9PED
 
 | | Cryo-EM structure of Arabidopsis thaliana Met1 in complex with DNA | | Descriptor: | DNA (5'-D(*AP*CP*TP*TP*AP*(5CM)P*GP*GP*AP*AP*GP*G)-3'), DNA (5'-D(*CP*CP*TP*TP*CP*(C49)P*GP*TP*AP*AP*GP*T)-3'), DNA (cytosine-5)-methyltransferase 1, ... | | Authors: | Lu, J, Chen, X, Song, J. | | Deposit date: | 2025-07-02 | | Release date: | 2025-10-22 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Structure and autoinhibitory regulation of MET1 in the maintenance of plant CG methylation.
Plant Cell, 2025
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9WF6
 | | Crystal Structure of Escherichia coli GroEL with Magnesium Ions and a Phosphorylated Serine Residue-3.0 A | | Descriptor: | BETA-MERCAPTOETHANOL, Chaperonin GroEL, HEXANE-1,6-DIOL, ... | | Authors: | Guo, Y, Zhang, L, Zheng, H, Li, J, Han, Q. | | Deposit date: | 2025-08-21 | | Release date: | 2025-09-03 | | Method: | X-RAY DIFFRACTION (2.99 Å) | | Cite: | Crystal Structure of Escherichia coli GroEL with Magnesium Ions and a Phosphorylated Serine Residue
To Be Published
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9P4Y
 | | Human EAAT3 with compound 3e and digitonin.glyco-diosgenin bound at inward facing state | | Descriptor: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, (4R)-8-bromo-2-(furan-2-yl)-N-(2-methylphenyl)imidazo[1,2-a]pyridin-3-amine, CHOLESTEROL, ... | | Authors: | Qiu, B, Boudker, O. | | Deposit date: | 2025-06-17 | | Release date: | 2025-07-30 | | Method: | ELECTRON MICROSCOPY (2.56 Å) | | Cite: | Mechanism and Structure-Guided Optimization of SLC1A1/EAAT3-Selective Inhibitors in Kidney Cancer.
Biorxiv, 2025
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9OIN
 | | The von Hippel Lindau-ElonginB-ElonginC (VCB) complex with fragment 13 | | Descriptor: | 1-(propan-2-yl)-4-[(pyridin-2-yl)methyl]piperazine, Elongin-B, Elongin-C, ... | | Authors: | Amporndanai, K, Katinas, J.M, Chopra, A, Fesik, S.W. | | Deposit date: | 2025-05-06 | | Release date: | 2025-07-09 | | Last modified: | 2025-09-03 | | Method: | X-RAY DIFFRACTION (2.41 Å) | | Cite: | NMR-Based Fragment Screen of the von Hippel-Lindau Elongin C&B Complex.
Acs Med.Chem.Lett., 16, 2025
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9P4X
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9P4S
 | | HmuS heme dechelatase: disordered domain 1, heme free. | | Descriptor: | HmuS heme dechelatase, SODIUM ION | | Authors: | Gauvin, C.C, Nath, A.K, Rodrigues da Silva, R, Akpoto, E, Dubois, J.L, Lawrence, C.M. | | Deposit date: | 2025-06-17 | | Release date: | 2025-09-24 | | Method: | ELECTRON MICROSCOPY (2.55 Å) | | Cite: | HmuS Heme Dechelatase: Disordered Domain 1, Heme Free
To Be Published
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9Q4D
 | | A DARPin fused to the double trigger 1TEL variant crystallization chaperone via a direct helical fusion | | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, POTASSIUM ION, ... | | Authors: | Averret, J.C, Bradford, M.J, Wilson, E.W, Averret, B.J, Anderson, E, Doukov, T, Moody, J.D. | | Deposit date: | 2025-08-20 | | Release date: | 2025-10-01 | | Method: | X-RAY DIFFRACTION (1.302 Å) | | Cite: | Opening Doors in Protein Crystallization: TELSAM Fusions with Two pH Triggers
To Be Published
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9QCY
 | | Crystal structure of Rhizobium etli L-asparaginase ReAV S80A mutant | | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Pokrywka, K, Grzechowiak, M, Loch, J.I, Ruszkowski, M, Gilski, M, Jaskolski, M. | | Deposit date: | 2025-03-05 | | Release date: | 2025-07-16 | | Last modified: | 2025-08-06 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Probing the Active Site of Class 3 L-Asparaginase by Mutagenesis: Mutations of the Ser-Lys Tandems of ReAV.
