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4V8V
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Structure and conformational variability of the Mycobacterium tuberculosis fatty acid synthase multienzyme complex
Descriptor: FLAVIN MONONUCLEOTIDE, TYPE-I FATTY ACID SYNTHASE
Authors:Ciccarelli, L, Connell, S.R, Enderle, M, Mills, D.J, Vonck, J, Grininger, M.
Deposit date:2013-04-18
Release date:2014-07-09
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (20 Å)
Cite:Structure and Conformational Variability of the Mycobacterium Tuberculosis Fatty Acid Synthase Multienzyme Complex.
Structure, 21, 2013
3V0Q
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BU of 3v0q by Molmil
Crystal structure of the Fucosylgalactoside alpha N-acetylgalactosaminyltransferase (GTA, cisAB mutant L266G, G268A) in complex with UDP and H-antigen acceptor
Descriptor: GLYCEROL, Histo-blood group ABO system transferase, MANGANESE (II) ION, ...
Authors:Palcic, M.M, Jorgensen, R.
Deposit date:2011-12-08
Release date:2013-01-23
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Base-modified Donor Analogues Reveal Novel Dynamic Features of a Glycosyltransferase.
J.Biol.Chem., 288, 2013
4V8R
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BU of 4v8r by Molmil
The crystal structures of the eukaryotic chaperonin CCT reveal its functional partitioning
Descriptor: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, ...
Authors:Kalisman, N, Schroder, G.F, Levitt, M.
Deposit date:2012-03-28
Release date:2014-07-09
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:The Crystal Structures of the Eukaryotic Chaperonin Cct Reveal its Functional Partitioning
Structure, 21, 2013
4V8Y
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BU of 4v8y by Molmil
Cryo-EM reconstruction of the 80S-eIF5B-Met-itRNAMet Eukaryotic Translation Initiation Complex
Descriptor: 18S RIBOSOMAL RNA, 25S RIBOSOMAL RNA, 40S RIBOSOMAL PROTEIN S0-A, ...
Authors:Fernandez, I.S, Bai, X.C, Hussain, T, Kelley, A.C, Lorsch, J.R, Ramakrishnan, V, Scheres, S.H.W.
Deposit date:2013-07-20
Release date:2014-07-09
Last modified:2024-10-16
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Molecular architecture of a eukaryotic translational initiation complex.
Science, 342, 2013
3UWX
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BU of 3uwx by Molmil
Crystal structure of UvrA-UvrB complex
Descriptor: Excinuclease ABC, A subunit, UvrABC system protein B, ...
Authors:Pakotiprapha, D, Jeruzalmi, D.
Deposit date:2011-12-03
Release date:2012-02-08
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (4.398 Å)
Cite:Structure and mechanism of the UvrA-UvrB DNA damage sensor.
Nat.Struct.Mol.Biol., 19, 2012
4V9K
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BU of 4v9k by Molmil
70S ribosome translocation intermediate GDPNP-I containing elongation factor EFG/GDPNP, mRNA, and tRNA bound in the pe*/E state.
Descriptor: 23S ribosomal RNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ...
Authors:Zhou, J, Lancaster, L, Donohue, J.P, Noller, H.F.
Deposit date:2013-04-24
Release date:2014-07-09
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Crystal structures of EF-G-ribosome complexes trapped in intermediate states of translocation.
Science, 340, 2013
3EM3
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BU of 3em3 by Molmil
Crystal structure of amprenavir (APV) in complex with a drug resistant HIV-1 protease variant (I50L/A71V).
Descriptor: ACETATE ION, Protease, {3-[(4-AMINO-BENZENESULFONYL)-ISOBUTYL-AMINO]-1-BENZYL-2-HYDROXY-PROPYL}-CARBAMIC ACID TETRAHYDRO-FURAN-3-YL ESTER
Authors:Prabu-Jeyabalan, M, King, N, Royer, C, Schiffer, C.
Deposit date:2008-09-23
Release date:2009-09-01
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Kinetic and Structural Studies on Atazanavir-specific I50L Drug-Resistant HIV-1 Protease Mutant
To be Published
3MWU
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BU of 3mwu by Molmil
Activated Calcium-Dependent Protein Kinase 1 from Cryptosporidium parvum (CpCDPK1) in complex with bumped kinase inhibitor RM-1-95
Descriptor: 3-(naphthalen-1-ylmethyl)-1-(piperidin-4-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, CALCIUM ION, Calmodulin-domain protein kinase 1
Authors:Larson, E.T, Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:2010-05-06
Release date:2010-07-21
Last modified:2025-10-22
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Discovery of Potent and Selective Inhibitors of Calcium-Dependent Protein Kinase 1 (CDPK1) from C. parvum and T. gondii.
