6VR8
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6vr8 by Molmil](/molmil-images/mine/6vr8) | Structure of a pseudomurein peptide ligase type E from Methanothermus fervidus | Descriptor: | 1,2-ETHANEDIOL, MAGNESIUM ION, Mur ligase middle domain protein, ... | Authors: | Carbone, V, Schofield, L.R, Sutherland-Smith, A.J, Ronimus, R.S, Subedi, B.P. | Deposit date: | 2020-02-06 | Release date: | 2021-08-11 | Last modified: | 2023-02-22 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural characterisation of methanogen pseudomurein cell wall peptide ligases homologous to bacterial MurE/F murein peptide ligases. Microbiology (Reading, Engl.), 168, 2022
|
|
1A9X
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1a9x by Molmil](/molmil-images/mine/1a9x) | |
3BG5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3bg5 by Molmil](/molmil-images/mine/3bg5) | Crystal Structure of Staphylococcus Aureus Pyruvate Carboxylase | Descriptor: | 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, ADENOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, ... | Authors: | Xiang, S, Tong, L. | Deposit date: | 2007-11-26 | Release date: | 2008-02-26 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal structures of human and Staphylococcus aureus pyruvate carboxylase and molecular insights into the carboxyltransfer reaction. Nat.Struct.Mol.Biol., 15, 2008
|
|
5DOU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5dou by Molmil](/molmil-images/mine/5dou) | Crystal Structure of Human Carbamoyl phosphate synthetase I (CPS1), ligand-bound form | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, ... | Authors: | de Cima, S, Polo, L.M, Fita, I, Rubio, V. | Deposit date: | 2015-09-11 | Release date: | 2015-12-09 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structure of human carbamoyl phosphate synthetase: deciphering the on/off switch of human ureagenesis. Sci Rep, 5, 2015
|
|
5DOT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5dot by Molmil](/molmil-images/mine/5dot) | Crystal Structure of Human Carbamoyl phosphate synthetase I (CPS1), apo form | Descriptor: | 1,2-ETHANEDIOL, Carbamoyl-phosphate synthase [ammonia], mitochondrial, ... | Authors: | Polo, L.M, de Cima, S, Fita, I, Rubio, V. | Deposit date: | 2015-09-11 | Release date: | 2015-12-09 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure of human carbamoyl phosphate synthetase: deciphering the on/off switch of human ureagenesis. Sci Rep, 5, 2015
|
|
2VXO
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2vxo by Molmil](/molmil-images/mine/2vxo) | Human GMP synthetase in complex with XMP | Descriptor: | GMP SYNTHASE [GLUTAMINE-HYDROLYZING], SULFATE ION, XANTHOSINE-5'-MONOPHOSPHATE | Authors: | Welin, M, Lehtio, L, Andersson, J, Arrowsmith, C.H, Berglund, H, Collins, R, Dahlgren, L.G, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, A, Johansson, I, Karlberg, T, Kotenyova, T, Moche, M, Nilsson, M.E, Nyman, T, Olesen, K, Persson, C, Sagemark, J, Schueler, H, Thorsell, A.G, Tresaugues, L, Van Den Berg, S, Wisniewska, M, Wikstrom, M, Nordlund, P. | Deposit date: | 2008-07-08 | Release date: | 2008-08-12 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Substrate Specificity and Oligomerization of Human Gmp Synthetase J.Mol.Biol., 425, 2013
|
|
2IO8
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2io8 by Molmil](/molmil-images/mine/2io8) | E. coli Bifunctional glutathionylspermidine synthetase/amidase Incomplex with Mg2+ and ADP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Bifunctional glutathionylspermidine synthetase/amidase, CYSTEINE, ... | Authors: | Pai, C.H, Chiang, B.Y, Ko, T.P, Chou, C.C, Chong, C.M, Yen, F.J, Coward, J.K, Wang, A.H.-J, Lin, C.H. | Deposit date: | 2006-10-10 | Release date: | 2006-12-12 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Dual binding sites for translocation catalysis by Escherichia coli glutathionylspermidine synthetase Embo J., 25, 2006
