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1L01	STRUCTURAL STUDIES OF MUTANTS OF THE LYSOZYME OF BACTERIOPHAGE T4. THE TEMPERATURE-SENSITIVE MUTANT PROTEIN THR157 (RIGHT ARROW) ILE Descriptor: T4 LYSOZYME Authors: Dao-Pin, S, Alber, T, Matthews, B.W. Deposit date: 1988-02-05 Release date: 1988-04-16 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Structural studies of mutants of the lysozyme of bacteriophage T4. The temperature-sensitive mutant protein Thr157----Ile. J.Mol.Biol., 197, 1987
1L07	CONTRIBUTIONS OF HYDROGEN BONDS OF THR 157 TO THE THERMODYNAMIC STABILITY OF PHAGE T4 LYSOZYME Descriptor: T4 LYSOZYME Authors: Dao-Pin, S, Faber, R, Alber, T, Matthews, B.W. Deposit date: 1988-02-05 Release date: 1988-04-16 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Contributions of hydrogen bonds of Thr 157 to the thermodynamic stability of phage T4 lysozyme. Nature, 330, 1987
1L08	CONTRIBUTIONS OF HYDROGEN BONDS OF THR 157 TO THE THERMODYNAMIC STABILITY OF PHAGE T4 LYSOZYME Descriptor: T4 LYSOZYME Authors: Dao-Pin, S, Alber, T, Matthews, B.W. Deposit date: 1988-02-05 Release date: 1988-04-16 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Contributions of hydrogen bonds of Thr 157 to the thermodynamic stability of phage T4 lysozyme. Nature, 330, 1987
1L19	ENHANCED PROTEIN THERMOSTABILITY FROM DESIGNED MUTATIONS THAT INTERACT WITH ALPHA-HELIX DIPOLES Descriptor: T4 LYSOZYME Authors: Nicholson, H, Matthews, B.W. Deposit date: 1989-05-01 Release date: 1990-01-15 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Enhanced protein thermostability from designed mutations that interact with alpha-helix dipoles. Nature, 336, 1988
1L22	CONTRIBUTIONS OF LEFT-HANDED HELICAL RESIDUES TO THE STRUCTURE AND STABILITY OF BACTERIOPHAGE T4 LYSOZYME Descriptor: T4 LYSOZYME Authors: Nicholson, H, Matthews, B.W. Deposit date: 1989-05-01 Release date: 1990-01-15 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Contributions of left-handed helical residues to the structure and stability of bacteriophage T4 lysozyme. J.Mol.Biol., 210, 1989
1LGX	T4 Lysozyme Mutant L99A/M102Q Bound by 3,5-difluoroaniline Descriptor: 3,5-DIFLUOROANILINE, BETA-MERCAPTOETHANOL, CHLORIDE ION, ... Authors: Wei, B.Q, Baase, W.A, Weaver, L.H, Matthews, B.W, Shoichet, B.K. Deposit date: 2002-04-16 Release date: 2002-05-08 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (1.9 Å) Cite: A Model Binding Site for Testing Scoring Functions in Molecular Docking J.Mol.Biol., 322, 2002
1L04	CONTRIBUTIONS OF HYDROGEN BONDS OF THR 157 TO THE THERMODYNAMIC STABILITY OF PHAGE T4 LYSOZYME Descriptor: T4 LYSOZYME Authors: Dao-Pin, S, Alber, T, Matthews, B.W. Deposit date: 1988-02-05 Release date: 1988-04-16 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Contributions of hydrogen bonds of Thr 157 to the thermodynamic stability of phage T4 lysozyme. Nature, 330, 1987
1L20	ENHANCED PROTEIN THERMOSTABILITY FROM DESIGNED MUTATIONS THAT INTERACT WITH ALPHA-HELIX DIPOLES Descriptor: T4 LYSOZYME Authors: Nicholson, H, Matthews, B.W. Deposit date: 1989-05-01 Release date: 1990-01-15 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Enhanced protein thermostability from designed mutations that interact with alpha-helix dipoles. Nature, 336, 1988
1L46	CUMULATIVE SITE-DIRECTED CHARGE-CHANGE REPLACEMENTS IN BACTERIOPHAGE T4 LYSOZYME SUGGEST THAT LONG-RANGE ELECTROSTATIC INTERACTIONS CONTRIBUTE LITTLE TO PROTEIN STABILITY Descriptor: T4 LYSOZYME Authors: Daopin, S, Matthews, B.W. Deposit date: 1991-01-28 Release date: 1991-10-15 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Cumulative site-directed charge-change replacements in bacteriophage T4 lysozyme suggest that long-range electrostatic interactions contribute little to protein stability. J.Mol.Biol., 221, 1991
