4XAY
 
 | | Cycles of destabilization and repair underlie evolutionary transitions in enzymes | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, CACODYLATE ION, Phosphotriesterase variant PTE-R8, ... | | Authors: | Jackson, C.J, Campbell, E, Kaltenbach, M, Tokuriki, N. | | Deposit date: | 2014-12-16 | | Release date: | 2015-12-16 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.84 Å) | | Cite: | The role of protein dynamics in the evolution of new enzyme function.
Nat.Chem.Biol., 12, 2016
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4XAZ
 | | Cycles of destabilization and repair underlie evolutionary transitions in enzymes | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, Phosphotriesterase variant PTE-R18, ZINC ION | | Authors: | Jackson, C.J, Campbell, E, Kaltenbach, M, Tokuriki, N. | | Deposit date: | 2014-12-16 | | Release date: | 2015-12-16 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | The role of protein dynamics in the evolution of new enzyme function.
Nat.Chem.Biol., 12, 2016
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4XD4
 | | Phosphotriesterase variant E2b | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, CACODYLATE ION, Phosphotriesterase variant PTE-R3, ... | | Authors: | Jackson, C.J, Campbell, E, Kaltenbach, M, Tokuriki, N. | | Deposit date: | 2014-12-19 | | Release date: | 2015-12-23 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | The role of protein dynamics in the evolution of new enzyme function.
Nat.Chem.Biol., 12, 2016
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4XAG
 | | Cycles of destabilization and repair underlie the evolution of new enzyme function | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, CACODYLATE ION, Phosphotriesterase variant PTE-R6, ... | | Authors: | Jackson, C.J, Campbell, E, Kaltenbach, M, Tokuriki, N. | | Deposit date: | 2014-12-14 | | Release date: | 2015-12-16 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | The role of protein dynamics in the evolution of new enzyme function.
Nat.Chem.Biol., 12, 2016
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4XD3
 | | Phosphotriesterase variant E3 | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, CACODYLATE ION, Phosphotriesterase variant PTE-E1, ... | | Authors: | Jackson, C.J, Campbell, E, Kaltenbach, M, Tokuriki, N. | | Deposit date: | 2014-12-19 | | Release date: | 2015-12-23 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.57 Å) | | Cite: | The role of protein dynamics in the evolution of new enzyme function.
Nat.Chem.Biol., 12, 2016
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4XD6
 | | Phosphotriesterase Variant E2a | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, CACODYLATE ION, Phosphotriesterase variant PTE-E2, ... | | Authors: | Jackson, C.J, Campbell, E, Kaltenbach, M, Tokuriki, N. | | Deposit date: | 2014-12-19 | | Release date: | 2015-12-23 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | The role of protein dynamics in the evolution of new enzyme function.
Nat.Chem.Biol., 12, 2016
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8GJ1
 | | E. coli clamp loader with open clamp on primed template DNA (form 2) | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Beta sliding clamp, DNA polymerase III subunit delta, ... | | Authors: | Oakley, A.J, Xu, Z.-Q, Dixon, N.E. | | Deposit date: | 2023-03-14 | | Release date: | 2024-03-27 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structural characterisation of the complete cycle of sliding clamp loading in Escherichia coli.
Nat Commun, 15, 2024
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8GJ2
 | | E. coli clamp loader with closed clamp on primed template DNA | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Beta sliding clamp, DNA polymerase III subunit delta, ... | | Authors: | Oakley, A.J, Xu, Z.-Q, Dixon, N.E. | | Deposit date: | 2023-03-14 | | Release date: | 2024-03-27 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (2.6 Å) | | Cite: | Structural characterisation of the complete cycle of sliding clamp loading in Escherichia coli.
Nat Commun, 15, 2024
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8GJ0
 | | E. coli clamp loader with open clamp on primed template DNA (form 1) | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Beta sliding clamp, DNA polymerase III subunit delta, ... | | Authors: | Oakley, A.J, Xu, Z.-Q, Dixon, N.E. | | Deposit date: | 2023-03-14 | | Release date: | 2024-03-27 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Structural characterisation of the complete cycle of sliding clamp loading in Escherichia coli.
