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1LYB	CRYSTAL STRUCTURES OF NATIVE AND INHIBITED FORMS OF HUMAN CATHEPSIN D: IMPLICATIONS FOR LYSOSOMAL TARGETING AND DRUG DESIGN Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CATHEPSIN D, PEPSTATIN, ... Authors: Baldwin, E.T, Bhat, T.N, Gulnik, S, Erickson, J.W. Deposit date: 1993-04-22 Release date: 1994-01-31 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Crystal structures of native and inhibited forms of human cathepsin D: implications for lysosomal targeting and drug design. Proc.Natl.Acad.Sci.USA, 90, 1993
1TTF	THE THREE-DIMENSIONAL STRUCTURE OF THE TENTH TYPE III MODULE OF FIBRONECTIN: AN INSIGHT INTO RGD-MEDIATED INTERACTIONS Descriptor: FIBRONECTIN Authors: Main, A.L, Harvey, T.S, Baron, M, Campbell, I.D. Deposit date: 1993-07-14 Release date: 1994-01-31 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: The three-dimensional structure of the tenth type III module of fibronectin: an insight into RGD-mediated interactions. Cell(Cambridge,Mass.), 71, 1992
3EGF	SOLUTION STRUCTURE OF MURINE EPIDERMAL GROWTH FACTOR DETERMINED BY NMR SPECTROSCOPY AND REFINED BY ENERGY MINIMIZATION WITH RESTRAINTS Descriptor: EPIDERMAL GROWTH FACTOR Authors: Montelione, G.T, Wuthrich, K, Scheraga, H.A. Deposit date: 1992-08-30 Release date: 1994-01-31 Last modified: 2022-03-16 Method: SOLUTION NMR Cite: Solution structure of murine epidermal growth factor determined by NMR spectroscopy and refined by energy minimization with restraints. Biochemistry, 31, 1992
2DRC	INVESTIGATION OF THE FUNCTIONAL ROLE OF TRYPTOPHAN-22 IN ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE BY SITE-DIRECTED MUTAGENESIS Descriptor: CALCIUM ION, CHLORIDE ION, DIHYDROFOLATE REDUCTASE, ... Authors: Brown, K.A, Kraut, J. Deposit date: 1992-06-10 Release date: 1994-01-31 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Investigation of the functional role of tryptophan-22 in Escherichia coli dihydrofolate reductase by site-directed mutagenesis. Biochemistry, 30, 1991
1HCY	CRYSTAL STRUCTURE OF HEXAMERIC HAEMOCYANIN FROM PANULIRUS INTERRUPTUS REFINED AT 3.2 ANGSTROMS RESOLUTION Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ARTHROPODAN HEMOCYANIN, COPPER (II) ION Authors: Volbeda, A, Hol, W.G.J. Deposit date: 1991-05-15 Release date: 1994-01-31 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Crystal structure of hexameric haemocyanin from Panulirus interruptus refined at 3.2 A resolution. J.Mol.Biol., 209, 1989
1MAT	STRUCTURE OF THE COBALT-DEPENDENT METHIONINE AMINOPEPTIDASE FROM ESCHERICHIA COLI: A NEW TYPE OF PROTEOLYTIC ENZYME Descriptor: COBALT (II) ION, METHIONYL AMINOPEPTIDASE Authors: Roderick, S.L, Matthews, B.W. Deposit date: 1992-12-02 Release date: 1994-01-31 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structure of the cobalt-dependent methionine aminopeptidase from Escherichia coli: a new type of proteolytic enzyme. Biochemistry, 32, 1993
