5D16
 
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8FZY
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5D7C
 | | Crystal structure of the ATP binding domain of S. aureus GyrB complexed with a ligand | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 1-ethyl-3-[1-(pyridin-2-yl)-6-(pyridin-3-yl)-1H-pyrrolo[3,2-b]pyridin-3-yl]urea, DNA gyrase subunit B, ... | | Authors: | Zhang, J, Yang, Q, Cross, J.B, Romero, J.A.C, Ryan, M.D, Lippa, B, Dolle, R.E, Andersen, O.A, Barker, J, Cheng, R.K, Kahmann, J, Felicetti, B, Wood, M, Scheich, C. | | Deposit date: | 2015-08-13 | | Release date: | 2015-11-25 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Discovery of Azaindole Ureas as a Novel Class of Bacterial Gyrase B Inhibitors.
J.Med.Chem., 58, 2015
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5V8O
 | | Discovery of a high affinity inhibitor of cGAS | | Descriptor: | 5-phenyltetrazolo[1,5-a]pyrimidin-7-ol, Cyclic GMP-AMP synthase, ZINC ION | | Authors: | Hall, J. | | Deposit date: | 2017-03-22 | | Release date: | 2017-09-27 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay.
PLoS ONE, 12, 2017
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1OP8
 | | Crystal Structure of Human Granzyme A | | Descriptor: | Granzyme A, SULFATE ION | | Authors: | Hink-Schauer, C, Estebanez-Perpina, E, Bode, W, Jenne, D. | | Deposit date: | 2003-03-05 | | Release date: | 2003-07-01 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal structure of the apoptosis-inducing human granzyme A dimer
NAT.STRUCT.BIOL., 10, 2003
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1ISQ
 | | Pyrococcus furiosus PCNA complexed with RFCL PIP-box peptide | | Descriptor: | Proliferating Cell Nuclear Antigen, replication factor C large subunit | | Authors: | Matsumiya, S, Ishino, S, Ishino, Y, Morikawa, K. | | Deposit date: | 2001-12-19 | | Release date: | 2002-10-23 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Physical interaction between proliferating cell nuclear antigen and
replication factor C from Pyrococcus furiosus
Genes Cells, 7, 2002
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7F84
 | | Crystal structure of CRISPR-associated Cas2c of Leptospira interrogans | | Descriptor: | CRISPR-associated endoribonuclease Cas2, GLYCEROL | | Authors: | Gogoi, P, Anand, V, Prabhakaran, H.S, Kumar, M, Kanaujia, S.P. | | Deposit date: | 2021-07-01 | | Release date: | 2022-07-06 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structural and functional characterization of Cas2 of CRISPR-Cas subtype I-C lacking the CRISPR component.
Front Mol Biosci, 9, 2022
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3ORY
 | | Crystal structure of Flap endonuclease 1 from hyperthermophilic archaeon Desulfurococcus amylolyticus | | Descriptor: | PHOSPHATE ION, flap endonuclease 1 | | Authors: | Mase, T, Kubota, K, Miyazono, K, Kawarabayashii, Y, Tanokura, M. | | Deposit date: | 2010-09-08 | | Release date: | 2011-02-09 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structure of flap endonuclease 1 from the hyperthermophilic archaeon Desulfurococcus amylolyticus
Acta Crystallogr.,Sect.F, 67, 2011
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4NRP
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5C8A
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3VLF
 | | Crystal structure of yeast proteasome interacting protein | | Descriptor: | 26S protease regulatory subunit 7 homolog, DNA mismatch repair protein HSM3 | | Authors: | Takagi, K, Kim, S, Kato, K, Tanaka, K, Saeki, Y, Mizushima, T. | | Deposit date: | 2011-12-01 | | Release date: | 2012-02-22 | | Last modified: | 2023-12-06 | | Method: | X-RAY DIFFRACTION (3.8 Å) | | Cite: | Structural basis for specific recognition of Rpt1, an ATPase subunit of the 26S proteasome, by a proteasome-dedicated chaperone Hsm3
J.Biol.Chem., 287, 2012
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4NRQ
