2AFS
 
 | | Crystal structure of the genetic mutant R54W of human glutaminyl cyclase | | Descriptor: | Glutaminyl-peptide cyclotransferase, SULFATE ION, ZINC ION | | Authors: | Huang, K.F, Liu, Y.L, Cheng, W.J, Ko, T.P, Wang, A.H.J. | | Deposit date: | 2005-07-26 | | Release date: | 2005-08-23 | | Last modified: | 2024-05-29 | | Method: | X-RAY DIFFRACTION (2.22 Å) | | Cite: | Crystal structures of human glutaminyl cyclase, an enzyme responsible for protein N-terminal pyroglutamate formation
Proc.Natl.Acad.Sci.Usa, 102, 2005
|
|
9BUD
 | | Human calcitonin Receptor in complex with Gs and cagrilintide in the CT-like conformation | | Descriptor: | Cagrilintide, Calcitonin receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Cao, J, Belousoff, M.J, Johnson, R.M, Sexton, P.M, Wootten, D.L. | | Deposit date: | 2024-05-16 | | Release date: | 2025-04-23 | | Method: | ELECTRON MICROSCOPY (2.5 Å) | | Cite: | Human calcitonin Receptor in complex with Gs and cagrilintide in the bypass conformation
To Be Published
|
|
9BQ3
 | | Human Amylin2 Receptor in Complex with Gs and Cagrilintide | | Descriptor: | Cagrilintide, Calcitonin receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Cao, J, Belousoff, M.J, Wootten, D.L, Sexton, P.M, Johnson, R.M. | | Deposit date: | 2024-05-08 | | Release date: | 2025-04-23 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Human Amylin2 Receptor in Complex with Gs and Cagrilintide
To Be Published
|
|
9BP3
 | | Human Amylin1 Receptor in complex with Gs and cagrilintide | | Descriptor: | (2S)-2-{[(1R)-1-hydroxyhexadecyl]oxy}-3-{[(1R)-1-hydroxyoctadecyl]oxy}propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, ... | | Authors: | Cao, J, Belousoff, M.J, Johnson, R.M, Sexton, P.M, Wootten, D.L. | | Deposit date: | 2024-05-06 | | Release date: | 2025-04-23 | | Method: | ELECTRON MICROSCOPY (2.2 Å) | | Cite: | Human Amylin1 Receptor in complex with Gs and cagrilintide
To Be Published
|
|
9BUC
 | | Human calcitonin Receptor in complex with Gs and cagrilintide in the bypass conformation (repeat) | | Descriptor: | Cagrilintide, Calcitonin receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Cao, J, Belousoff, M.J, Johnson, R.M, Sexton, P.M, Wootten, D.L. | | Deposit date: | 2024-05-16 | | Release date: | 2025-04-23 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Human Amylin1 Receptor in complex with Gs and cagrilintide
To Be Published
|
|
3DUI
 | | Crystal structure of the oxidized CG-1B: an adhesion/growth-regulatory lectin from chicken | | Descriptor: | BETA-MERCAPTOETHANOL, Beta-galactoside-binding lectin | | Authors: | Romero, A, Lopez-Lucendo, M.I.F, Solis, D, Gabius, H.-J. | | Deposit date: | 2008-07-17 | | Release date: | 2009-06-30 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Homodimeric chicken galectin CG-1B (C-14): Crystal structure and detection of unique redox-dependent shape changes involving inter- and intrasubunit disulfide bridges by gel filtration, ultracentrifugation, site-directed mutagenesis, and peptide mass fingerprinting
J.Mol.Biol., 386, 2009
|
|
6UH6
 | | EV-A71 strain 11316 complexed with MADAL compound 22 | | Descriptor: | SPHINGOSINE, VP1, VP2, ... | | Authors: | Lee, H, Hafenstein, S. | | Deposit date: | 2019-09-26 | | Release date: | 2019-12-18 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (2.98 Å) | | Cite: | Scaffold Simplification Strategy Leads to a Novel Generation of Dual Human Immunodeficiency Virus and Enterovirus-A71 Entry Inhibitors.
