PDB: 203978 resultsInfo pagesStatus searchChemie searchBIRD

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7OY9	Crystal structure of GMP reductase from mycobacterium smegmatis. Descriptor: Guanosine 5'-monophosphate reductase Authors: Dolezal, M, Klima, M, Pichova, I. Deposit date: 2021-06-24 Release date: 2022-04-27 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.8 Å) Cite: The mycobacterial guaB1 gene encodes a guanosine 5'-monophosphate reductase with a cystathionine-beta-synthase domain. Febs J., 289, 2022
7B0L	Neisseria gonorrhoeae transaldolase, low-dose inhouse Descriptor: CITRIC ACID, Transaldolase Authors: Rabe von Pappenheim, F, Wensien, M, Tittmann, K. Deposit date: 2020-11-20 Release date: 2021-03-24 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (1.65 Å) Cite: A lysine-cysteine redox switch with an NOS bridge regulates enzyme function. Nature, 593, 2021
3HOM	Crystal structure of oxidized A66C mutant of Human acidic fibroblast growth factor Descriptor: Acidic fibroblast growth factor, FORMIC ACID, SULFATE ION Authors: Blaber, M, Lee, J. Deposit date: 2009-06-02 Release date: 2009-10-06 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural basis of conserved cysteine in the fibroblast growth factor family: evidence for a vestigial half-cystine. J.Mol.Biol., 393, 2009
9FSL	Crystal structure of CyuA from Methanococcus maripaludis with [2Fe-2S] clusters solved by Fe-SAD Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, FE2/S2 (INORGANIC) CLUSTER, ... Authors: Pecqueur, L, He, N, Golinelli-Pimpaneau, B. Deposit date: 2024-06-21 Release date: 2025-07-02 Method: X-RAY DIFFRACTION (2.417 Å) Cite: Insights into the phylogenetic distribution, structure and function of [4Fe-4S]-dependent L-cysteine desulfidase, an enzyme that supplies sulfide to the archaeon Methanococcus maripaludis To Be Published
4N6N	Crystal structure of oxidized legumain in complex with cystatin E/M Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cystatin-M, IODIDE ION, ... Authors: Dall, E, Brandstetter, H. Deposit date: 2013-10-14 Release date: 2015-02-18 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.87 Å) Cite: Structure and mechanism of an aspartimide-dependent Peptide ligase in human legumain. Angew.Chem.Int.Ed.Engl., 54, 2015
8QHP	Cysteine tRNA ligase homodimer Descriptor: Cysteine--tRNA ligase, ZINC ION Authors: Pacesa, M, Correia, B.E, Levy, E.D. Deposit date: 2023-09-08 Release date: 2023-11-29 Last modified: 2024-02-28 Method: ELECTRON MICROSCOPY (2.8 Å) Cite: An atlas of protein homo-oligomerization across domains of life. Cell, 187, 2024
6GRE	Crystal structure of the tandem DUF26 ectodomain from the Arabidopsis thaliana cysteine-rich receptor-like protein PDLP5. Descriptor: 1,2-ETHANEDIOL, 2-(2-ETHOXYETHOXY)ETHANOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Brandt, B, Hothorn, M. Deposit date: 2018-06-11 Release date: 2018-12-26 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (1.29 Å) Cite: Mechanistic insights into the evolution of DUF26-containing proteins in land plants. Commun Biol, 2, 2019
6CJZ	Solution Structure of Amebosin Descriptor: Amoebiasin-1 Authors: Mendoza, A, Flores-Solis, D, Del Rio Portilla, F, Brieba de Castro, L. Deposit date: 2018-02-27 Release date: 2019-02-06 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Solution structure of the inhibitor of cysteine proteases 1 from Entamoeba histolytica reveals a possible auto regulatory mechanism. Biochim Biophys Acta Proteins Proteom, 1868, 2020
7RDL	Crystal structure of PCDN-22A, an anti-HIV antibody from the PCDN bnAb lineage Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, PCDN-22A Fab heavy chain, PCDN-22A Fab light chain Authors: Omorodion, O, Wilson, I.A. Deposit date: 2021-07-09 Release date: 2021-11-10 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (2.71 Å) Cite: Structural and Biochemical Characterization of Cysteinylation in Broadly Neutralizing Antibodies to HIV-1. J.Mol.Biol., 433, 2021
