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1DLR	METHOTREXATE-RESISTANT VARIANTS OF HUMAN DIHYDROFOLATE REDUCTASE WITH SUBSTITUTION OF LEUCINE 22: KINETICS, CRYSTALLOGRAPHY AND POTENTIAL AS SELECTABLE MARKERS Descriptor: 6-(2,5-DIMETHOXY-BENZYL)-5-METHYL-PYRIDO[2,3-D]PYRIMIDINE-2,4-DIAMINE, DIHYDROFOLATE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Cody, V, Galitsky, N, Luft, J.R, Pangborn, W. Deposit date: 1995-01-25 Release date: 1995-04-20 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Methotrexate-resistant variants of human dihydrofolate reductase with substitutions of leucine 22. Kinetics, crystallography, and potential as selectable markers. J.Biol.Chem., 270, 1995
1DLS	METHOTREXATE-RESISTANT VARIANTS OF HUMAN DIHYDROFOLATE REDUCTASE WITH SUBSTITUTION OF LEUCINE 22: KINETICS, CRYSTALLOGRAPHY AND POTENTIAL AS SELECTABLE MARKERS Descriptor: DIHYDROFOLATE REDUCTASE, METHOTREXATE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Cody, V, Galitsky, N, Luft, J.R, Pangborn, W. Deposit date: 1995-01-25 Release date: 1995-04-20 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Methotrexate-resistant variants of human dihydrofolate reductase with substitutions of leucine 22. Kinetics, crystallography, and potential as selectable markers. J.Biol.Chem., 270, 1995
1LPP	ANALOGS OF REACTION INTERMEDIATES IDENTIFY A UNIQUE SUBSTRATE BINDING SITE IN CANDIDA RUGOSA LIPASE Descriptor: 1-HEXADECANOSULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Grochulski, P.G, Cygler, M.C. Deposit date: 1995-01-17 Release date: 1995-04-20 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (2.18 Å) Cite: Analogs of reaction intermediates identify a unique substrate binding site in Candida rugosa lipase. Biochemistry, 33, 1994
1LPO	ANALOGS OF REACTION INTERMEDIATES IDENTIFY A UNIQUE SUBSTRATE BINDING SITE IN CANDIDA RUGOSA LIPASE Descriptor: 1-HEXADECANOSULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Grochulski, P.G, Cygler, M.C. Deposit date: 1995-01-13 Release date: 1995-04-20 Last modified: 2024-10-09 Method: X-RAY DIFFRACTION (2.18 Å) Cite: Analogs of reaction intermediates identify a unique substrate binding site in Candida rugosa lipase. Biochemistry, 33, 1994
1AOR	STRUCTURE OF A HYPERTHERMOPHILIC TUNGSTOPTERIN ENZYME, ALDEHYDE FERREDOXIN OXIDOREDUCTASE Descriptor: ALDEHYDE FERREDOXIN OXIDOREDUCTASE, FE (III) ION, IRON/SULFUR CLUSTER, ... Authors: Chan, M.K, Mukund, S, Kletzin, A, Adams, M.W.W, Rees, D.C. Deposit date: 1995-02-13 Release date: 1995-04-20 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structure of a hyperthermophilic tungstopterin enzyme, aldehyde ferredoxin oxidoreductase. Science, 267, 1995
1TNM	TERTIARY STRUCTURE OF AN IMMUNOGLOBULIN-LIKE DOMAIN FROM THE GIANT MUSCLE PROTEIN TITIN: A NEW MEMBER OF THE I SET Descriptor: TITIN MODULE M5 Authors: Pfuhl, M, Pastore, A. Deposit date: 1995-01-17 Release date: 1995-04-20 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: Tertiary structure of an immunoglobulin-like domain from the giant muscle protein titin: a new member of the I set. Structure, 3, 1995
