PDB: 2596 resultsInfo pagesStatus searchChemie searchBIRD

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8B90	Crystal structure of PPARG and NCOR2 with an inverse agonist (compound 7d) Descriptor: 5-chloranyl-~{N}3-phenyl-~{N}1-(phenylmethyl)benzene-1,3-dicarboxamide, Nuclear receptor corepressor 2, Peroxisome proliferator-activated receptor gamma Authors: Friberg, A, Orsi, D.L, Pook, E, Siegel, S, Lemke, C.T, Stellfeld, T, Puetter, V, Goldstein, J. Deposit date: 2022-10-05 Release date: 2022-12-28 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Discovery and characterization of orally bioavailable 4-chloro-6-fluoroisophthalamides as covalent PPARG inverse-agonists. Bioorg.Med.Chem., 78, 2022
8B91	Crystal structure of mutant PPARG (C313A) and NCOR2 with an inverse agonist (compound SI-1) Descriptor: Nuclear receptor corepressor 2, Peroxisome proliferator-activated receptor gamma, ~{N}3-[4-[bis(fluoranyl)methoxy]-3-fluoranyl-phenyl]-4-chloranyl-6-fluoranyl-~{N}1-[(2-methoxyphenyl)methyl]benzene-1,3-dicarboxamide Authors: Friberg, A, Orsi, D.L, Pook, E, Siegel, S, Lemke, C.T, Stellfeld, T, Puetter, V, Goldstein, J. Deposit date: 2022-10-05 Release date: 2022-12-28 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (2.23 Å) Cite: Discovery and characterization of orally bioavailable 4-chloro-6-fluoroisophthalamides as covalent PPARG inverse-agonists. Bioorg.Med.Chem., 78, 2022
1JHF	LEXA G85D MUTANT Descriptor: LEXA REPRESSOR, SULFATE ION Authors: Luo, Y, Pfuetzner, R.A, Mosimann, S, Little, J.W, Strynadka, N.C.J. Deposit date: 2001-06-27 Release date: 2001-09-19 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Crystal structure of LexA: a conformational switch for regulation of self-cleavage. Cell(Cambridge,Mass.), 106, 2001
1DGD	AN ALKALI METAL ION SIZE-DEPENDENT SWITCH IN THE ACTIVE SITE STRUCTURE OF DIALKYLGLYCINE DECARBOXYLASE Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DIALKYLGLYCINE DECARBOXYLASE, LITHIUM ION, ... Authors: Hohenester, E, Jansonius, J.N. Deposit date: 1994-06-29 Release date: 1994-09-30 Last modified: 2017-11-29 Method: X-RAY DIFFRACTION (2.8 Å) Cite: An alkali metal ion size-dependent switch in the active site structure of dialkylglycine decarboxylase. Biochemistry, 33, 1994
1DGE	AN ALKALI METAL ION SIZE-DEPENDENT SWITCH IN THE ACTIVE SITE STRUCTURE OF DIALKYLGLYCINE DECARBOXYLASE Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DIALKYLGLYCINE DECARBOXYLASE, PYRIDOXAL-5'-PHOSPHATE, ... Authors: Hohenester, E, Jansonius, J.N. Deposit date: 1994-06-29 Release date: 1994-09-30 Last modified: 2017-11-29 Method: X-RAY DIFFRACTION (2.8 Å) Cite: An alkali metal ion size-dependent switch in the active site structure of dialkylglycine decarboxylase. Biochemistry, 33, 1994
6PDZ	Crystal structure of PPARgamma ligand binding domain in complex with SMRT peptide and inverse agonist T0070907 Descriptor: 2-chloro-5-nitro-N-(pyridin-4-yl)benzamide, Nuclear receptor corepressor 2, Peroxisome proliferator-activated receptor gamma Authors: Shang, J, Kojetin, D.J. Deposit date: 2019-06-19 Release date: 2020-03-04 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.1 Å) Cite: A molecular switch regulating transcriptional repression and activation of PPAR gamma. Nat Commun, 11, 2020
3H6Z	Crystal Structure of the Four MBT Repeats of Drosophila melanogaster Sfmbt in Complex with Peptide RHR (me)K VLR Descriptor: 'HR(MLZ)VLR, Polycomb protein Sfmbt, beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose Authors: Grimm, C, Mueller, C.W. Deposit date: 2009-04-24 Release date: 2009-06-16 Last modified: 2021-11-10 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Molecular recognition of histone lysine methylation by the Polycomb group repressor dSfmbt Embo J., 28, 2009
4C5G	Crystal structure of the minimal Pho-Sfmbt complex (P6122 spacegroup) Descriptor: POLYCOMB PROTEIN PHO, POLYCOMB PROTEIN SFMBT Authors: Alfieri, C, Glatt, S, Mueller, C.W. Deposit date: 2013-09-11 Release date: 2013-11-13 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structural Basis for Targeting the Chromatin Repressor Sfmbt to Polycomb Response Elements Genes Dev., 27, 2013