8ULM	Chickpea (Cicer arientinum) nodule-specific cysteine-rich peptide NCR13: Solution NMR structure of the isomer with C4:C23, C15:C30, and C10:C28 disulfide bonds Descriptor: Nodule cysteine-rich protein 13 Authors: Buchko, G.W, Zhou, M, Shah, D.M, Velivelli, S.L.S. Deposit date: 2023-10-16 Release date: 2023-11-01 Last modified: 2024-12-25 Method: SOLUTION NMR Cite: Chickpea NCR13 disulfide cross-linking variants exhibit profound differences in antifungal activity and modes of action. Plos Pathog., 20, 2024
4N6O	Crystal structure of reduced legumain in complex with cystatin E/M Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, IODIDE ION, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Dall, E, Brandstetter, H. Deposit date: 2013-10-14 Release date: 2015-02-11 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structure and mechanism of an aspartimide-dependent Peptide ligase in human legumain. Angew.Chem.Int.Ed.Engl., 54, 2015
8V7Z	Phosphorylated, ATP-bound, E1371Q human cystic fibrosis transmembrane conductance regulator (E1371Q-CFTR) Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, ADENOSINE-5'-TRIPHOSPHATE, CHOLESTEROL, ... Authors: Gao, X, Hwang, T. Deposit date: 2023-12-04 Release date: 2024-07-17 Last modified: 2025-05-28 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Allosteric inhibition of CFTR gating by CFTRinh-172 binding in the pore. Nat Commun, 15, 2024
8V81	Phosphorylated, ATP-bound, inhibitor 172-bound E1371Q human cystic fibrosis transmembrane conductance regulator Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 4-[(Z)-{(3M)-4-oxo-2-sulfanylidene-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-5-ylidene}methyl]benzoic acid, ADENOSINE-5'-TRIPHOSPHATE, ... Authors: Gao, X, Hwang, T. Deposit date: 2023-12-04 Release date: 2024-07-17 Last modified: 2025-05-28 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Allosteric inhibition of CFTR gating by CFTRinh-172 binding in the pore. Nat Commun, 15, 2024
6GDJ	Crystal structure of Mto2 twin-cysteine dimerisation domain Descriptor: GLYCEROL, Mto2 Authors: Thakur, H.C, Sawin, K.E, Cook, A.G. Deposit date: 2018-04-23 Release date: 2019-05-01 Last modified: 2024-05-15 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Crystal structure of Mto2 twin-cysteine dimerisation domain To Be Published
6GL7	Neurturin-GFRa2-RET extracellular complex Descriptor: GDNF family receptor alpha-2, Neurturin, Proto-oncogene tyrosine-protein kinase receptor Ret Authors: Bigalke, J.M, Aibara, S, Sandmark, J, Amunts, A. Deposit date: 2018-05-23 Release date: 2019-08-14 Last modified: 2024-11-20 Method: ELECTRON MICROSCOPY (6.3 Å) Cite: Cryo-EM structure of the activated RET signaling complex reveals the importance of its cysteine-rich domain. Sci Adv, 5, 2019
9EBE	Solution structure of sigma-S-GVIIIA conotoxin extracted from Conus geographus Descriptor: Sigma-conotoxin GVIIIA Authors: Peck, Y, Daly, N.L. Deposit date: 2024-11-12 Release date: 2025-05-07 Last modified: 2025-07-09 Method: SOLUTION NMR Cite: Structural characterisation of a cysteine-rich conotoxin, sigma( sigma )S-GVIIIA, extracted from the defensive venom of the marine cone snail Conus geographus. Biochem.J., 482, 2025
6R7U	Selenomethionine variant of Tannerella forsythia promirolysin mutant E225A Descriptor: BORIC ACID, CALCIUM ION, GLYCEROL, ... Authors: Rodriguez-Banqueri, A, Guevara, T, Ksiazek, M, Potempa, J, Gomis-Ruth, F.X. Deposit date: 2019-03-29 Release date: 2020-02-05 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Structure-based mechanism of cysteine-switch latency and of catalysis by pappalysin-family metallopeptidases. Iucrj, 7, 2020
6GRF	Crystal structure of the tandem DUF26 ectodomain from the Arabidopsis thaliana cysteine-rich receptor-like protein PDLP8. Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Cysteine-rich repeat secretory protein 15 Authors: Brandt, B, Hothorn, M. Deposit date: 2018-06-11 Release date: 2018-12-19 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Mechanistic insights into the evolution of DUF26-containing proteins in land plants. Commun Biol, 2, 2019
