8WTL
 
 | | Crystal structure of Cas3-DExD+MG+ATP | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CRISPR-associated helicase Cas3, MAGNESIUM ION | | Authors: | Mo, X. | | Deposit date: | 2023-10-18 | | Release date: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.94 Å) | | Cite: | Structural insight into dynamic characteristic of the polymerized forms of kinetoplastid membrane protein-11
To be published
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8RDY
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9G8M
 | | human 80S ribosome bound by a SKI2-exosome complex | | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ... | | Authors: | Koegel, A, Keidel, A, Loukeri, M.J, Kuhn, C.C, Langer, L.M, Schaefer, I.B, Conti, E. | | Deposit date: | 2024-07-23 | | Release date: | 2024-10-23 | | Last modified: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structural basis of mRNA decay by the human exosome-ribosome supercomplex.
Nature, 2024
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9AVR
 | | Human eIF4A-1 in complex with AMP-PNP, RNA, and the inhibitor silvestrol | | Descriptor: | Eukaryotic initiation factor 4A-I, IODIDE ION, MAGNESIUM ION, ... | | Authors: | Bhatt, G.B, Naineni, S.K, Cencic, R.C, Jiramongkolsiri, E.J, Huang, S.H, Pelletier, J.P, Nagar, B.N. | | Deposit date: | 2024-03-04 | | Release date: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (1.91 Å) | | Cite: | Human eIF4A-1 in complex with AMP-PNP, RNA, and the inhibitor silvestrol
To Be Published
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9G8N
 | | 80S-bound human Ski2-exosome complex | | Descriptor: | CrPV-IRES RNA, DIS3-like exonuclease 1, Exosome complex component CSL4, ... | | Authors: | Koegel, A, Keidel, A, Loukeri, M.J, Kuhn, C.C, Langer, L.M, Schaefer, I.B, Conti, E. | | Deposit date: | 2024-07-23 | | Release date: | 2024-10-16 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Structural basis of mRNA decay by the human exosome-ribosome supercomplex.
Nature, 2024
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9G8Q
 | | 40S-bound human SKI238 complex in the open state (Gatekeeping module) | | Descriptor: | Helicase SKI2W, Superkiller complex protein 3, WD repeat-containing protein 61 | | Authors: | Koegel, A, Keidel, A, Loukeri, M.J, Kuhn, C.C, Langer, L.M, Schaefer, I.B, Conti, E. | | Deposit date: | 2024-07-23 | | Release date: | 2024-10-16 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (4.1 Å) | | Cite: | Structural basis of mRNA decay by the human exosome-ribosome supercomplex.
Nature, 2024
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9G8P
 | | 40S-bound human SKI2-exosome complex | | Descriptor: | CrPV-IRES RNA, DIS3-like exonuclease 1, Exosome complex component CSL4, ... | | Authors: | Koegel, A, Keidel, A, Loukeri, M.J, Kuhn, C.C, Langer, L.M, Schaefer, I.B, Conti, E. | | Deposit date: | 2024-07-23 | | Release date: | 2024-10-16 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (7 Å) | | Cite: | Structural basis of mRNA decay by the human exosome-ribosome supercomplex.
Nature, 2024
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9G8O
 | | human 40S ribosome bound by a SKI238-exosome complex | | Descriptor: | 18S ribosomal RNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | | Authors: | Koegel, A, Keidel, A, Loukeri, M.J, Kuhn, C.C, Langer, L.M, Schaefer, I.B, Conti, E. | | Deposit date: | 2024-07-23 | | Release date: | 2024-10-16 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structural basis of mRNA decay by the human exosome-ribosome supercomplex.
Nature, 2024
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9G8R
 | | human SKI7-SKI238 complex in the open state | | Descriptor: | Isoform 2 of HBS1-like protein, Superkiller complex protein 2, Superkiller complex protein 3, ... | | Authors: | Koegel, A, Keidel, A, Loukeri, M.J, Kuhn, C.C, Langer, L.M, Schaefer, I.B, Conti, E. | | Deposit date: | 2024-07-23 | | Release date: | 2024-10-16 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structural basis of mRNA decay by the human exosome-ribosome supercomplex.
Nature, 2024
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8RO2
 | | Integrative Structure of the human intron lariat Spliceosome (ILS'') | | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, ATP-dependent RNA helicase DHX15, CWF19-like protein 1, ... | | Authors: | Rothe, P, Vorlaender, M.K, Plaschka, C. | | Deposit date: | 2024-01-11 | | Release date: | 2024-09-18 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Mechanism for the initiation of spliceosome disassembly.
Nature, 632, 2024
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8YRS
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9BLN
 | | The structure of human Pdcd4 bound to the 40S-eIF4A-eIF3-eIF1 complex | | Descriptor: | 40S ribosomal protein S14, ACETIC ACID, Eukaryotic initiation factor 4A-I, ... | | Authors: | Brito Querido, J, Sokabe, M, Diaz-Lopez, I, Gordiyenko, Y, Zuber, P, Yifei, D, Albacete-Albacete, L, Ramakrishnan, V, S Fraser, C. | | Deposit date: | 2024-04-30 | | Release date: | 2024-09-04 | | Last modified: | 2024-10-09 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Human tumor suppressor protein Pdcd4 binds at the mRNA entry channel in the 40S small ribosomal subunit.