J.Med.Chem., 63, 2020
|
|
2AFZ
 | | Crystal structure of human glutaminyl cyclase in complex with 1-vinylimidazole | | Descriptor: | 1-VINYLIMIDAZOLE, Glutaminyl-peptide cyclotransferase, SULFATE ION, ... | | Authors: | Huang, K.F, Liu, Y.L, Cheng, W.J, Ko, T.P, Wang, A.H.J. | | Deposit date: | 2005-07-26 | | Release date: | 2005-08-23 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.68 Å) | | Cite: | Crystal structures of human glutaminyl cyclase, an enzyme responsible for protein N-terminal pyroglutamate formation
Proc.Natl.Acad.Sci.Usa, 102, 2005
|
|
3E0U
 | | Crystal structure of T. cruzi GPX1 | | Descriptor: | AMMONIUM ION, GLYCEROL, Glutathione peroxidase | | Authors: | Patel, S.H, Hussain, S, Harris, R, Driscoll, P, Djordjevic, S. | | Deposit date: | 2008-08-01 | | Release date: | 2009-08-04 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural insights into the catalytic mechanism of Trypanosoma cruzi GPXI (glutathione peroxidase-like enzyme I).
Biochem.J., 425, 2010
|
|
3E1I
 | |
2AQ5
 | |
2AXA
 | | Crystal Structure Of The Androgen Receptor Ligand Binding Domain In Complex With S-1 | | Descriptor: | Androgen receptor, S-3-(4-FLUOROPHENOXY)-2-HYDROXY-2-METHYL-N-[4-NITRO-3-(TRIFLUOROMETHYL)PHENYL]PROPANAMIDE | | Authors: | Bohl, C.E, Miller, D.D, Chen, J, Bell, C.E, Dalton, J.T. | | Deposit date: | 2005-09-03 | | Release date: | 2005-09-20 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structural Basis for Accommodation of Nonsteroidal Ligands in the Androgen Receptor
J.Biol.Chem., 280, 2005
|
|
1UND
 | | Solution structure of the human advillin C-terminal headpiece subdomain | | Descriptor: | ADVILLIN | | Authors: | Vermeulen, W, Van Troys, M, Vanhaesebrouck, P, Verschueren, M, Fant, F, Ampe, C, Martins, J, Borremans, F. | | Deposit date: | 2003-09-09 | | Release date: | 2004-07-15 | | Last modified: | 2024-10-16 | | Method: | SOLUTION NMR | | Cite: | Solution Structures of the C-Terminal Headpiece Subdomains of Human Villin and Advillin, Evaluation of Headpiece F-Actin-Binding Requirements
Protein Sci., 13, 2004
|
|
9C82
 | | Structure of human ULK1C:PI3KC3-C1 supercomplex | | Descriptor: | Beclin 1-associated autophagy-related key regulator, Beclin-1, Phosphatidylinositol 3-kinase catalytic subunit type 3, ... | | Authors: | Chen, M, Hurley, J.H. | | Deposit date: | 2024-06-11 | | Release date: | 2024-07-03 | | Last modified: | 2025-06-18 | | Method: | ELECTRON MICROSCOPY (6.84 Å) | | Cite: | Structure and activation of the human autophagy-initiating ULK1C:PI3KC3-C1 supercomplex.
Nat.Struct.Mol.Biol., 2025
|
|
6U8M
 | | BRD4-BD1 in complex with the cyclic peptide 3.2_1 | | Descriptor: | AMINO GROUP, Bromodomain-containing protein 4, cyclic peptide 3.2_1 | | Authors: | Patel, K, Walshe, J.L, Walport, L.J, Mackay, J.P. | | Deposit date: | 2019-09-05 | | Release date: | 2020-08-19 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Cyclic peptides can engage a single binding pocket through highly divergent modes.
Proc.Natl.Acad.Sci.USA, 117, 2020
|
|
3DQS
 | | Structure of endothelial NOS heme domain in complex with a inhibitor (+-)-N1-{cis-4'-[(6"-amino-4"-methylpyridin-2"-yl)methyl]pyrrolidin-3'-yl}-N2-(4'-chlorobenzyl)ethane-1,2-diamine | | Descriptor: | 5,6,7,8-TETRAHYDROBIOPTERIN, ACETATE ION, CACODYLATE ION, ... | | Authors: | Igarashi, J, Li, H, Poulos, T.L. | | Deposit date: | 2008-07-09 | | Release date: | 2009-03-31 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.03 Å) | | Cite: | Crystal structures of constitutive nitric oxide synthases in complex with de novo designed inhibitors.
J.Med.Chem., 52, 2009
|
|
3DTU
 | | Catalytic core subunits (I and II) of cytochrome c oxidase from Rhodobacter sphaeroides complexed with deoxycholic acid | | Descriptor: | (3ALPHA,5BETA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC ACID, CADMIUM ION, CALCIUM ION, ... | | Authors: | Qin, L, Mills, D.A, Buhrow, L, Hiser, C, Ferguson-Miller, S. | | Deposit date: | 2008-07-15 | | Release date: | 2008-09-16 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | A conserved steroid binding site in cytochrome C oxidase.
