9Y5Q
 
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9YB6
 | | Human Mitochondrial Aspartate Aminotransferase complex with PLP at 1.5 Angstrom. | | Descriptor: | Aspartate aminotransferase, mitochondrial, CHLORIDE ION, ... | | Authors: | Krinkel, B.A, Yosaatmadja, Y, Squire, C.J, Loomes, K.M. | | Deposit date: | 2025-09-16 | | Release date: | 2025-09-24 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Human mitochondrial GOT2 crystal structure and...
To Be Published
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9QEY
 | | Cryo-EM structure of the actin filament bound by a single Coronin-1B molecule. | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, cytoplasmic 1, ... | | Authors: | Oosterheert, W, Boiero Sanders, M, Hofnagel, O, Bieling, P, Raunser, S. | | Deposit date: | 2025-03-11 | | Release date: | 2025-10-08 | | Last modified: | 2025-10-22 | | Method: | ELECTRON MICROSCOPY (2.74 Å) | | Cite: | Choreography of rapid actin filament disassembly by coronin, cofilin, and AIP1.
Cell, 2025
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9WD8
 | | structure of human KCNQ1-KCNE3-CaM complex with two PIP2 | | Descriptor: | (2R)-3-{[(S)-hydroxy{[(1R,2R,3S,4R,5R,6S)-2,3,6-trihydroxy-4,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl di[(9Z)-octadec-9-enoate], CALCIUM ION, Calmodulin-1, ... | | Authors: | Cui, C, Sun, J. | | Deposit date: | 2025-08-18 | | Release date: | 2025-09-03 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Mechanisms of KCNQ1 gating modulation by KCNE1/3 for cell-specific function.
Cell Res., 2025
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9VS1
 | | Crystal structure of SARS-CoV-2 3CL protease in complex with compound 15 | | Descriptor: | 1,2-ETHANEDIOL, 3C-like proteinase, 4-chloranyl-3-[6-methyl-3-[(1-methyl-1,2,4-triazol-3-yl)methyl]-2,4,5-tris(oxidanylidene)-1-[[3,4,5-tris(fluoranyl)phenyl]methyl]pyrido[4,3-d]pyrimidin-7-yl]benzenecarbonitrile | | Authors: | Yamamoto, S, Taoda, Y. | | Deposit date: | 2025-07-08 | | Release date: | 2025-09-24 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Design, synthesis and biological evaluation of novel quinazolinedione derivatives as non-covalent SARS-CoV-2 3CL protease inhibitors.
Bioorg.Med.Chem.Lett., 129, 2025
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9QFB
 | | Cryo-EM structure of the fully Coronin-1B-decorated actin filament in the ADP state. | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, cytoplasmic 1, ... | | Authors: | Oosterheert, W, Boiero Sanders, M, Hofnagel, O, Bieling, P, Raunser, S. | | Deposit date: | 2025-03-11 | | Release date: | 2025-10-08 | | Last modified: | 2025-10-22 | | Method: | ELECTRON MICROSCOPY (2.74 Å) | | Cite: | Choreography of rapid actin filament disassembly by coronin, cofilin, and AIP1.
Cell, 2025
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9Y76
 | | Crystal structure of the human DCAF1 WDR domain in complex with OICR-40120 | | Descriptor: | (4P,5M)-N-[(1S)-3-amino-1-(3-chloro-4-fluorophenyl)-3-oxopropyl]-4-(4-chloro-2-fluorophenyl)-5-{1-[2-(morpholin-4-yl)ethyl]-1H-pyrazol-4-yl}-1H-pyrrole-3-carboxamide, DDB1- and CUL4-associated factor 1, UNKNOWN LIGAND | | Authors: | kimani, S, Dong, A, Li, Y, Seitova, A, Mamai, A, Al-awar, R, Ackloo, S, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) | | Deposit date: | 2025-09-09 | | Release date: | 2025-10-15 | | Method: | X-RAY DIFFRACTION (1.56 Å) | | Cite: | Crystal structure of the human DCAF1 WDR domain in complex with OICR-40120
To be published
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9QF2
 | | Cryo-EM structure of the fully Coronin-1B-decorated actin filament in the ADP state. | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, cytoplasmic 1, ... | | Authors: | Oosterheert, W, Boiero Sanders, M, Hofnagel, O, Bieling, P, Raunser, S. | | Deposit date: | 2025-03-11 | | Release date: | 2025-10-08 | | Last modified: | 2025-10-22 | | Method: | ELECTRON MICROSCOPY (2.42 Å) | | Cite: | Choreography of rapid actin filament disassembly by coronin, cofilin, and AIP1.