Nat Commun, 15, 2024
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9BP9
 | | Human DNA polymerase theta helicase domain in complex with inhibitor AB25583, dimer form | | Descriptor: | (4P)-N-{5-[(4-chlorophenyl)methoxy]-1,3,4-thiadiazol-2-yl}-4-(2-methoxyphenyl)pyridine-3-carboxamide, DNA polymerase theta | | Authors: | Ito, F, Li, Z, Chen, X.S. | | Deposit date: | 2024-05-07 | | Release date: | 2024-08-28 | | Method: | ELECTRON MICROSCOPY (3.21 Å) | | Cite: | Structural basis for a Pol theta helicase small-molecule inhibitor revealed by cryo-EM.
Nat Commun, 15, 2024
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9BPA
 | | Human DNA polymerase theta helicase domain in complex with inhibitor AB25583, tetramer form | | Descriptor: | (4P)-N-{5-[(4-chlorophenyl)methoxy]-1,3,4-thiadiazol-2-yl}-4-(2-methoxyphenyl)pyridine-3-carboxamide, DNA polymerase theta | | Authors: | Ito, F, Li, Z, Chen, X.S. | | Deposit date: | 2024-05-07 | | Release date: | 2024-08-28 | | Method: | ELECTRON MICROSCOPY (3.21 Å) | | Cite: | Structural basis for a Pol theta helicase small-molecule inhibitor revealed by cryo-EM.
Nat Commun, 15, 2024
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8RO0
 | | Structure of the C. elegans Intron Lariat Spliceosome primed for disassembly (ILS') | | Descriptor: | Cell division cycle 5-like protein, Coiled-coil domain-containing protein 12, GCF C-terminal domain-containing protein, ... | | Authors: | Vorlaender, M.K, Rothe, P, Plaschka, C. | | Deposit date: | 2024-01-11 | | Release date: | 2024-08-07 | | Last modified: | 2024-08-21 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Mechanism for the initiation of spliceosome disassembly.
Nature, 632, 2024
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8RO1
 | | Structure of the C. elegans Intron Lariat Spliceosome double-primed for disassembly (ILS'') | | Descriptor: | CWF19-like protein 1 homolog, CWF19-like protein 2 homolog, Cell division cycle 5-like protein, ... | | Authors: | Vorlaender, M.K, Rothe, P, Plaschka, C. | | Deposit date: | 2024-01-11 | | Release date: | 2024-08-07 | | Last modified: | 2024-08-21 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Mechanism for the initiation of spliceosome disassembly.
Nature, 632, 2024
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8I0T
 | | The cryo-EM structure of human Bact-III complex | | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, Cell division cycle 5-like protein, Crooked neck-like protein 1, ... | | Authors: | Zhan, X, Lu, Y, Shi, Y. | | Deposit date: | 2023-01-11 | | Release date: | 2024-07-31 | | Last modified: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Molecular basis for the activation of human spliceosome.
Nat Commun, 15, 2024
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8I0V
 | | The cryo-EM structure of human post-Bact complex | | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, Cell division cycle 5-like protein, Crooked neck-like protein 1, ... | | Authors: | Zhan, X, Lu, Y, Shi, Y. | | Deposit date: | 2023-01-11 | | Release date: | 2024-07-31 | | Last modified: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Molecular basis for the activation of human spliceosome.
Nat Commun, 15, 2024
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8I0P
 | | The cryo-EM structure of human pre-Bact complex | | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, BUD13 homolog, Cell division cycle 5-like protein, ... | | Authors: | Zhan, X, Lu, Y, Shi, Y. | | Deposit date: | 2023-01-11 | | Release date: | 2024-07-31 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Molecular basis for the activation of human spliceosome.
Nat Commun, 15, 2024
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8I0R
 | | The cryo-EM structure of human Bact-I complex | | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, BUD13 homolog, Cell division cycle 5-like protein, ... | | Authors: | Zhan, X, Lu, Y, Shi, Y. | | Deposit date: | 2023-01-11 | | Release date: | 2024-07-31 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Molecular basis for the activation of human spliceosome.
Nat Commun, 15, 2024
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8I0S
 | | The cryo-EM structure of human Bact-II complex | | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, Cell division cycle 5-like protein, Crooked neck-like protein 1, ... | | Authors: | Zhan, X, Lu, Y, Shi, Y. | | Deposit date: | 2023-01-11 | | Release date: | 2024-07-31 | | Last modified: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (4.2 Å) | | Cite: | Molecular basis for the activation of human spliceosome.
Nat Commun, 15, 2024
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8I0W
 | | The cryo-EM structure of human C complex | | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, Cell division cycle 5-like protein, Coiled-coil domain-containing protein 94, ... | | Authors: | Zhan, X, Lu, Y, Shi, Y. | | Deposit date: | 2023-01-11 | | Release date: | 2024-07-31 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Molecular basis for the activation of human spliceosome.
Nat Commun, 15, 2024
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8I0U
 | | The cryo-EM structure of human Bact-IV complex | | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, Cell division cycle 5-like protein, Crooked neck-like protein 1, ... | | Authors: | Zhan, X, Lu, Y, Shi, Y. | | Deposit date: | 2023-01-11 | | Release date: | 2024-07-31 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Molecular basis for the activation of human spliceosome.
Nat Commun, 15, 2024
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8WTK
 | | Crystal structure of Cas3-DExD+MG | | Descriptor: | CRISPR-associated helicase Cas3, MAGNESIUM ION | | Authors: | Mo, X. | | Deposit date: | 2023-10-18 | | Release date: | 2024-07-24 | | Method: | X-RAY DIFFRACTION (3.08 Å) | | Cite: | Structural insight into dynamic characteristic of the polymerized forms of kinetoplastid membrane protein-11
To be published
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9FMD
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