Biomolecules, 15, 2025
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9OK1
 | | Crystal structure of E. coli ApaH in complex with CDP | | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Bis(5'-nucleosyl)-tetraphosphatase [symmetrical], CYTIDINE-5'-DIPHOSPHATE, ... | | Authors: | Nuthanakanti, A, Serganov, A. | | Deposit date: | 2025-05-08 | | Release date: | 2025-09-03 | | Method: | X-RAY DIFFRACTION (1.81 Å) | | Cite: | ApaH decaps Np 4 N-capped RNAs in two alternative orientations.
Nat.Chem.Biol., 2025
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9NYO
 | | Clostridium acetobutylicum alcohol dehydrogenase bound to NADP+, disordered nicotinamide | | Descriptor: | 1,2-ETHANEDIOL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Oxidoreductase | | Authors: | Madzelan, P, Wilson, M.A. | | Deposit date: | 2025-03-28 | | Release date: | 2025-07-02 | | Last modified: | 2025-09-10 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Is a Malleable Active Site Loop the Key to High Substrate Promiscuity? Hybrid, Biocatalytic Route to Structurally Diverse Taxoid Side Chains with Remarkable Dual Stereocontrol.
Angew.Chem.Int.Ed.Engl., 64, 2025
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9R5Z
 | | Crystal structure of JAK3 with GCL258 | | Descriptor: | 1-phenylurea, 3-(3-cyclohexyl-3,8,10-triazatricyclo[7.3.0.0^{2,6}]dodeca-1,4,6,8,11-pentaen-5-yl)benzenesulfonyl fluoride, Tyrosine-protein kinase JAK3 | | Authors: | Wang, G.Q, Chaikuad, A, Hillebrand, L, Gehringer, M, Knapp, S, Structural Genomics Consortium (SGC) | | Deposit date: | 2025-05-11 | | Release date: | 2025-08-20 | | Last modified: | 2025-10-22 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | A twist in the tale: shifting from covalent targeting of a tyrosine in JAK3 to a lysine in MK2.
Rsc Med Chem, 16, 2025
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9ON7
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9Y0K
 | | Structure of Plasmodium falciparum 20S proteasome with bound J80 | | Descriptor: | N,N-diethyl-N~2~-hexanoyl-D-asparaginyl-N-{(1S)-2-(2,4-difluorophenyl)-1-[(2S,3S,5S,6S)-5-formyl-2-hydroxy-3-(hydroxymethyl)-3,6-dimethylmorpholin-2-yl]ethyl}-4-fluoro-L-phenylalaninamide, Proteasome endopeptidase complex, Proteasome subunit alpha type-1, ... | | Authors: | Zhang, H, Zhao, J, Fajtova, P, O'Donoghue, A.J. | | Deposit date: | 2025-08-28 | | Release date: | 2025-10-29 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structure of Plasmodium falciparum 20S proteasome with bound J80.
To Be Published
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9OND
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1EEX
 | | CRYSTAL STRUCTURE OF THE DIOL DEHYDRATASE-ADENINYLPENTYLCOBALAMIN COMPLEX FROM KLEBSIELLA OXYTOCA | | Descriptor: | CO-(ADENIN-9-YL-PENTYL)-COBALAMIN, POTASSIUM ION, PROPANEDIOL DEHYDRATASE, ... | | Authors: | Shibata, N, Masuda, J, Toraya, T, Morimoto, Y, Yasuoka, N. | | Deposit date: | 2000-02-04 | | Release date: | 2001-02-07 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | How a protein generates a catalytic radical from coenzyme B(12): X-ray structure of a diol-dehydratase-adeninylpentylcobalamin complex.
Structure Fold.Des., 8, 2000
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9RM4
 | | Crystal Structure of ZIKV NS2B-NS3 protease in complex with ASAP-0015373 | | Descriptor: | SODIUM ION, Serine protease subunit NS2B,Serine protease NS3, ~{N}-[3-chloranyl-5-[(2-methyl-1-oxidanyl-propan-2-yl)carbamoyl]phenyl]-5-[(dimethylamino)methyl]-1~{H}-pyrrole-2-carboxamide | | Authors: | Ni, X, Marples, P.G, Godoy, A.S, Koekemoer, L, Aschenbrenner, J.C, Balcomb, B.H, Fairhead, M, Lithgo, R.M, Lee, A, Kenton, N, Thompson, W, Tomlinson, C.W.E, Wild, C, Winokan, M, Williams, E.P, Fearon, D, von Delft, F. | | Deposit date: | 2025-06-17 | | Release date: | 2025-07-23 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Crystal Structure of ZIKV NS2B-NS3 protease in complex with ASAP-0015373
To Be Published
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9OJX
 | | Crystal structure of E. coli ApaH in complex with GDP | | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Bis(5'-nucleosyl)-tetraphosphatase [symmetrical], GUANOSINE-5'-DIPHOSPHATE, ... | | Authors: | Nuthanakanti, A, Serganov, A. | | Deposit date: | 2025-05-08 | | Release date: | 2025-09-03 | | Method: | X-RAY DIFFRACTION (1.83 Å) | | Cite: | ApaH decaps Np 4 N-capped RNAs in two alternative orientations.