Biochemistry, 47, 2008
|
|
2AX7
 | | Crystal Structure Of The Androgen Receptor Ligand Binding Domain T877A Mutant In Complex With S-1 | | Descriptor: | Androgen receptor, S-3-(4-FLUOROPHENOXY)-2-HYDROXY-2-METHYL-N-[4-NITRO-3-(TRIFLUOROMETHYL)PHENYL]PROPANAMIDE | | Authors: | Bohl, C.E, Miller, D.D, Chen, J, Bell, C.E, Dalton, J.T. | | Deposit date: | 2005-09-03 | | Release date: | 2005-09-20 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural Basis for Accommodation of Nonsteroidal Ligands in the Androgen Receptor
J.Biol.Chem., 280, 2005
|
|
3DLL
 | | The oxazolidinone antibiotics perturb the ribosomal peptidyl-transferase center and effect tRNA positioning | | Descriptor: | 50S ribosomal protein L11, 50S ribosomal protein L13, 50S ribosomal protein L14, ... | | Authors: | Wilson, D.N, Schluenzen, F, Harms, J.M, Starosta, A.L, Connell, S.R, Fucini, P. | | Deposit date: | 2008-06-27 | | Release date: | 2008-09-16 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | The oxazolidinone antibiotics perturb the ribosomal peptidyl-transferase center and effect tRNA positioning
Proc.Natl.Acad.Sci.Usa, 105, 2008
|
|
3DRI
 | | Crystal structure of Lactococcal OppA co-crystallized with an octamer peptide in an open conformation | | Descriptor: | Oligopeptide-binding protein oppA, peptide AASASA | | Authors: | Berntsson, R.P.-A, Doeven, M.K, Duurkens, R.H, Sengupta, D, Marrink, S.-J, Thunnissen, A.-M, Poolman, B, Slotboom, D.-J. | | Deposit date: | 2008-07-11 | | Release date: | 2009-03-31 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | The structural basis for peptide selection by the transport receptor OppA
Embo J., 28, 2009
|
|
3DRJ
 | | Crystal structure of Lactococcal OppA co-crystallized with pTH-related peptide in an open conformation | | Descriptor: | Oligopeptide-binding protein oppA, pTH-related peptide | | Authors: | Berntsson, R.P.-A, Doeven, M.K, Duurkens, R.H, Sengupta, D, Marrink, S.-J, Thunnissen, A.-M, Poolman, B, Slotboom, D.-J. | | Deposit date: | 2008-07-11 | | Release date: | 2009-03-31 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | The structural basis for peptide selection by the transport receptor OppA
Embo J., 28, 2009
|
|
2B4E
 | |
3DRH
 | | Crystal structure of Lactococcal OppA co-crystallized with Leu-enkephalin in an open conformation | | Descriptor: | Oligopeptide-binding protein oppA, peptide AAAAAA | | Authors: | Berntsson, R.P.-A, Doeven, M.K, Duurkens, R.H, Sengupta, D, Marrink, S.-J, Thunnissen, A.-M, Poolman, B, Slotboom, D.-J. | | Deposit date: | 2008-07-11 | | Release date: | 2009-03-31 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | The structural basis for peptide selection by the transport receptor OppA
Embo J., 28, 2009
|
|
3DQR
 | | Structure of neuronal NOS D597N/M336V mutant heme domain in complex with a inhibitor (+-)-N1-{cis-4'-[(6"-aminopyridin-2"-yl)methyl]pyrrolidin-3'-yl}ethane-1,2-diamine | | Descriptor: | 5,6,7,8-TETRAHYDROBIOPTERIN, ACETATE ION, N-{(3S,4S)-4-[(6-aminopyridin-2-yl)methyl]pyrrolidin-3-yl}ethane-1,2-diamine, ... | | Authors: | Igarashi, J, Li, H, Poulos, T.L. | | Deposit date: | 2008-07-09 | | Release date: | 2009-03-31 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Crystal structures of constitutive nitric oxide synthases in complex with de novo designed inhibitors.
J.Med.Chem., 52, 2009
|
|
3DRF
 | | Lactococcal OppA complexed with an endogenous peptide in the closed conformation | | Descriptor: | Oligopeptide-binding protein oppA, endogenous peptide | | Authors: | Berntsson, R.P.-A, Doeven, M.K, Duurkens, R.H, Sengupta, D, Marrink, S.-J, Thunnissen, A.-M, Poolman, B, Slotboom, D.-J. | | Deposit date: | 2008-07-11 | | Release date: | 2009-03-31 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | The structural basis for peptide selection by the transport receptor OppA
Embo J., 28, 2009
|
|