1L65	TOLERANCE OF T4 LYSOZYME TO MULTIPLE XAA (RIGHT ARROW) ALA SUBSTITUTIONS: A POLYALANINE ALPHA-HELIX CONTAINING TEN CONSECUTIVE ALANINES Descriptor: BETA-MERCAPTOETHANOL, CHLORIDE ION, LYSOZYME Authors: Heinz, D, Matthews, B.W. Deposit date: 1991-09-23 Release date: 1991-10-15 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Folding and function of a T4 lysozyme containing 10 consecutive alanines illustrate the redundancy of information in an amino acid sequence. Proc.Natl.Acad.Sci.USA, 89, 1992
1L72	MULTIPLE STABILIZING ALANINE REPLACEMENTS WITHIN ALPHA-HELIX 126-134 OF T4 LYSOZYME HAVE INDEPENDENT, ADDITIVE EFFECTS ON BOTH STRUCTURE AND STABILITY Descriptor: BETA-MERCAPTOETHANOL, CHLORIDE ION, LYSOZYME Authors: Zhang, X, Matthews, B.W. Deposit date: 1991-09-23 Release date: 1991-10-15 Last modified: 2017-11-29 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Multiple alanine replacements within alpha-helix 126-134 of T4 lysozyme have independent, additive effects on both structure and stability. Protein Sci., 1, 1992
1L11	CONTRIBUTIONS OF HYDROGEN BONDS OF THR 157 TO THE THERMODYNAMIC STABILITY OF PHAGE T4 LYSOZYME Descriptor: BETA-MERCAPTOETHANOL, T4 LYSOZYME Authors: Dao-Pin, S, Wilson, K, Alber, T, Matthews, B.W. Deposit date: 1988-02-05 Release date: 1988-04-16 Last modified: 2022-11-23 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Contributions of hydrogen bonds of Thr 157 to the thermodynamic stability of phage T4 lysozyme. Nature, 330, 1987
1L86	SIMILAR HYDROPHOBIC REPLACEMENTS OF LEU 99 AND PHE 153 WITHIN THE CORE OF T4 LYSOZYME HAVE DIFFERENT STRUCTURAL AND THERMODYNAMIC CONSEQUENCES Descriptor: BETA-MERCAPTOETHANOL, CHLORIDE ION, T4 LYSOZYME Authors: Eriksson, A.E, Matthews, B.W. Deposit date: 1992-01-21 Release date: 1993-10-31 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Similar hydrophobic replacements of Leu99 and Phe153 within the core of T4 lysozyme have different structural and thermodynamic consequences. J.Mol.Biol., 229, 1993
1L14	CONTRIBUTIONS OF HYDROGEN BONDS OF THR 157 TO THE THERMODYNAMIC STABILITY OF PHAGE T4 LYSOZYME Descriptor: T4 LYSOZYME Authors: Dao-Pin, S, Alber, T, Matthews, B.W. Deposit date: 1988-02-05 Release date: 1988-04-16 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Contributions of hydrogen bonds of Thr 157 to the thermodynamic stability of phage T4 lysozyme. Nature, 330, 1987
1L90	SIMILAR HYDROPHOBIC REPLACEMENTS OF LEU 99 AND PHE 153 WITHIN THE CORE OF T4 LYSOZYME HAVE DIFFERENT STRUCTURAL AND THERMODYNAMIC CONSEQUENCES Descriptor: BETA-MERCAPTOETHANOL, CHLORIDE ION, T4 LYSOZYME Authors: Eriksson, A.E, Matthews, B.W. Deposit date: 1992-01-21 Release date: 1993-10-31 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Similar hydrophobic replacements of Leu99 and Phe153 within the core of T4 lysozyme have different structural and thermodynamic consequences. J.Mol.Biol., 229, 1993
1L95	SIMILAR HYDROPHOBIC REPLACEMENTS OF LEU 99 AND PHE 153 WITHIN THE CORE OF T4 LYSOZYME HAVE DIFFERENT STRUCTURAL AND THERMODYNAMIC CONSEQUENCES Descriptor: BETA-MERCAPTOETHANOL, CHLORIDE ION, T4 LYSOZYME Authors: Eriksson, A.E, Matthews, B.W. Deposit date: 1992-01-21 Release date: 1993-10-31 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2 Å) Cite: Similar hydrophobic replacements of Leu99 and Phe153 within the core of T4 lysozyme have different structural and thermodynamic consequences. J.Mol.Biol., 229, 1993
1L57	ANALYSIS OF THE INTERACTION BETWEEN CHARGED SIDE CHAINS AND THE ALPHA-HELIX DIPOLE USING DESIGNED THERMOSTABLE MUTANTS OF PHAGE T4 LYSOZYME Descriptor: BETA-MERCAPTOETHANOL, CHLORIDE ION, LYSOZYME Authors: Nicholson, H, Matthews, B.W. Deposit date: 1991-05-06 Release date: 1991-10-15 Last modified: 2017-11-29 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Analysis of the interaction between charged side chains and the alpha-helix dipole using designed thermostable mutants of phage T4 lysozyme. Biochemistry, 30, 1991
