PDB: 224004 resultsInfo pagesStatus searchChemie searchBIRD

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2F3E	Crystal Structure of the Bace complex with AXQ093, a macrocyclic inhibitor Descriptor: Beta-secretase 1, {(E)-(3R,6S,9R)-3-[(1S,3R)-3-((S)-1 -BUTYLCARBAMOYL-2-METHYL-PROPYLCARB AMOYL)-1-HYDROXY-BUTYL]-6-METHYL-5, 8-DIOXO-1,11-DITHIA-4,7-DIAZA-CYCLO PENTADEC-13-EN-9-YL}-CARBAMIC ACID TERT-BUTYL ESTER Authors: Rondeau, J.-M. Deposit date: 2005-11-21 Release date: 2006-09-05 Last modified: 2017-10-18 Method: X-RAY DIFFRACTION (2.11 Å) Cite: Structure-based design and synthesis of macroheterocyclic peptidomimetic inhibitors of the aspartic protease beta-site amyloid precursor protein cleaving enzyme (BACE). J.Med.Chem., 49, 2006
2F3Y	Calmodulin/IQ domain complex Descriptor: CALCIUM ION, Calmodulin, MAGNESIUM ION, ... Authors: Fallon, J.L, Quiocho, F.A. Deposit date: 2005-11-22 Release date: 2005-12-27 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Structure of Calmodulin Bound to the Hydrophobic IQ Domain of the Cardiac Ca(v)1.2 Calcium Channel. Structure, 13, 2005
2F7A	BenM effector binding domain with its effector, cis,cis-muconate Descriptor: (2Z,4Z)-HEXA-2,4-DIENEDIOIC ACID, ACETATE ION, BENZOIC ACID, ... Authors: Clark, T, Haddad, S, Ezezika, O, Neidle, E, Momany, C. Deposit date: 2005-11-30 Release date: 2006-10-31 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Distinct Effector-binding Sites Enable Synergistic Transcriptional Activation by BenM, a LysR-type Regulator. J.Mol.Biol., 367, 2007
2I55	Complex of glucose-1,6-bisphosphate with phosphomannomutase from Leishmania mexicana Descriptor: 1,6-di-O-phosphono-beta-D-glucopyranose, CHLORIDE ION, MAGNESIUM ION, ... Authors: Smith, B.J. Deposit date: 2006-08-24 Release date: 2007-04-17 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Structure of Leishmania mexicana phosphomannomutase highlights similarities with human isoforms J.Mol.Biol., 363, 2006
2HRW	Crystal Structure of Phosphonopyruvate Hydrolase Descriptor: CHLORIDE ION, Phosphonopyruvate hydrolase, SODIUM ION Authors: Chen, C.C.H, Herzberg, O. Deposit date: 2006-07-20 Release date: 2006-10-03 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structure and Kinetics of Phosphonopyruvate Hydrolase from Voriovorax sp. Pal2: New Insight into the Divergence of Catalysis within the PEP Mutase/Isocitrate Lyase Superfamily Biochemistry, 45, 2006
2HRT	Asymmetric structure of trimeric AcrB from Escherichia coli Descriptor: Acriflavine resistance protein B, CITRATE ANION Authors: Seeger, M.A, Schiefner, A, Eicher, T, Verrey, F, Diederichs, K, Pos, K.M. Deposit date: 2006-07-20 Release date: 2006-09-12 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (3 Å) Cite: Structural Asymmetry of AcrB Trimer Suggests a Peristaltic Pump Mechanism. Science, 313, 2006
2HUW	X-ray crystal structure of the Grb2 SH2 domain complexed to a constrained and cyclopropane-derived ligand Descriptor: Growth factor receptor-bound protein 2, N-({(1R,2R,3S)-2-(methylcarbamoyl)-3-[4-(phosphonooxy)phenyl]cyclopropyl}carbonyl)-L-valyl-L-aspartamide, PHOSPHATE ION Authors: Benfield, A.P, Martin, S.F. Deposit date: 2006-07-27 Release date: 2006-08-15 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Ligand Preorganization May Be Accompanied by Entropic Penalties in Protein-Ligand Interactions. Angew.Chem.Int.Ed.Engl., 45, 2006
2I6K	Crystal structure of human type I IPP isomerase complexed with a substrate analog Descriptor: ACETIC ACID, AMINOETHANOLPYROPHOSPHATE, Isopentenyl-diphosphate delta-isomerase 1, ... Authors: Zhang, C, Wei, Z, Gong, W. Deposit date: 2006-08-29 Release date: 2007-06-05 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal structures of human IPP isomerase: new insights into the catalytic mechanism J.Mol.Biol., 366, 2007
2I74	Crystal structure of mouse Peptide N-Glycanase C-terminal domain in complex with mannopentaose Descriptor: ACETATE ION, GLYCEROL, PNGase, ... Authors: Zhou, X, Zhao, G, Wang, L, Li, G, Lennarz, W.J, Schindelin, H. Deposit date: 2006-08-30 Release date: 2006-10-24 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Structural and biochemical studies of the C-terminal domain of mouse peptide-N-glycanase identify it as a mannose-binding module. Proc.Natl.Acad.Sci.Usa, 103, 2006
