PDB: 46188 resultsInfo pagesStatus searchChemie searchBIRD

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4QP2	Crystal Structure of ERKs in complex with 5-chlorobenzo[d]oxazol-2-amine Descriptor: 5-chloro-1,3-benzoxazol-2-amine, IMIDAZOLE, Mitogen-activated protein kinase 1 Authors: Yin, J, Wang, W. Deposit date: 2014-06-22 Release date: 2015-09-23 Last modified: 2015-12-16 Method: X-RAY DIFFRACTION (2.23 Å) Cite: Fragment-based discovery of potent ERK2 pyrrolopyrazine inhibitors. Bioorg.Med.Chem.Lett., 25, 2015
4L55	X-ray structure of the adduct between bovine pancreatic ribonuclease and AziRu Descriptor: RUTHENIUM ION, Ribonuclease pancreatic Authors: Vergara, A, Russo Krauss, I, Merlino, A. Deposit date: 2013-06-10 Release date: 2014-01-29 Last modified: 2024-10-09 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Investigating the ruthenium metalation of proteins: X-ray structure and Raman microspectroscopy of the complex between RNase A and AziRu. Inorg.Chem., 52, 2013
4QP8	Crystal Structure of ERK2 in complex with 2-(1H-pyrazol-4-yl)-7-(pyridin-3-yl)-5H-pyrrolo[2,3-b]pyrazine Descriptor: 2-(1H-pyrazol-4-yl)-7-(pyridin-3-yl)-5H-pyrrolo[2,3-b]pyrazine, Mitogen-activated protein kinase 1 Authors: Yin, J, Wang, W. Deposit date: 2014-06-22 Release date: 2015-09-23 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.446 Å) Cite: Fragment-based discovery of potent ERK2 pyrrolopyrazine inhibitors. Bioorg.Med.Chem.Lett., 25, 2015
4GT3	ATP-bound form of the ERK2 kinase Descriptor: ADENOSINE-5'-TRIPHOSPHATE, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... Authors: Pozharski, E, Zhang, J, Shapiro, P. Deposit date: 2012-08-28 Release date: 2012-09-12 Method: X-RAY DIFFRACTION (1.68 Å) Cite: ATP-bound form of the ERK2 kinase TO BE PUBLISHED
2ERK	PHOSPHORYLATED MAP KINASE ERK2 Descriptor: EXTRACELLULAR SIGNAL-REGULATED KINASE 2 Authors: Canagarajah, B.J, Goldsmith, E.J. Deposit date: 1997-06-26 Release date: 1998-07-01 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Activation mechanism of the MAP kinase ERK2 by dual phosphorylation. Cell(Cambridge,Mass.), 90, 1997
4QPG	Crystal structure of empty hepatitis A virus Descriptor: CHLORIDE ION, Capsid protein VP0, Capsid protein VP1, ... Authors: Wang, X, Ren, J, Gao, Q, Hu, Z, Sun, Y, Li, X, Rowlands, D.J, Yin, W, Wang, J, Stuart, D.I, Rao, Z, Fry, E.E. Deposit date: 2014-06-23 Release date: 2014-10-15 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (3.5 Å) Cite: Hepatitis A virus and the origins of picornaviruses. Nature, 517, 2015
2KJ9	NMR structure of IntB phage-integrase-like protein fragment 90-199 from Erwinia carotova subsp. atroseptica: Northeast Structural Genomics Consortium target EwR217E Descriptor: Integrase Authors: Cort, J.R, Ramelot, T.A, Wang, D, Ciccosanti, C, Janjua, H, Nair, R, Rost, B, Swapna, G, Acton, T.B, Xiao, R, Everett, J.K, Montelione, G.T, Kennedy, M.A, Northeast Structural Genomics Consortium (NESG) Deposit date: 2009-05-25 Release date: 2009-07-07 Last modified: 2024-05-08 Method: SOLUTION NMR Cite: NMR structure of IntB phage-integrase-like protein fragment 90-199 from Erwinia carotova subsp. atroseptica To be Published
3JPV	Crystal structure of human proto-oncogene serine threonine kinase (PIM1) in complex with a consensus peptide and a pyrrolo[2,3-a]carbazole ligand Descriptor: 1,10-dihydropyrrolo[2,3-a]carbazole-3-carbaldehyde, Peptide (PIMTIDE) ARKRRRHPSGPPTA, Proto-oncogene serine/threonine-protein kinase Pim-1 Authors: Filippakopoulos, P, Bullock, A.N, Fedorov, O, Akue-Gedu, R, Rossignol, E, Azzaro, S, Bain, J, Cohen, P, Prudhomme, M, Moreau, P, Amizon, F, von Delft, F, Arrowsmith, C.H, Weigelt, J, Edwards, A, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) Deposit date: 2009-09-04 Release date: 2009-10-27 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Synthesis, kinase inhibitory potencies, and in vitro antiproliferative evaluation of new pim kinase inhibitors. J.Med.Chem., 52, 2009
