8VYQ
 
 | | Cryo-EM Structure of the BRAF V600K monomer | | Descriptor: | 14-3-3 protein zeta/delta, Serine/threonine-protein kinase B-raf | | Authors: | Lavoie, H, Lajoie, D, Jin, T, Decossas, M, Maisonneuve, P, Therrien, M. | | Deposit date: | 2024-02-09 | | Release date: | 2025-05-28 | | Last modified: | 2025-06-25 | | Method: | ELECTRON MICROSCOPY (4.43 Å) | | Cite: | BRAF oncogenic mutants evade autoinhibition through a common mechanism.
Science, 388, 2025
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8VYU
 | | Cryo-EM Structure of the BRAF WT monomer bound to PLX8394 | | Descriptor: | (3S)-N-{3-[5-(2-cyclopropylpyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluorophenyl}-3-fluoropyrrolidine-1-sulfonamide, 14-3-3 protein zeta/delta, Serine/threonine-protein kinase B-raf | | Authors: | Lavoie, H, Lajoie, D, Jin, T, Decossas, M, Maisonneuve, P, Therrien, M. | | Deposit date: | 2024-02-09 | | Release date: | 2025-05-28 | | Last modified: | 2025-06-25 | | Method: | ELECTRON MICROSCOPY (4.07 Å) | | Cite: | BRAF oncogenic mutants evade autoinhibition through a common mechanism.
Science, 388, 2025
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8VYV
 | | Cryo-EM Structure of the BRAF K601E monomer | | Descriptor: | 14-3-3 protein zeta/delta, Serine/threonine-protein kinase B-raf | | Authors: | Lavoie, H, Lajoie, D, Jin, T, Decossas, M, Maisonneuve, P, Therrien, M. | | Deposit date: | 2024-02-09 | | Release date: | 2025-05-28 | | Last modified: | 2025-06-25 | | Method: | ELECTRON MICROSCOPY (5.86 Å) | | Cite: | BRAF oncogenic mutants evade autoinhibition through a common mechanism.
Science, 388, 2025
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8VYP
 | | Cryo-EM Structure of the BRAF V600E monomer | | Descriptor: | 14-3-3 protein zeta/delta, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Serine/threonine-protein kinase B-raf | | Authors: | Lavoie, H, Lajoie, D, Jin, T, Decossas, M, Maisonneuve, P, Therrien, M. | | Deposit date: | 2024-02-09 | | Release date: | 2025-05-28 | | Last modified: | 2025-06-25 | | Method: | ELECTRON MICROSCOPY (3.29 Å) | | Cite: | BRAF oncogenic mutants evade autoinhibition through a common mechanism.
Science, 388, 2025
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8VYR
 | | Cryo-EM Structure of the BRAF V600E monomer bound to GDC0879 | | Descriptor: | 14-3-3 protein zeta/delta, Serine/threonine-protein kinase B-raf | | Authors: | Lavoie, H, Lajoie, D, Jin, T, Decossas, M, Maisonneuve, P, Therrien, M. | | Deposit date: | 2024-02-09 | | Release date: | 2025-05-28 | | Last modified: | 2025-06-25 | | Method: | ELECTRON MICROSCOPY (4.32 Å) | | Cite: | BRAF oncogenic mutants evade autoinhibition through a common mechanism.
Science, 388, 2025
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8VYS
 | | Cryo-EM Structure of the BRAF V600E monomer bound to PLX8394 | | Descriptor: | (3S)-N-{3-[5-(2-cyclopropylpyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluorophenyl}-3-fluoropyrrolidine-1-sulfonamide, 14-3-3 protein zeta/delta, Serine/threonine-protein kinase B-raf | | Authors: | Lavoie, H, Lajoie, D, Jin, T, Decossas, M, Maisonneuve, P, Therrien, M. | | Deposit date: | 2024-02-09 | | Release date: | 2025-05-28 | | Last modified: | 2025-06-25 | | Method: | ELECTRON MICROSCOPY (3.06 Å) | | Cite: | BRAF oncogenic mutants evade autoinhibition through a common mechanism.
Science, 388, 2025
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8VYW
 | | Cryo-EM Structure of the BRAF D594G monomer | | Descriptor: | 14-3-3 protein zeta/delta, Serine/threonine-protein kinase B-raf | | Authors: | Lavoie, H, Lajoie, D, Jin, T, Decossas, M, Maisonneuve, P, Therrien, M. | | Deposit date: | 2024-02-09 | | Release date: | 2025-05-28 | | Last modified: | 2025-06-25 | | Method: | ELECTRON MICROSCOPY (4.76 Å) | | Cite: | BRAF oncogenic mutants evade autoinhibition through a common mechanism.
Science, 388, 2025
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8VYO
 | | Cryo-EM Structure of the BRAF WT monomer | | Descriptor: | 14-3-3 protein zeta/delta, Serine/threonine-protein kinase B-raf, ZINC ION | | Authors: | Lavoie, H, Lajoie, D, Jin, T, Decossas, M, Maisonneuve, P, Therrien, M. | | Deposit date: | 2024-02-09 | | Release date: | 2025-05-28 | | Last modified: | 2025-06-25 | | Method: | ELECTRON MICROSCOPY (3.74 Å) | | Cite: | BRAF oncogenic mutants evade autoinhibition through a common mechanism.
Science, 388, 2025
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