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1CNW	SECONDARY INTERACTIONS SIGNIFICANTLY REMOVED FROM THE SULFONAMIDE BINDING POCKET OF CARBONIC ANHYDRASE II INFLUENCE BINDING CONSTANTS Descriptor: AMINOMETHYLENECARBONYLAMINODI(ETHYLOXY)ETHYLAMINOCARBONYLBENZENESULFONAMIDE, CARBONIC ANHYDRASE II, MERCURY (II) ION, ... Authors: Boriack, P.A, Christianson, D.W. Deposit date: 1995-07-21 Release date: 1995-11-14 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2 Å) Cite: Secondary interactions significantly removed from the sulfonamide binding pocket of carbonic anhydrase II influence inhibitor binding constants. J.Med.Chem., 38, 1995
1CIM	THE POSITIONS OF HIS-64 AND A BOUND WATER IN HUMAN CARBONIC ANHYDRASE II UPON BINDING THREE STRUCTURALLY RELATED INHIBITORS Descriptor: (4S-TRANS)-4-(AMINO)-5,6-DIHYDRO-6-METHYL-4H-THIENO (2,3-B)THIOPYRAN-2-SULFONAMIDE-7,7-DIOXIDE, CARBONIC ANHYDRASE II, METHYL MERCURY ION, ... Authors: Smith, G.M, Alexander, R.S, Christianson, D.W, Mckeever, B.M, Ponticello, G.S, Springer, J.P, Randall, W.C, Baldwin, J.J, Habecker, C.N. Deposit date: 1993-10-20 Release date: 1994-01-31 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Positions of His-64 and a bound water in human carbonic anhydrase II upon binding three structurally related inhibitors. Protein Sci., 3, 1994
3MC2	Crystal Structure of the Murine Inhibitor of Carbonic Anhydrase Descriptor: Inhibitor of Carbonic Anhydrase Authors: Eckenroth, B.E, Mason, A.B, Everse, S.J. Deposit date: 2010-03-26 Release date: 2010-07-28 Last modified: 2021-10-06 Method: X-RAY DIFFRACTION (2.4 Å) Cite: The structure and evolution of the murine inhibitor of carbonic anhydrase: A member of the transferrin superfamily. Protein Sci., 19, 2010
5CJF	The crystal structure of the human carbonic anhydrase XIV in complex with a 1,1'-biphenyl-4-sulfonamide inhibitor. Descriptor: 4'-(4-aminobenzoyl)biphenyl-4-sulfonamide, Carbonic anhydrase 14, GLYCEROL, ... Authors: Alterio, V, De Simone, G. Deposit date: 2015-07-14 Release date: 2015-11-04 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.83 Å) Cite: Discovery of 1,1'-Biphenyl-4-sulfonamides as a New Class of Potent and Selective Carbonic Anhydrase XIV Inhibitors. J.Med.Chem., 58, 2015
1CAZ	WILD-TYPE AND E106Q MUTANT CARBONIC ANHYDRASE COMPLEXED WITH ACETATE Descriptor: ACETIC ACID, CARBONIC ANHYDRASE II, ZINC ION Authors: Hakansson, K, Briand, C, Zaitsev, V, Xue, Y, Liljas, A. Deposit date: 1993-02-26 Release date: 1993-10-31 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Wild-type and E106Q mutant carbonic anhydrase complexed with acetate. Acta Crystallogr.,Sect.D, 50, 1994
4WAJ	H. influenzae beta-carbonic anhydase variant P48S/A49P Descriptor: Carbonic anhydrase 2, SULFATE ION, ZINC ION Authors: Rowlett, R.S, Hoffmann, K.M. Deposit date: 2014-08-29 Release date: 2014-12-31 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Allosteric Reversion of Haemophilus influenzae beta-Carbonic Anhydrase via a Proline Shift. Biochemistry, 54, 2015
4UOV	The structure of a tetrameric alpha-carbonic anhydrase from Thermovibrio ammonificans reveals a core formed around intermolecular disulfides, which contribute to its thermostability. Descriptor: 1-METHOXY-2-[2-(2-METHOXY-ETHOXY]-ETHANE, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3,6,9,12,15,18,21,24,27,30,33,36,39-TRIDECAOXAHENTETRACONTANE-1,41-DIOL, ... Authors: James, P, Isupov, M, Sayer, C, Berg, S, Lioliou, M, Kotlar, H, Littlechild, J. Deposit date: 2014-06-10 Release date: 2014-10-15 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.85 Å) Cite: The Structure of a Tetrameric [Alpha]-Carbonic Anhydrase from Thermovibrio Ammonificans Reveals a Core Formed Around Intermolecular Disulfides that Contribute to its Thermostability Acta Crystallogr.,Sect.D, 70, 2014
