2KNF
 
 | | Solution structure and functional characterization of human plasminogen kringle 5 | | Descriptor: | Plasminogen | | Authors: | Battistel, M.D, Grishaev, A, An, S.A, Castellino, F.J, Llinas, M. | | Deposit date: | 2009-08-21 | | Release date: | 2009-10-27 | | Last modified: | 2021-10-13 | | Method: | SOLUTION NMR | | Cite: | Solution structure and functional characterization of human plasminogen kringle 5.
Biochemistry, 48, 2009
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7OCM
 | | K1K1H6, a potent recombinant minimal hepatocyte growth factor/scatter factor mimic | | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Hepatocyte growth factor alpha chain,Hepatocyte growth factor alpha chain | | Authors: | de Jonge, H, de Nola, G, Gherardi, E. | | Deposit date: | 2021-04-27 | | Release date: | 2021-07-07 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Dimerization of kringle 1 domain from hepatocyte growth factor/scatter factor provides a potent MET receptor agonist.
Life Sci Alliance, 5, 2022
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7OCL
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7TNG
 | | Kringle domain of human Receptor Tyrosine Kinase-Like Orphan Receptor 1 (ROR1) | | Descriptor: | Inactive tyrosine-protein kinase transmembrane receptor ROR1 | | Authors: | Guarino, S.R, Di Bello, A, Palamini, M, Forneris, F. | | Deposit date: | 2022-01-21 | | Release date: | 2022-05-11 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Crystal structure of the kringle domain of human receptor tyrosine kinase-like orphan receptor 1 (hROR1)
Acta Crystallogr.,Sect.F, 78, 2022
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6RX7
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1TPK
 | | CRYSTAL STRUCTURE OF THE KRINGLE-2 DOMAIN OF TISSUE PLASMINOGEN ACTIVATOR AT 2.4-ANGSTROMS RESOLUTION | | Descriptor: | CHLORIDE ION, TISSUE PLASMINOGEN ACTIVATOR | | Authors: | De vos, A.M, Ultsch, M.H, Kelley, R.F, Padmanabhan, K, Tulinsky, A, Westbrook, M.L, Kossiakoff, A.A. | | Deposit date: | 1991-09-24 | | Release date: | 1992-07-15 | | Last modified: | 2017-11-29 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Crystal structure of the kringle 2 domain of tissue plasminogen activator at 2.4-A resolution.
Biochemistry, 31, 1992
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1URK
 | | SOLUTION STRUCTURE OF THE AMINO TERMINAL FRAGMENT OF UROKINASE-TYPE PLASMINOGEN ACTIVATOR | | Descriptor: | PLASMINOGEN ACTIVATOR, alpha-L-fucopyranose | | Authors: | Hansen, A.P, Petros, A.M, Meadows, R.P, Nettesheim, D.G, Mazar, A.P, Olejniczak, E.T, Xu, R.X, Pederson, T.M, Henkin, J, Fesik, S.W. | | Deposit date: | 1994-01-10 | | Release date: | 1995-05-08 | | Last modified: | 2020-07-29 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the amino-terminal fragment of urokinase-type plasminogen activator.
Biochemistry, 33, 1994
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1B2I
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3KIV
 | | RECOMBINANT KRINGLE IV-10/M66 VARIANT OF HUMAN APOLIPOPROTEIN(A) | | Descriptor: | 6-AMINOHEXANOIC ACID, APOLIPOPROTEIN | | Authors: | Mochalkin, I, Tulinsky, A, Scanu, A. | | Deposit date: | 1998-09-08 | | Release date: | 1999-05-18 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Recombinant kringle IV-10 modules of human apolipoprotein(a): structure, ligand binding modes, and biological relevance.
Biochemistry, 38, 1999
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4KIV
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5Z55
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1CEA
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1CEB
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6BA5
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6BAN
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2L0S
 | | Solution Structure of Human Plasminogen Kringle 3 | | Descriptor: | Plasminogen | | Authors: | Christen, M.T, Frank, P, Schaller, J, Llinas, M. | | Deposit date: | 2010-07-15 | | Release date: | 2010-08-04 | | Last modified: | 2011-07-13 | | Method: | SOLUTION NMR | | Cite: | Human plasminogen kringle 3: solution structure, functional insights, phylogenetic landscape.
Biochemistry, 49, 2010
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2PK4
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8TCE
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8V9B
 | | Lipoprotein(a) Kringle IV domain 7 - Lp(a) KIV7 in complex with LY3441732 | | Descriptor: | (2S,2'S)-3,3'-[carbonylbis(azanediyl-3,1-phenylene)]bis{2-[(3R)-pyrrolidin-1-ium-3-yl]propanoate}, Apolipoprotein(a), MAGNESIUM ION, ... | | Authors: | Hendle, J, Weichert, K, Sauder, J.M. | | Deposit date: | 2023-12-07 | | Release date: | 2024-05-08 | | Last modified: | 2024-06-19 | | Method: | X-RAY DIFFRACTION (1.19 Å) | | Cite: | Discovery of potent small-molecule inhibitors of lipoprotein(a) formation.
Nature, 629, 2024
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8V8Z
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2I9A
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5HPG
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6OSV
 | | Potent and Selective Antitumor Antibody Targeting a Membrane-Proximal Epitope of ROR2 | | Descriptor: | Antibody heavy chain variable region, Antibody light chain variable region, Tyrosine-protein kinase transmembrane receptor ROR2 | | Authors: | Park, H, Rader, C. | | Deposit date: | 2019-05-02 | | Release date: | 2020-04-01 | | Last modified: | 2020-05-13 | | Method: | X-RAY DIFFRACTION (1.34 Å) | | Cite: | Affinity maturation, humanization, and co-crystallization of a rabbit anti-human ROR2 monoclonal antibody for therapeutic applications.
J.Biol.Chem., 295, 2020
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6OSH
 | | Potent and Selective Antitumor Antibody Targeting a Membrane-Proximal Epitope of ROR2 | | Descriptor: | Antibody Light chain variable region, Antibody heavy chain variable region, Tyrosine-protein kinase transmembrane receptor ROR2 | | Authors: | Park, H, Rader, C. | | Deposit date: | 2019-05-01 | | Release date: | 2020-04-01 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.117 Å) | | Cite: | Affinity maturation, humanization, and co-crystallization of a rabbit anti-human ROR2 monoclonal antibody for therapeutic applications.
J.Biol.Chem., 295, 2020
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6OSN
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