2NRT	Crystal structure of the C-terminal half of UvrC Descriptor: CHLORIDE ION, UvrABC system protein C Authors: Karakas, E, Truglio, J.J, Kisker, C. Deposit date: 2006-11-02 Release date: 2007-02-06 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Structure of the C-terminal half of UvrC reveals an RNase H endonuclease domain with an Argonaute-like catalytic triad. Embo J., 26, 2007
2ZP8	The Nature of the TRAP:Anti-TRAP complex Descriptor: TRYPTOPHAN, Transcription attenuation protein mtrB, Tryptophan RNA-binding attenuator protein-inhibitory protein, ... Authors: Watanabe, M, Heddle, J.G, Unzai, S, Akashi, S, Park, S.Y, Tame, J.R.H. Deposit date: 2008-07-08 Release date: 2009-02-03 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (3.2 Å) Cite: The nature of the TRAP-Anti-TRAP complex. Proc.Natl.Acad.Sci.USA, 106, 2009
4LFX	X-ray structure of the adduct between hen egg white lysozyme and Auoxo6, a dinuclear gold(III) complex with -dioxo bridges linking the two metal centers Descriptor: CHLORIDE ION, GOLD ION, Lysozyme C, ... Authors: Vergara, A, Merlino, A. Deposit date: 2013-06-27 Release date: 2013-10-02 Last modified: 2013-10-23 Method: X-RAY DIFFRACTION (2.1 Å) Cite: The mode of action of anticancer gold-based drugs: a structural perspective. Chem.Commun.(Camb.), 49, 2013
4LGB	ABA-mimicking ligand N-(1-METHYL-2-OXO-1,2,3,4-TETRAHYDROQUINOLIN-6-YL)-1-(4-METHYLPHENYL)METHANESULFONAMIDE in complex with ABA receptor PYL2 and PP2C HAB1 Descriptor: Abscisic acid receptor PYL2, MAGNESIUM ION, N-(1-methyl-2-oxo-1,2,3,4-tetrahydroquinolin-6-yl)-1-(4-methylphenyl)methanesulfonamide, ... Authors: Zhou, X.E, Gao, M, Liu, X, Zhang, Y, Xue, X, Melcher, K, Gao, P, Wang, F, Zeng, L, Zhao, Y, Zhao, Y, Deng, P, Zhong, D, Zhu, J.-K, Xu, Y, Xu, H.E. Deposit date: 2013-06-27 Release date: 2013-08-14 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (3.15 Å) Cite: An ABA-mimicking ligand that reduces water loss and promotes drought resistance in plants. Cell Res., 23, 2013
6ZTQ	Cryo-EM structure of respiratory complex I from Mus musculus inhibited by piericidin A at 3.0 A Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, ADENOSINE-5'-TRIPHOSPHATE, ... Authors: Bridges, H.R, Blaza, J.N, Agip, A.N.A, Hirst, J. Deposit date: 2020-07-20 Release date: 2020-10-21 Last modified: 2020-10-28 Method: ELECTRON MICROSCOPY (3 Å) Cite: Structure of inhibitor-bound mammalian complex I. Nat Commun, 11, 2020
4LFP	X-ray structure of the adduct between hen egg white lysozyme and a homoleptic gold(I) complex with the saccharynate ligand Descriptor: CHLORIDE ION, GOLD ION, Lysozyme C, ... Authors: Vergara, A, Merlino, A. Deposit date: 2013-06-27 Release date: 2013-10-02 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (1.72 Å) Cite: The mode of action of anticancer gold-based drugs: a structural perspective. Chem.Commun.(Camb.), 49, 2013
4LG5	ABA-mimicking ligand QUINABACTIN in complex with ABA receptor PYL2 and PP2C HAB1 Descriptor: Abscisic acid receptor PYL2, MAGNESIUM ION, Protein phosphatase 2C 16, ... Authors: Zhou, X.E, Gao, M, Liu, X, Zhang, Y, Xue, X, Melcher, K, Gao, P, Wang, F, Zeng, L, Zhao, Y, Zhao, Y, Deng, P, Zhong, D, Zhu, J.-K, Xu, Y, Xu, H.E. Deposit date: 2013-06-27 Release date: 2013-08-14 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.88 Å) Cite: An ABA-mimicking ligand that reduces water loss and promotes drought resistance in plants. Cell Res., 23, 2013
4LGA	ABA-mimicking ligand N-(2-OXO-1-PROPYL-1,2,3,4-TETRAHYDROQUINOLIN-6-YL)-1-PHENYLMETHANESULFONAMIDE in complex with ABA receptor PYL2 and PP2C HAB1 Descriptor: Abscisic acid receptor PYL2, MAGNESIUM ION, N-(2-oxo-1-propyl-1,2,3,4-tetrahydroquinolin-6-yl)-1-phenylmethanesulfonamide, ... Authors: Zhou, X.E, Gao, M, Liu, X, Zhang, Y, Xue, X, Melcher, K, Gao, P, Wang, F, Zeng, L, Zhao, Y, Zhao, Y, Deng, P, Zhong, D, Zhu, J.-K, Xu, Y, Xu, H.E. Deposit date: 2013-06-27 Release date: 2013-08-14 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.7 Å) Cite: An ABA-mimicking ligand that reduces water loss and promotes drought resistance in plants. Cell Res., 23, 2013
