1OA5
 
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3DMT
 | | Structure of Glycosomal Glyceraldehyde-3-Phosphate Dehydrogenase from Trypanosoma cruzi in complex with the irreversible iodoacetate inhibitor | | Descriptor: | GLYCEROL, Glyceraldehyde-3-phosphate dehydrogenase, glycosomal, ... | | Authors: | Guido, R.V.C, Balliano, T.L, Andricopulo, A.D, Oliva, G. | | Deposit date: | 2008-07-01 | | Release date: | 2008-10-21 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Kinetic and Crystallographic Studies on Glyceraldehyde-3-Phosphate Dehydrogenase from Trypanosoma cruzi in Complex with Iodoacetate.
Letters in drug design & discovery, 6, 2009
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3E0U
 | | Crystal structure of T. cruzi GPX1 | | Descriptor: | AMMONIUM ION, GLYCEROL, Glutathione peroxidase | | Authors: | Patel, S.H, Hussain, S, Harris, R, Driscoll, P, Djordjevic, S. | | Deposit date: | 2008-08-01 | | Release date: | 2009-08-04 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural insights into the catalytic mechanism of Trypanosoma cruzi GPXI (glutathione peroxidase-like enzyme I).
Biochem.J., 425, 2010
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1OA6
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3GUE
 | | Crystal Structure of UDP-glucose phosphorylase from Trypanosoma Brucei, (Tb10.389.0330) | | Descriptor: | (2R,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, GLYCEROL, SULFATE ION, ... | | Authors: | Wernimont, A.K, Marino, K, Lin, Y.H, Mackenzie, F, Kozieradzki, I, Cossar, D, Zhao, Y, Schapira, M, Bochkarev, A, Arrowsmith, C.H, Bountra, C, Weigelt, J, Edwards, A.M, Ferguson, M.A.J, Hui, R, Amani, M, Structural Genomics Consortium (SGC) | | Deposit date: | 2009-03-29 | | Release date: | 2009-08-18 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.92 Å) | | Cite: | Crystal Structure of UDP-glucose phosphorylase from Trypanosoma Brucei, (Tb10.389.0330)
To be Published
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3H9U
 | | S-adenosyl homocysteine hydrolase (SAHH) from Trypanosoma brucei | | Descriptor: | ADENOSINE, Adenosylhomocysteinase, GLYCEROL, ... | | Authors: | Siponen, M.I, Schutz, P, Arrowsmith, C.H, Berglund, H, Bountra, C, Collins, R, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, A, Johansson, I, Karlberg, T, Kragh Nielsen, T, Kotenyova, T, Kotzsch, A, Moche, M, Nordlund, P, Nyman, T, Persson, C, Sagemark, J, Thorsell, A.G, Tresaugues, L, Van Den Berg, S, Weigelt, J, Welin, M, Wisniewska, M, Schueler, H, Structural Genomics Consortium (SGC) | | Deposit date: | 2009-04-30 | | Release date: | 2009-09-29 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal structure of S-adenosyl homocysteine hydrolase (SAHH) from Trypanosoma brucei
To be Published
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2B4J
 | | Structural basis for the recognition between HIV-1 integrase and LEDGF/p75 | | Descriptor: | GLYCEROL, Integrase (IN), PC4 and SFRS1 interacting protein, ... | | Authors: | Cherepanov, P, Ambrosio, A.L, Rahman, S, Ellenberger, T, Engelman, A. | | Deposit date: | 2005-09-24 | | Release date: | 2005-10-25 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.02 Å) | | Cite: | Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75
Proc.Natl.Acad.Sci.Usa, 102, 2005
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3JWD
 | | Structure of HIV-1 gp120 with gp41-Interactive Region: Layered Architecture and Basis of Conformational Mobility | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, FAB 48D HEAVY CHAIN, FAB 48D LIGHT CHAIN, ... | | Authors: | Pancera, M, Majeed, S, Ban, Y.A, Chen, L, Huang, C.C, Kong, L, Kwon, Y.D, Stuckey, J, Zhou, T, Robinson, J.E, Schief, W.R, Sodroski, J, Wyatt, R, Kwong, P.D. | | Deposit date: | 2009-09-18 | | Release date: | 2009-12-29 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.61 Å) | | Cite: | Structure of HIV-1 gp120 with gp41-interactive region reveals layered envelope architecture and basis of conformational mobility.
Proc.Natl.Acad.Sci.USA, 107, 2010
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405D
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5ZU4
 | | Crystal structure of Lamprey immune protein | | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Li, Q.W, Pang, Y. | | Deposit date: | 2018-05-06 | | Release date: | 2019-06-12 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.39 Å) | | Cite: | Structure of a pore-forming protein
To Be Published
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5E93
 | | Crystal Structure of Trypanosoma cruzi Dihydroorotate Dehydrogenase in Complex with Neq0071 | | Descriptor: | 1,2-ETHANEDIOL, 5-[(E)-3-(furan-2-yl)prop-2-enylidene]-1,3-diazinane-2,4,6-trione, CACODYLATE ION, ... | | Authors: | Rocha, J.R, Inaoka, D.K, Cheleski, J, Shiba, T, Harada, S, Montanari, C.A, Kita, K. | | Deposit date: | 2015-10-14 | | Release date: | 2016-10-19 | | Last modified: | 2020-02-19 | | Method: | X-RAY DIFFRACTION (1.41 Å) | | Cite: | Exploring Trypanosoma cruzi Dihydroorotate Dehydrogenase Active Site Plasticity for the Discovery of Potent and Selective Inhibitors with Trypanocidal Activity
To be Published
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7OP2
 | | Chadox1/ Chimpanzee adenovirus Y25 fiber knob protein | | Descriptor: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, ... | | Authors: | Rizkallah, P.J, Baker, A.T, Parker, A.L, Teijeira Crespo, A, Lipka-Lloyd, M. | | Deposit date: | 2021-05-28 | | Release date: | 2021-06-23 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.59 Å) | | Cite: | ChAdOx1 interacts with CAR and PF4 with implications for thrombosis with thrombocytopenia syndrome.
