8G4Z
 
 | | E. coli DHFR complex with NADP+ and folate: EF-X off model by Laue diffraction (no electric field) | | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Klureza, M.A, Hekstra, D.R. | | Deposit date: | 2023-02-10 | | Release date: | 2024-01-03 | | Last modified: | 2024-07-24 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism.
Proc.Natl.Acad.Sci.USA, 121, 2024
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8G50
 | | E. coli DHFR complex with NADP+ and folate: EF-X excited state model by Laue diffraction (electric field along b axis; 8-fold extrapolation of structure factor differences) | | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Klureza, M.A, Hekstra, D.R. | | Deposit date: | 2023-02-10 | | Release date: | 2024-01-03 | | Last modified: | 2024-07-24 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism.
Proc.Natl.Acad.Sci.USA, 121, 2024
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8DAI
 | | E. coli DHFR complex with NADP+ and 10-methylfolate | | Descriptor: | Dihydrofolate reductase, MANGANESE (II) ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | Authors: | Greisman, J.B, Brookner, D.E, Hekstra, D.R. | | Deposit date: | 2022-06-13 | | Release date: | 2023-06-21 | | Last modified: | 2024-07-24 | | Method: | X-RAY DIFFRACTION (1.14 Å) | | Cite: | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism.
Proc.Natl.Acad.Sci.USA, 121, 2024
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5SST
 | | DHFR:NADP+:FOL complex at 270 K (crystal 2) | | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | | Deposit date: | 2022-07-03 | | Release date: | 2023-08-23 | | Last modified: | 2024-07-24 | | Method: | X-RAY DIFFRACTION (1.07 Å) | | Cite: | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism.
Proc.Natl.Acad.Sci.USA, 121, 2024
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5SSS
 | | DHFR:NADP+:FOL complex at 270 K (crystal 1) | | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | | Deposit date: | 2022-07-03 | | Release date: | 2023-08-23 | | Last modified: | 2024-07-24 | | Method: | X-RAY DIFFRACTION (1.14 Å) | | Cite: | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism.
Proc.Natl.Acad.Sci.USA, 121, 2024
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5SSU
 | | DHFR:NADP+:FOL complex at 270 K (crystal 3) | | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | | Deposit date: | 2022-07-03 | | Release date: | 2023-08-23 | | Last modified: | 2024-07-24 | | Method: | X-RAY DIFFRACTION (1.12 Å) | | Cite: | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism.
Proc.Natl.Acad.Sci.USA, 121, 2024
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5SSW
 | | DHFR:NADP+:FOL complex at 270 K (multi-crystal) | | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | | Deposit date: | 2022-07-03 | | Release date: | 2023-08-23 | | Last modified: | 2024-07-24 | | Method: | X-RAY DIFFRACTION (1.06 Å) | | Cite: | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism.
Proc.Natl.Acad.Sci.USA, 121, 2024
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5SSV
 | | DHFR:NADP+:FOL complex at 270 K (crystal 4) | | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | | Deposit date: | 2022-07-03 | | Release date: | 2023-08-23 | | Last modified: | 2024-07-24 | | Method: | X-RAY DIFFRACTION (1.08 Å) | | Cite: | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism.
Proc.Natl.Acad.Sci.USA, 121, 2024
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7FPL
 | | DHFR:NADP+:FOL complex at 280 K (crystal 1) | | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | | Deposit date: | 2022-09-09 | | Release date: | 2023-09-20 | | Last modified: | 2024-07-24 | | Method: | X-RAY DIFFRACTION (1.17 Å) | | Cite: | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism.
Proc.Natl.Acad.Sci.USA, 121, 2024
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7FQ2
 | | DHFR:NADP+:FOL complex at 300 K (multi-crystal) | | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | | Deposit date: | 2022-09-10 | | Release date: | 2023-09-20 | | Last modified: | 2024-07-24 | | Method: | X-RAY DIFFRACTION (1.07 Å) | | Cite: | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism.
Proc.Natl.Acad.Sci.USA, 121, 2024
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7FPM
 | | DHFR:NADP+:FOL complex at 280 K (crystal 2) | | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | | Deposit date: | 2022-09-09 | | Release date: | 2023-09-20 | | Last modified: | 2024-07-24 | | Method: | X-RAY DIFFRACTION (1.04 Å) | | Cite: | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism.
Proc.Natl.Acad.Sci.USA, 121, 2024
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7FQ5
 | | DHFR:NADP+:FOL complex at 310 K (crystal 3) | | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | | Deposit date: | 2022-09-12 | | Release date: | 2023-09-20 | | Last modified: | 2024-07-24 | | Method: | X-RAY DIFFRACTION (1.35 Å) | | Cite: | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism.
