PDB: 46006 resultsInfo pagesStatus searchChemie searchBIRD

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4MD7	Crystal Structure of full-length symmetric CK2 holoenzyme Descriptor: Casein kinase II subunit alpha, Casein kinase II subunit beta, ZINC ION Authors: Lolli, G, Ranchio, A, Battistutta, R. Deposit date: 2013-08-22 Release date: 2013-11-20 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (3.1 Å) Cite: Active Form of the Protein Kinase CK2 alpha 2 beta 2 Holoenzyme Is a Strong Complex with Symmetric Architecture. Acs Chem.Biol., 9, 2014
8BYE	fragment-linked stabilizer for ERa - 14-3-3 interaction (1075313) Descriptor: 14-3-3 protein sigma, ERalpha peptide, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-1-(4-chloranylphenoxy)cyclobutane-1-carboxamide Authors: Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. Deposit date: 2022-12-12 Release date: 2023-08-02 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.6 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8C4G	Small molecule amidine soak in 14-3-3/ERa (AZ132) Descriptor: 14-3-3 protein sigma, ERalpha peptide, MAGNESIUM ION, ... Authors: Visser, E.J, Sijbesma, E, Ottmann, C. Deposit date: 2023-01-03 Release date: 2023-08-02 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.46 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BYB	fragment-linked stabilizer for ERa - 14-3-3 interaction (1074398) Descriptor: 14-3-3 protein sigma, ERalpha peptide, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-1-(4-chloranylphenoxy)cyclohexane-1-carboxamide Authors: Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. Deposit date: 2022-12-12 Release date: 2023-08-02 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.6 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BX4	fragment-linked stabilizer for ERa - 14-3-3 interaction (1074392) Descriptor: 14-3-3 protein sigma, 2-[3,4-bis(chloranyl)phenoxy]-~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-2-methyl-propanamide, ERalpha peptide Authors: Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. Deposit date: 2022-12-07 Release date: 2023-08-02 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.6 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BXO	fragment-linked stabilizer for ERa - 14-3-3 interaction (1075287) Descriptor: 14-3-3 protein sigma, ERalpha peptide, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-4,4-bis(fluoranyl)-1-phenoxy-cyclohexane-1-carboxamide Authors: Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. Deposit date: 2022-12-09 Release date: 2023-08-02 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.6 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BWZ	fragment-linked stabilizer for ERa - 14-3-3 interaction (1074393) Descriptor: 14-3-3 protein sigma, ERalpha peptide, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-2-(4-ethanoylphenoxy)-2-methyl-propanamide Authors: Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. Deposit date: 2022-12-07 Release date: 2023-08-02 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.6 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
6U80	Discovery and optimization of salicyclic acid-derived sulfonamide inhibitors of the WDR5:MYC protein-protein interaction Descriptor: 5-bromo-N-(4-hydroxy[1,1'-biphenyl]-3-yl)-2-methoxybenzene-1-sulfonamide, WD repeat-containing protein 5 Authors: Zhao, B, Wang, F. Deposit date: 2019-09-04 Release date: 2019-12-04 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Discovery and Optimization of Salicylic Acid-Derived Sulfonamide Inhibitors of the WD Repeat-Containing Protein 5-MYC Protein-Protein Interaction. J.Med.Chem., 62, 2019
8BXQ	fragment-linked stabilizer for ERa - 14-3-3 interaction (1075296) Descriptor: 14-3-3 protein sigma, ERalpha peptide, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-1-phenoxy-cyclohexane-1-carboxamide Authors: Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. Deposit date: 2022-12-09 Release date: 2023-08-02 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.6 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BYF	fragment-linked stabilizer for ERa - 14-3-3 interaction (1047455) Descriptor: 14-3-3 protein sigma, PHE-PRO-ALA-TPO-VAL, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-2-(4-chloranylphenoxy)-2-methyl-propanamide Authors: Visser, E.J, Sijbesma, E, Ottmann, C. Deposit date: 2022-12-12 Release date: 2023-08-02 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.65 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BY9	fragment-linked stabilizer for ERa - 14-3-3 interaction (1075292) Descriptor: 14-3-3 protein sigma, ERalpha peptide, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-1-(4-chloranylphenoxy)-4,4-bis(fluoranyl)cyclohexane-1-carboxamide Authors: Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. Deposit date: 2022-12-12 Release date: 2023-08-02 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.6 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BZB	co-soak stabilizers for ERa - 14-3-3 interaction (884_AZ275) Descriptor: 14-3-3 protein sigma, 2-(4-chloranylphenoxy)-2-methyl-~{N}-(2-sulfanylethyl)propanamide, 4-ethoxy-1-benzothiophene-2-carboximidamide, ... Authors: Visser, E.J, Sijbesma, E, Ottmann, C. Deposit date: 2022-12-14 Release date: 2023-08-02 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.7 