PDB: 664 resultsInfo pagesStatus searchChemie searchBIRD

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3VVP	Crystal structure of MATE in complex with Br-NRF Descriptor: 6-bromo-1-ethyl-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid, Putative uncharacterized protein Authors: Tanaka, Y, Ishitani, R, Nureki, O. Deposit date: 2012-07-27 Release date: 2013-04-03 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.91 Å) Cite: Structural basis for the drug extrusion mechanism by a MATE multidrug transporter. Nature, 496, 2013
3W4T	Crystal structure of MATE P26A mutant Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Putative uncharacterized protein Authors: Tanaka, Y, Ishitani, R, Nureki, O. Deposit date: 2013-01-16 Release date: 2013-04-03 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.096 Å) Cite: Structural basis for the drug extrusion mechanism by a MATE multidrug transporter. Nature, 496, 2013
3VVO	Crystal structure of MATE in the bent conformation Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Putative uncharacterized protein Authors: Tanaka, Y, Ishitani, R, Nureki, O. Deposit date: 2012-07-27 Release date: 2013-04-03 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.504 Å) Cite: Structural basis for the drug extrusion mechanism by a MATE multidrug transporter. Nature, 496, 2013
3VVN	Crystal structure of MATE in the straight conformation Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Putative uncharacterized protein Authors: Tanaka, Y, Ishitani, R, Nureki, O. Deposit date: 2012-07-27 Release date: 2013-04-03 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.398 Å) Cite: Structural basis for the drug extrusion mechanism by a MATE multidrug transporter. Nature, 496, 2013
3WBN	Crystal structure of MATE in complex with MaL6 Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, MaL6, Putative uncharacterized protein Authors: Tanaka, Y, Ishitani, R, Nureki, O. Deposit date: 2013-05-20 Release date: 2013-06-12 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.45 Å) Cite: Structural basis for the drug extrusion mechanism by a MATE multidrug transporter. Nature, 496, 2013
6IDR	Crystal structure of Vibrio cholerae MATE transporter VcmN in the bent form Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, MATE family efflux transporter Authors: Kusakizako, T, Claxton, D.P, Tanaka, Y, Maturana, A.D, Kuroda, T, Ishitani, R, Mchaourab, H.S, Nureki, O. Deposit date: 2018-09-11 Release date: 2019-01-16 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (2.502 Å) Cite: Structural Basis of H+-Dependent Conformational Change in a Bacterial MATE Transporter. Structure, 27, 2019
6IDS	Crystal structure of Vibrio cholerae MATE transporter VcmN D35N mutant Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, MATE family efflux transporter Authors: Kusakizako, T, Claxton, D.P, Tanaka, Y, Maturana, A.D, Kuroda, T, Ishitani, R, Mchaourab, H.S, Nureki, O. Deposit date: 2018-09-11 Release date: 2019-01-16 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (2.79 Å) Cite: Structural Basis of H+-Dependent Conformational Change in a Bacterial MATE Transporter. Structure, 27, 2019
6IDP	Crystal structure of Vibrio cholerae MATE transporter VcmN in the straight form Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, MATE family efflux transporter Authors: Kusakizako, T, Claxton, D.P, Tanaka, Y, Maturana, A.D, Kuroda, T, Ishitani, R, Mchaourab, H.S, Nureki, O. Deposit date: 2018-09-11 Release date: 2019-01-16 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (2.205 Å) Cite: Structural Basis of H+-Dependent Conformational Change in a Bacterial MATE Transporter. Structure, 27, 2019