|
|
2IOA
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2ioa by Molmil](/molmil-images/mine/2ioa) | E. coli Bifunctional glutathionylspermidine synthetase/amidase Incomplex with Mg2+ and ADP and phosphinate inhibitor | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Bifunctional glutathionylspermidine synthetase/amidase, D-GAMMA-GLUTAMYL-N-{[(R)-{4-[(4-AMINOBUTYL)AMINO]BUTYL}(PHOSPHONOOXY)PHOSPHORYL]METHYL}-D-ALANINAMIDE, ... | Authors: | Pai, C.H, Chiang, B.Y, Ko, T.P, Chou, C.C, Chong, C.M, Yen, F.J, Coward, J.K, Wang, A.H.-J, Lin, C.H. | Deposit date: | 2006-10-10 | Release date: | 2006-12-12 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Dual binding sites for translocation catalysis by Escherichia coli glutathionylspermidine synthetase Embo J., 25, 2006
|
|
2IO9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2io9 by Molmil](/molmil-images/mine/2io9) | E. coli Bifunctional glutathionylspermidine synthetase/amidase Incomplex with Mg2+ ,GSH and ADP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Bifunctional glutathionylspermidine synthetase/amidase, GLUTATHIONE, ... | Authors: | Pai, C.H, Chiang, B.Y, Ko, T.P, Chou, C.C, Chong, C.M, Yen, F.J, Coward, J.K, Wang, A.H.-J, Lin, C.H. | Deposit date: | 2006-10-10 | Release date: | 2006-12-12 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Dual binding sites for translocation catalysis by Escherichia coli glutathionylspermidine synthetase Embo J., 25, 2006
|
|
2IOB
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2iob by Molmil](/molmil-images/mine/2iob) | E. coli Bifunctional glutathionylspermidine synthetase/amidase Apo protein | Descriptor: | Bifunctional glutathionylspermidine synthetase/amidase | Authors: | Pai, C.H, Chiang, B.Y, Ko, T.P, Chou, C.C, Chong, C.M, Yen, F.J, Coward, J.K, Wang, A.H.-J, Lin, C.H. | Deposit date: | 2006-10-10 | Release date: | 2006-12-12 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Dual binding sites for translocation catalysis by Escherichia coli glutathionylspermidine synthetase Embo J., 25, 2006
|
|
2IO7
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2io7 by Molmil](/molmil-images/mine/2io7) | E. coli Bifunctional glutathionylspermidine synthetase/amidase Incomplex with Mg2+ and AMPPNP | Descriptor: | Bifunctional glutathionylspermidine synthetase/amidase, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | Authors: | Pai, C.H, Chiang, B.Y, Ko, T.P, Chong, C.M, Yen, F.J, Coward, J.K, Wang, A.H.-J, Lin, C.H. | Deposit date: | 2006-10-10 | Release date: | 2006-12-12 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Dual binding sites for translocation catalysis by Escherichia coli glutathionylspermidine synthetase Embo J., 25, 2006
|
|
1WXI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1wxi by Molmil](/molmil-images/mine/1wxi) | E.coli NAD Synthetase, AMP.PP | Descriptor: | ADENOSINE MONOPHOSPHATE, DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Jauch, R, Humm, A, Huber, R, Wahl, M.C. | Deposit date: | 2005-01-23 | Release date: | 2005-02-15 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structures of Escherichia coli NAD Synthetase with Substrates and Products Reveal Mechanistic Rearrangements J.Biol.Chem., 280, 2005
|
|