1HGG	BINDING OF INFLUENZA VIRUS HEMAGGLUTININ TO ANALOGS OF ITS CELL-SURFACE RECEPTOR, SIALIC ACID: ANALYSIS BY PROTON NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY AND X-RAY CRYSTALLOGRAPHY Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, HEMAGGLUTININ, CHAIN HA1, ... Authors: Sauter, N.K, Hanson, J.E, Glick, G.D, Brown, J.H, Crowther, R.L, Park, S.-J, Skehel, J.J, Wiley, D.C. Deposit date: 1991-11-01 Release date: 1994-01-31 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Binding of influenza virus hemagglutinin to analogs of its cell-surface receptor, sialic acid: analysis by proton nuclear magnetic resonance spectroscopy and X-ray crystallography. Biochemistry, 31, 1992
1MFE	RECOGNITION OF A CELL-SURFACE OLIGO-SACCHARIDE OF PATHOGENIC SALMONELLA BY AN ANTIBODY FAB FRAGMENT Descriptor: IGG1-LAMBDA SE155-4 FAB (HEAVY CHAIN), IGG1-LAMBDA SE155-4 FAB (LIGHT CHAIN), alpha-D-galactopyranose-(1-2)-[alpha-D-Abequopyranose-(1-3)]alpha-D-mannopyranose Authors: Cygler, M. Deposit date: 1993-10-25 Release date: 1994-01-31 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (2 Å) Cite: Recognition of a cell-surface oligosaccharide of pathogenic Salmonella by an antibody Fab fragment. Science, 253, 1991
2AAD	THE ROLE OF HISTIDINE-40 IN RIBONUCLEASE T1 CATALYSIS: THREE-DIMENSIONAL STRUCTURES OF THE PARTIALLY ACTIVE HIS40LYS MUTANT Descriptor: CALCIUM ION, GUANOSINE-2'-MONOPHOSPHATE, RIBONUCLEASE T1 ISOZYME Authors: Zegers, I, Verhelst, P, Choe, C.W, Steyaert, J, Heinemann, U, Wyns, L, Saenger, W. Deposit date: 1992-09-15 Release date: 1994-01-31 Last modified: 2017-11-29 Method: X-RAY DIFFRACTION (2 Å) Cite: Role of histidine-40 in ribonuclease T1 catalysis: three-dimensionalstructures of the partially active His40Lys mutant. Biochemistry, 31, 1992
1KAB	STRESS AND STRAIN IN STAPHYLOCOCCAL NUCLEASE Descriptor: STAPHYLOCOCCAL NUCLEASE Authors: Hodel, A, Fox, R.O. Deposit date: 1992-12-18 Release date: 1994-01-31 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Stress and strain in staphylococcal nuclease. Protein Sci., 2, 1993
1MAQ	CRYSTAL STRUCTURES OF TRUE ENZYMATIC REACTION INTERMEDIATES: ASPARTATE AND GLUTAMATE KETIMINES IN ASPARTATE AMINOTRANSFERASE Descriptor: ASPARTATE AMINOTRANSFERASE, N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)-L-glutamic acid Authors: Malashkevich, V.N, Jansonius, J.N. Deposit date: 1993-09-10 Release date: 1994-01-31 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Crystal structures of true enzymatic reaction intermediates: aspartate and glutamate ketimines in aspartate aminotransferase. Biochemistry, 32, 1993
1TOP	STRUCTURE OF CHICKEN SKELETAL MUSCLE TROPONIN-C AT 1.78 ANGSTROMS RESOLUTION Descriptor: CALCIUM ION, SULFATE ION, TROPONIN C Authors: Sundaralingam, M. Deposit date: 1993-08-11 Release date: 1994-01-31 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.78 Å) Cite: Structure of chicken skeletal muscle troponin C at 1.78 A resolution. Acta Crystallogr.,Sect.D, 50, 1994
1TYC	STRUCTURAL ANALYSIS OF A SERIES OF MUTANTS OF TYROSYL-TRNA SYNTHETASE: ENHANCEMENT OF CATALYSIS BY HYDROPHOBIC INTERACTIONS Descriptor: TYROSYL-tRNA SYNTHETASE Authors: Brown, K.A, Brick, P, De Meester, P, Blow, D.M. Deposit date: 1992-07-06 Release date: 1994-01-31 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structural Analysis of a Series of Mutants of Tyrosyl-tRNA Synthetase: Enhancement of Catalysis by Hydrophobic Interactions To be Published
