3APX
| Crystal structure of the A variant of human alpha1-acid glycoprotein and chlorpromazine complex | Descriptor: | 3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-amine, ACETIC ACID, Alpha-1-acid glycoprotein 2 | Authors: | Nishi, K, Ono, T, Nakamura, T, Fukunaga, N, Izumi, M, Watanabe, H, Suenaga, A, Maruyama, T, Yamagata, Y, Curry, S, Otagiri, M. | Deposit date: | 2010-10-21 | Release date: | 2011-02-23 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural insights into differences in drug-binding selectivity between two forms of human alpha1-acid glycoprotein genetic variants, the A and F1*S forms. J. Biol. Chem., 286, 2011
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1C9C
| ASPARTATE AMINOTRANSFERASE COMPLEXED WITH C3-PYRIDOXAL-5'-PHOSPHATE | Descriptor: | ALANYL-PYRIDOXAL-5'-PHOSPHATE, ASPARTATE AMINOTRANSFERASE | Authors: | Ishijima, J, Nakai, T, Kawaguchi, S, Hirotsu, K, Kuramitsu, S. | Deposit date: | 1999-08-02 | Release date: | 2000-12-20 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Free energy requirement for domain movement of an enzyme J.Biol.Chem., 275, 2000
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1CQ6
| ASPARTATE AMINOTRANSFERASE COMPLEX WITH C4-PYRIDOXAL-5P-PHOSPHATE | Descriptor: | 2-[O-PHOSPHONOPYRIDOXYL]-AMINO- BUTYRIC ACID, ASPARTATE AMINOTRANSFERASE | Authors: | Ishijima, J, Nakai, T, Kawaguchi, S, Hirotsu, K, Kuramitsu, S. | Deposit date: | 1999-08-06 | Release date: | 2000-12-20 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Free energy requirement for domain movement of an enzyme J.Biol.Chem., 275, 2000
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3BCK
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3BK9
| H55A mutant of tryptophan 2,3-dioxygenase from Xanthomonas campestris | Descriptor: | PROTOPORPHYRIN IX CONTAINING FE, TRYPTOPHAN, Tryptophan 2,3-dioxygenase | Authors: | Bruckmann, C, Mowat, C.G. | Deposit date: | 2007-12-06 | Release date: | 2008-09-30 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Histidine 55 of tryptophan 2,3-dioxygenase is not an active site base but regulates catalysis by controlling substrate binding Biochemistry, 47, 2008
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1CQ7
| ASPARTATE AMINOTRANSFERASE (E.C. 2.6.1.1) COMPLEXED WITH C5-PYRIDOXAL-5P-PHOSPHATE | Descriptor: | 2-[O-PHOSPHONOPYRIDOXYL]-AMINO-PENTANOIC ACID, ASPARTATE AMINOTRANSFERASE | Authors: | Ishijima, J, Nakai, T, Kawaguchi, S, Hirotsu, K, Kuramitsu, S. | Deposit date: | 1999-08-06 | Release date: | 2000-12-20 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Free energy requirement for domain movement of an enzyme J.Biol.Chem., 275, 2000
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2ZNS
| Crystal structure of the ligand-binding core of the human ionotropic glutamate receptor, GluR5, in complex with glutamate | Descriptor: | GLUTAMIC ACID, Glutamate receptor, ionotropic kainate 1 | Authors: | Unno, M, Sasaki, M, Ikeda-Saito, M. | Deposit date: | 2008-05-01 | Release date: | 2009-05-05 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Binding and Selectivity of the Marine Toxin Neodysiherbaine A and Its Synthetic Analogues to GluK1 and GluK2 Kainate Receptors. J.Mol.Biol., 413, 2011
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2ZNU
| Crystal structure of the ligand-binding core of the human ionotropic glutamate receptor, GluR5, in complex with a novel selective agonist, neodysiherbaine A | Descriptor: | (2R,3aR,6R,7R,7aR)-2-[(2S)-2-amino-2-carboxyethyl]-6,7-dihydroxyhexahydro-2H-furo[3,2-b]pyran-2-carboxylic acid, BETA-MERCAPTOETHANOL, Glutamate receptor, ... | Authors: | Unno, M, Sasaki, M, Ikeda-Saito, M. | Deposit date: | 2008-05-01 | Release date: | 2009-05-05 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Binding and Selectivity of the Marine Toxin Neodysiherbaine A and Its Synthetic Analogues to GluK1 and GluK2 Kainate Receptors. J.Mol.Biol., 413, 2011
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3BCI
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3BD2
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1TK7
| NMR structure of WW domains (WW3-4) from Suppressor of Deltex | Descriptor: | CG4244-PB | Authors: | Fedoroff, O.Y, Avis, J.M, Golovanov, A.P, Baron, M, Townson, S.A. | Deposit date: | 2004-06-08 | Release date: | 2004-07-20 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | The structure and dynamics of tandem WW domains in a negative regulator of notch signaling, Suppressor of deltex J.Biol.Chem., 279, 2004
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1DF6
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2ZNT