7NEZ	Structure of topotecan-bound ABCG2 Descriptor: (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 5D3(Fab) heavy chain variable domain, ... Authors: Kowal, J, Locher, K, Ni, D, Stahlberg, H. Deposit date: 2021-02-05 Release date: 2021-04-21 Last modified: 2021-05-12 Method: ELECTRON MICROSCOPY (3.39 Å) Cite: Structural Basis of Drug Recognition by the Multidrug Transporter ABCG2. J.Mol.Biol., 433, 2021
7NFD	Structure of mitoxantrone-bound ABCG2 Descriptor: 1,4-DIHYDROXY-5,8-BIS({2-[(2-HYDROXYETHYL)AMINO]ETHYL}AMINO)-9,10-ANTHRACENEDIONE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5D3(Fab) heavy chain variable domain, ... Authors: Kowal, J, Locher, K, Ni, D, Stahlberg, H. Deposit date: 2021-02-06 Release date: 2021-04-21 Last modified: 2021-05-12 Method: ELECTRON MICROSCOPY (3.51 Å) Cite: Structural Basis of Drug Recognition by the Multidrug Transporter ABCG2. J.Mol.Biol., 433, 2021
7NEQ	Structure of tariquidar-bound ABCG2 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 5D3(Fab) heavy chain variable domain, 5D3(Fab) light chain variable domain, ... Authors: Kowal, J, Locher, K. Deposit date: 2021-02-04 Release date: 2021-04-21 Last modified: 2021-05-12 Method: ELECTRON MICROSCOPY (3.12 Å) Cite: Structural Basis of Drug Recognition by the Multidrug Transporter ABCG2. J.Mol.Biol., 433, 2021
6EUQ	MdfA(Q131R/L339E) Descriptor: (3ALPHA,5BETA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC ACID, ACETATE ION, HEXANE, ... Authors: Tam, H.K, Zomot, E, Bibi, E, Pos, K.M. Deposit date: 2017-10-31 Release date: 2018-08-08 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.2 Å) Cite: A New Critical Conformational Determinant of Multidrug Efflux by an MFS Transporter. J. Mol. Biol., 430, 2018
7SVX	Structure of EmrE-D3 mutant in complex with monobody L10 and harmane Descriptor: 1-methyl-9H-pyrido[3,4-b]indole, L10 monobody, Multidrug transporter EmrE Authors: Kermani, A.A, Stockbridge, R.B. Deposit date: 2021-11-19 Release date: 2022-03-02 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (3.9 Å) Cite: Crystal structures of bacterial small multidrug resistance transporter EmrE in complex with structurally diverse substrates. Elife, 11, 2022
7SV9	Structure of EmrE-D3 mutant in complex with monobody L10 and TPP Descriptor: L10 monobody, Multidrug transporter EmrE, TETRAPHENYLPHOSPHONIUM Authors: Kermani, A.A, Stockbridge, R.B. Deposit date: 2021-11-18 Release date: 2022-03-02 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (3.36 Å) Cite: Crystal structures of bacterial small multidrug resistance transporter EmrE in complex with structurally diverse substrates. Elife, 11, 2022
7T00	Structure of EmrE-D3 mutant in complex with monobody L10 and benzyltrimethylammonium Descriptor: L10 monobody, Multidrug transporter EmrE, benzyltrimethylammonium Authors: Kermani, A.A, Stockbridge, R.B. Deposit date: 2021-11-29 Release date: 2022-03-02 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (3.91 Å) Cite: Crystal structures of bacterial small multidrug resistance transporter EmrE in complex with structurally diverse substrates. Elife, 11, 2022
7SSU	Structure of EmrE-D3 mutant in complex with monobody L10 and methyltriphenylphosphonium Descriptor: L10 monobody, Multidrug transporter EmrE, methyltriphenylphosphonium Authors: Kermani, A.A, Stockbridge, R.B. Deposit date: 2021-11-11 Release date: 2022-03-02 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (3.22 Å) Cite: Crystal structures of bacterial small multidrug resistance transporter EmrE in complex with structurally diverse substrates. Elife, 11, 2022
7BG4	Multidrug resistance transporter BmrA mutant E504A bound with ATP, Mg, and Rhodamine 6G solved by Cryo-EM Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Multidrug resistance ABC transporter ATP-binding/permease protein BmrA, ... Authors: Wiseman, B, Chaptal, V, Zampieri, V, Magnard, S, Hogbom, M, Falson, P. Deposit date: 2021-01-05 Release date: 2022-01-12 Last modified: 2024-07-10 Method: ELECTRON MICROSCOPY (4.2 Å) Cite: Substrate-bound and substrate-free outward-facing structures of a multidrug ABC exporter. Sci Adv, 8, 2022