8SAG	Carbonic anhydrase II in complex with the coumarin benzene sulfonamide SG1-57 Descriptor: 2-[(2-oxo-2H-1-benzopyran-7-yl)oxy]-N-[(4-sulfamoylphenyl)methyl]acetamide, Carbonic anhydrase 2, GLYCEROL, ... Authors: Combs, J.E, Mckenna, R. Deposit date: 2023-03-31 Release date: 2024-04-03 Method: X-RAY DIFFRACTION (1.52 Å) Cite: Carbonic anhydrase II in complex with novel coumarin benzene sulfonamides To Be Published
6OTK	Carbonic Anhydrase IX mimic complexed with ureido benzene sulfonamide MB10-596B Descriptor: 4-hydroxy-3-{[(4-hydroxybutyl)carbamoyl]amino}benzene-1-sulfonamide, Carbonic anhydrase 2, GLYCEROL, ... Authors: Kota, A, McKenna, R. Deposit date: 2019-05-03 Release date: 2020-05-06 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.123 Å) Cite: Carbonic Anhydrase IX mimic complexed with ureido benzene sulfonamide MB9-561B To Be Published
6OTQ	Carbonic Anhydrase II complexed with ureic benzene sulfonamide MB10-596B Descriptor: 4-hydroxy-3-{[(4-hydroxybutyl)carbamoyl]amino}benzene-1-sulfonamide, Carbonic anhydrase 2, DIMETHYL SULFOXIDE, ... Authors: Kota, A, McKenna, R. Deposit date: 2019-05-03 Release date: 2020-05-06 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.467 Å) Cite: Carbonic Anhydrase II complexed with benzene sulfonamide MB9-561B To Be Published
6OUF	Carbonic Anhydrase IX mimic complexed with benzene sulfonamide MB11-707A Descriptor: 4-{[(4-hydroxybutyl)carbamoyl]amino}benzene-1-sulfonamide, Carbonic anhydrase 2, GLYCEROL, ... Authors: Kota, A, McKenna, R. Deposit date: 2019-05-04 Release date: 2020-05-06 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.358 Å) Cite: Carbonic Anhydrase IX mimic complexed with ureido benzene sulfonamide MB9-561B To Be Published
8OLK	Carbonic Anhydrase 2 in Complex with Steriod_Sulphamoyl AKI_13 Descriptor: 1,2-ETHANEDIOL, Carbonic anhydrase 2, ZINC ION, ... Authors: Brynda, J, Rezacova, P.M, Kudova, E. Deposit date: 2023-03-30 Release date: 2024-04-10 Method: X-RAY DIFFRACTION (1.27 Å) Cite: Carbonic Anhydrase in Complex with Steriod_Sulphamoyl To Be Published
6OTO	Carbonic Anhydrase II complexed with ureic benzene sulfonamide MB9-561B Descriptor: 4-hydroxy-3-({[(pyridin-4-yl)methyl]carbamoyl}amino)benzene-1-sulfonamide, Carbonic anhydrase 2, DIMETHYL SULFOXIDE, ... Authors: Kota, A, McKenna, R. Deposit date: 2019-05-03 Release date: 2020-05-06 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.496 Å) Cite: Carbonic Anhydrase II complexed with ureido benzene sulfonamide MB9-561B To Be Published
6OUB	Carbonic Anhydrase II complexed with benzene sulfonamide MB11-694B Descriptor: 4-{[(2-hydroxyethyl)carbamoyl]amino}benzene-1-sulfonamide, Carbonic anhydrase 2, GLYCEROL, ... Authors: Kota, A, McKenna, R. Deposit date: 2019-05-04 Release date: 2020-05-06 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.418 Å) Cite: Carbonic Anhydrase II complexed with ureido benzene sulfonamide MB11-694B To Be Published
6OUE	Carbonic Anhydrase II complexed with benzene sulfonamide MB11-707A Descriptor: 4-{[(4-hydroxybutyl)carbamoyl]amino}benzene-1-sulfonamide, Carbonic anhydrase 2, GLYCEROL, ... Authors: Kota, A, McKenna, R. Deposit date: 2019-05-04 Release date: 2020-05-06 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.415 Å) Cite: Carbonic Anhydrase II complexed with ureido benzene sulfonamide MB11-707A To Be Published
6OUM	Carbonic Anhydrase IX mimic complexed with benzene sulfonamide MB10-580B Descriptor: (2Z)-2-(hydroxyimino)-2,3-dihydro-1,3-benzoxazole-5-sulfonamide, Carbonic anhydrase 2, GLYCEROL, ... Authors: Kota, A, McKenna, R. Deposit date: 2019-05-04 Release date: 2020-05-06 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.559 Å) Cite: Carbonic Anhydrase IX mimic complexed with ureido benzene sulfonamide MB10-580B To Be Published
