7JZ6
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6H7W
| Model of retromer-Vps5 complex assembled on membrane. | Descriptor: | Putative vacuolar protein sorting-associated protein, Vacuolar protein sorting-associated protein 26-like protein, Vacuolar protein sorting-associated protein 29, ... | Authors: | Kovtun, O, Leneva, N, Ariotti, N, Rohan, T.S, Owen, D.J, Briggs, J.A.G, Collins, B.M. | Deposit date: | 2018-07-31 | Release date: | 2018-09-26 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (11.4 Å) | Cite: | Structure of the membrane-assembled retromer coat determined by cryo-electron tomography. Nature, 561, 2018
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6BQW
| AlfA Filament bound to AMPPNP | Descriptor: | Bacterial actin AlfA, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | Authors: | Usluer, G.D, Kollman, J.M, DiMaio, F. | Deposit date: | 2017-11-28 | Release date: | 2018-02-28 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Cryo-EM structure of the bacterial actin AlfA reveals unique assembly and ATP-binding interactions and the absence of a conserved subdomain. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6CJQ
| Structure of the SthK cyclic nucleotide-gated potassium channel | Descriptor: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, SthK cyclic nucleotide-gated potassium channel | Authors: | Nimigean, C.M, Rheinberger, J. | Deposit date: | 2018-02-26 | Release date: | 2018-08-01 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.42 Å) | Cite: | Ligand discrimination and gating in cyclic nucleotide-gated ion channels from apo and partial agonist-bound cryo-EM structures. Elife, 7, 2018
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3JUH
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9CPG
| Structures of small molecules bound to RNA repeat expansions that cause Huntington's disease-like 2 and myotonic dystrophy type 1 | Descriptor: | 4-carbamimidamidophenyl 4-carbamimidamidobenzoate, RNA (5'-R(*GP*AP*CP*AP*GP*CP*UP*GP*CP*UP*GP*UP*C)-3') | Authors: | Chen, J.L, Taghavi, A, Disney, M.D, Fountain, M.A, Childs-Disney, J.L. | Deposit date: | 2024-07-18 | Release date: | 2024-08-07 | Method: | SOLUTION NMR | Cite: | Structures of small molecules bound to RNA repeat expansions that cause Huntington's disease-like 2 and myotonic dystrophy type 1. Bioorg.Med.Chem.Lett., 2024
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9CPD
| Structures of small molecules bound to RNA repeat expansions that cause Huntington's disease-like 2 and myotonic dystrophy type 1 | Descriptor: | 4-[(3-methoxyphenyl)amino]-2-methylquinoline-6-carboximidamide, RNA (5'-R(*GP*AP*CP*AP*GP*CP*UP*GP*CP*UP*GP*UP*C)-3') | Authors: | Chen, J.L, Taghavi, A, Disney, M.D, Fountain, M.A, Childs-Disney, J.L. | Deposit date: | 2024-07-18 | Release date: | 2024-08-07 | Last modified: | 2024-08-14 | Method: | SOLUTION NMR | Cite: | NMR structures of small molecules bound to a model of a CUG RNA repeat expansion. Bioorg.Med.Chem.Lett., 111, 2024
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9BXI
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9CPI
| Structures of small molecules bound to RNA repeat expansions that cause Huntington's disease-like 2 and myotonic dystrophy type 1 | Descriptor: | 4-[1-(2-aminoethyl)-4,5-dihydro-1H-imidazol-2-yl]-N-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]benzamide, RNA (5'-R(*GP*AP*CP*AP*GP*CP*UP*GP*CP*UP*GP*UP*C)-3') | Authors: | Chen, J.L, Taghavi, A, Disney, M.D, Fountain, M.A, Childs-Disney, J.L. | Deposit date: | 2024-07-18 | Release date: | 2024-08-07 | Last modified: | 2024-08-14 | Method: | SOLUTION NMR | Cite: | NMR structures of small molecules bound to a model of a CUG RNA repeat expansion. Bioorg.Med.Chem.Lett., 111, 2024
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9BXQ
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6L3H
| Cryo-EM structure of dimeric quinol dependent Nitric Oxide Reductase (qNOR) from the pathogen Neisseria meninigitidis | Descriptor: | CALCIUM ION, FE (III) ION, Nitric-oxide reductase, ... | Authors: | Jamali, M.M.A, Gopalasingam, C.C, Johnson, R.M, Tosha, T, Muench, S.P, Muramoto, K, Antonyuk, S.V, Shiro, Y, Hasnain, S.S. | Deposit date: | 2019-10-11 | Release date: | 2020-04-01 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.06 Å) | Cite: | The active form of quinol-dependent nitric oxide reductase fromNeisseria meningitidisis a dimer. Iucrj, 7, 2020
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9BXR
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9CPJ
| Structures of small molecules bound to RNA repeat expansions that cause Huntington's disease-like 2 and myotonic dystrophy type 1 | Descriptor: | RNA (5'-R(*GP*AP*CP*AP*GP*CP*UP*GP*CP*UP*GP*UP*C)-3') | Authors: | Chen, J.L, Taghavi, A, Disney, M.D, Fountain, M.A, Childs-Disney, J.L. | Deposit date: | 2024-07-18 | Release date: | 2024-08-07 | Method: | SOLUTION NMR | Cite: | Structures of small molecules bound to RNA repeat expansions that cause Huntington's disease-like 2 and myotonic dystrophy type 1. Bioorg.Med.Chem.Lett., 2024
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6V21
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3ONW