1WXG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1wxg by Molmil](/molmil-images/mine/1wxg) | E.coli NAD Synthetase, DND | Descriptor: | MAGNESIUM ION, NH(3)-dependent NAD(+) synthetase, NICOTINIC ACID ADENINE DINUCLEOTIDE | Authors: | Jauch, R, Humm, A, Huber, R, Wahl, M.C. | Deposit date: | 2005-01-23 | Release date: | 2005-02-15 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structures of Escherichia coli NAD Synthetase with Substrates and Products Reveal Mechanistic Rearrangements J.Biol.Chem., 280, 2005
|
|
1WXH
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1wxh by Molmil](/molmil-images/mine/1wxh) | E.coli NAD Synthetase, NAD | Descriptor: | NH(3)-dependent NAD(+) synthetase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | Authors: | Jauch, R, Humm, A, Huber, R, Wahl, M.C. | Deposit date: | 2005-01-23 | Release date: | 2005-02-15 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structures of Escherichia coli NAD Synthetase with Substrates and Products Reveal Mechanistic Rearrangements J.Biol.Chem., 280, 2005
|
|
8AXZ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8axz by Molmil](/molmil-images/mine/8axz) | Crystal structure of human methionine adenosyltransferase 2A (MAT2A) in complex with S-adenosylmethionine, adenosin and diphosphono-aminophosphonic acid. | Descriptor: | (DIPHOSPHONO)AMINOPHOSPHONIC ACID, ADENOSINE, DI(HYDROXYETHYL)ETHER, ... | Authors: | Nawrotek, A, Vuillard, L, Miallau, L. | Deposit date: | 2022-09-01 | Release date: | 2022-10-05 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.154 Å) | Cite: | Crystal structure of human methionine adenosyltransferase 2A (MAT2A) in complex with S-adenosylmethionine, adenosin and diphosphono-aminophosphonic acid. To Be Published
|
|
7KW7
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7kw7 by Molmil](/molmil-images/mine/7kw7) | Atomic cryoEM structure of Hsp90-Hsp70-Hop-GR | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Glucocorticoid receptor, Heat shock 70 kDa protein 1A, ... | Authors: | Wang, R.Y, Noddings, C.M, Kirschke, E, Myasnikov, A, Johnson, J.L, Agard, D.A. | Deposit date: | 2020-11-30 | Release date: | 2021-12-08 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.57 Å) | Cite: | Structure of Hsp90-Hsp70-Hop-GR reveals the Hsp90 client-loading mechanism. Nature, 601, 2022
|
|
1WXE
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1wxe by Molmil](/molmil-images/mine/1wxe) | E.coli NAD Synthetase, AMP | Descriptor: | ADENOSINE MONOPHOSPHATE, MAGNESIUM ION, NH(3)-dependent NAD(+) synthetase | Authors: | Jauch, R, Humm, A, Huber, R, Wahl, M.C. | Deposit date: | 2005-01-23 | Release date: | 2005-02-15 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structures of Escherichia coli NAD Synthetase with Substrates and Products Reveal Mechanistic Rearrangements J.Biol.Chem., 280, 2005
|
|
1WXF
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1wxf by Molmil](/molmil-images/mine/1wxf) | E.coli NAD Synthetase | Descriptor: | NH(3)-dependent NAD(+) synthetase | Authors: | Jauch, R, Humm, A, Huber, R, Wahl, M.C. | Deposit date: | 2005-01-23 | Release date: | 2005-02-15 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structures of Escherichia coli NAD Synthetase with Substrates and Products Reveal Mechanistic Rearrangements J.Biol.Chem., 280, 2005
|
|
8UPI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8upi by Molmil](/molmil-images/mine/8upi) | Structure of a periplasmic peptide binding protein from Mesorhizobium sp. AP09 bound to aminoserine | Descriptor: | 1,2-ETHANEDIOL, AMINOSERINE, CALCIUM ION, ... | Authors: | Frkic, R.L, Smith, O.B, Rahman, M, Kaczmarski, J.A, Jackson, C.J. | Deposit date: | 2023-10-22 | Release date: | 2023-11-08 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Identification and Characterization of a Bacterial Periplasmic Solute Binding Protein That Binds l-Amino Acid Amides. Biochemistry, 63, 2024
|
|
4R3Z
