PDB: 13252 resultsInfo pagesStatus searchChemie searchBIRD

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5I62	Crystal structure of the insertion loop deletion mutant of the RNA-dependent RNA polymerase of a human picorbirnavirus Descriptor: Potential RNA-dependent RNA polymerase Authors: Collier, A.M, Guo, Y.R, Tao, Y.J. Deposit date: 2016-02-15 Release date: 2016-03-16 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.001 Å) Cite: Initiation of RNA Polymerization and Polymerase Encapsidation by a Small dsRNA Virus. Plos Pathog., 12, 2016
6ZFB	Structure of the B. subtilis RNA POLYMERASE in complex with HelD (dimer) Descriptor: DNA helicase, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Pei, H.-P, Hilal, T, Huang, Y.-H, Said, N, Loll, B, Wahl, M.C. Deposit date: 2020-06-17 Release date: 2020-10-14 Last modified: 2024-05-15 Method: ELECTRON MICROSCOPY (3.9 Å) Cite: The delta subunit and NTPase HelD institute a two-pronged mechanism for RNA polymerase recycling. Nat Commun, 11, 2020
5HFZ	Mmi1 YTH domain Descriptor: YTH domain-containing protein mmi1 Authors: Chatterjee, D, Goldgur, Y, Shuman, S. Deposit date: 2016-01-07 Release date: 2016-02-10 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.96 Å) Cite: Transcription of lncRNA prt, clustered prt RNA sites for Mmi1 binding, and RNA polymerase II CTD phospho-sites govern the repression of pho1 gene expression under phosphate-replete conditions in fission yeast. Rna, 22, 2016
5H8A	Mmi1 YTH domain Descriptor: YTH domain-containing protein mmi1 Authors: Chatterjee, D, Goldgur, Y, Shuman, S. Deposit date: 2015-12-23 Release date: 2016-01-13 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.751 Å) Cite: Transcription of lncRNA prt, clustered prt RNA sites for Mmi1 binding, and RNA polymerase II CTD phospho-sites govern the repression of pho1 gene expression under phosphate-replete conditions in fission yeast. Rna, 22, 2016
2HCN	Crystal structure of RNA dependent RNA polymerase domain from west nile virus Descriptor: CALCIUM ION, RNA-directed RNA polymerase (NS5), ZINC ION Authors: Egloff, M.P, Malet, H, Marseilles Structural Genomics Program @ AFMB (MSGP) Deposit date: 2006-06-17 Release date: 2007-02-06 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Crystal structure of the RNA polymerase domain of the West Nile virus non-structural protein 5 J.Biol.Chem., 282, 2007
2PPB	Crystal structure of the T. thermophilus RNAP polymerase elongation complex with the ntp substrate analog and antibiotic streptolydigin Descriptor: DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, DNA (5'-D(*AP*AP*CP*GP*CP*CP*AP*GP*AP*CP*AP*GP*GP*G)-3'), DNA (5'-D(P*CP*CP*CP*TP*GP*TP*CP*TP*GP*GP*CP*GP*TP*TP*CP*GP*CP*GP*CP*GP*CP*CP*G)-3'), ... Authors: Vassylyev, D.G, Vassylyeva, M.N, Artsimovitch, I, Landick, R. Deposit date: 2007-04-28 Release date: 2007-07-17 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (3 Å) Cite: Structural basis for substrate loading in bacterial RNA polymerase. Nature, 448, 2007
5HMX	Dengue serotype 3 RNA-dependent RNA polymerase bound to compound 10 Descriptor: 2,2'-(5-(thiophen-2-yl)-1,3-phenylene)diacetic acid, RNA-directed RNA polymerase NS5, ZINC ION Authors: Noble, C.G. Deposit date: 2016-01-17 Release date: 2016-03-30 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design J.Med.Chem., 59, 2016
5HMZ	Dengue serotype 3 RNA-dependent RNA polymerase bound to compound 23 Descriptor: 5-(5-(3-hydroxyprop-1-yn-1-yl)thiophen-2-yl)-4-methoxy-2-methyl-N-(methylsulfonyl)benzamide, RNA-directed RNA polymerase NS5, ZINC ION Authors: Noble, C.G. Deposit date: 2016-01-17 Release date: 2016-03-30 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.99 Å) Cite: Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design J.Med.Chem., 59, 2016