| Structure of a G-alpha-i1 mutant with enhanced affinity for the RGS14 GoLoco motif. | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(i) subunit alpha-1, Regulator of G-protein signaling 14, ... | Authors: | Bosch, D, Kimple, A.J, Sammond, D.W, Miley, M.J, Machius, M, Kuhlman, B, Willard, F.S, Siderovski, D.P. | Deposit date: | 2010-08-30 | Release date: | 2010-11-24 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.38 Å) | Cite: | Structural Determinants of Affinity Enhancement between GoLoco Motifs and G-Protein {alpha} Subunit Mutants. J.Biol.Chem., 286, 2011
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6VAU
| Bare actin filament from a partially cofilin-decorated sample | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | Authors: | Huehn, A.R, Bibeau, J.P, Schramm, A.C, Cao, W, De La Cruz, E.M, Sindelar, C.V. | Deposit date: | 2019-12-17 | Release date: | 2020-01-01 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structures of cofilin-induced structural changes reveal local and asymmetric perturbations of actin filaments. Proc.Natl.Acad.Sci.USA, 117, 2020
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6VM1
| Chloroplast ATP synthase (C3, CF1FO) | Descriptor: | ATP synthase delta chain, chloroplastic, ATP synthase epsilon chain, ... | Authors: | Yang, J.-H, Williams, D, Kandiah, E, Fromme, P, Chiu, P.-L. | Deposit date: | 2020-01-27 | Release date: | 2020-09-09 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (7.9 Å) | Cite: | Structural basis of redox modulation on chloroplast ATP synthase. Commun Biol, 3, 2020
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2UZK
| Crystal structure of the human FOXO3a-DBD bound to DNA | Descriptor: | 5'-D(*CP*TP*AP*TP*GP*TP*AP*AP*AP*CP*AP*AP*C)-3', 5'-D(*GP*TP*TP*GP*TP*TP*TP*AP*CP*AP*TP*AP*G)-3', FORKHEAD BOX PROTEIN O3A | Authors: | Tsai, K.-L, Sun, Y.-J, Huang, C.-Y, Yang, J.-Y, Hung, M.-C, Hsiao, C.-D. | Deposit date: | 2007-04-30 | Release date: | 2008-05-13 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal Structure of the Human Foxo3A-Dbd/DNA Complex Suggests the Effects of Post-Translational Modification. Nucleic Acids Res., 35, 2007
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6T6V
| Glu-494-Ala inactive monomer of a quinol dependent Nitric Oxide Reductase (qNOR) from Alcaligenes xylosoxidans | Descriptor: | CALCIUM ION, Nitric oxide reductase subunit B, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Gopalasingam, C.C, Johnson, R.M, Antonyuk, S.V, Muench, S.P, Hasnain, S.S. | Deposit date: | 2019-10-19 | Release date: | 2020-04-01 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | The active form of quinol-dependent nitric oxide reductase fromNeisseria meningitidisis a dimer. Iucrj, 7, 2020
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6ZBB
| bovine ATP synthase Fo domain | Descriptor: | 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, ATP synthase F(0) complex subunit B1, mitochondrial, ... | Authors: | Spikes, T, Montgomery, M.G, Walker, J.E. | Deposit date: | 2020-06-08 | Release date: | 2020-09-09 | Last modified: | 2020-09-30 | Method: | ELECTRON MICROSCOPY (3.61 Å) | Cite: | Structure of the dimeric ATP synthase from bovine mitochondria. Proc.Natl.Acad.Sci.USA, 117, 2020
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4JIB
| Crystal structure of of PDE2-inhibitor complex | Descriptor: | 1-(2-hydroxyethyl)-3-(2-methylbutan-2-yl)-5-[4-(2-methyl-1H-imidazol-1-yl)phenyl]-6,7-dihydropyrazolo[4,3-e][1,4]diazepin-8(1H)-one, MAGNESIUM ION, ZINC ION, ... | Authors: | Pandit, J. | Deposit date: | 2013-03-05 | Release date: | 2013-05-01 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.72 Å) | Cite: | Discovery of potent, selective, bioavailable phosphodiesterase 2 (PDE2) inhibitors active in an osteoarthritis pain model, Part I: Transformation of selective pyrazolodiazepinone phosphodiesterase 4 (PDE4) inhibitors into selective PDE2 inhibitors. Bioorg.Med.Chem.Lett., 23, 2013
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6MRL
| Cucumber Leaf Spot Virus | Descriptor: | CALCIUM ION, p41 | Authors: | Sherman, M.B, Smith, T.J. | Deposit date: | 2018-10-14 | Release date: | 2019-10-16 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Near-Atomic-Resolution Cryo-Electron Microscopy Structures of Cucumber Leaf Spot Virus and Red Clover Necrotic Mosaic Virus: Evolutionary Divergence at the Icosahedral Three-Fold Axes. J.Virol., 94, 2020
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8DEW
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6GPW
| Structure of human Heat shock protein 90-alpha N-terminal domain (Hsp90-NTD) | Descriptor: | CHLORIDE ION, Heat shock protein HSP 90-alpha, MAGNESIUM ION | Authors: | Tassone, G, Pozzi, C, Mangani, S, Botta, M. | Deposit date: | 2018-06-07 | Release date: | 2018-10-03 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Probing the role of Arg97 in Heat shock protein 90 N-terminal domain from the parasite Leishmania braziliensis through site-directed mutagenesis on the human counterpart. Biochim Biophys Acta Proteins Proteom, 1866, 2018
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2X0B
| Crystal structure of human angiotensinogen complexed with renin | Descriptor: | ANGIOTENSINOGEN, RENIN | Authors: | Zhou, A, Wei, Z, Yan, Y, Carrell, R.W, Read, R.J. | Deposit date: | 2009-12-08 | Release date: | 2010-10-20 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (4.33 Å) | Cite: | A Redox Switch in Angiotensinogen Modulates Angiotensin Release. Nature, 468, 2010
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