Nat Commun, 15, 2024
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9E87
 | | De Novo Mycobacterium tuberculosis transcription initiation pre-RPO promoter complex with open Beta' clamp (RNA Polymerase with Sigma-A, CarD, and RbpA) | | Descriptor: | DNA (54-MER), DNA (62-MER), DNA-directed RNA polymerase subunit alpha, ... | | Authors: | Brewer, J.J, Campbell, E.A, Darst, S.A. | | Deposit date: | 2024-11-05 | | Release date: | 2025-10-01 | | Last modified: | 2025-12-03 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Structural Insights into De Novo Promoter Escape by Mycobacterium tuberculosis RNA Polymerase.
Nat Commun, 16, 2025
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9E86
 | | De Novo Mycobacterium tuberculosis transcription initiation promoter complex with 5-mer RNA and open Beta' clamp (RNA Polymerase with Sigma-A, CarD, and RbpA) | | Descriptor: | DNA (48-MER), DNA (52-MER), DNA-directed RNA polymerase subunit alpha, ... | | Authors: | Brewer, J.J, Campbell, E.A, Darst, S.A. | | Deposit date: | 2024-11-05 | | Release date: | 2025-10-01 | | Last modified: | 2025-12-03 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Structural Insights into De Novo Promoter Escape by Mycobacterium tuberculosis RNA Polymerase.
Nat Commun, 16, 2025
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9E85
 | | De Novo Mycobacterium tuberculosis transcription initiation promoter complex with 6-mer RNA and closed Beta' clamp (RNA Polymerase with Sigma-A, CarD, and RbpA) | | Descriptor: | DNA (47-MER), DNA (48-MER), DNA-directed RNA polymerase subunit alpha, ... | | Authors: | Brewer, J.J, Campbell, E.A, Darst, S.A. | | Deposit date: | 2024-11-05 | | Release date: | 2025-10-01 | | Last modified: | 2025-12-03 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structural Insights into De Novo Promoter Escape by Mycobacterium tuberculosis RNA Polymerase.
Nat Commun, 16, 2025
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8VVP
 | | Codon sampling state obtained from Anisomycin-treated mammalian ribosomes | | Descriptor: | 18S rRNA, 28S rRNA, 5.8S rRNA, ... | | Authors: | Loerch, S, Petrossian, E, Smith, P.R, Campbell, Z.T. | | Deposit date: | 2024-01-31 | | Release date: | 2025-07-30 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Rapid purification reveals structural insights into transient ribosome states
To Be Published
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7Q2X
 | | Cryo-EM structure of clamped S.cerevisiae condensin-DNA complex (Form I) | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Condensin complex subunit 1, ... | | Authors: | Lee, B.-G, Rhodes, J, Lowe, J. | | Deposit date: | 2021-10-26 | | Release date: | 2022-03-23 | | Last modified: | 2024-11-20 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Clamping of DNA shuts the condensin neck gate.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7Q2Y
 | | Cryo-EM structure of clamped S.cerevisiae condensin-DNA complex (form II) | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Condensin complex subunit 1, ... | | Authors: | Lee, B.-G, Rhodes, J, Lowe, J. | | Deposit date: | 2021-10-26 | | Release date: | 2022-03-23 | | Last modified: | 2023-09-13 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Clamping of DNA shuts the condensin neck gate.
Proc.Natl.Acad.Sci.USA, 119, 2022
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8VVQ
 | | Codon sampling state of elongation inhibitor-treated mammalian ribosomes obtained from merged datasets | | Descriptor: | 18S rRNA, 28S rRNA, 5.8S rRNA, ... | | Authors: | Loerch, S, Petrossian, E, Smith, P.R, Campbell, Z.T. | | Deposit date: | 2024-01-31 | | Release date: | 2025-07-30 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Rapid purification reveals structural insights into transient ribosome states
To Be Published
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3FDS
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3DSG
 | | XC1028 from Xanthomonas campestris Adopts a PilZ Domain-like Structure Yet with Trivial c-di-GMP Binding Activity | | Descriptor: | Type IV fimbriae assembly protein | | Authors: | Li, T.N, Chin, K.H, Liu, J.H, Wang, A.H.J, Chou, S.H. | | Deposit date: | 2008-07-12 | | Release date: | 2009-05-19 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.09 Å) | | Cite: | XC1028 from Xanthomonas campestris adopts a PilZ domain-like structure without a c-di-GMP switch.
