PDB: 44 resultsInfo pagesStatus searchChemie searchBIRD

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8S0F	H. sapiens OC1M bound to double stranded DNA Descriptor: DNA (39-mer), DNA replication factor Cdt1, DNA replication licensing factor MCM2, ... Authors: Greiwe, J.F, Weissmann, F, Diffley, J.F.X, Costa, A. Deposit date: 2024-02-13 Release date: 2024-10-02 Last modified: 2024-12-25 Method: ELECTRON MICROSCOPY (4.1 Å) Cite: MCM double hexamer loading visualized with human proteins. Nature, 636, 2024
8S0E	H. sapiens OCCM bound to double stranded DNA Descriptor: Cell division control protein 6 homolog, DNA (39-mer), DNA replication factor Cdt1, ... Authors: Greiwe, J.F, Weissmann, F, Diffley, J.F.X, Costa, A. Deposit date: 2024-02-13 Release date: 2024-10-02 Last modified: 2024-12-25 Method: ELECTRON MICROSCOPY (3.8 Å) Cite: MCM double hexamer loading visualized with human proteins. Nature, 636, 2024
8RWV	Human OCCM DNA licensing intermediate Descriptor: Cell division control protein 6 homolog, DNA, DNA replication factor Cdt1, ... Authors: Wells, J.N, Leber, V, Edwards, L.V, Allyjaun, S, Peach, M, Tomkins, J, Kefala-Stavridi, A, Faull, S.V, Aramayo, R, Pestana, C.M, Ranjha, L, Speck, C. Deposit date: 2024-02-05 Release date: 2025-02-05 Method: ELECTRON MICROSCOPY (6.68 Å) Cite: Reconstitution of human DNA licensing and the structural and functional analysis of key intermediates. Nat Commun, 16, 2025
7TJI	S. cerevisiae ORC bound to 84 bp ARS1 DNA and Cdc6 (state 2) with flexible Orc6 N-terminal domain Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 6, DNA, ... Authors: Schmidt, J.M, Yang, R, Kumar, A, Hunker, O, Bleichert, F. Deposit date: 2022-01-16 Release date: 2022-10-05 Last modified: 2025-05-28 Method: ELECTRON MICROSCOPY (2.7 Å) Cite: A mechanism of origin licensing control through autoinhibition of S. cerevisiae ORC·DNA·Cdc6. Nat Commun, 13, 2022
7TJH	S. cerevisiae ORC bound to 84 bp ARS1 DNA and Cdc6 (state 1) with flexible Orc6 N-terminal domain Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 6, DNA, ... Authors: Schmidt, J.M, Yang, R, Kumar, A, Hunker, O, Bleichert, F. Deposit date: 2022-01-16 Release date: 2022-10-05 Last modified: 2025-06-04 Method: ELECTRON MICROSCOPY (2.5 Å) Cite: A mechanism of origin licensing control through autoinhibition of S. cerevisiae ORC·DNA·Cdc6. Nat Commun, 13, 2022
7TJK	S. cerevisiae ORC bound to 84 bp ARS1 DNA and Cdc6 (state 2) with docked Orc6 N-terminal domain Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 6, DNA, ... Authors: Schmidt, J.M, Yang, R, Kumar, A, Hunker, O, Bleichert, F. Deposit date: 2022-01-16 Release date: 2022-10-05 Last modified: 2025-06-04 Method: ELECTRON MICROSCOPY (2.7 Å) Cite: A mechanism of origin licensing control through autoinhibition of S. cerevisiae ORC·DNA·Cdc6. Nat Commun, 13, 2022
7TJJ	S. cerevisiae ORC bound to 84 bp ARS1 DNA and Cdc6 (state 1) with docked Orc6 N-terminal domain Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 6, DNA, ... Authors: Schmidt, J.M, Yang, R, Kumar, A, Hunker, O, Bleichert, F. Deposit date: 2022-01-16 Release date: 2022-10-05 Last modified: 2025-06-04 Method: ELECTRON MICROSCOPY (2.7 Å) Cite: A mechanism of origin licensing control through autoinhibition of S. cerevisiae ORC·DNA·Cdc6. Nat Commun, 13, 2022
7TJF	S. cerevisiae ORC bound to 84 bp ARS1 DNA Descriptor: ADENOSINE-5'-TRIPHOSPHATE, DNA, 84 bp ARS1, ... Authors: Schmidt, J.M, Yang, R, Kumar, A, Hunker, O, Bleichert, F. Deposit date: 2022-01-16 Release date: 2023-01-18 Last modified: 2025-06-04 Method: ELECTRON MICROSCOPY (2.6 Å) Cite: A mechanism of origin licensing control through autoinhibition of S. cerevisiae ORC·DNA·Cdc6. Nat Commun, 13, 2022
7JGS	Structure of Drosophila ORC bound to poly(dA/dT) DNA and Cdc6 (conformation 2) Descriptor: ADENOSINE-5'-TRIPHOSPHATE, AT22044p1, Cell division control protein, ... Authors: Schmidt, J.M, Bleichert, F. Deposit date: 2020-07-19 Release date: 2020-09-09 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Structural mechanism for replication origin binding and remodeling by a metazoan origin recognition complex and its co-loader Cdc6. Nat Commun, 11, 2020