6OTI	Carbonic Anhydrase IX mimic complexed with ureic benzene sulfonamide MB9-561B Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 4-hydroxy-3-({[(pyridin-4-yl)methyl]carbamoyl}amino)benzene-1-sulfonamide, Carbonic anhydrase 2, ... Authors: Kota, A, McKenna, R. Deposit date: 2019-05-03 Release date: 2020-05-06 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2 Å) Cite: Carbonic Anhydrase IX mimic complexed with ureido benzene sulfonamide MB9-561B To Be Published
6OTM	Carbonic Anhydrase IX mimic complexed with ureic benzene sulfonamide MB10-586B Descriptor: 4-hydroxy-3-({[2-(pyridin-2-yl)ethyl]carbamoyl}amino)benzene-1-sulfonamide, Carbonic anhydrase 2, GLYCEROL, ... Authors: Kota, A, McKenna, R. Deposit date: 2019-05-03 Release date: 2020-05-06 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.307 Å) Cite: Carbonic Anhydrase IX mimic complexed with ureido benzene sulfonamide MB9-561B To Be Published
6OTP	Carbonic Anhydrase II complexed with ureic benzene sulfonamide MB10-586B Descriptor: 4-hydroxy-3-({[2-(pyridin-2-yl)ethyl]carbamoyl}amino)benzene-1-sulfonamide, Carbonic anhydrase 2, ZINC ION Authors: Kota, A, McKenna, R. Deposit date: 2019-05-03 Release date: 2020-05-06 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.466 Å) Cite: Carbonic Anhydrase IX mimic complexed with ureido benzene sulfonamide MB9-561B To Be Published
6OUI	Carbonic Anhydrase IX mimic complexed with benzene sulfonamide MB11-710A Descriptor: 3-{[(4-hydroxybutyl)carbamoyl]amino}benzene-1-sulfonamide, Carbonic anhydrase 2, DIMETHYL SULFOXIDE, ... Authors: Kota, A, McKenna, R. Deposit date: 2019-05-04 Release date: 2020-05-06 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.528 Å) Cite: Carbonic Anhydrase IX mimic complexed with ureido benzene sulfonamide MB11-710A To Be Published
5JN3	Carbonic Anhydrase IX-mimic IN Complex WITH U-F Descriptor: 4-{[(4-fluorophenyl)carbamoyl]amino}benzenesulfonamide, Carbonic anhydrase 2, DIMETHYL SULFOXIDE, ... Authors: McKenna, R, Mboge, M.Y, Mahon, B.P. Deposit date: 2016-04-29 Release date: 2017-05-03 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Carbonic Anhydrase IX-mimic IN Complex WITH U-F To Be Published
5JN7	Carbonic Anhydrase II In Complex WITH U-CH3 Descriptor: 4-{[(3,5-dimethylphenyl)carbamoyl]amino}benzene-1-sulfonamide, Carbonic anhydrase 2, DIMETHYL SULFOXIDE, ... Authors: McKenna, R, Mboge, M.Y, Mahon, B.P. Deposit date: 2016-04-29 Release date: 2017-05-03 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.517 Å) Cite: Carbonic Anhydrase II In Complex WITH U-CH3 To Be Published
5JMZ	Carbonic Anhydrase IX-mimic IN Complex WITH U-NO2 Descriptor: 4-{[(3-nitrophenyl)carbamoyl]amino}benzenesulfonamide, Carbonic anhydrase 2, DIMETHYL SULFOXIDE, ... Authors: McKenna, R, Mboge, M.Y, Mahon, B.P. Deposit date: 2016-04-29 Release date: 2017-05-03 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Carbonic Anhydrase IX-mimic IN Complex WITH U-NO2 To Be Published
2QO8	Crystal structure of the complex of hcaii with an indane-sulfonamide inhibitor Descriptor: Carbonic anhydrase 2, GLYCEROL, MERCURIBENZOIC ACID, ... Authors: D'Ambrosio, K, De Simone, G. Deposit date: 2007-07-20 Release date: 2008-01-22 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Carbonic Anhydrase Inhibitors: Binding of Indanesulfonamides to the Human Isoform II. Chemmedchem, 3, 2007
6OUH	Carbonic Anhydrase II mimic complexed with benzene sulfonamide MB11-710A Descriptor: 3-{[(4-hydroxybutyl)carbamoyl]amino}benzene-1-sulfonamide, Carbonic anhydrase 2, GLYCEROL, ... Authors: Kota, A, McKenna, R. Deposit date: 2019-05-04 Release date: 2020-05-06 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.449 Å) Cite: Carbonic Anhydrase II mimic complexed with benzene sulfonamide MB11-710A To Be Published

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