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4r3z by Molmil](/molmil-images/mine/4r3z) | Crystal structure of human ArgRS-GlnRS-AIMP1 complex | Descriptor: | Aminoacyl tRNA synthase complex-interacting multifunctional protein 1, Arginine--tRNA ligase, cytoplasmic, ... | Authors: | Fu, Y, Kim, Y, Cho, Y. | Deposit date: | 2014-08-18 | Release date: | 2014-10-08 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (4.033 Å) | Cite: | Structure of the ArgRS-GlnRS-AIMP1 complex and its implications for mammalian translation Proc.Natl.Acad.Sci.USA, 111, 2014
|
|
1CE8
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1ce8 by Molmil](/molmil-images/mine/1ce8) | CARBAMOYL PHOSPHATE SYNTHETASE FROM ESCHERICHIS COLI WITH COMPLEXED WITH THE ALLOSTERIC LIGAND IMP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, INOSINIC ACID, ... | Authors: | Thoden, J.B, Raushel, F.M, Holden, H.M. | Deposit date: | 1999-03-18 | Release date: | 1999-07-26 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The binding of inosine monophosphate to Escherichia coli carbamoyl phosphate synthetase. J.Biol.Chem., 274, 1999
|
|
5KIR
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5kir by Molmil](/molmil-images/mine/5kir) | The Structure of Vioxx Bound to Human COX-2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, AMMONIUM ION, GLYCEROL, ... | Authors: | Orlando, B.J, Malkowski, M.G. | Deposit date: | 2016-06-16 | Release date: | 2016-09-28 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.697 Å) | Cite: | Crystal structure of rofecoxib bound to human cyclooxygenase-2. Acta Crystallogr.,Sect.F, 72, 2016
|
|
7KCT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7kct by Molmil](/molmil-images/mine/7kct) | Crystal Structure of the Hydrogenobacter thermophilus 2-Oxoglutarate Carboxylase (OGC) Biotin Carboxylase (BC) Domain Dimer in Complex with Adenosine 5'-Diphosphate Magnesium Salt (MgADP), Adenosine 5'-Diphosphate (ADP, and Bicarbonate Anion (Hydrogen Carbonate/HCO3-) | Descriptor: | 2-oxoglutarate carboxylase small subunit, ADENOSINE-5'-DIPHOSPHATE, BICARBONATE ION, ... | Authors: | Buhrman, G.K, Rose, R.B, Enriquez, P, Truong, V. | Deposit date: | 2020-10-07 | Release date: | 2021-01-27 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.02 Å) | Cite: | Structure, Function, and Thermal Adaptation of the Biotin Carboxylase Domain Dimer from Hydrogenobacter thermophilus 2-Oxoglutarate Carboxylase. Biochemistry, 60, 2021
|
|
7KC7
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7kc7 by Molmil](/molmil-images/mine/7kc7) | Biotin Carboxylase domain of Thermophilic 2-Oxoglutarate Carboxylase bound to ADP without Magnesium with disordered phosphate tail | Descriptor: | 2-oxoglutarate carboxylase small subunit, ADENOSINE-5'-DIPHOSPHATE, PHOSPHATE ION | Authors: | Buhrman, G.K, Rose, R.B, Enriquez, P, Truong, V. | Deposit date: | 2020-10-05 | Release date: | 2021-01-27 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure, Function, and Thermal Adaptation of the Biotin Carboxylase Domain Dimer from Hydrogenobacter thermophilus 2-Oxoglutarate Carboxylase. Biochemistry, 60, 2021
|
|
7KBL
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7kbl by Molmil](/molmil-images/mine/7kbl) | Biotin Carboxylase domain of Thermophilic 2-Oxoglutarate Carboxylase bound to Bicarbonate | Descriptor: | 2-oxoglutarate carboxylase small subunit, BICARBONATE ION | Authors: | Buhrman, G.K, Rose, R.B, Enriquez, P, Truong, V. | Deposit date: | 2020-10-02 | Release date: | 2021-01-27 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure, Function, and Thermal Adaptation of the Biotin Carboxylase Domain Dimer from Hydrogenobacter thermophilus 2-Oxoglutarate Carboxylase. Biochemistry, 60, 2021
|
|