1ALF	CONFORMATION OF TWO PEPTIDES CORRESPONDING TO HUMAN APOLIPOPROTEIN C-I RESIDUES 7-24 AND 35-53 IN THE PRESENCE OF SODIUM DODECYLSULFATE BY CD AND NMR SPECTROSCOPY Descriptor: APOLIPOPROTEIN C-I PRECURSOR Authors: Rozek, A, Buchko, G.W, Cushley, R.J. Deposit date: 1995-02-20 Release date: 1995-04-20 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: Conformation of two peptides corresponding to human apolipoprotein C-I residues 7-24 and 35-53 in the presence of sodium dodecyl sulfate by CD and NMR spectroscopy. Biochemistry, 34, 1995
2CND	STRUCTURAL STUDIES ON CORN NITRATE REDUCTASE: REFINED STRUCTURE OF THE CYTOCHROME B REDUCTASE FRAGMENT AT 2.5 ANGSTROMS, ITS ADP COMPLEX AND AN ACTIVE SITE MUTANT AND MODELING OF THE CYTOCHROME B DOMAIN Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, NADH-DEPENDENT NITRATE REDUCTASE Authors: Lu, G, Lindqvist, Y, Schneider, G. Deposit date: 1995-02-01 Release date: 1995-04-20 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structural studies on corn nitrate reductase: refined structure of the cytochrome b reductase fragment at 2.5 A, its ADP complex and an active-site mutant and modeling of the cytochrome b domain. J.Mol.Biol., 248, 1995
1ANG	CRYSTAL STRUCTURE OF HUMAN ANGIOGENIN REVEALS THE STRUCTURAL BASIS FOR ITS FUNCTIONAL DIVERGENCE FROM RIBONUCLEASE Descriptor: ANGIOGENIN Authors: Acharya, K.R, Allen, S, Shapiro, R, Riordan, J.F, Vallee, B.L. Deposit date: 1994-01-18 Release date: 1995-04-20 Last modified: 2024-10-09 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Crystal structure of human angiogenin reveals the structural basis for its functional divergence from ribonuclease. Proc.Natl.Acad.Sci.USA, 91, 1994
1LPM	A STRUCTURAL BASIS FOR THE CHIRAL PREFERENCES OF LIPASES Descriptor: (1R)-MENTHYL HEXYL PHOSPHONATE GROUP, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Grochulski, P.G, Cygler, M.C. Deposit date: 1995-01-06 Release date: 1995-04-20 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (2.18 Å) Cite: A Structural Basis for the Chiral Preferences of Lipases J.Am.Chem.Soc., 116, 1994
1LPN	ANALOGS OF REACTION INTERMEDIATES IDENTIFY A UNIQUE SUBSTRATE BINDING SITE IN CANDIDA RUGOSA LIPASE Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... Authors: Grochulski, P.G, Cygler, M.C. Deposit date: 1995-01-11 Release date: 1995-04-20 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (2.18 Å) Cite: Analogs of reaction intermediates identify a unique substrate binding site in Candida rugosa lipase. Biochemistry, 33, 1994
1EMY	CRYSTAL STRUCTURE OF ASIAN ELEPHANT (ELEPHAS MAXIMUS) CYANO-MET MYOGLOBIN AT 1.78 ANGSTROMS RESOLUTION. PHE 29 (B10) ACCOUNTS FOR ITS UNUSUAL LIGAND BINDING PROPERTIES Descriptor: CYANIDE ION, MYOGLOBIN, PROTOPORPHYRIN IX CONTAINING FE Authors: Bisig, D.A, Piontek, K. Deposit date: 1995-02-22 Release date: 1995-04-20 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.78 Å) Cite: Crystal structure of Asian elephant (Elephas maximus) cyano-metmyoglobin at 1.78-A resolution. Phe29(B10) accounts for its unusual ligand binding properties. J.Biol.Chem., 270, 1995