4C5H	Crystal structure of the minimal Pho-Sfmbt complex (P3121 spacegroup) Descriptor: POLYCOMB PROTEIN PHO, POLYCOMB PROTEIN SFMBT Authors: Alfieri, C, Glatt, S, Mueller, C.W. Deposit date: 2013-09-11 Release date: 2013-11-13 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Structural Basis for Targeting the Chromatin Repressor Sfmbt to Polycomb Response Elements Genes Dev., 27, 2013
6TE1	Structure of the KDM1A/CoREST complex with the inhibitor 2-[3-{4-chloro-3-[(4-chlorophenyl)ethynyl]phenyl}-1-(3-morpholin-4-ylpropyl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]-2-oxoethanol Descriptor: 5-[4-cyclobutyl-1-[2-(4-piperidin-4-yloxyphenoxy)ethyl]imidazol-2-yl]-4-methyl-thieno[3,2-b]pyrrole, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... Authors: Pasqualato, S, Cecatiello, V. Deposit date: 2019-11-11 Release date: 2020-06-03 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (3.11 Å) Cite: Discovery of Reversible Inhibitors of KDM1A Efficacious in Acute Myeloid Leukemia Models. Acs Med.Chem.Lett., 11, 2020
4C5E	Crystal structure of the minimal Pho-Sfmbt complex (P21 spacegroup) Descriptor: POLYCOMB PROTEIN PHO, POLYCOMB PROTEIN SFMBT Authors: Alfieri, C, Glatt, S, Mueller, C.W. Deposit date: 2013-09-11 Release date: 2013-11-13 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.951 Å) Cite: Structural Basis for Targeting the Chromatin Repressor Sfmbt to Polycomb Response Elements Genes Dev., 27, 2013
4CIH	Structure of LntA-K180D-K181D from Listeria monocytogenes Descriptor: LISTERIA NUCLEAR TARGETED PROTEIN A Authors: Lebreton, A, Job, V, Ragon, M, Le Monnier, A, Dessen, A, Cossart, P, Bierne, H. Deposit date: 2013-12-09 Release date: 2014-02-05 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.22 Å) Cite: Structural basis for the inhibition of the chromatin repressor BAHD1 by the bacterial nucleomodulin LntA. MBio, 5, 2014
2ZNZ	Crystal structure of FFRP Descriptor: LYSINE, Uncharacterized HTH-type transcriptional regulator PH1519 Authors: Yamada, M, Suzuki, M. Deposit date: 2008-05-02 Release date: 2009-03-17 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.39 Å) Cite: Interactions between the archaeal transcription repressor FL11 and its coregulators lysine and arginine. Proteins, 74, 2009
2ZNY	Crystal structure of the FFRP Descriptor: ARGININE, Uncharacterized HTH-type transcriptional regulator PH1519 Authors: Yamada, M, Suzuki, M. Deposit date: 2008-05-02 Release date: 2009-03-17 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.59 Å) Cite: Interactions between the archaeal transcription repressor FL11 and its coregulators lysine and arginine. Proteins, 74, 2009
1GDR	MODEL FOR A DNA MEDIATED SYNAPTIC COMPLEX SUGGESTED BY CRYSTAL PACKING OF GAMMA DELTA RESOLVASE SUBUNITS Descriptor: GAMMA DELTA-RESOLVASE Authors: Rice, P.A, Steitz, T.A. Deposit date: 1993-08-31 Release date: 1994-04-30 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (3.5 Å) Cite: Model for a DNA-mediated synaptic complex suggested by crystal packing of gamma delta resolvase subunits. EMBO J., 13, 1994
1D7S	CRYSTAL STRUCTURE OF THE COMPLEX OF 2,2-DIALKYLGLYCINE DECARBOXYLASE WITH DCS Descriptor: D-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL]-N,O-CYCLOSERYLAMIDE, POTASSIUM ION, PROTEIN (2,2-DIALKYLGLYCINE DECARBOXYLASE (PYRUVATE)), ... Authors: Malashkevich, V.N, Toney, M.D, Strop, P, Keller, J, Jansonius, J.N. Deposit date: 1999-10-19 Release date: 1999-11-19 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Crystal structures of dialkylglycine decarboxylase inhibitor complexes. J.Mol.Biol., 294, 1999
3SSX	E. coli trp aporeporessor L75F mutant Descriptor: TRIS(HYDROXYETHYL)AMINOMETHANE, Trp operon repressor Authors: Benoff, B, Carey, J, Berman, H.M, Lawson, C.L. Deposit date: 2011-07-08 Release date: 2011-07-20 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.5801 Å) Cite: Environment-dependent long-range structural distortion in a temperature-sensitive point mutant. Protein Sci., 21, 2012