7JPS	ORC-DNA: Human Origin Recognition Complex (ORC) with DNA bound in the core Descriptor: ADENOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*AP*TP*AP*TP*AP*TP*AP*TP*AP*TP*AP*AP*T)-3'), DNA (5'-D(*AP*TP*TP*AP*TP*AP*TP*AP*TP*AP*TP*AP*T)-3'), ... Authors: Jaremko, M.J, Joshua-Tor, L. Deposit date: 2020-08-09 Release date: 2020-09-09 Last modified: 2024-05-15 Method: ELECTRON MICROSCOPY (4.4 Å) Cite: The dynamic nature of the human Origin Recognition Complex revealed through five cryoEM structures. Elife, 9, 2020
7JK5	Structure of Drosophila ORC bound to DNA Descriptor: ADENOSINE-5'-TRIPHOSPHATE, DNA (32-MER), MAGNESIUM ION, ... Authors: Schmidt, J.M, Bleichert, F. Deposit date: 2020-07-27 Release date: 2020-09-09 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (3.9 Å) Cite: Structural mechanism for replication origin binding and remodeling by a metazoan origin recognition complex and its co-loader Cdc6. Nat Commun, 11, 2020
7JK6	Structure of Drosophila ORC in the active conformation Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Origin recognition complex subunit 1, ... Authors: Schmidt, J.M, Bleichert, F. Deposit date: 2020-07-27 Release date: 2020-09-09 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (4 Å) Cite: Structural mechanism for replication origin binding and remodeling by a metazoan origin recognition complex and its co-loader Cdc6. Nat Commun, 11, 2020
7JPP	ORC-O2WH: Human Origin Recognition Complex (ORC) with dynamic/unresolved ORC1 AAA+ domain Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Origin recognition complex subunit 1, ... Authors: Jaremko, M.J, Joshua-Tor, L. Deposit date: 2020-08-09 Release date: 2020-09-09 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: The dynamic nature of the human Origin Recognition Complex revealed through five cryoEM structures. Elife, 9, 2020
7JK4	Structure of Drosophila ORC bound to AT-rich DNA and Cdc6 Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein, DNA (34-MER), ... Authors: Schmidt, J.M, Bleichert, F. Deposit date: 2020-07-27 Release date: 2020-09-09 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Structural mechanism for replication origin binding and remodeling by a metazoan origin recognition complex and its co-loader Cdc6. Nat Commun, 11, 2020
7JGR	Structure of Drosophila ORC bound to DNA (84 bp) and Cdc6 Descriptor: ADENOSINE-5'-TRIPHOSPHATE, AT22044p1, Cell division control protein, ... Authors: Schmidt, J.M, Bleichert, F. Deposit date: 2020-07-19 Release date: 2020-09-09 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (3.9 Å) Cite: Structural mechanism for replication origin binding and remodeling by a metazoan origin recognition complex and its co-loader Cdc6. Nat Commun, 11, 2020
7JK3	Structure of Drosophila ORC bound to GC-rich DNA and Cdc6 Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein, DNA (33-MER), ... Authors: Schmidt, J.M, Bleichert, F. Deposit date: 2020-07-27 Release date: 2020-09-09 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Structural mechanism for replication origin binding and remodeling by a metazoan origin recognition complex and its co-loader Cdc6. Nat Commun, 11, 2020
7JK2	Structure of Drosophila ORC bound to poly(dA/dT) DNA and Cdc6 (conformation 1) Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein, DNA (33-MER), ... Authors: Schmidt, J.M, Bleichert, F. Deposit date: 2020-07-27 Release date: 2020-09-09 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Structural mechanism for replication origin binding and remodeling by a metazoan origin recognition complex and its co-loader Cdc6. Nat Commun, 11, 2020
7JPR	ORC-OPEN: Human Origin Recognition Complex (ORC) in an open conformation Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Origin recognition complex subunit 1, ... Authors: Jaremko, M.J, Joshua-Tor, L. Deposit date: 2020-08-09 Release date: 2020-09-09 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (4 Å) Cite: The dynamic nature of the human Origin Recognition Complex revealed through five cryoEM structures. Elife, 9, 2020
7JPO	ORC-O1AAA: Human Origin Recognition Complex (ORC) with dynamic/unresolved ORC2 WH Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Origin recognition complex subunit 1, ... Authors: Jaremko, M.J, Joshua-Tor, L. Deposit date: 2020-08-09 Release date: 2020-09-02 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: The dynamic nature of the human Origin Recognition Complex revealed through five cryoEM structures. Elife, 9, 2020

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