1ALE	CONFORMATION OF TWO PEPTIDES CORRESPONDING TO HUMAN APOLIPOPROTEIN C-I RESIDUES 7-24 AND 35-53 IN THE PRESENCE OF SODIUM DODECYLSULFATE BY CD AND NMR SPECTROSCOPY Descriptor: APOLIPOPROTEIN C-I PRECURSOR Authors: Rozek, A, Buchko, G.W, Cushley, R.J. Deposit date: 1995-02-20 Release date: 1995-04-20 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: Conformation of two peptides corresponding to human apolipoprotein C-I residues 7-24 and 35-53 in the presence of sodium dodecyl sulfate by CD and NMR spectroscopy. Biochemistry, 34, 1995
1HTL	MUTATION OF A BURIED RESIDUE CAUSES LACK OF ACTIVITY BUT NO CONFORMATIONAL CHANGE: CRYSTAL STRUCTURE OF E. COLI HEAT-LABILE ENTEROTOXIN MUTANT VAL 97--> LYS Descriptor: HEAT-LABILE ENTEROTOXIN, SUBUNIT A, SUBUNIT B Authors: Merritt, E.A, Hol, W.G.J. Deposit date: 1995-02-15 Release date: 1995-04-20 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Mutation of a buried residue causes loss of activity but no conformational change in the heat-labile enterotoxin of Escherichia coli. Nat.Struct.Biol., 2, 1995
1BQL	STRUCTURE OF AN ANTI-HEL FAB FRAGMENT COMPLEXED WITH BOBWHITE QUAIL LYSOZYME Descriptor: BOBWHITE QUAIL LYSOZYME, HYHEL-5 FAB (HEAVY CHAIN), HYHEL-5 FAB (LIGHT CHAIN) Authors: Chacko, S, Davies, D.R. Deposit date: 1995-02-03 Release date: 1995-04-20 Last modified: 2017-12-20 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Refined structures of bobwhite quail lysozyme uncomplexed and complexed with the HyHEL-5 Fab fragment. Proteins, 26, 1996
1EBG	CHELATION OF SER 39 TO MG2+ LATCHES A GATE AT THE ACTIVE SITE OF ENOLASE: STRUCTURE OF THE BIS(MG2+) COMPLEX OF YEAST ENOLASE AND THE INTERMEDIATE ANALOG PHOSPHONOACETOHYDROXAMATE AT 2.1 ANGSTROMS RESOLUTION Descriptor: ENOLASE, MAGNESIUM ION, PHOSPHONOACETOHYDROXAMIC ACID Authors: Wedekind, J.E, Reed, G.H, Rayment, I. Deposit date: 1994-04-27 Release date: 1995-04-27 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Chelation of serine 39 to Mg2+ latches a gate at the active site of enolase: structure of the bis(Mg2+) complex of yeast enolase and the intermediate analog phosphonoacetohydroxamate at 2.1-A resolution. Biochemistry, 33, 1994
107D	SOLUTION STRUCTURE OF THE COVALENT DUOCARMYCIN A-DNA DUPLEX COMPLEX Descriptor: 4-HYDROXY-2,8-DIMETHYL-1-OXO-6-(4,5,6-TRIMETHOXY-1H-INDOLE-2-CARBONYL)-1,2,3,6,7,8-HEXAHYDRO-3,6-DIAZA-AS-INDACENE-2-CARBOXYLIC ACID METHYL ESTER, DNA (5'-D(*CP*CP*TP*TP*TP*TP*C)-3'), DNA (5'-D(*GP*AP*AP*AP*AP*GP*G)-3') Authors: Lin, C.H, Patel, D.J. Deposit date: 1995-01-17 Release date: 1995-05-08 Last modified: 2024-03-13 Method: SOLUTION NMR Cite: Solution structure of the covalent duocarmycin A-DNA duplex complex. J.Mol.Biol., 248, 1995
1ITG	CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HIV-1 INTEGRASE: SIMILARITY TO OTHER POLYNUCLEOTIDYL TRANSFERASES Descriptor: CACODYLATE ION, HIV-1 INTEGRASE Authors: Dyda, F, Hickman, A.B, Jenkins, T.M, Engelman, A, Craigie, R, Davies, D.R. Deposit date: 1994-11-21 Release date: 1995-05-08 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Crystal structure of the catalytic domain of HIV-1 integrase: similarity to other polynucleotidyl transferases. Science, 266, 1994