8JW4	Cryo-EM structure of Plasmodium falciparum multidrug resistance protein 1 in the apo state without H1 helix Descriptor: Multidrug resistance protein 1 Authors: Li, M, Si, K. Deposit date: 2023-06-28 Release date: 2023-08-30 Method: ELECTRON MICROSCOPY (3.13 Å) Cite: The structure of Plasmodium falciparum multidrug resistance protein 1 reveals an N-terminal regulatory domain. Proc.Natl.Acad.Sci.USA, 120, 2023
8JVH	Cryo-EM structure of Plasmodium falciparum multidrug resistance protein 1 in the apo state with H1 helix Descriptor: Multidrug resistance protein 1 Authors: Li, M, Si, K. Deposit date: 2023-06-28 Release date: 2023-08-30 Method: ELECTRON MICROSCOPY (3.19 Å) Cite: The structure of Plasmodium falciparum multidrug resistance protein 1 reveals an N-terminal regulatory domain. Proc.Natl.Acad.Sci.USA, 120, 2023
6ETI	Structure of inhibitor-bound ABCG2 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5D3(Fab) heavy chain variable domain, 5D3(Fab) light chain variable domain, ... Authors: Jackson, S.M, Manolaridis, I, Kowal, J, Zechner, M, Altmann, K.H, Locher, K.P. Deposit date: 2017-10-26 Release date: 2018-04-11 Last modified: 2020-07-29 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Structural basis of small-molecule inhibition of human multidrug transporter ABCG2. Nat. Struct. Mol. Biol., 25, 2018
6FEQ	Structure of inhibitor-bound ABCG2 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 5D3(Fab) heavy chain variable domain, 5D3(Fab) light chain variable domain, ... Authors: Jackson, S.M, Manolaridis, I, Kowal, J, Zechner, M, Altmann, K.H, Locher, K.P. Deposit date: 2018-01-03 Release date: 2018-04-11 Last modified: 2020-07-29 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Structural basis of small-molecule inhibition of human multidrug transporter ABCG2. Nat. Struct. Mol. Biol., 25, 2018
8TGY	Crystal structure of Gdx-Clo from Small Multidrug Resistance family of transporters in complex with guanylurea Descriptor: DECYL-BETA-D-MALTOPYRANOSIDE, L10 Monobody, LAURYL DIMETHYLAMINE-N-OXIDE, ... Authors: Lucero, R.M, Stockbridge, R.B. Deposit date: 2023-07-13 Release date: 2023-08-02 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.18 Å) Cite: Transport of metformin metabolites by guanidinium exporters of the Small Multidrug Resistance family. Biorxiv, 2023
7MH6	Structure of EmrE-D3 mutant in complex with monobody L10 in low pH (protonated state) Descriptor: Monobody L10, Multidrug transporter EmrE Authors: Kermani, A.A, Stockbridge, R.B. Deposit date: 2021-04-14 Release date: 2022-03-02 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.85 Å) Cite: Crystal structures of bacterial small multidrug resistance transporter EmrE in complex with structurally diverse substrates. Elife, 11, 2022
7MGX	Structure of EmrE-D3 mutant in complex with monobody L10 and methyl viologen Descriptor: 1,1'-dimethyl-4,4'-bipyridin-1-ium, L10 Monobody, Multidrug transporter EmrE Authors: Kermani, A.A, Stockbridge, R.B. Deposit date: 2021-04-13 Release date: 2022-03-02 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (3.13 Å) Cite: Crystal structures of bacterial small multidrug resistance transporter EmrE in complex with structurally diverse substrates. Elife, 11, 2022
1T9U	Structural Basis of Multidrug Transport by the AcrB Multidrug Efflux Pump Descriptor: 1-CYCLOPROPYL-6-FLUORO-4-OXO-7-PIPERAZIN-1-YL-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID, Acriflavine resistance protein B Authors: Yu, E.W, McDermott, G, Nikaido, H. Deposit date: 2004-05-18 Release date: 2005-10-04 Last modified: 2021-10-27 Method: X-RAY DIFFRACTION (3.11 Å) Cite: A Periplasmic Drug-Binding Site of the AcrB Multidrug Efflux Pump: a Crystallographic and Site-Directed Mutagenesis Study J.Bacteriol., 187, 2005

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