2I7F	Sphingomonas yanoikuyae B1 ferredoxin Descriptor: CITRIC ACID, FE2/S2 (INORGANIC) CLUSTER, Ferredoxin component of dioxygenase, ... Authors: Ramaswamy, S, Brown, E.N. Deposit date: 2006-08-30 Release date: 2007-03-20 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural investigations of the ferredoxin and terminal oxygenase components of the biphenyl 2,3-dioxygenase from Sphingobium yanoikuyae B1. Bmc Struct.Biol., 7, 2007
2G6W	Suicide inhibition of a-Oxamine Synthase: Structures of the Covalent Adducts of 8-Amino-7-oxonanoate Synthase with trifluoroalanine Descriptor: (4-{(E)-[(2,2-DIFLUOROETHYL)IMINO]METHYL}-5-HYDROXY-6-METHYLPYRIDIN-3-YL)METHYL DIHYDROGEN PHOSPHATE, 8-amino-7-oxononanoate synthase Authors: Alexeev, D. Deposit date: 2006-02-26 Release date: 2006-04-25 Last modified: 2017-10-18 Method: X-RAY DIFFRACTION (2.14 Å) Cite: Suicide inhibition of alpha-oxamine synthases: structures of the covalent adducts of 8-amino-7-oxononanoate synthase with trifluoroalanine. Org.Biomol.Chem., 4, 2006
2G78	Crystal Structure of the R132K:Y134F Mutant of Cellular Retinoic Acid Binding Protein Type II in Complex with All-Trans-Retinoic Acid at 1.70 Angstroms Resolution Descriptor: Cellular retinoic acid-binding protein 2, RETINOIC ACID, SODIUM ION Authors: Vaezeslami, S, Geiger, J.H. Deposit date: 2006-02-27 Release date: 2007-04-17 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Protein design: reengineering cellular retinoic acid binding protein II into a rhodopsin protein mimic. J.Am.Chem.Soc., 129, 2007
2GAK	X-ray crystal structure of murine leukocyte-type Core 2 b1,6-N-acetylglucosaminyltransferase (C2GnT-L) Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, beta-1,6-N-acetylglucosaminyltransferase Authors: Pak, J.E, Rini, J.M. Deposit date: 2006-03-09 Release date: 2006-07-11 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2 Å) Cite: X-ray Crystal Structure of Leukocyte Type Core 2 beta1,6-N-Acetylglucosaminyltransferase: Evidence for a covergence of metal ion independent glycosyltransferase mechanism. J.Biol.Chem., 281, 2006
2GB4	Crystal structure of Thiopurine methyltransferase (18204406) from Mus musculus at 1.35 A resolution Descriptor: S-ADENOSYL-L-HOMOCYSTEINE, Thiopurine S-methyltransferase Authors: Joint Center for Structural Genomics (JCSG) Deposit date: 2006-03-09 Release date: 2006-09-19 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.25 Å) Cite: Crystal structure of Thiopurine methyltransferase (18204406) from Mus musculus at 1.35 A resolution To be published
2GBT	C6A/C111A CuZn Superoxide dismutase Descriptor: COPPER (I) ION, Superoxide dismutase [Cu-Zn], ZINC ION Authors: Hornberg, A, Logan, D.T, Marklund, S.L, Oliveberg, M. Deposit date: 2006-03-11 Release date: 2007-01-02 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.7 Å) Cite: The Coupling between Disulphide Status, Metallation and Dimer Interface Strength in Cu/Zn Superoxide Dismutase J.Mol.Biol., 365, 2007
2G7B	Crystal Structure of the R132K:R111L:L121E mutant of Cellular Retinoic Acid Binding Protein Type II In Complex With All-Trans-Retinal At 1.18 Angstroms Resolution Descriptor: ALL-TRANS AXEROPHTHENE, Cellular retinoic acid-binding protein 2, SODIUM ION Authors: Vaezeslami, S, Geiger, J.H. Deposit date: 2006-02-27 Release date: 2007-04-17 Last modified: 2021-10-20 Method: X-RAY DIFFRACTION (1.18 Å) Cite: Protein design: reengineering cellular retinoic acid binding protein II into a rhodopsin protein mimic. J.Am.Chem.Soc., 129, 2007
2GFH	Crystal structure of a n-acetylneuraminic acid phosphatase (nanp) from mus musculus at 1.90 A resolution Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, PHOSPHATE ION, ... Authors: Joint Center for Structural Genomics (JCSG) Deposit date: 2006-03-21 Release date: 2006-04-18 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystal structure of Protein C20orf147 homolog (17391249) from Mus musculus at 1.90 A resolution To be published