Nat.Chem.Biol., 2025
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9UFR
 | | Crystal structure of L-asparaginase from Thermococcus Sibiricus double mutation D54G/T56Q | | Descriptor: | DI(HYDROXYETHYL)ETHER, GLYCEROL, GLYCINE, ... | | Authors: | Matyuta, I.O, Varfolomeeva, L.A, Minyaev, M.E, Dumina, M, Zhdanov, D, Zhgun, A, Pokrovskaya, M, Aleksandrova, S, El'darov, M, Popov, V.O, Boyko, K.M. | | Deposit date: | 2025-04-10 | | Release date: | 2025-06-11 | | Last modified: | 2025-07-09 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Hyperthermophilic L-Asparaginase from Thermococcus sibiricus and Its Double Mutant with Increased Activity: Insights into Substrate Specificity and Structure.
Int J Mol Sci, 26, 2025
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8T7W
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9PLN
 | | Locally-refined structure of alpha2a adrenergic receptor in complex with Go heterotrimer, scFv16, and N-(5-methylnaphthalen-1-yl)pyridin-4-amine (compound 4905) | | Descriptor: | Alpha-2A adrenergic receptor, N-(5-methylnaphthalen-1-yl)pyridin-4-amine | | Authors: | Srinivasan, K, Xu, X, Mailhot, O, Manglik, A, Shoichet, B. | | Deposit date: | 2025-07-15 | | Release date: | 2025-08-20 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Toward a Random Background for Ligand Optimization
To Be Published
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9NXJ
 | | The GH43 domain of an alpha-l-arabinofuranosidase (AtAbf43C_GH43) from Acetivibrio thermocellus DSM1313 | | Descriptor: | Glycoside hydrolase family 43, SULFATE ION, alpha-L-arabinofuranose | | Authors: | Galindo, J.L, Jeffrey, P.D, Conway, J.M. | | Deposit date: | 2025-03-25 | | Release date: | 2025-08-20 | | Last modified: | 2025-10-15 | | Method: | X-RAY DIFFRACTION (2.32 Å) | | Cite: | Functional and structural characterization of AtAbf43C: an exo-1,5-alpha-L-arabinofuranosidase from Acetivibrio thermocellus DSM1313.
Biochem.J., 482, 2025
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9RM6
 | | Crystal Structure of ZIKV NS2B-NS3 protease in complex with ASAP-0027808 | | Descriptor: | 6-chloranyl-~{N}-(2,3-dihydro-1~{H}-isoindol-5-yl)-1~{H}-indazole-4-carboxamide, DIMETHYL SULFOXIDE, SULFATE ION, ... | | Authors: | Ni, X, Marples, P.G, Godoy, A.S, Koekemoer, L, Aschenbrenner, J.C, Balcomb, B.H, Fairhead, M, Lithgo, R.M, Lee, A, Kenton, N, Thompson, W, Tomlinson, C.W.E, Wild, C, Winokan, M, Williams, E.P, Fearon, D, von Delft, F. | | Deposit date: | 2025-06-17 | | Release date: | 2025-07-23 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Crystal Structure of ZIKV NS2B-NS3 protease in complex with ASAP-0027808
To Be Published
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9QVL
 | | Crystal structure of the CtaG_C11A variant from Ruminiclostridium cellulolyticum (P2(1)2(1)2(1)-small) | | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Butirosin biosynthesis protein H N-terminal domain-containing protein, IMIDAZOLE, ... | | Authors: | Gude, F, Bohne, A, Dell, M, Franke, J, Dunbar, K.L, Groll, M, Hertweck, C. | | Deposit date: | 2025-04-11 | | Release date: | 2025-10-01 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Distal peptide elongation by a protease-like ligase and two distinct carrier proteins
Chem, 2025
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9IO1
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9RJ0
 | | SARS-CoV-2 with a bound inhibitor | | Descriptor: | 1-(benzimidazol-1-yl)-3-[(4~{S})-6-fluoranyl-3,4-dihydro-2~{H}-thiochromen-4-yl]urea, 3C-like proteinase nsp5, SODIUM ION | | Authors: | Mac Sweeney, A. | | Deposit date: | 2025-06-12 | | Release date: | 2025-07-09 | | Method: | X-RAY DIFFRACTION (1.709 Å) | | Cite: | SARS-CoV-2 with a bound inhibitor
To Be Published
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