 | | Crystal structure of human ALKBH5 in complex with pyridine-2,4-dicarboxylate | | Descriptor: | MANGANESE (II) ION, PYRIDINE-2,4-DICARBOXYLIC ACID, RNA demethylase ALKBH5 | | Authors: | Feng, C, Chen, Z, Liu, Y. | | Deposit date: | 2013-11-27 | | Release date: | 2014-03-19 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal structures of the human RNA demethylase Alkbh5 reveal basis for substrate recognition
J.Biol.Chem., 289, 2014
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3VZH
 | | Crystal Structure of CRISPR-associated Protein | | Descriptor: | Putative uncharacterized protein | | Authors: | Bae, E, Yoon, K. | | Deposit date: | 2012-10-12 | | Release date: | 2013-03-27 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Conservation and Variability in the Structure and Function of the Cas5d Endoribonuclease in the CRISPR-Mediated Microbial Immune System
J.Mol.Biol., 425, 2013
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6FGS
 | | Solution structure of p300Taz2-p73TA1 | | Descriptor: | Histone acetyltransferase p300,Tumor protein p73, ZINC ION | | Authors: | Gebel, J, Kazemi, S, Lohr, F, Guntert, P, Dotsch, V. | | Deposit date: | 2018-01-11 | | Release date: | 2018-05-30 | | Last modified: | 2024-06-19 | | Method: | SOLUTION NMR | | Cite: | Regulation of the Activity in the p53 Family Depends on the Organization of the Transactivation Domain.
Structure, 26, 2018
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3PSS
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3VZI
 | | Crystal Structure of CRISPR-associated Protein | | Descriptor: | Crispr-associated protein Cas5, dvulg subtype | | Authors: | Bae, E, Koo, Y. | | Deposit date: | 2012-10-12 | | Release date: | 2013-03-27 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.66 Å) | | Cite: | Conservation and Variability in the Structure and Function of the Cas5d Endoribonuclease in the CRISPR-Mediated Microbial Immune System
J.Mol.Biol., 425, 2013
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4NRO
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6FGN
 | | Solution Structure of p300Taz2-p63TA | | Descriptor: | Histone acetyltransferase p300,Tumor protein 63, ZINC ION | | Authors: | Gebel, J, Kazemi, S, Lohr, F, Guntert, P, Dotsch, V. | | Deposit date: | 2018-01-11 | | Release date: | 2018-05-30 | | Last modified: | 2024-06-19 | | Method: | SOLUTION NMR | | Cite: | Regulation of the Activity in the p53 Family Depends on the Organization of the Transactivation Domain.
Structure, 26, 2018
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4O26
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3PSZ
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4NRM
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1K2J
 | | NMR MINIMIZED AVERAGE STRUCTURE OF d(CGTACG)2 | | Descriptor: | 5'-D(*CP*GP*TP*AP*CP*G)-3' | | Authors: | Lam, S.L, Ip, L.N. | | Deposit date: | 2001-09-27 | | Release date: | 2002-04-10 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Low temperature solution structures and base pair stacking of double helical d(CGTACG)(2).
J.Biomol.Struct.Dyn., 19, 2002
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6G7E
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4O7X
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3QIO
 | | Crystal Structure of HIV-1 RNase H with engineered E. coli loop and N-hydroxy quinazolinedione inhibitor | | Descriptor: | 3-hydroxy-6-(phenylsulfonyl)quinazoline-2,4(1H,3H)-dione, Gag-Pol polyprotein,Ribonuclease HI,Gag-Pol polyprotein, MANGANESE (II) ION, ... | | Authors: | Lansdon, E.B, Liu, Q. | | Deposit date: | 2011-01-27 | | Release date: | 2011-04-20 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.4011 Å) | | Cite: | Structural and Binding Analysis of Pyrimidinol Carboxylic Acid and N-Hydroxy Quinazolinedione HIV-1 RNase H Inhibitors.
Antimicrob.Agents Chemother., 55, 2011
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