9JBP	Cryo-EM structure of human SOD1 (C6A/C111A) amyloid filament Descriptor: Superoxide dismutase [Cu-Zn], Unassigned poly-alanine model Authors: Baek, Y, Kim, H, Lee, D, Kim, D, Jo, E, Roh, S.-H, Ha, N.-C. Deposit date: 2024-08-27 Release date: 2025-01-15 Last modified: 2025-02-05 Method: ELECTRON MICROSCOPY (3.18 Å) Cite: Structural insights into the role of reduced cysteine residues in SOD1 amyloid filament formation. Proc.Natl.Acad.Sci.USA, 122, 2025
9JBO	Cryo-EM structure of human SOD1 (WT) amyloid filament Descriptor: Superoxide dismutase [Cu-Zn] Authors: Baek, Y, Kim, H, Lee, D, Kim, D, Jo, E, Roh, S.-H, Ha, N.-C. Deposit date: 2024-08-27 Release date: 2025-01-15 Last modified: 2025-02-05 Method: ELECTRON MICROSCOPY (3.39 Å) Cite: Structural insights into the role of reduced cysteine residues in SOD1 amyloid filament formation. Proc.Natl.Acad.Sci.USA, 122, 2025
5FEW	HydE from T. maritima in complex with S-adenosyl-L-cysteine (final product) Descriptor: (2R,4R)-2-methyl-1,3-thiazolidine-2,4-dicarboxylic acid, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, CHLORIDE ION, ... Authors: Rohac, R, Amara, P, Benjdia, A, Martin, L, Ruffie, P, Favier, A, Berteau, O, Mouesca, J.M, Fontecilla-Camps, J.C, Nicolet, Y. Deposit date: 2015-12-17 Release date: 2016-04-06 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.17 Å) Cite: Carbon-sulfur bond-forming reaction catalysed by the radical SAM enzyme HydE. Nat.Chem., 8, 2016
6ZWF	Neisseria gonorrhoeae transaldolase Descriptor: 1,2-ETHANEDIOL, BETA-MERCAPTOETHANOL, CITRIC ACID, ... Authors: Rabe von Pappenheim, F, Wensien, M, Funk, L.-M, Sautner, V, Tittmann, K. Deposit date: 2020-07-28 Release date: 2021-03-24 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.05 Å) Cite: A lysine-cysteine redox switch with an NOS bridge regulates enzyme function. Nature, 593, 2021
7ORZ	Crystal structure of UDP-N-acetylenolpyruvoylglucosamine reductase (MurB) from Pseudomonas aeruginosa in complex with FAD and a pyrazole derivative (fragment 18) Descriptor: 1-phenyl-5-(trifluoromethyl)pyrazole-4-carboxylic acid, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... Authors: Acebron-Garcia de Eulate, M, Blundell, T.L, Kim, S.Y, Mendes, V, Abell, C. Deposit date: 2021-06-06 Release date: 2021-11-03 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Discovery of Novel Inhibitors of Uridine Diphosphate- N -Acetylenolpyruvylglucosamine Reductase (MurB) from Pseudomonas aeruginosa , an Opportunistic Infectious Agent Causing Death in Cystic Fibrosis Patients. J.Med.Chem., 65, 2022
7OR2	Crystal structure of UDP-N-acetylenolpyruvoylglucosamine reductase (MurB) from Pseudomonas aeruginosa in complex with FAD and a pyrazole derivative (fragment 4) Descriptor: 5-methyl-1-phenyl-pyrazole-4-carboxylic acid, FLAVIN-ADENINE DINUCLEOTIDE, UDP-N-acetylenolpyruvoylglucosamine reductase Authors: Acebron-Garcia de Eulate, M, Blundell, T.L, Kim, S.Y, Mendes, V, Abell, C. Deposit date: 2021-06-04 Release date: 2021-11-03 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Discovery of Novel Inhibitors of Uridine Diphosphate- N -Acetylenolpyruvylglucosamine Reductase (MurB) from Pseudomonas aeruginosa , an Opportunistic Infectious Agent Causing Death in Cystic Fibrosis Patients. J.Med.Chem., 65, 2022
7OSQ	Crystal structure of UDP-N-acetylenolpyruvoylglucosamine reductase (MurB) from Pseudomonas aeruginosa in complex with FAD and a pyrazole derivative (fragment 18) Descriptor: 5-methyl-1-phenyl-1,2,3-triazole-4-carboxylic acid, FLAVIN-ADENINE DINUCLEOTIDE, UDP-N-acetylenolpyruvoylglucosamine reductase Authors: Acebron-Garcia de Eulate, M, Mayol-Llinas, J, Blundell, T.L, Kim, S.Y, Mendes, V, Abell, C. Deposit date: 2021-06-09 Release date: 2021-11-03 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.07 Å) Cite: Discovery of Novel Inhibitors of Uridine Diphosphate- N -Acetylenolpyruvylglucosamine Reductase (MurB) from Pseudomonas aeruginosa , an Opportunistic Infectious Agent Causing Death in Cystic Fibrosis Patients. J.Med.Chem., 65, 2022

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