Proc.Natl.Acad.Sci.USA, 121, 2024
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7FPO
 | | DHFR:NADP+:FOL complex at 280 K (crystal 4) | | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | | Deposit date: | 2022-09-09 | | Release date: | 2023-09-20 | | Last modified: | 2024-07-24 | | Method: | X-RAY DIFFRACTION (1.06 Å) | | Cite: | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism.
Proc.Natl.Acad.Sci.USA, 121, 2024
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7FQF
 | | DHFR:NADP+:FOL complex (crystal 2, pass 4, 310 K) | | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | | Deposit date: | 2022-09-12 | | Release date: | 2023-09-20 | | Last modified: | 2024-07-24 | | Method: | X-RAY DIFFRACTION (1.23 Å) | | Cite: | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism.
Proc.Natl.Acad.Sci.USA, 121, 2024
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7FPS
 | | DHFR:NADP+:FOL complex at 290 K (crystal 2) | | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | | Deposit date: | 2022-09-10 | | Release date: | 2023-09-20 | | Last modified: | 2024-07-24 | | Method: | X-RAY DIFFRACTION (1.26 Å) | | Cite: | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism.
Proc.Natl.Acad.Sci.USA, 121, 2024
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7FPN
 | | DHFR:NADP+:FOL complex at 280 K (crystal 3) | | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | | Deposit date: | 2022-09-09 | | Release date: | 2023-09-20 | | Last modified: | 2024-07-24 | | Method: | X-RAY DIFFRACTION (1.04 Å) | | Cite: | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism.
Proc.Natl.Acad.Sci.USA, 121, 2024
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7FQ8
 | | DHFR:NADP+:FOL complex (crystal 1, pass 2, 310 K) | | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | | Deposit date: | 2022-09-12 | | Release date: | 2023-09-20 | | Last modified: | 2024-07-24 | | Method: | X-RAY DIFFRACTION (1.21 Å) | | Cite: | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism.
Proc.Natl.Acad.Sci.USA, 121, 2024
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7FQE
 | | DHFR:NADP+:FOL complex (crystal 2, pass 3, 295 K) | | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | | Deposit date: | 2022-09-12 | | Release date: | 2023-09-20 | | Last modified: | 2024-07-24 | | Method: | X-RAY DIFFRACTION (1.18 Å) | | Cite: | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism.
Proc.Natl.Acad.Sci.USA, 121, 2024
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7FPR
 | | DHFR:NADP+:FOL complex at 290 K (crystal 1) | | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | | Deposit date: | 2022-09-10 | | Release date: | 2023-09-20 | | Last modified: | 2024-07-24 | | Method: | X-RAY DIFFRACTION (1.07 Å) | | Cite: | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism.
Proc.Natl.Acad.Sci.USA, 121, 2024
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7FQG
 | | DHFR:NADP+:FOL complex (crystal 2, pass 5, 295 K) | | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | | Deposit date: | 2022-09-12 | | Release date: | 2023-09-20 | | Last modified: | 2024-07-24 | | Method: | X-RAY DIFFRACTION (1.19 Å) | | Cite: | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism.
Proc.Natl.Acad.Sci.USA, 121, 2024
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7FPU
 | | DHFR:NADP+:FOL complex at 290 K (crystal 4) | | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | | Deposit date: | 2022-09-10 | | Release date: | 2023-09-20 | | Last modified: | 2024-07-24 | | Method: | X-RAY DIFFRACTION (1.05 Å) | | Cite: | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism.
Proc.Natl.Acad.Sci.USA, 121, 2024
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7FPW
 | | DHFR:NADP+:FOL complex at 290 K (multi-crystal) | | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | | Deposit date: | 2022-09-10 | | Release date: | 2023-09-20 | | Last modified: | 2024-07-24 | | Method: | X-RAY DIFFRACTION (1.04 Å) | | Cite: | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism.
Proc.Natl.Acad.Sci.USA, 121, 2024
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7FPV
 | | DHFR:NADP+:FOL complex at 290 K (crystal 5) | | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | | Deposit date: | 2022-09-10 | | Release date: | 2023-09-20 | | Last modified: | 2024-07-24 | | Method: | X-RAY DIFFRACTION (1.04 Å) | | Cite: | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism.
Proc.Natl.Acad.Sci.USA, 121, 2024
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7FPT
 | | DHFR:NADP+:FOL complex at 290 K (crystal 3) | | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | | Deposit date: | 2022-09-10 | | Release date: | 2023-09-20 | | Last modified: | 2024-07-24 | | Method: | X-RAY DIFFRACTION (1.07 Å) | | Cite: | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism.
Proc.Natl.Acad.Sci.USA, 121, 2024
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7FPY
 | | DHFR:NADP+:FOL complex at 300 K (crystal 2) | | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | | Deposit date: | 2022-09-10 | | Release date: | 2023-09-20 | | Last modified: | 2024-07-24 | | Method: | X-RAY DIFFRACTION (1.12 Å) | | Cite: | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism.
Proc.Natl.Acad.Sci.USA, 121, 2024
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