistance of a zwitterionic RNA. Proc.Natl.Acad.Sci.USA, 96, 1999
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4J02
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![BU of 4j02 by Molmil](/molmil-images/mine/4j02) | Crystal structure of hcv ns5b polymerase in complex with [(1R)-5,8-DICHLORO-1-PROPYL-1,3,4,9-TETRAHYDROPYRANO[3,4-B]INDOL-1-YL]ACETIC ACID | Descriptor: | Genome polyprotein, SODIUM ION, SULFATE ION, ... | Authors: | Coulombe, R. | Deposit date: | 2013-01-30 | Release date: | 2013-04-17 | Last modified: | 2013-05-01 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Discovery of a novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors. Bioorg.Med.Chem.Lett., 23, 2013
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4J06
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4J08
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