PDB: 250 resultsInfo pagesStatus searchChemie searchBIRD

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8TUF	Crystal structure of human norovirus RNA-dependent RNA-polymerase Descriptor: 1,2-ETHANEDIOL, MAGNESIUM ION, RNA-dependent RNA-polymerase Authors: Prasad, B.V.V, Kaundal, S, Sankaran, B. Deposit date: 2023-08-16 Release date: 2024-12-18 Method: X-RAY DIFFRACTION (2.03 Å) Cite: Crystal structure of human norovirus RNA-dependent RNA-polymerase To Be Published
9JKD	Crystal structure of Aspergillus fumigatus polymycovirus 1 ploymerase elongation complex Descriptor: GLYCEROL, RNA (30-MER), RNA (5'-R(P*GP*GP*AP*UP*AP*UP*AP*AP*U)-3'), ... Authors: Jia, H, Gong, P. Deposit date: 2024-09-15 Release date: 2025-03-26 Last modified: 2025-04-30 Method: X-RAY DIFFRACTION (2.34 Å) Cite: An evolutionarily unique viral RdRP suggests a common dual-function feature of the priming element. Sci Adv, 11, 2025
9JKC	Crystal structure of Aspergillus fumigatus polymycovirus 1 ploymerase (residues 85-763) in its apo state Descriptor: RNA dependent RNA polymerase Authors: Jia, H, Cao, S, Gong, P. Deposit date: 2024-09-15 Release date: 2025-03-26 Last modified: 2025-04-30 Method: X-RAY DIFFRACTION (3.4 Å) Cite: An evolutionarily unique viral RdRP suggests a common dual-function feature of the priming element. Sci Adv, 11, 2025
6LSF	Crystal structure of the enterovirus 71 polymerase elongation complex (C2S6RA/C2S6RB form) Descriptor: Genome polyprotein, RNA (35-MER), RNA (5'-R(*UP*GP*UP*UP*CP*GP*AP*CP*GP*AP*GP*AP*GP*AP*GP*AP*CP*C)-3'), ... Authors: Wang, M, Shu, B, Jing, X, Gong, P. Deposit date: 2020-01-17 Release date: 2020-04-29 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.152 Å) Cite: Stringent control of the RNA-dependent RNA polymerase translocation revealed by multiple intermediate structures. Nat Commun, 11, 2020
2D7S	Foot and Mouth Disease Virus RNA-dependent RNA polymerase in complex with VPg protein Descriptor: RNA-dependent RNA polymerase, VPg1 protein Authors: Ferrer-Orta, C, Arias, A, Perez-Luque, R, Escarmis, C, Domingo, E, Verdaguer, N. Deposit date: 2005-11-29 Release date: 2006-03-28 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (3 Å) Cite: The structure of a protein primer-polymerase complex in the initiation of genome replication Embo J., 25, 2006
2EC0	RNA-dependent RNA polymerase of foot-and-mouth disease virus in complex with a template-primer RNA and ATP Descriptor: 5'-R(*GP*GP*GP*CP*CP*CP*A)-3', 5'-R(P*AP*UP*GP*GP*GP*CP*CP*C)-3', MAGNESIUM ION, ... Authors: Ferrer-Orta, C, Arias, A, Perez-Luque, R, Escarmis, C, Domingo, E, Verdaguer, N. Deposit date: 2007-02-09 Release date: 2007-06-26 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.75 Å) Cite: Sequential structures provide insights into the fidelity of RNA replication Proc.Natl.Acad.Sci.Usa, 104, 2007
7W9S	Crystal structure of the enterovirus 71 polymerase elongation complex (C1S3 form) Descriptor: CYTIDINE-5'-TRIPHOSPHATE, Genome polyprotein, MAGNESIUM ION, ... Authors: Wang, M, Gong, P. Deposit date: 2021-12-10 Release date: 2022-11-16 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.53 Å) Cite: Crystal structure of a pre-chemistry viral RNA-dependent RNA polymerase suggests participation of two basic residues in catalysis. Nucleic Acids Res., 50, 2022
1HHS	RNA dependent RNA polymerase from dsRNA bacteriophage phi6 Descriptor: MANGANESE (II) ION, RNA-DIRECTED RNA POLYMERASE Authors: Grimes, J.M, Butcher, S.J, Makeyev, E.V, Bamford, D.H, Stuart, D.I. Deposit date: 2000-12-28 Release date: 2001-03-27 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2 Å) Cite: A Mechanism for Initiating RNA-Dependent RNA Polymerization Nature, 410, 2001
