7OM8
 
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4G55
 | | Clathrin terminal domain complexed with pitstop 2 | | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, Clathrin heavy chain 1, ... | | Authors: | Bulut, H, Von Kleist, L, Saenger, W, Haucke, V. | | Deposit date: | 2012-07-17 | | Release date: | 2012-08-01 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.69 Å) | | Cite: | Role of the clathrin terminal domain in regulating coated pit dynamics revealed by small molecule inhibition.
Cell(Cambridge,Mass.), 146, 2011
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7ZX4
 | | Clathrin N-terminal domain in complex with a HURP phospho-peptide | | Descriptor: | CHLORIDE ION, Clathrin heavy chain 1, Disks large-associated protein 5, ... | | Authors: | Kliche, J, Badgujar, D, Dobritzsch, D, Ivarsson, Y. | | Deposit date: | 2022-05-20 | | Release date: | 2023-03-29 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2.08 Å) | | Cite: | Large-scale phosphomimetic screening identifies phospho-modulated motif-based protein interactions.
Mol.Syst.Biol., 19, 2023
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6E4L
 | | The structure of the N-terminal domain of human clathrin heavy chain 1 (nTD) in complex with ES9 | | Descriptor: | 1,2-ETHANEDIOL, 5-bromo-N-(4-nitrophenyl)thiophene-2-sulfonamide, ACETATE ION, ... | | Authors: | Dejonghe, W, Sharma, I, Denoo, B, Munck, S.D, Bulut, H, Mylle, E, Vasileva, M, Lu, Q, Savatin, D.V, Mishev, K, Nerinckx, W, Staes, A, Drozdzecki, A, Audenaert, D, Madder, A, Friml, J, Damme, D.V, Gevaert, K, Haucke, V, Savvides, S, Winne, J, Russinova, E. | | Deposit date: | 2018-07-17 | | Release date: | 2019-04-24 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Disruption of endocytosis through chemical inhibition of clathrin heavy chain function.
Nat.Chem.Biol., 15, 2019
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2XZG
 | | Clathrin Terminal Domain Complexed with Pitstop 1 | | Descriptor: | 2-(4-AMINOBENZYL)-1,3-DIOXO-2,3-DIHYDRO-1H-BENZO[DE]ISOQUINOLINE-5-SULFONATE, ACETATE ION, CLATHRIN HEAVY CHAIN 1, ... | | Authors: | Bulut, H, Von Kleist, L, Saenger, W, Haucke, V. | | Deposit date: | 2010-11-25 | | Release date: | 2011-08-17 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Role of the Clathrin Terminal Domain in Regulating Coated Pit Dynamics Revealed by Small Molecule Inhibition.
Cell(Cambridge,Mass.), 146, 2011
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1BPO
 | | CLATHRIN HEAVY-CHAIN TERMINAL DOMAIN AND LINKER | | Descriptor: | PROTEIN (CLATHRIN) | | Authors: | Harr, E.T, Musacchio, A, Harrison, S.C, Kirchhausen, T. | | Deposit date: | 1998-08-11 | | Release date: | 1998-12-16 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Atomic structure of clathrin: a beta propeller terminal domain joins an alpha zigzag linker.
Cell(Cambridge,Mass.), 95, 1998
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9C0Z
 | | Clathrin terminal domain complexed with pitstop 2d | | Descriptor: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETATE ION, ... | | Authors: | Bulut, H, Horatscheck, A, Krauss, M, Santos, K.F, McCluskey, A, Wahl, C.W, Nazare, M, Haucke, V. | | Deposit date: | 2024-05-28 | | Release date: | 2024-06-26 | | Last modified: | 2025-04-16 | | Method: | X-RAY DIFFRACTION (1.51 Å) | | Cite: | Next-generation small molecule inhibitors of clathrin function acutely inhibit endocytosis.
Structure, 2025
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9C0Y
 | | Clathrin terminal domain complexed with Pitstop 2c | | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, Clathrin heavy chain 1, ... | | Authors: | Bulut, H, Horatscheck, A, Krauss, M, Santos, K.F, McCluskey, A, Wahl, C.W, Nazare, M, Haucke, V. | | Deposit date: | 2024-05-28 | | Release date: | 2024-06-26 | | Last modified: | 2025-04-16 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Next-generation small molecule inhibitors of clathrin function acutely inhibit endocytosis.
Structure, 2025
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1C9L
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1C9I
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6QNN
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6QNP
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7BN2
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7BN1
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5M5T
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5M5R
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5M61
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1UTC
 | | Clathrin terminal domain complexed with TLPWDLWTT | | Descriptor: | AMPHIPHYSIN, CLATHRIN HEAVY CHAIN | | Authors: | Miele, A.E, Evans, P.R, Owen, D.J. | | Deposit date: | 2003-12-08 | | Release date: | 2004-02-25 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Two distinct interaction motifs in amphiphysin bind two independent sites on the clathrin terminal domain beta-propeller.
Nat. Struct. Mol. Biol., 11, 2004
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5ODS
 | | Structure of a phosphoprotein-protein complex | | Descriptor: | Clathrin heavy chain 1, LYS-GLU-SER-ALA-LEU-ARG-LYS-GLN-SEP-LEU-TYR-LEU-LYS-PHE-ASP-PRO-LEU-LEU | | Authors: | Mukherjee, M, Bayliss, R. | | Deposit date: | 2017-07-06 | | Release date: | 2018-03-14 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (3.09 Å) | | Cite: | Structure of a phosphoprotein-protein complex
Embo J., 2018
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5M5V
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5M5U
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5M5S
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9EXF
 | | Crystal structure of Yeast Clathrin Heavy Chain N-terminal domain bound to YAP1801 peptide (LIDM) | | Descriptor: | CHLORIDE ION, Clathrin coat assembly protein AP180A, Clathrin heavy chain, ... | | Authors: | Defelipe, L.A, Bento, I, Garcia Alai, M.M. | | Deposit date: | 2024-04-08 | | Release date: | 2024-11-13 | | Last modified: | 2024-11-27 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Subtleties in Clathrin heavy chain binding boxes provide selectivity among adaptor proteins of budding yeast.
Nat Commun, 15, 2024
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9EXG
 | | Crystal structure of Yeast Clathrin Heavy Chain N-terminal domain bound to Epsin-2 peptide (LIDL) | | Descriptor: | Clathrin heavy chain, Epsin-2, GLYCEROL, ... | | Authors: | Defelipe, L.A, Bento, I, Garcia Alai, M.M. | | Deposit date: | 2024-04-08 | | Release date: | 2024-11-13 | | Last modified: | 2024-11-27 | | Method: | X-RAY DIFFRACTION (1.744 Å) | | Cite: | Subtleties in Clathrin heavy chain binding boxes provide selectivity among adaptor proteins of budding yeast.
Nat Commun, 15, 2024
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9EX5
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