ACS Med Chem Lett, 1, 2010
6NPA
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BU of 6npa by Molmil
X-ray crystal structure of TmpB, (R)-1-hydroxy-2-trimethylaminoethylphosphonate oxygenase, with (R)-1-hydroxy-2-trimethylaminoethylphosphonate
Descriptor: (2R)-2-hydroxy-N,N,N-trimethyl-2-phosphonoethan-1-aminium, FE (II) ION, FE (III) ION, ...
Authors:Rajakovich, L.J, Mitchell, A.J, Boal, A.K.
Deposit date:2019-01-17
Release date:2019-03-06
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:A New Microbial Pathway for Organophosphonate Degradation Catalyzed by Two Previously Misannotated Non-Heme-Iron Oxygenases.
Biochemistry, 58, 2019
3EEQ
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BU of 3eeq by Molmil
Crystal structure of a putative cobalamin biosynthesis protein G homolog from Sulfolobus solfataricus
Descriptor: SULFATE ION, putative Cobalamin biosynthesis protein G homolog
Authors:Bonanno, J.B, Gilmore, M, Bain, K.T, Chang, S, Romero, R, Wasserman, S, Sauder, J.M, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2008-09-05
Release date:2008-09-30
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of a putative cobalamin biosynthesis protein G homolog from Sulfolobus solfataricus
To be Published
3V2R
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BU of 3v2r by Molmil
COMPcc in complex with fatty acids
Descriptor: Cartilage Oligomerization matrix protein (coiled-coil domain), OLEIC ACID
Authors:Stetefeld, J.
Deposit date:2011-12-12
Release date:2013-01-16
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:COMPcc in complex with fatty acids
To be Published
3EMK
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BU of 3emk by Molmil
2.5A crystal structure of glucose/ribitol dehydrogenase from brucella melitensis
Descriptor: GLUCOSE/RIBITOL DEHYDROGENASE
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2008-09-24
Release date:2008-10-28
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:2.5A crystal structure of glucose/ribitol dehydrogenase from brucella melitensis
To be Published
6NKA
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BU of 6nka by Molmil
Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with 2'-deoxycytidine
Descriptor: 2'-DEOXYCYTIDINE, ATP-dependent dethiobiotin synthetase BioD, SULFATE ION
Authors:Thompson, A.P, Polyak, S.W, Wegener, K.L, Bruning, J.B.
Deposit date:2019-01-07
Release date:2020-01-15
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with 2'-deoxycytidine
To Be Published
3UZW
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BU of 3uzw by Molmil
Crystal structure of 5beta-reductase (AKR1D1) E120H mutant in complex with NADP+
Descriptor: 3-oxo-5-beta-steroid 4-dehydrogenase, CHLORIDE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Chen, M, Christianson, D.W, Penning, T.M.
Deposit date:2011-12-07
Release date:2012-03-21
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.892 Å)
Cite:Conversion of Human Steroid 5beta-Reductase (AKR1D1) into 3β-Hydroxysteroid Dehydrogenase by Single Point Mutation E120H: EXAMPLE OF PERFECT ENZYME ENGINEERING.
J.Biol.Chem., 287, 2012
5WCK
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BU of 5wck by Molmil
Native FEZ-1 metallo-beta-lactamase from Legionella gormanii
Descriptor: FEZ-1 protein, GLYCEROL, SULFATE ION, ...
Authors:Garcia-Saez, I, Mercuri, P.S, Kahn, R, Papamicael, C, Shabalin, I.G, Raczynska, J.E, Jaskolski, M, Minor, W, Frere, J.M, Galleni, M, Dideberg, O.
Deposit date:2017-06-30
Release date:2018-06-20
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Three-dimensional structure of FEZ-1, a monomeric subclass B3 metallo-beta-lactamase from Fluoribacter gormanii, in native form and in complex with D-captopril.
J. Mol. Biol., 325, 2003
3V53
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BU of 3v53 by Molmil
Crystal structure of human RBM25
Descriptor: RNA-binding protein 25
Authors:Gong, D.S.
Deposit date:2011-12-16
Release date:2012-12-12
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure and functional characterization of the human RBM25 PWI domain and its flanking basic region
Biochem.J., 450, 2013
3EG2
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BU of 3eg2 by Molmil
Crystal structure of the N114Q mutant of ABL-SH3 domain
Descriptor: GLYCEROL, Proto-oncogene tyrosine-protein kinase ABL1
Authors:Camara-Artigas, A.
Deposit date:2008-09-10
Release date:2009-09-15
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Role of interfacial water molecules in proline-rich ligand recognition by the Src homology 3 domain of Abl.