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BZ0	single soak stabilizer for ERa - 14-3-3 interaction (AZ275) Descriptor: 14-3-3 protein sigma, 4-ethoxy-1-benzothiophene-2-carboximidamide, ERalpha peptide, ... Authors: Visser, E.J, Sijbesma, E, Ottmann, C. Deposit date: 2022-12-14 Release date: 2023-08-02 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.2 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BZA	single soak stabilizer for ERa - 14-3-3 interaction (AZ555) Descriptor: 14-3-3 protein sigma, 4-methyl-5-phenyl-thiophene-2-carboximidamide, ERalpha peptide, ... Authors: Visser, E.J, Sijbesma, E, Ottmann, C. Deposit date: 2022-12-14 Release date: 2023-08-02 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.25 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BXI	fragment-linked stabilizer for ERa - 14-3-3 interaction (1074361) Descriptor: 14-3-3 protein sigma, ERalpha peptide, MAGNESIUM ION, ... Authors: Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. Deposit date: 2022-12-08 Release date: 2023-08-02 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.2 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BYD	fragment-linked stabilizer for ERa - 14-3-3 interactions (1075288) Descriptor: 14-3-3 protein sigma, ERalpha peptide, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-1-(4-chloranylphenoxy)cyclopentane-1-carboxamide Authors: Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. Deposit date: 2022-12-12 Release date: 2023-08-02 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.6 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BYC	fragment-linked stabilizer for ERa - 14-3-3 interaction (1075316) Descriptor: 14-3-3 protein sigma, ERalpha peptide, MAGNESIUM ION, ... Authors: Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. Deposit date: 2022-12-12 Release date: 2023-08-02 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.6 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
2IOQ	Crystal Structure of full-length HTPG, the Escherichia coli HSP90 Descriptor: Chaperone protein htpG Authors: Shiau, A.K, Harris, S.F, Agard, D.A. Deposit date: 2006-10-10 Release date: 2006-11-21 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (3.5 Å) Cite: Structural Analysis of E. coli hsp90 reveals dramatic nucleotide-dependent conformational rearrangements. Cell(Cambridge,Mass.), 127, 2006
8C0K	fragment-linked stabilizer for ERa - 14-3-3 interaction (1075302) Descriptor: 14-3-3 protein sigma, ERalpha peptide, MAGNESIUM ION, ... Authors: Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. Deposit date: 2022-12-17 Release date: 2023-08-02 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.4 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BX3	fragment-linked stabilizer for ERa - 14-3-3 interaction (1074372) Descriptor: 14-3-3 protein sigma, 2-(4-bromanylphenoxy)-~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-2-methyl-propanamide, ERalpha peptide, ... Authors: Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. Deposit date: 2022-12-07 Release date: 2023-08-02 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.2 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BXN	fragment-linked stabilizer for ERa - 14-3-3 interaction (1074399) Descriptor: 14-3-3 protein sigma, ERalpha peptide, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-4-phenoxy-oxane-4-carboxamide Authors: Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. Deposit date: 2022-12-09 Release date: 2023-08-02 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.6 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BYY	fragment-linked stabilizer for ERa - 14-3-3 interaction (1074395) Descriptor: 14-3-3 protein sigma, ERalpha peptide, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-2-[(4-chlorophenyl)amino]-2-methyl-propanamide Authors: Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. Deposit date: 2022-12-14 Release date: 2023-08-02 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.6 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8C04	Co-soaked stabilizers for ERa - 14-3-3 interaction (884_AZ354) Descriptor: 14-3-3 protein sigma, 2-(4-chloranylphenoxy)-2-methyl-~{N}-(2-sulfanylethyl)propanamide, 4-chloranyl-7-propan-2-yloxy-1-benzothiophene-2-carboximidamide, ... Authors: Visser, E.J, Sijbesma, E, Ottmann, C. Deposit date: 2022-12-15 Release date: 2023-08-02 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.1 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8C4F	Small molecule amidine soak in 14-3-3/ERa (AZ037) Descriptor: 14-3-3 protein sigma, 5-(cyclohexylamino)-4-phenyl-thiophene-2-carboximidamide, ERalpha peptide, ... Authors: Visser, E.J, Sijbesma, E, Ottmann, C. Deposit date: 2023-01-03 Release date: 2023-08-02 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.4 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
2J7Z	Crystal Structure of recombinant Human Stromal Cell-Derived Factor- 1alpha Descriptor: STROMAL CELL-DERIVED FACTOR 1 ALPHA Authors: Ryu, E.K, Kim, T.G, Kwon, T.H, Jung, I.D, Ryu, D.W, Park, Y.-M, Ahn, K, Ban, C. Deposit date: 2006-10-18 Release date: 2006-10-23 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Crystal Structure of Recombinant Human Stromal Cell-Derived Factor-1Alpha. Proteins, 67, 2007

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