2GBI	rat DPP-IV with xanthine inhibitor 4 Descriptor: 2-({8-[(3R)-3-AMINOPIPERIDIN-1-YL]-1,3-DIMETHYL-2,6-DIOXO-1,2,3,6-TETRAHYDRO-7H-PURIN-7-YL}METHYL)BENZONITRILE, Dipeptidyl peptidase 4 Authors: Longenecker, K.L, Jakob, C.G, Fry, E.H, Wilk, S. Deposit date: 2006-03-10 Release date: 2006-07-04 Last modified: 2017-10-18 Method: X-RAY DIFFRACTION (3.3 Å) Cite: Crystal Structures of DPP-IV (CD26) from Rat Kidney Exhibit Flexible Accommodation of Peptidase-Selective Inhibitors. Biochemistry, 45, 2006
2GHS	CRYSTAL STRUCTURE OF A CALCIUM-BINDING PROTEIN, REGUCALCIN (AGR_C_1268) FROM AGROBACTERIUM TUMEFACIENS STR. C58 AT 1.55 A RESOLUTION Descriptor: 1,2-ETHANEDIOL, AGR_C_1268p, CHLORIDE ION, ... Authors: Joint Center for Structural Genomics (JCSG) Deposit date: 2006-03-27 Release date: 2006-04-11 Last modified: 2023-01-25 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Crystal structure of Calcium-binding protein, regucalcin (15155668) from AGROBACTERIUM TUMEFACIENS at 1.55 A resolution To be published
2G30	beta appendage of AP2 complexed with ARH peptide Descriptor: 16-mer peptide from Low density lipoprotein receptor adapter protein 1, AP-2 complex subunit beta-1, peptide sequence AAF Authors: Edeling, M.A, Collins, B.M, Traub, L.M, Owen, D.J. Deposit date: 2006-02-17 Release date: 2006-03-14 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Molecular Switches Involving the AP-2 beta2 Appendage Regulate Endocytic Cargo Selection and Clathrin Coat Assembly Dev.Cell, 10, 2006
2G0C	Structure of the RNA binding domain (residues 404-479) of the Bacillus subtilis YxiN protein Descriptor: ATP-dependent RNA helicase dbpA, SULFATE ION Authors: McKay, D.B. Deposit date: 2006-02-11 Release date: 2006-04-18 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.7 Å) Cite: The domain of the Bacillus subtilis DEAD-box helicase YxiN that is responsible for specific binding of 23S rRNA has an RNA recognition motif fold. RNA, 12, 2006
2G50	The location of the allosteric amino acid binding site of muscle pyruvate kinase. Descriptor: 1,2-ETHANEDIOL, 2-{2-[2-2-(METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, ALANINE, ... Authors: Holyoak, T, Williams, R, Fenton, A.W. Deposit date: 2006-02-22 Release date: 2006-05-09 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Differentiating a Ligand's Chemical Requirements for Allosteric Interactions from Those for Protein Binding. Phenylalanine Inhibition of Pyruvate Kinase. Biochemistry, 45, 2006
2GA1	Crystal structure of a duf433 member protein (ava_0674) from anabaena variabilis atcc 29413 at 2.00 A resolution Descriptor: GLYCEROL, Protein of unknown function DUF433 Authors: Joint Center for Structural Genomics (JCSG) Deposit date: 2006-03-07 Release date: 2006-03-28 Last modified: 2023-01-25 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal structure of (YP_321193.1) from Anabaena variabilis ATCC 29413 at 2.00 A resolution To be published
2FEU	P450CAM from Pseudomonas putida reconstituted with manganic protoporphyrin IX Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CAMPHOR, Cytochrome P450-cam, ... Authors: von Koenig, K, Makris, T.M, Sligar, S.G, Schlichting, I. Deposit date: 2005-12-16 Release date: 2006-03-14 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.7 Å) Cite: The status of high-valent metal oxo complexes in the P450 cytochromes. J.Inorg.Biochem., 100, 2006
2FJA	adenosine 5'-phosphosulfate reductase in complex with substrate Descriptor: ADENOSINE-5'-PHOSPHOSULFATE, FLAVIN-ADENINE DINUCLEOTIDE, IRON/SULFUR CLUSTER, ... Authors: Schiffer, A, Fritz, G, Kroneck, P.M, Ermler, U. Deposit date: 2006-01-02 Release date: 2006-03-28 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2 Å) Cite: Reaction mechanism of the iron-sulfur flavoenzyme adenosine-5'-phosphosulfate reductase based on the structural characterization of different enzymatic states Biochemistry, 45, 2006

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