Cell, 2025
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9RPX
 | | Fragment screening of FosAKP, cryo structure in complex with fragment F2X-entry B06 | | Descriptor: | (1S)-1-(4-nitrophenyl)ethan-1-ol, 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, ... | | Authors: | Guenther, S, Galchenkova, M, Fischer, P, Reinke, P.Y.A, Falke, S, Thekku Veedu, S, Rodrigues, A.C, Senst, J, Meents, A. | | Deposit date: | 2025-06-25 | | Release date: | 2025-10-15 | | Last modified: | 2025-10-22 | | Method: | X-RAY DIFFRACTION (1.27 Å) | | Cite: | Room-temperature X-ray fragment screening with serial crystallography.
Nat Commun, 16, 2025
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9R40
 | | HaloTag bound to compound MRC71 | | Descriptor: | (2~{S},4~{S})-1-[(3~{S})-3-azanyl-3-(2-methoxyphenyl)propanoyl]-~{N}-[(2~{R})-1-[2-[2-[2-[2-(6-chloranylhexoxy)ethoxy]ethoxy]ethoxy]ethylamino]-1-oxidanylidene-3-pyridin-4-yl-propan-2-yl]-4-cyclohexyl-pyrrolidine-2-carboxamide, CHLORIDE ION, Haloalkane dehalogenase | | Authors: | Luptak, J. | | Deposit date: | 2025-05-06 | | Release date: | 2025-10-08 | | Method: | X-RAY DIFFRACTION (2.043 Å) | | Cite: | Development of TRIM21 PROTAC molecules
To Be Published
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9QBY
 | | Yeast 20S proteasome mutant: beta5_G128V (b5-propeptide in trans) in complex with ONX0914 | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.]PYRAZOLE, ... | | Authors: | Huber, E.M, Heinemeyer, W, Groll, M. | | Deposit date: | 2025-03-04 | | Release date: | 2025-10-08 | | Last modified: | 2025-10-15 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Proteasome-associated autoinflammatory syndromes: The impact of mutations in proteasome subunits on particle assembly, structure, and activity.
Structure, 2025
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9QFW
 | | Cryo-EM structure of the cofilactin barbed end bound by two AIP1 molecules | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, cytoplasmic 1, ... | | Authors: | Oosterheert, W, Boiero Sanders, M, Hofnagel, O, Bieling, P, Raunser, S. | | Deposit date: | 2025-03-12 | | Release date: | 2025-10-08 | | Last modified: | 2025-10-22 | | Method: | ELECTRON MICROSCOPY (3.16 Å) | | Cite: | Choreography of rapid actin filament disassembly by coronin, cofilin, and AIP1.
Cell, 2025
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9QBW
 | | Yeast 20S proteasome mutant: beta5_G128V (b5-propeptide in trans) in complex with Carfilzomib | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.]PYRAZOLE, ... | | Authors: | Huber, E.M, Heinemeyer, W, Groll, M. | | Deposit date: | 2025-03-03 | | Release date: | 2025-10-08 | | Last modified: | 2025-10-15 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Proteasome-associated autoinflammatory syndromes: The impact of mutations in proteasome subunits on particle assembly, structure, and activity.
Structure, 2025
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9QDF
 | | Yeast 20S proteasome mutant: beta1_G128V (b1-propeptide deleted) in complex with Bortezomib | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.]PYRAZOLE, CHLORIDE ION, ... | | Authors: | Huber, E.M, Heinemeyer, W, Groll, M. | | Deposit date: | 2025-03-06 | | Release date: | 2025-10-08 | | Last modified: | 2025-10-15 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Proteasome-associated autoinflammatory syndromes: The impact of mutations in proteasome subunits on particle assembly, structure, and activity.
Structure, 2025
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9QB1
 | | Yeast 20S proteasome mutant: beta5_T3M in complex with Bortezomib | | Descriptor: | 3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.]PYRAZOLE, CHLORIDE ION, MAGNESIUM ION, ... | | Authors: | Huber, E.M, Heinemeyer, W, Groll, M. | | Deposit date: | 2025-02-28 | | Release date: | 2025-10-08 | | Last modified: | 2025-10-15 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Proteasome-associated autoinflammatory syndromes: The impact of mutations in proteasome subunits on particle assembly, structure, and activity.
