2FAK
| Crystal structure of Salinosporamide A in complex with the yeast 20S proteasome | Descriptor: | (3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE, Proteasome component C1, Proteasome component C11, ... | Authors: | Groll, M, Potts, B.C. | Deposit date: | 2005-12-07 | Release date: | 2006-04-18 | Last modified: | 2023-05-31 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal Structures of Salinosporamide A (NPI-0052) and B (NPI-0047) in Complex with the 20S Proteasome Reveal Important Consequences of beta-Lactone Ring Opening and a Mechanism for Irreversible Binding. J.Am.Chem.Soc., 128, 2006
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