| Crystal structure of the ligand-binding core of the human ionotropic glutamate receptor, GluR5, in complex with a novel selective agonist, dysiherbaine | Descriptor: | (2R,3aR,6S,7R,7aR)-2-[(2S)-2-amino-2-carboxyethyl]-6-hydroxy-7-(methylamino)hexahydro-2H-furo[3,2-b]pyran-2-carboxylic acid, BETA-MERCAPTOETHANOL, Glutamate receptor, ... | Authors: | Unno, M, Sasaki, M, Ikeda-Saito, M. | Deposit date: | 2008-05-01 | Release date: | 2009-05-05 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Binding and Selectivity of the Marine Toxin Neodysiherbaine A and Its Synthetic Analogues to GluK1 and GluK2 Kainate Receptors. J.Mol.Biol., 413, 2011
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3CEB
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1CQ8
| ASPARTATE AMINOTRANSFERASE (E.C. 2.6.1.1) COMPLEXED WITH C6-PYRIDOXAL-5P-PHOSPHATE | Descriptor: | 2-[O-PHOSPHONOPYRIDOXYL]-AMINO-HEXANOIC ACID, ASPARTATE AMINOTRANSFERASE (2.6.1.1) | Authors: | Ishijima, J, Nakai, T, Kawaguchi, S, Hirotsu, K, Kuramitsu, S. | Deposit date: | 1999-08-06 | Release date: | 2000-12-20 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Free energy requirement for domain movement of an enzyme J.Biol.Chem., 275, 2000
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1TN5
| Structure of bacterorhodopsin mutant K41P | Descriptor: | Bacteriorhodopsin, RETINAL | Authors: | Yohannan, S, Yang, D, Faham, S, Boulting, G, Whitelegge, J, Bowie, J.U. | Deposit date: | 2004-06-11 | Release date: | 2004-10-19 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Proline substitutions are not easily accommodated in a membrane protein J.Mol.Biol., 341, 2004
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1TMY
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1TN0
| Structure of bacterorhodopsin mutant A51P | Descriptor: | Bacteriorhodopsin, RETINAL | Authors: | Yohannan, S, Yang, D, Faham, S, Boulting, G, Whitelegge, J, Bowie, J.U. | Deposit date: | 2004-06-11 | Release date: | 2004-10-12 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Proline substitutions are not easily accommodated in a membrane protein J.Mol.Biol., 341, 2004
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1ARH
| ASPARTATE AMINOTRANSFERASE, Y225R/R386A MUTANT | Descriptor: | 2-[(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYLENE)-AMINO]-SUCCINIC ACID, ASPARTATE AMINOTRANSFERASE | Authors: | Malashkevich, V.N, Jansonius, J.N. | Deposit date: | 1995-08-23 | Release date: | 1995-11-14 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Changing the reaction specificity of a pyridoxal-5'-phosphate-dependent enzyme. Eur.J.Biochem., 232, 1995
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1ARG
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2YV7
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8HXP
| Crystal structure of B1 VIM-2 MBL in complex with 2-amino-5-(but-3-en-1-yl)thiazole-4-carboxylic acid | Descriptor: | 2-azanyl-5-but-3-enyl-1,3-thiazole-4-carboxylic acid, Beta-lactamase class B VIM-2, ZINC ION | Authors: | Yan, Y.-H, Zhu, K.-R, Li, G.-B. | Deposit date: | 2023-01-05 | Release date: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.94 Å) | Cite: | Discovery of 2-Aminothiazole-4-carboxylic Acids as Broad-Spectrum Metallo-beta-lactamase Inhibitors by Mimicking Carbapenem Hydrolysate Binding. J.Med.Chem., 66, 2023
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8HXN
| Crystal structure of B2 Sfh-I MBL in complex with 2-amino-5-(4-(but-3-en-1-yloxy)benzyl)thiazole-4-carboxylic acid | Descriptor: | 2-azanyl-5-[(4-but-3-enoxyphenyl)methyl]-1,3-thiazole-4-carboxylic acid, Beta-lactamase, ETHANOL, ... | Authors: | Yan, Y.-H, Zhu, K.-R, Li, G.-B. | Deposit date: | 2023-01-05 | Release date: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Discovery of 2-Aminothiazole-4-carboxylic Acids as Broad-Spectrum Metallo-beta-lactamase Inhibitors by Mimicking Carbapenem Hydrolysate Binding. J.Med.Chem., 66, 2023
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8HXO
| Crystal structure of B1 VIM-2 MBL in complex with 2-amino-5-isobutylthiazole-4-carboxylic acid | Descriptor: | 2-azanyl-5-(2-methylpropyl)-1,3-thiazole-4-carboxylic acid, Beta-lactamase class B VIM-2, GLYCEROL, ... | Authors: | Yan, Y.-H, Zhu, K.-R, Li, G.-B. | Deposit date: | 2023-01-05 | Release date: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.902 Å) | Cite: | Discovery of 2-Aminothiazole-4-carboxylic Acids as Broad-Spectrum Metallo-beta-lactamase Inhibitors by Mimicking Carbapenem Hydrolysate Binding. J.Med.Chem., 66, 2023
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8HXU
| Crystal structure of B1 VIM-2 MBL in complex with 2-amino-5-pentylthiazole-4-carboxylic acid | Descriptor: | 2-azanyl-5-pentyl-1,3-thiazole-4-carboxylic acid, Beta-lactamase class B VIM-2, FORMIC ACID, ... | Authors: | Yan, Y.-H, Zhu, K.-R, Li, G.-B. | Deposit date: | 2023-01-05 | Release date: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.945 Å) | Cite: | Discovery of 2-Aminothiazole-4-carboxylic Acids as Broad-Spectrum Metallo-beta-lactamase Inhibitors by Mimicking Carbapenem Hydrolysate Binding. J.Med.Chem., 66, 2023
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