J.Biol.Chem., 285, 2010
4UZN
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BU of 4uzn by Molmil
The native structure of the family 46 carbohydrate-binding module (CBM46) of endo-beta-1,4-glucanase B (Cel5B) from Bacillus halodurans
Descriptor: ENDO-BETA-1,4-GLUCANASE (CELULASE B)
Authors:Venditto, I, Santos, H, Ferreira, L.M.A, Sakka, K, Fontes, C.M.G.A, Najmudin, S.
Deposit date:2014-09-05
Release date:2015-02-25
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.46 Å)
Cite:Family 46 Carbohydrate-Binding Modules Contribute to the Enzymatic Hydrolysis of Xyloglucan and Beta-1,3-1,4-Glucans Through Distinct Mechanisms.
J.Biol.Chem., 290, 2015
6NKT
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BU of 6nkt by Molmil
Ternary complex crystal structure of K289M variant of DNA polymerase Beta with beta-gamma difluoro analogue of dGTP
Descriptor: 2'-DEOXY-5'-O-[({[DIFLUORO(PHOSPHONO)METHYL](HYDROXY)PHOSPHORYL}OXY)(HYDROXY)PHOSPHORYL]GUANOSINE, DNA (5'-D(*CP*CP*GP*AP*CP*CP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(DOC))-3'), ...
Authors:Batra, V.K, Wilson, S.H.
Deposit date:2019-01-07
Release date:2020-01-08
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Revealing an Internal Stabilization Deficiency in the DNA Polymerase beta K289M Cancer Variant through the Combined Use of Chemical Biology and X-ray Crystallography.
Biochemistry, 59, 2020
3V2L
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BU of 3v2l by Molmil
Structure of Anopheles gambiae odorant binding protein 20 bound to polyethylene glycol
Descriptor: AGAP005208-PA, TETRAETHYLENE GLYCOL
Authors:Ziemba, B.P, Jones, D.N.
Deposit date:2011-12-12
Release date:2012-10-17
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A novel mechanism of ligand binding and release in the odorant binding protein 20 from the malaria mosquito Anopheles gambiae.
Protein Sci., 22, 2013
3MWG
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BU of 3mwg by Molmil
Crystal structure of Staphylococcus aureus SirA
Descriptor: Iron-regulated ABC transporter siderophore-binding protein SirA
Authors:Grigg, J.C, Murphy, M.E.P.
Deposit date:2010-05-05
Release date:2010-09-01
Last modified:2024-11-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Staphylococcus aureus SirA specificity for staphyloferrin B is driven by localized conformational change
To be Published
3EGG
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BU of 3egg by Molmil
Crystal structure of a complex between Protein Phosphatase 1 alpha (PP1) and the PP1 binding and PDZ domains of Spinophilin
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLYCEROL, MANGANESE (II) ION, ...
Authors:Ragusa, M.J, Page, R, Peti, W.
Deposit date:2008-09-10
Release date:2010-03-23
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Spinophilin directs protein phosphatase 1 specificity by blocking substrate binding sites.
Nat.Struct.Mol.Biol., 17, 2010
3MWW
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BU of 3mww by Molmil
Crystal structure of HCV NS5B polymerase
Descriptor: 1-[2-(4-carboxypiperidin-1-yl)-2-oxoethyl]-3-cyclohexyl-2-furan-3-yl-1H-indole-6-carboxylic acid, Genome polyprotein, SULFATE ION
Authors:Coulombe, R.
Deposit date:2010-05-06
Release date:2010-10-27
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Importance of ligand bioactive conformation in the discovery of potent indole-diamide inhibitors of the hepatitis C virus NS5B.
J.Am.Chem.Soc., 132, 2010
3V2O
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BU of 3v2o by Molmil
Crystal Structure of the Peptide Bound Complex of the Ankyrin Repeat Domains of Human ANKRA2
Descriptor: Ankyrin repeat family A protein 2, Low-density lipoprotein receptor-related protein 2
Authors:Lam, R, Xu, C, Bian, C.B, Kania, J, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2011-12-12
Release date:2012-04-04
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Sequence-Specific Recognition of a PxLPxI/L Motif by an Ankyrin Repeat Tumbler Lock.
Sci.Signal., 5, 2012
3EP5
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BU of 3ep5 by Molmil
Human AdoMetDC E178Q mutant with no putrescine bound
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, PYRUVIC ACID, S-adenosylmethionine decarboxylase alpha chain, ...
Authors:Bale, S, Lopez, M.M, Makhatadze, G.I, Fang, Q, Pegg, A.E, Ealick, S.E.
Deposit date:2008-09-29
Release date:2008-12-23
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Structural Basis for Putrescine Activation of Human S-Adenosylmethionine Decarboxylase.
Biochemistry, 47, 2008

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數據於2025-10-29公開中

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