5HMY	Dengue serotype 3 RNA-dependent RNA polymerase bound to compound 15 Descriptor: 2,2'-(5-(5-(3-hydroxyprop-1-yn-1-yl)thiophen-2-yl)-1,3-phenylene)diacetic acid, RNA-directed RNA polymerase NS5, ZINC ION Authors: Noble, C.G. Deposit date: 2016-01-17 Release date: 2016-03-30 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design. J.Med.Chem., 59, 2016
5HMW	Dengue serotype 3 RNA-dependent RNA polymerase bound to compound 5 Descriptor: 2,2'-biphenyl-3,5-diyldiacetic acid, RNA-directed RNA polymerase NS5, ZINC ION Authors: Noble, C.G. Deposit date: 2016-01-17 Release date: 2016-03-30 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design J.Med.Chem., 59, 2016
1WNE	Foot and Mouth Disease Virus RNA-dependent RNA polymerase in complex with a template-primer RNA Descriptor: 5'-R(*CP*AP*UP*GP*GP*GP*CP*C)-3', 5'-R(*GP*GP*CP*CP*C)-3', MAGNESIUM ION, ... Authors: Ferrer-Orta, C, Arias, A, Perez-Luque, R, Escarmis, C, Domingo, E, Verdaguer, N. Deposit date: 2004-07-31 Release date: 2004-08-31 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (3 Å) Cite: Structure of Foot-and-Mouth Disease Virus RNA-dependent RNA Polymerase and Its Complex with a Template-Primer RNA J.Biol.Chem., 279, 2004
5HN0	Dengue serotype 3 RNA-dependent RNA polymerase bound to compound 4 Descriptor: (6-hydroxybiphenyl-3-yl)acetic acid, RNA-directed RNA polymerase NS5, ZINC ION Authors: Noble, C.G. Deposit date: 2016-01-17 Release date: 2016-03-30 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design. J.Med.Chem., 59, 2016
7ASV	Crystal structure of tWHD2 of Rpc5 subunit of human RNA Polymerase III Descriptor: ACETATE ION, DNA-directed RNA polymerase III subunit RPC5 Authors: Vannini, A, Abascal-Palacios, G, Ramsay, E.P. Deposit date: 2020-10-28 Release date: 2020-12-30 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Structure of human RNA polymerase III. Nat Commun, 11, 2020
7ASU	Crystal structure of tWHD1 of Rpc5 subunit of human RNA Polymerase III Descriptor: DNA-directed RNA polymerase III subunit RPC5, ZINC ION Authors: Vannini, A, Abascal-Palacios, G, Ramsay, E.P. Deposit date: 2020-10-28 Release date: 2020-12-30 Method: X-RAY DIFFRACTION (2.23 Å) Cite: Structure of human RNA polymerase III. Nat Commun, 11, 2020
3DXJ	Crystal structure of thermus thermophilus rna polymerase holoenzyme in complex with the antibiotic myxopyronin Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, BACTERIAL RNA POLYMERASE BETA SUBUNIT; CHAIN C, M, ... Authors: Das, K, Arnold, E. Deposit date: 2008-07-24 Release date: 2008-10-14 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (3 Å) Cite: The RNA polymerase "switch region" is a target for inhibitors. Cell(Cambridge,Mass.), 135, 2008
2HFZ	Crystal structure of RNA dependent RNA polymerase domain from West Nile virus Descriptor: MAGNESIUM ION, RNA-directed RNA polymerase(NS5), ZINC ION Authors: Egloff, M.P, Malet, H, Marseilles Structural Genomics Program @ AFMB (MSGP) Deposit date: 2006-06-26 Release date: 2007-02-06 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (3 Å) Cite: Crystal structure of the RNA polymerase domain of the West Nile virus non-structural protein 5 J.Biol.Chem., 282, 2007
1MSW	Structural basis for the transition from initiation to elongation transcription in T7 RNA polymerase Descriptor: DNA-directed RNA polymerase, Non-Template DNA, RNA message, ... Authors: Yin, Y.W, Steitz, T.A. Deposit date: 2002-09-19 Release date: 2002-11-15 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structural Basis for the Transition from Initiation to Elongation Transcription in T7 RNA Polymerase Science, 298, 2002