Sci Adv, 7, 2021
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3BF3
 | | Type III pantothenate kinase from Thermotoga maritima complexed with product phosphopantothenate | | Descriptor: | MAGNESIUM ION, N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanine, Type III pantothenate kinase | | Authors: | Yang, K, Huerta, C, Strauss, E, Zhang, H. | | Deposit date: | 2007-11-20 | | Release date: | 2008-06-24 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.63 Å) | | Cite: | Structural basis for substrate binding and the catalytic mechanism of type III pantothenate kinase.
Biochemistry, 47, 2008
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3HRK
 | | Histidyl-tRNA synthetase from Trypanosoma cruzi (Histidyl-adenylate complex) | | Descriptor: | CHLORIDE ION, HISTIDYL-ADENOSINE MONOPHOSPHATE, Histidyl-tRNA synthetase | | Authors: | Arakaki, T.L, Merritt, E.A, Larson, E.T, Medical Structural Genomics of Pathogenic Protozoa (MSGPP) | | Deposit date: | 2009-06-09 | | Release date: | 2009-12-01 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (3.05 Å) | | Cite: | Crystal structures of trypanosomal histidyl-tRNA synthetase illuminate differences between eukaryotic and prokaryotic homologs.
J.Mol.Biol., 397, 2010
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3LC0
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4BER
 | | Crystal structure of the Legionella pneumophila FIC domain-containing effector AnkX protein in complex with cytidine monophosphate | | Descriptor: | CYTIDINE-5'-MONOPHOSPHATE, GLYCEROL, PHOSPHATE ION, ... | | Authors: | Campanacci, V, Mukherjee, S, Roy, C.R, Cherfils, J. | | Deposit date: | 2013-03-12 | | Release date: | 2013-04-24 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structure of the Legionella Effector Ankx Reveals the Mechanism of Phosphocholine Transfer by the Fic Domain.
Embo J., 32, 2013
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4BET
 | | Crystal structure of the Legionella pneumophila FIC domain-containing effector AnkX protein (inactive H229A mutant) in complex with cytidine-diphosphate-choline | | Descriptor: | GLYCEROL, PHOSPHOCHOLINE TRANSFERASE ANKX, SULFATE ION, ... | | Authors: | Campanacci, V, Mukherjee, S, Roy, C.R, Cherfils, J. | | Deposit date: | 2013-03-12 | | Release date: | 2013-04-24 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.55 Å) | | Cite: | Structure of the Legionella Effector Ankx Reveals the Mechanism of Phosphocholine Transfer by the Fic Domain.
Embo J., 32, 2013
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3IBA
 | | Crystal structure of the complex of Trypanosoma cruzi farnesyl diphosphate synthase with zoledronate, IPP and Mg2+ | | Descriptor: | 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, Farnesyl pyrophosphate synthase, MAGNESIUM ION, ... | | Authors: | Amzel, L.M, Huang, C.H, Gabelli, S.B, Oldfield, E. | | Deposit date: | 2009-07-15 | | Release date: | 2010-02-09 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Binding of nitrogen-containing bisphosphonates (N-BPs) to the Trypanosoma cruzi farnesyl diphosphate synthase homodimer.
Proteins, 78, 2010
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3HRI
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4NLB
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4NLC
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8IU6
 | | Crystal structure of peptidyl-tRNA hydrolase mutant from Enterococcus faecium | | Descriptor: | GLYCEROL, Peptidyl-tRNA hydrolase | | Authors: | Pandey, R, Tripathi, S, Lanka, A.K, Zohib, M, Pal, R.K, Arora, A. | | Deposit date: | 2023-03-23 | | Release date: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Crystal structure of peptidyl-tRNA hydrolase mutant from Enterococcus faecium
To Be Published
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6DIG
 | | Crystal structure of DQA1*01:02/DQB1*06:02 in complex with a hypocretin peptide | | Descriptor: | 13-mer peptide: ALA-GLY-ASN-HIS-ALA-ALA-GLY-ILE-LEU-THR-LEU-GLY-LYS, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Birtley, J.R, Stern, L.J, Mellins, E.D, Jiang, W. | | Deposit date: | 2018-05-23 | | Release date: | 2019-05-08 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | In vivo clonal expansion and phenotypes of hypocretin-specific CD4+T cells in narcolepsy patients and controls.
Nat Commun, 10, 2019
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5LY9
 | | Structure of MITat 1.1 | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLYCEROL, Variant surface glycoprotein MITAT 1.1, ... | | Authors: | Schaefer, C, Bartossek, T, Jones, N, Kuper, J, Kisker, C, Engstler, M. | | Deposit date: | 2016-09-26 | | Release date: | 2017-09-20 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Structural basis for the shielding function of the dynamic trypanosome variant surface glycoprotein coat.
Nat Microbiol, 2, 2017
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4YRM
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