1HHT	RNA dependent RNA polymerase from dsRNA bacteriophage phi6 plus template Descriptor: DNA (5'-(*TP*TP*TP*CP*C)-3'), MANGANESE (II) ION, P2 PROTEIN Authors: Grimes, J.M, Butcher, S.J, Makeyev, E.V, Bamford, D.H, Stuart, D.I. Deposit date: 2000-12-28 Release date: 2001-03-27 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.9 Å) Cite: A Mechanism for Initiating RNA-Dependent RNA Polymerization Nature, 410, 2001
1HI1	RNA dependent RNA polymerase from dsRNA bacteriophage phi6 plus bound NTP Descriptor: ADENOSINE-5'-TRIPHOSPHATE, P2 PROTEIN Authors: Grimes, J.M, Butcher, S.J, Makeyev, E.V, Bamford, D.H, Stuart, D.I. Deposit date: 2001-01-01 Release date: 2001-03-27 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (3 Å) Cite: A Mechanism for Initiating RNA-Dependent RNA Polymerization Nature, 410, 2001
6LSH	Crystal structure of the enterovirus 71 polymerase elongation complex (C2S6M form) Descriptor: Genome polyprotein, RNA (35-MER), RNA (5'-R(*UP*GP*UP*UP*CP*GP*AP*CP*GP*AP*GP*AP*GP*AP*GP*AP*CP*C)-3'), ... Authors: Li, R, Wang, M, Jing, X, Gong, P. Deposit date: 2020-01-17 Release date: 2020-04-29 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.231 Å) Cite: Stringent control of the RNA-dependent RNA polymerase translocation revealed by multiple intermediate structures. Nat Commun, 11, 2020
6LSG	Crystal structure of the enterovirus 71 polymerase elongation complex (C0S6M form) Descriptor: Genome polyprotein, RNA (35-MER), RNA (5'-R(*UP*GP*UP*UP*CP*GP*AP*CP*GP*AP*GP*AP*GP*AP*GP*A)-3'), ... Authors: Li, R, Wang, M, Jing, X, Gong, P. Deposit date: 2020-01-17 Release date: 2020-04-29 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.14 Å) Cite: Stringent control of the RNA-dependent RNA polymerase translocation revealed by multiple intermediate structures. Nat Commun, 11, 2020
2F8E	Foot and Mouth Disease Virus RNA-dependent RNA polymerase in complex with uridylylated VPg protein Descriptor: MAGNESIUM ION, MANGANESE (II) ION, RNA-dependent RNA polymerase, ... Authors: Ferrer-Orta, C, Arias, A, Perez-Luque, R, Escarmis, C, Domingo, E, Verdaguer, N. Deposit date: 2005-12-02 Release date: 2006-03-28 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (2.9 Å) Cite: The structure of a protein primer-polymerase complex in the initiation of genome replication Embo J., 25, 2006
1HI0	RNA dependent RNA polymerase from dsRNA bacteriophage phi6 plus initiation complex Descriptor: DNA (5'-(*TP*TP*TP*CP*C)-3'), GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... Authors: Grimes, J.M, Butcher, S.J, Makeyev, E.V, Bamford, D.H, Stuart, D.I. Deposit date: 2000-12-31 Release date: 2001-03-27 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (3 Å) Cite: A Mechanism for Initiating RNA-Dependent RNA Polymerization Nature, 410, 2001
1HI8	RNA dependent RNA polymerase from dsRNA bacteriophage phi6 Descriptor: MAGNESIUM ION, P2 PROTEIN Authors: Grimes, J.M, Butcher, S.J, Makeyev, E.V, Bamford, D.H, Stuart, D.I. Deposit date: 2001-01-03 Release date: 2001-03-27 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (2.5 Å) Cite: A Mechanism for Initiating RNA-Dependent RNA Polymerization Nature, 410, 2001
2E9Z	Foot-and-mouth disease virus RNA-polymerase in complex with a template- primer RNA, ATP and UTP Descriptor: 5'-R(*CP*AP*UP*GP*GP*GP*CP*CP*C)-3', 5'-R(*GP*GP*GP*CP*CP*CP*A)-3', MAGNESIUM ION, ... Authors: Ferrer-Orta, C, Arias, A, Perez-Luque, R, Escarmis, C, Domingo, E, Verdaguer, N. Deposit date: 2007-01-29 Release date: 2007-06-26 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (3 Å) Cite: Sequential structures provide insights into the fidelity of RNA replication Proc.Natl.Acad.Sci.Usa, 104, 2007
1KHV	Crystal Structure of Rabbit Hemorrhagic Disease Virus RNA-dependent RNA polymerase complexed with Lu3+ Descriptor: LUTETIUM (III) ION, RNA-DIRECTED RNA POLYMERASE Authors: Ng, K.K, Cherney, M.M, Vazquez, A.L, Machin, A, Alonso, J.M, Parra, F, James, M.N. Deposit date: 2001-12-01 Release date: 2002-01-16 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Crystal structures of active and inactive conformations of a caliciviral RNA-dependent RNA polymerase. J.Biol.Chem., 277, 2002