1NTN	THE CRYSTAL STRUCTURE OF NEUROTOXIN-I FROM NAJA NAJA OXIANA AT 1.9 ANGSTROMS RESOLUTION Descriptor: NEUROTOXIN I Authors: Mikhailov, A.M, Nickitenko, A.V, Vainshtein, B.K, Betzel, C, Wilson, K. Deposit date: 1994-09-26 Release date: 1995-05-08 Last modified: 2017-11-29 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Three-dimensional structure of neurotoxin-1 from Naja naja oxiana venom at 1.9 A resolution. Febs Lett., 320, 1993
1LNE	A STRUCTURAL ANALYSIS OF METAL SUBSTITUTIONS IN THERMOLYSIN Descriptor: CADMIUM ION, CALCIUM ION, DIMETHYL SULFOXIDE, ... Authors: Holland, D.R, Hausrath, A.C, Juers, D, Matthews, B.W. Deposit date: 1994-05-13 Release date: 1995-05-08 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Structural analysis of zinc substitutions in the active site of thermolysin. Protein Sci., 4, 1995
1ASY	CLASS II AMINOACYL TRANSFER RNA SYNTHETASES: CRYSTAL STRUCTURE OF YEAST ASPARTYL-TRNA SYNTHETASE COMPLEXED WITH TRNA ASP Descriptor: ASPARTYL-tRNA SYNTHETASE, T-RNA (75-MER) Authors: Ruff, M, Cavarelli, J, Rees, B, Krishnaswamy, S, Thierry, J.C, Moras, D. Deposit date: 1995-01-19 Release date: 1995-05-08 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Class II aminoacyl transfer RNA synthetases: crystal structure of yeast aspartyl-tRNA synthetase complexed with tRNA(Asp). Science, 252, 1991
1HCG	STRUCTURE OF HUMAN DES(1-45) FACTOR XA AT 2.2 ANGSTROMS RESOLUTION Descriptor: BLOOD COAGULATION FACTOR XA Authors: Tulinsky, A, Padmanabhan, K. Deposit date: 1993-05-05 Release date: 1995-05-08 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structure of human des(1-45) factor Xa at 2.2 A resolution. J.Mol.Biol., 232, 1993
1LNF	A structural analysis of metal substitutions in thermolysin Descriptor: CALCIUM ION, DIMETHYL SULFOXIDE, LYSINE, ... Authors: Holland, D.R, Matthews, B.W. Deposit date: 1994-05-13 Release date: 1995-05-08 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Structural analysis of zinc substitutions in the active site of thermolysin. Protein Sci., 4, 1995
1LND	A STRUCTURAL ANALYSIS OF METAL SUBSTITUTIONS IN THERMOLYSIN Descriptor: CALCIUM ION, DIMETHYL SULFOXIDE, LYSINE, ... Authors: Holland, D.R, Hausrath, A.C, Juers, D, Matthews, B.W. Deposit date: 1994-05-13 Release date: 1995-05-08 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Structural analysis of zinc substitutions in the active site of thermolysin. Protein Sci., 4, 1995
1SSO	SOLUTION STRUCTURE AND DNA-BINDING PROPERTIES OF A THERMOSTABLE PROTEIN FROM THE ARCHAEON SULFOLOBUS SOLFATARICUS Descriptor: SSO7D Authors: Baumann, H, Knapp, S, Lundback, T, Ladenstein, R, Hard, T. Deposit date: 1995-03-31 Release date: 1995-05-08 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: Solution structure and DNA-binding properties of a thermostable protein from the archaeon Sulfolobus solfataricus. Nat.Struct.Biol., 1, 1994

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