Proteins, 75, 2009
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2HXU
 | | Crystal structure of K220A mutant of L-Fuconate Dehydratase from Xanthomonas campestris liganded with Mg++ and L-fuconate | | Descriptor: | 6-deoxy-L-galactonic acid, L-fuconate dehydratase, MAGNESIUM ION, ... | | Authors: | Fedorov, A.A, Fedorov, E.V, Yew, W.S, Rakus, J.F, Gerlt, J.A, Almo, S.C. | | Deposit date: | 2006-08-03 | | Release date: | 2006-12-19 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Evolution of Enzymatic Activities in the Enolase Superfamily: l-Fuconate Dehydratase from Xanthomonas campestris.
Biochemistry, 45, 2006
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2HXT
 | | Crystal structure of L-Fuconate Dehydratase from Xanthomonas campestris liganded with Mg++ and D-erythronohydroxamate | | Descriptor: | (2R,3R)-N,2,3,4-TETRAHYDROXYBUTANAMIDE, L-fuconate dehydratase, MAGNESIUM ION | | Authors: | Fedorov, A.A, Fedorov, E.V, Yew, W.S, Rakus, J.F, Gerlt, J.A, Almo, S.C. | | Deposit date: | 2006-08-03 | | Release date: | 2006-12-19 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Evolution of Enzymatic Activities in the Enolase Superfamily: l-Fuconate Dehydratase from Xanthomonas campestris.
Biochemistry, 45, 2006
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2L2R
 | | Helical hairpin structure of a novel antimicrobial peptide EcAMP1 from seeds of barnyard grass (Echinochloa crus-galli) | | Descriptor: | Antimicrobial peptide EcAMP1 | | Authors: | Nolde, S.B, Barinov, N.A, Balashova, T.A, Arseniev, A.S, Vassilevski, A.A, Rogozhin, E.A, Egorov, T.A, Grishin, E.V. | | Deposit date: | 2010-08-26 | | Release date: | 2011-05-11 | | Last modified: | 2024-10-09 | | Method: | SOLUTION NMR | | Cite: | Disulfide-stabilized Helical Hairpin Structure and Activity of a Novel Antifungal Peptide EcAMP1 from Seeds of Barnyard Grass (Echinochloa crus-galli).
J.Biol.Chem., 286, 2011
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2LHB
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8Z7V
 | | Slc19A3-Amprolium outward structure | | Descriptor: | Amprolium, Thiamine transporter 2 | | Authors: | Li, P.P, Zhu, Z.N, Wang, Y, Gao, P, Qu, Q.H. | | Deposit date: | 2024-04-21 | | Release date: | 2025-01-08 | | Last modified: | 2025-07-16 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Substrate transport and drug interaction of human thiamine transporters SLC19A2/A3.
Nat Commun, 15, 2024
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2HY7
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1FMO
 | | CRYSTAL STRUCTURE OF A POLYHISTIDINE-TAGGED RECOMBINANT CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH THE PEPTIDE INHIBITOR PKI(5-24) AND ADENOSINE | | Descriptor: | ADENOSINE, CAMP-DEPENDENT PROTEIN KINASE, HEAT STABLE RABBIT SKELETAL MUSCLE INHIBITOR PROTEIN | | Authors: | Narayana, N, Cox, S, Shaltiel, S, Taylor, S.S, Xuong, N.-H. | | Deposit date: | 1997-07-08 | | Release date: | 1998-01-14 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Crystal structure of a polyhistidine-tagged recombinant catalytic subunit of cAMP-dependent protein kinase complexed with the peptide inhibitor PKI(5-24) and adenosine.
Biochemistry, 36, 1997
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