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PDB: 2 results

Crystal structure of human thymidylate synthase Y202A in inactive conformation.
Descriptor:	SULFATE ION, Thymidylate synthase
Authors:	Tochowicz, A, Stroud, R.M, Wade, R.C.
Deposit date:	2013-02-26
Release date:	2014-08-20
Last modified:	2024-10-16
Method:	X-RAY DIFFRACTION (2.311 Å)
Cite:	Hotspots in an obligate homodimeric anticancer target. Structural and functional effects of interfacial mutations in human thymidylate synthase. J.Med.Chem., 58, 2015

Crystal structure of His-tagged human thymidylate synthase R175A mutant
Descriptor:	1,2-ETHANEDIOL, SULFATE ION, Thymidylate synthase
Authors:	Pozzi, C, Mangani, S.
Deposit date:	2013-05-14
Release date:	2014-05-14
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (2.03 Å)
Cite:	Hotspots in an obligate homodimeric anticancer target. Structural and functional effects of interfacial mutations in human thymidylate synthase. J.Med.Chem., 58, 2015