2E9T	Foot-and-mouth disease virus RNA-polymerase RNA dependent in complex with a template-primer RNA and 5F-UTP Descriptor: 5'-R(*GP*GP*GP*CP*CP*CP*(5FU))-3', 5'-R(P*UP*AP*GP*GP*GP*CP*CP*C)-3', MAGNESIUM ION, ... Authors: Ferrer-Orta, C, Arias, A, Perez-Luque, R, Escarmis, C, Domingo, E, Verdaguer, N. Deposit date: 2007-01-26 Release date: 2007-06-26 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Sequential structures provide insights into the fidelity of RNA replication Proc.Natl.Acad.Sci.Usa, 104, 2007
2E9R	Foot-and-mouth disease virus RNA-dependent RNA polymerase in complex with a template-primer RNA and with ribavirin Descriptor: 5'-R(*CP*AP*UP*GP*GP*GP*CP*CP*C)-3', 5'-R(*CP*CP*C*GP*GP*GP*CP*CP*C)-3', MAGNESIUM ION, ... Authors: Ferrer-Orta, C, Arias, A, Perez-Luque, R, Escarmis, C, Domingo, E, Verdaguer, N. Deposit date: 2007-01-26 Release date: 2007-06-26 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.81 Å) Cite: Sequential structures provide insights into the fidelity of RNA replication Proc.Natl.Acad.Sci.Usa, 104, 2007
3OL9	Poliovirus polymerase elongation complex with 3'-deoxy-CTP Descriptor: ISOPROPYL ALCOHOL, PYROPHOSPHATE 2-, Polymerase, ... Authors: Gong, P, Peersen, O.B. Deposit date: 2010-08-25 Release date: 2010-12-22 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Structural basis for active site closure by the poliovirus RNA-dependent RNA polymerase. Proc.Natl.Acad.Sci.USA, 107, 2010
3OL7	Poliovirus polymerase elongation complex with CTP Descriptor: DI(HYDROXYETHYL)ETHER, GLYCEROL, ISOPROPYL ALCOHOL, ... Authors: Gong, P, Peersen, O.B. Deposit date: 2010-08-25 Release date: 2010-12-22 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Structural basis for active site closure by the poliovirus RNA-dependent RNA polymerase. Proc.Natl.Acad.Sci.USA, 107, 2010
3OL8	Poliovirus polymerase elongation complex with CTP-Mn Descriptor: GLYCEROL, ISOPROPYL ALCOHOL, MANGANESE (II) ION, ... Authors: Gong, P, Peersen, O.B. Deposit date: 2010-08-25 Release date: 2010-12-22 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.75 Å) Cite: Structural basis for active site closure by the poliovirus RNA-dependent RNA polymerase. Proc.Natl.Acad.Sci.USA, 107, 2010
3OL6	Poliovirus polymerase elongation complex Descriptor: ISOPROPYL ALCOHOL, Polymerase, RNA (5'-R(*AP*AP*GP*UP*CP*UP*CP*CP*AP*GP*GP*UP*CP*UP*CP*UP*CP*GP*UP*CP*CP*GP*GP*AP*AP*A)-3'), ... Authors: Gong, P, Peersen, O.B. Deposit date: 2010-08-25 Release date: 2010-12-22 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structural basis for active site closure by the poliovirus RNA-dependent RNA polymerase. Proc.Natl.Acad.Sci.USA, 107, 2010
3OLA	Poliovirus polymerase elongation complex with 2'-deoxy-CTP Descriptor: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, DI(HYDROXYETHYL)ETHER, DNA/RNA (5'-R(*GP*CP*CP*CP*GP*GP*AP*CP*GP*AP*GP*AP*GP*A)-D(P*C)-3'), ... Authors: Gong, P, Peersen, O.B. Deposit date: 2010-08-25 Release date: 2010-12-22 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.55 Å) Cite: Structural basis for active site closure by the poliovirus RNA-dependent RNA polymerase. Proc.Natl.Acad.Sci.USA, 107, 2010
2JLF	STRUCTURAL EXPLANATION FOR THE ROLE OF MN IN THE ACTIVITY OF PHI6 RNA- DEPENDENT RNA POLYMERASE Descriptor: MANGANESE (II) ION, RNA-DIRECTED RNA POLYMERASE Authors: Poranen, M.M, Salgado, P.S, Koivunen, M.R.L, Wright, S, Bamford, D.H, Stuart, D.I, Grimes, J.M. Deposit date: 2008-09-08 Release date: 2008-11-04 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Structural Explanation for the Role of Mn2+ in the Activity of {Phi}6 RNA-Dependent RNA Polymerase. Nucleic Acids Res., 36, 2008

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