2JLF	STRUCTURAL EXPLANATION FOR THE ROLE OF MN IN THE ACTIVITY OF PHI6 RNA- DEPENDENT RNA POLYMERASE Descriptor: MANGANESE (II) ION, RNA-DIRECTED RNA POLYMERASE Authors: Poranen, M.M, Salgado, P.S, Koivunen, M.R.L, Wright, S, Bamford, D.H, Stuart, D.I, Grimes, J.M. Deposit date: 2008-09-08 Release date: 2008-11-04 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Structural Explanation for the Role of Mn2+ in the Activity of {Phi}6 RNA-Dependent RNA Polymerase. Nucleic Acids Res., 36, 2008
2JLG	STRUCTURAL EXPLANATION FOR THE ROLE OF MN IN THE ACTIVITY OF PHI6 RNA-DEPENDENT RNA POLYMERASE Descriptor: 5'-D(*DT DT DT DC DCP)-3', GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, ... Authors: Poranen, M.M, Salgado, P.S, Koivunen, M.R.L, Wright, S, Bamford, D.H, Stuart, D.I, Grimes, J.M. Deposit date: 2008-09-09 Release date: 2008-11-04 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structural Explanation for the Role of Mn2+ in the Activity of {Phi}6 RNA-Dependent RNA Polymerase. Nucleic Acids Res., 36, 2008
1S49	Crystal Structure of RNA-dependent RNA polymerase construct 1 (residues 71-679) from bovine viral diarrhea virus complexed with GTP Descriptor: GUANOSINE-5'-TRIPHOSPHATE, RNA-dependent RNA polymerase Authors: Choi, K.H, Groarke, J.M, Young, D.C, Kuhn, R.J, Smith, J.L, Pevear, D.C, Rossmann, M.G. Deposit date: 2004-01-15 Release date: 2004-04-06 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (3 Å) Cite: The structure of the RNA-dependent RNA polymerase from bovine viral diarrhea virus establishes the role of GTP in de novo initiation. Proc.Natl.Acad.Sci.Usa, 101, 2004
2PUS	Unprecedented activation mechanism of a non-canonical RNA-dependent RNA polymerase Descriptor: IBDV VP1 RNA-dependant RNA polymerase Authors: Garriga, D, Navarro, A, Querol-Audi, J, Abaitua, F, Rodriguez, J.F, Verdaguer, N. Deposit date: 2007-05-09 Release date: 2007-11-27 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Activation mechanism of a noncanonical RNA-dependent RNA polymerase. Proc.Natl.Acad.Sci.Usa, 104, 2007
1IW7	Crystal structure of the RNA polymerase holoenzyme from Thermus thermophilus at 2.6A resolution Descriptor: LEAD (II) ION, MAGNESIUM ION, RNA polymerase alpha subunit, ... Authors: RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2002-04-22 Release date: 2002-06-26 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Crystal structure of a bacterial RNA polymerase holoenzyme at 2.6 A resolution NATURE, 417, 2002
1ARO	T7 RNA POLYMERASE COMPLEXED WITH T7 LYSOZYME Descriptor: MERCURY (II) ION, T7 LYSOZYME, T7 RNA POLYMERASE Authors: Steitz, T, Jeruzalmi, D. Deposit date: 1997-08-08 Release date: 1998-10-21 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structure of T7 RNA polymerase complexed to the transcriptional inhibitor T7 lysozyme. EMBO J., 17, 1998
3MLQ	Crystal structure of the Thermus thermophilus transcription-repair coupling factor RNA polymerase interacting domain with the Thermus aquaticus RNA polymerase beta1 domain Descriptor: DNA-directed RNA polymerase subunit beta, PHOSPHATE ION, Transcription-repair coupling factor Authors: Darst, S.A, Westblade, L.F, Campbell, E.A. Deposit date: 2010-04-18 Release date: 2010-10-13 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.91 Å) Cite: Structural basis for the bacterial transcription-repair coupling factor/RNA polymerase interaction. Nucleic Acids Res., 38, 2010
3N6L	The crystal structure of RNA-dependent RNA polymerase of EV71 virus Descriptor: NICKEL (II) ION, RNA-dependent RNA polymerase Authors: Wu, Y, Rao, Z.H. Deposit date: 2010-05-26 Release date: 2011-06-15 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structures of EV71 RNA-dependent RNA polymerase in complex with substrate and analogue provide a drug target against the hand-foot-and-mouth disease pandemic in China. Protein Cell, 1, 2010

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