1D7V	CRYSTAL STRUCTURE OF THE COMPLEX OF 2,2-DIALKYLGLYCINE DECARBOXYLASE WITH NMA Descriptor: N-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL]-2-METHYLALANINE, POTASSIUM ION, PROTEIN (2,2-DIALKYLGLYCINE DECARBOXYLASE (PYRUVATE)), ... Authors: Malashkevich, V.N, Toney, M.D, Strop, P, Keller, J, Jansonius, J.N. Deposit date: 1999-10-19 Release date: 1999-11-19 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Crystal structures of dialkylglycine decarboxylase inhibitor complexes. J.Mol.Biol., 294, 1999
1D7R	CRYSTAL STRUCTURE OF THE COMPLEX OF 2,2-DIALKYLGLYCINE DECARBOXYLASE WITH 5PA Descriptor: N-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-Y-LMETHYL]-1-AMINO-CYCLOPROPANECARBOXYLIC ACID, POTASSIUM ION, PROTEIN (2,2-DIALKYLGLYCINE DECARBOXYLASE (PYRUVATE)), ... Authors: Malashkevich, V.N, Toney, M.D, Strop, P, Keller, J, Jansonius, J.N. Deposit date: 1999-10-19 Release date: 1999-11-19 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal structures of dialkylglycine decarboxylase inhibitor complexes. J.Mol.Biol., 294, 1999
1D7U	Crystal structure of the complex of 2,2-dialkylglycine decarboxylase with LCS Descriptor: POTASSIUM ION, PROTEIN (2,2-DIALKYLGLYCINE DECARBOXYLASE (PYRUVATE)), SODIUM ION, ... Authors: Malashkevich, V.N, Toney, M.D, Strop, P, Keller, J, Jansonius, J.N. Deposit date: 1999-10-19 Release date: 1999-11-19 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Crystal structures of dialkylglycine decarboxylase inhibitor complexes. J.Mol.Biol., 294, 1999
1MNM	YEAST MATALPHA2/MCM1/DNA TERNARY TRANSCRIPTION COMPLEX CRYSTAL STRUCTURE Descriptor: DNA (STE6 OPERATOR DNA), PROTEIN (MAT ALPHA-2 TRANSCRIPTIONAL REPRESSOR), PROTEIN (MCM1 TRANSCRIPTIONAL REGULATOR) Authors: Tan, S, Richmond, T.J. Deposit date: 1997-11-03 Release date: 1998-03-18 Last modified: 2023-08-02 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Crystal structure of the yeast MATalpha2/MCM1/DNA ternary complex. Nature, 391, 1998
1ZNM	A zinc finger with an artificial beta-turn, original sequence taken from the third zinc finger domain of the human transcriptional repressor protein YY1 (YING and YANG 1, a delta transcription factor), nmr, 34 structures Descriptor: YY1, ZINC ION Authors: Viles, J.H, Patel, S.U, Mitchell, J.B.O, Moody, C.M, Justice, D.E, Uppenbrink, J, Doyle, P.M, Harris, C.J, Sadler, P.J, Thornton, J.M. Deposit date: 1997-11-20 Release date: 1998-04-01 Last modified: 2017-11-29 Method: SOLUTION NMR Cite: Design, synthesis and structure of a zinc finger with an artificial beta-turn. J.Mol.Biol., 279, 1998
3V8K	Crystal structure of Staphylococcus aureus biotin protein ligase in complex with biotin Descriptor: BIOTIN, Biotin ligase Authors: Yap, M.Y, Pendini, N.R. Deposit date: 2011-12-23 Release date: 2012-12-26 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (3.23 Å) Cite: Selective inhibition of biotin protein ligase from Staphylococcus aureus. J.Biol.Chem., 287, 2012
3V8L	Crystal structure of Staphylococcus aureus biotin protein ligase in complex with biotinyl-5'-AMP Descriptor: BIOTINYL-5-AMP, Biotin ligase Authors: Yap, M.Y. Deposit date: 2011-12-23 Release date: 2012-12-26 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Selective inhibition of biotin protein ligase from Staphylococcus aureus. J.Biol.Chem., 287, 2012
6XXS	Crystal structure of an NCoR1BBD2-BCL6BTB chimera in complex with the NcoR1 BBD1 corepressor peptide. Descriptor: B-cell lymphoma 6 protein, Nuclear receptor corepressor 1 Authors: Zacharchenko, T, Wright, S.C. Deposit date: 2020-01-28 Release date: 2020-12-02 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (3.25 Å) Cite: Functionalization of the BCL6 BTB domain into a noncovalent crystallization chaperone. Iucrj, 8, 2021

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