Structure, 2025
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9QBE
 | | Yeast 20S proteasome mutant: beta5_T3M in complex with ONX0914 | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.]PYRAZOLE, CHLORIDE ION, ... | | Authors: | Huber, E.M, Heinemeyer, W, Groll, M. | | Deposit date: | 2025-03-02 | | Release date: | 2025-10-08 | | Last modified: | 2025-10-15 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Proteasome-associated autoinflammatory syndromes: The impact of mutations in proteasome subunits on particle assembly, structure, and activity.
Structure, 2025
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9V21
 | | Cryo- EM structure of 75S ribosome with P- tRNA from Entamoeba histolytica | | Descriptor: | 17S rRNA, 25S rRNA, 40S ribosomal protein S10, ... | | Authors: | Sharma, S, Mishra, S, Gourinath, S, Kaushal, P.S. | | Deposit date: | 2025-05-19 | | Release date: | 2025-10-08 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Cryo-EM structure of ribosome from pathogenic protozoa Entamoeba histolytica reveals unique features of its architecture.
Nat Commun, 16, 2025
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9QDS
 | | Yeast 20S proteasome mutant: beta1_G128V (b1-propeptide deleted) in complex with Carfilzomib | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.]PYRAZOLE, CHLORIDE ION, ... | | Authors: | Huber, E.M, Heinemeyer, W, Groll, M. | | Deposit date: | 2025-03-06 | | Release date: | 2025-10-08 | | Last modified: | 2025-10-15 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Proteasome-associated autoinflammatory syndromes: The impact of mutations in proteasome subunits on particle assembly, structure, and activity.
Structure, 2025
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9QFD
 | | Cryo-EM structure of the fully cofilin-1-decorated actin filament (cofilactin) | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, cytoplasmic 1, ... | | Authors: | Oosterheert, W, Boiero Sanders, M, Hofnagel, O, Bieling, P, Raunser, S. | | Deposit date: | 2025-03-11 | | Release date: | 2025-10-08 | | Last modified: | 2025-10-22 | | Method: | ELECTRON MICROSCOPY (2.61 Å) | | Cite: | Choreography of rapid actin filament disassembly by coronin, cofilin, and AIP1.
Cell, 2025
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9QFQ
 | | Cryo-EM structure of the cofilactin barbed end bound by AIP1 | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, cytoplasmic 1, ... | | Authors: | Oosterheert, W, Boiero Sanders, M, Hofnagel, O, Bieling, P, Raunser, S. | | Deposit date: | 2025-03-12 | | Release date: | 2025-10-08 | | Last modified: | 2025-10-22 | | Method: | ELECTRON MICROSCOPY (2.76 Å) | | Cite: | Choreography of rapid actin filament disassembly by coronin, cofilin, and AIP1.
Cell, 2025
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4W8S
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8VS7
 | | Crystal structure of ADI-19425 Fab in complex with anti-idiotypic 2C1 Fab | | Descriptor: | 1,2-ETHANEDIOL, 2C1 Heavy Chain, 2C1 Light Chain, ... | | Authors: | Kher, G, Homad, L.J, McGuire, A.T, Pancera, M. | | Deposit date: | 2024-01-23 | | Release date: | 2024-09-18 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2.41 Å) | | Cite: | A novel RSV vaccine candidate derived from anti-idiotypic antibodies targets putative neutralizing B-cells in bulk PBMCs
To Be Published
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5IDV
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7M77
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4W4X
 | | JNK2/3 in complex with 3-(4-{[(4-fluorophenyl)carbamoyl]amino}-1H-pyrazol-1-yl)-N-(2-methylpyridin-4-yl)benzamide | | Descriptor: | 3-(4-{[(4-fluorophenyl)carbamoyl]amino}-1H-pyrazol-1-yl)-N-(2-methylpyridin-4-yl)benzamide, c-jun NH2-terminal kinase 3 | | Authors: | Park, H, Iqbal, S, Hernandez, P, Mora, R, Zheng, K, Feng, Y, LoGrasso, P. | | Deposit date: | 2014-08-15 | | Release date: | 2015-02-11 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.65 Å) | | Cite: | Structural Basis and Biological Consequences for JNK2/3 Isoform Selective Aminopyrazoles.
Sci Rep, 5, 2015
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