1TYD	STRUCTURE OF TYROSYL-TRNA SYNTHETASE REFINED AT 2.3 ANGSTROMS RESOLUTION. INTERACTION OF THE ENZYME WITH THE TYROSYL ADENYLATE INTERMEDIATE Descriptor: TYROSINE, TYROSYL-tRNA SYNTHETASE Authors: Brown, K.A, De Meester, P, Blow, D.M. Deposit date: 1992-07-06 Release date: 1994-01-31 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structure of tyrosyl-tRNA synthetase refined at 2.3 A resolution. Interaction of the enzyme with the tyrosyl adenylate intermediate. J.Mol.Biol., 208, 1989
2INT	CRYSTAL STRUCTURE OF RECOMBINANT HUMAN INTERLEUKIN-4 Descriptor: INTERLEUKIN-4 Authors: Walter, M.R, Cook, W.J, Zhao, B.G, Cameron Junior, R, Ealick, S.E, Walter Junior, R.L, Reichert, P, Nagabhushan, T.L, Trotta, P.P, Bugg, C.E. Deposit date: 1993-07-22 Release date: 1994-01-31 Last modified: 2019-08-14 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Crystal structure of recombinant human interleukin-4. J.Biol.Chem., 267, 1992
1HGH	BINDING OF INFLUENZA VIRUS HEMAGGLUTININ TO ANALOGS OF ITS CELL-SURFACE RECEPTOR, SIALIC ACID: ANALYSIS BY PROTON NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY AND X-RAY CRYSTALLOGRAPHY Descriptor: 2-O-methyl-5-N-acetyl-alpha-D-neuraminic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, HEMAGGLUTININ, ... Authors: Sauter, N.K, Hanson, J.E, Glick, G.D, Brown, J.H, Crowther, R.L, Park, S.-J, Skehel, J.J, Wiley, D.C. Deposit date: 1991-11-01 Release date: 1994-01-31 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Binding of influenza virus hemagglutinin to analogs of its cell-surface receptor, sialic acid: analysis by proton nuclear magnetic resonance spectroscopy and X-ray crystallography. Biochemistry, 31, 1992
1TSI	STRUCTURE OF THE COMPLEX BETWEEN TRYPANOSOMAL TRIOSEPHOSPHATE ISOMERASE AND N-HYDROXY-4-PHOSPHONO-BUTANAMIDE: BINDING AT THE ACTIVE SITE DESPITE AN "OPEN" FLEXIBLE LOOP Descriptor: N-HYDROXY-4-PHOSPHONO-BUTANAMIDE, TRIOSEPHOSPHATE ISOMERASE Authors: Verlinde, C.L.M.J. Deposit date: 1992-11-19 Release date: 1994-01-31 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.84 Å) Cite: Structure of the complex between trypanosomal triosephosphate isomerase and N-hydroxy-4-phosphono-butanamide: binding at the active site despite an "open" flexible loop conformation. Protein Sci., 1, 1992
1TYA	STRUCTURAL ANALYSIS OF A SERIES OF MUTANTS OF TYROSYL-TRNA SYNTHETASE: ENHANCEMENT OF CATALYSIS BY HYDROPHOBIC INTERACTIONS Descriptor: TYROSINE, TYROSYL-tRNA SYNTHETASE Authors: Brown, K.A, De Meester, P, Blow, D.M. Deposit date: 1992-07-06 Release date: 1994-01-31 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structural Analysis of a Series of Mutants of Tyrosyl-tRNA Synthetase: Enhancement of Catalysis by Hydrophobic Interactions To be Published
1MCE	PRINCIPLES AND PITFALLS IN DESIGNING SITE DIRECTED PEPTIDE LIGANDS Descriptor: Immunoglobulin lambda-1 light chain, PEPTIDE N-ACETYL-L-GLN-D-PHE-L-HIS-D-PRO-B-ALA-OH Authors: Edmundson, A.B, Harris, D.L, Fan, Z.-C, Guddat, L.W. Deposit date: 1993-02-25 Release date: 1994-01-31 Last modified: 2022-04-20 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Principles and pitfalls in designing site-directed peptide ligands. Proteins, 16, 1993