1L81	DESIGN AND STRUCTURAL ANALYSIS OF ALTERNATIVE HYDROPHOBIC CORE PACKING ARRANGEMENTS IN BACTERIOPHAGE T4 LYSOZYME Descriptor: BETA-MERCAPTOETHANOL, CHLORIDE ION, T4 LYSOZYME Authors: Hurley, J.H, Matthews, B.W. Deposit date: 1991-11-12 Release date: 1993-04-15 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2 Å) Cite: Design and structural analysis of alternative hydrophobic core packing arrangements in bacteriophage T4 lysozyme. J.Mol.Biol., 224, 1992
1L88	SIMILAR HYDROPHOBIC REPLACEMENTS OF LEU 99 AND PHE 153 WITHIN THE CORE OF T4 LYSOZYME HAVE DIFFERENT STRUCTURAL AND THERMODYNAMIC CONSEQUENCES Descriptor: BETA-MERCAPTOETHANOL, CHLORIDE ION, T4 LYSOZYME Authors: Eriksson, A.E, Matthews, B.W. Deposit date: 1992-01-21 Release date: 1993-10-31 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Similar hydrophobic replacements of Leu99 and Phe153 within the core of T4 lysozyme have different structural and thermodynamic consequences. J.Mol.Biol., 229, 1993
1L42	CUMULATIVE SITE-DIRECTED CHARGE-CHANGE REPLACEMENTS IN BACTERIOPHAGE T4 LYSOZYME SUGGEST THAT LONG-RANGE ELECTROSTATIC INTERACTIONS CONTRIBUTE LITTLE TO PROTEIN STABILITY Descriptor: T4 LYSOZYME Authors: Daopin, S, Matthews, B.W. Deposit date: 1991-01-28 Release date: 1991-10-15 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Cumulative site-directed charge-change replacements in bacteriophage T4 lysozyme suggest that long-range electrostatic interactions contribute little to protein stability. J.Mol.Biol., 221, 1991
1LYI	DISSECTION OF HELIX CAPPING IN T4 LYSOZYME BY STRUCTURAL AND THERMODYNAMIC ANALYSIS OF SIX AMINO ACID SUBSTITUTIONS AT THR 59 Descriptor: BETA-MERCAPTOETHANOL, CHLORIDE ION, T4 LYSOZYME Authors: Bell, J.A, Becktel, W.J, Sauer, U, Baase, W.A, Matthews, B.W. Deposit date: 1992-08-10 Release date: 1993-10-31 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2 Å) Cite: Dissection of helix capping in T4 lysozyme by structural and thermodynamic analysis of six amino acid substitutions at Thr 59. Biochemistry, 31, 1992
1LWG	Multiple Methionine Substitutions are Tolerated in T4 Lysozyme and have Coupled Effects on Folding and Stability Descriptor: 2-HYDROXYETHYL DISULFIDE, CHLORIDE ION, Lysozyme, ... Authors: Gassner, N.C, Baase, W.A, Mooers, B.H.M, Busam, R.D, Weaver, L.H, Lindstrom, J.D, Quillin, M.L, Matthews, B.M. Deposit date: 2002-05-31 Release date: 2003-05-20 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Multiple methionine substitutions are tolerated in T4 lysozyme and have coupled effects on folding and stability. Biophys.Chem., 100, 2003
1LW9	Multiple methionine substitutions are tolerated in T4 lysozyme and have coupled effects on folding and stability Descriptor: 2-HYDROXYETHYL DISULFIDE, CHLORIDE ION, LYSOZYME, ... Authors: Gassner, N.C, Baase, W.A, Mooers, B.H.M, Busam, R.D, Weaver, L.H, Lindstrom, J.D, Quillin, M.L, Matthews, B.W. Deposit date: 2002-05-30 Release date: 2003-05-20 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Multiple methionine substitutions are tolerated in T4 lysozyme and have coupled effects on folding and stability. Biophys.Chem., 100, 2003
1P5C	Circular permutation of Helix A in T4 lysozyme Descriptor: Lysozyme Authors: Sagermann, M, Gay, L, Baase, W.A, Matthews, B.W. Deposit date: 2003-04-25 Release date: 2004-05-04 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Relocation or duplication of the helix A sequence of T4 lysozyme causes only modest changes in structure but can increase or decrease the rate of folding. Biochemistry, 43, 2004
1P6Y	T4 LYSOZYME CORE REPACKING MUTANT M120Y/TA Descriptor: 2-HYDROXYETHYL DISULFIDE, CHLORIDE ION, LYSOZYME, ... Authors: Mooers, B.H, Datta, D, Baase, W.A, Zollars, E.S, Mayo, S.L, Matthews, B.W. Deposit date: 2003-04-30 Release date: 2003-10-07 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (1.54 Å) Cite: Repacking the Core of T4 Lysozyme by Automated Design J.Mol.Biol., 332, 2003

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