3JXW	Discovery of 3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as Potent, Highly Selective and Orally Bioavailable Pim Kinases Inhibitors Descriptor: 8-[(E)-2-cyclopropylethenyl]-2-[(dimethylamino)methyl][1]benzothieno[3,2-d]pyrimidin-4(3H)-one, Proto-oncogene serine/threonine-protein kinase Pim-1 Authors: Stoll, V.S. Deposit date: 2009-09-21 Release date: 2009-11-10 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Discovery of 3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as Potent, Highly Selective and Orally Bioavailable Pim Kinases Inhibitors TO BE PUBLISHED
4GVA	ADP-bound form of the ERK2 kinase Descriptor: ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, Mitogen-activated protein kinase 1 Authors: Pozharski, E, Zhang, J, Shapiro, P. Deposit date: 2012-08-30 Release date: 2012-09-12 Method: X-RAY DIFFRACTION (1.83 Å) Cite: ADP-bound form of the ERK2 kinase TO BE PUBLISHED
4LKM	Crystal structure of Plk1 Polo-box domain in complex with PL-74 Descriptor: GLYCEROL, PL-74, SULFATE ION, ... Authors: Lee, W.C, Song, J.H, Kim, H.Y. Deposit date: 2013-07-08 Release date: 2013-12-11 Last modified: 2024-10-09 Method: X-RAY DIFFRACTION (2 Å) Cite: Exploring the binding nature of pyrrolidine pocket-dependent interactions in the polo-box domain of polo-like kinase 1 Plos One, 8, 2013
2ZCZ	Crystal structures and thermostability of mutant TRAP3 A7 (ENGINEERED TRAP) Descriptor: TRYPTOPHAN, Transcription attenuation protein mtrB Authors: Watanabe, M, Mishima, Y, Yamashita, I, Park, S.Y, Tame, J.R.H, Heddle, J.G. Deposit date: 2007-11-15 Release date: 2008-04-29 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Intersubunit linker length as a modifier of protein stability: crystal structures and thermostability of mutant TRAP. Protein Sci., 17, 2008
8B7F	Nuclease from C. glutamicum Descriptor: Ubiquitin-like protein SMT3,MksG Authors: Wehenkel, A, Ben Assaya, M, Haouz, A. Deposit date: 2022-09-29 Release date: 2023-03-29 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (4.6 Å) Cite: The MksG nuclease is the executing part of the bacterial plasmid defense system MksBEFG. Nucleic Acids Res., 51, 2023
3JBO	Cryo-electron microscopy reconstruction of the Plasmodium falciparum 80S ribosome bound to P/E-tRNA Descriptor: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein eS1, ... Authors: Sun, M, Li, W, Blomqvist, K, Das, S, Hashem, Y, Dvorin, J.D, Frank, J. Deposit date: 2015-09-16 Release date: 2015-10-14 Last modified: 2024-02-21 Method: ELECTRON MICROSCOPY (5.8 Å) Cite: Dynamical features of the Plasmodium falciparum ribosome during translation. Nucleic Acids Res., 43, 2015
3DJI	Crystal Structure of Macrophage Migration Inhibitory Factor Bound to an Acetaminophen Dimer Derived from NAPQI Descriptor: CHLORIDE ION, Macrophage migration inhibitory factor, N,N'-(6,6'-dihydroxybiphenyl-3,3'-diyl)diacetamide Authors: Crichlow, G.V, Lolis, E. Deposit date: 2008-06-23 Release date: 2008-12-23 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Structural and kinetic analyses of macrophage migration inhibitory factor active site interactions. Biochemistry, 48, 2009
3JV0	Crystal structure of a mutant of RelB dimerization domain(M6) Descriptor: Transcription factor RelB Authors: Vu, D, Huang, D.B, Ghosh, G. Deposit date: 2009-09-15 Release date: 2010-11-24 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.65 Å) Cite: Instability of the RelB dimerization domain is functionally importent To be Published
3JBN	Cryo-electron microscopy reconstruction of the Plasmodium falciparum 80S ribosome bound to P-tRNA Descriptor: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein eS1, ... Authors: Sun, M, Li, W, Blomqvist, K, Das, S, Hashem, Y, Dvorin, J.D, Frank, J. Deposit date: 2015-09-16 Release date: 2015-10-14 Last modified: 2024-02-21 Method: ELECTRON MICROSCOPY (4.7 Å) Cite: Dynamical features of the Plasmodium falciparum ribosome during translation. Nucleic Acids Res., 43, 2015

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