1TYB	STRUCTURAL ANALYSIS OF A SERIES OF MUTANTS OF TYROSYL-TRNA SYNTHETASE: ENHANCEMENT OF CATALYSIS BY HYDROPHOBIC INTERACTIONS Descriptor: TYROSINE, TYROSYL-tRNA SYNTHETASE Authors: Brown, K.A, De Meester, P, Blow, D.M. Deposit date: 1992-07-06 Release date: 1994-01-31 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structural Analysis of a Series of Mutants of Tyrosyl-tRNA Synthetase: Enhancement of Catalysis by Hydrophobic Interactions To be Published
1MCN	PRINCIPLES AND PITFALLS IN DESIGNING SITE DIRECTED PEPTIDE LIGANDS Descriptor: IMMUNOGLOBULIN LAMBDA DIMER MCG (LIGHT CHAIN), PEPTIDE N-ACETYL-D-HIS-L-PRO-NH2 Authors: Edmundson, A.B, Harris, D.L, Fan, Z.-C, Guddat, L.W. Deposit date: 1993-02-25 Release date: 1994-01-31 Last modified: 2017-11-29 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Principles and pitfalls in designing site-directed peptide ligands. Proteins, 16, 1993
1TRB	CONVERGENT EVOLUTION OF SIMILAR FUNCTION IN TWO STRUCTURALLY DIVERGENT ENZYMES Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, THIOREDOXIN REDUCTASE Authors: Kuriyan, J, Krishna, T.S.R. Deposit date: 1991-09-07 Release date: 1994-01-31 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2 Å) Cite: Convergent evolution of similar function in two structurally divergent enzymes. Nature, 352, 1991
1BSB	CRYSTAL STRUCTURAL ANALYSIS OF MUTATIONS IN THE HYDROPHOBIC CORES OF BARNASE Descriptor: BARNASE Authors: Buckle, A.M, Henrick, K, Fersht, A.R. Deposit date: 1993-07-19 Release date: 1994-01-31 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal structural analysis of mutations in the hydrophobic cores of barnase. J.Mol.Biol., 234, 1993
1HGJ	BINDING OF INFLUENZA VIRUS HEMAGGLUTININ TO ANALOGS OF ITS CELL-SURFACE RECEPTOR, SIALIC ACID: ANALYSIS BY PROTON NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY AND X-RAY CRYSTALLOGRAPHY Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, HEMAGGLUTININ, CHAIN HA1, ... Authors: Sauter, N.K, Hanson, J.E, Glick, G.D, Brown, J.H, Crowther, R.L, Park, S.-J, Skehel, J.J, Wiley, D.C. Deposit date: 1991-11-01 Release date: 1994-01-31 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Binding of influenza virus hemagglutinin to analogs of its cell-surface receptor, sialic acid: analysis by proton nuclear magnetic resonance spectroscopy and X-ray crystallography. Biochemistry, 31, 1992
1TYP	SUBSTRATE INTERACTIONS BETWEEN TRYPANOTHIONE REDUCTASE AND N1-GLUTATHIONYLSPERMIDINE DISULPHIDE AT 0.28-NM RESOLUTION Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, GLUTATHIONE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... Authors: Bailey, S, Hunter, W.N. Deposit date: 1992-06-29 Release date: 1994-01-31 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Substrate interactions between trypanothione reductase and N1-glutathionylspermidine disulphide at 0.28-nm resolution. Eur.J.Biochem., 213, 1993

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