9BKY
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1WFJ
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1WFM
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6LCY
| Crystal structure of Synaptotagmin-7 C2B in complex with IP6 | Descriptor: | INOSITOL HEXAKISPHOSPHATE, Synaptotagmin-7 | Authors: | Zhang, Y, Zhang, X, Rao, F, Wang, C. | Deposit date: | 2019-11-20 | Release date: | 2021-03-03 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.301 Å) | Cite: | 5-IP 7 is a GPCR messenger mediating neural control of synaptotagmin-dependent insulin exocytosis and glucose homeostasis. Nat Metab, 3, 2021
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5LO8
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2Z0U
| Crystal structure of C2 domain of KIBRA protein | Descriptor: | WW domain-containing protein 1 | Authors: | Murayama, K, Kato-Murayama, M, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2007-05-07 | Release date: | 2008-05-13 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of C2 domain of KIBRA protein To be Published
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7K6B
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7KRB
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5A4X
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5A50
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3RDJ
| Rat PKC C2 domain Apo | Descriptor: | Protein kinase C alpha type | Authors: | Li, P. | Deposit date: | 2011-04-01 | Release date: | 2011-09-07 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Pb2+ as modulator of protein-membrane interactions. J.Am.Chem.Soc., 133, 2011
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6NYT
| Munc13-1 C2B-domain, calcium bound | Descriptor: | CALCIUM ION, CHLORIDE ION, GLYCEROL, ... | Authors: | Tomchick, D.R, Rizo, J, Machius, M, Lu, J. | Deposit date: | 2019-02-12 | Release date: | 2019-02-20 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.369 Å) | Cite: | Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis. Nat. Struct. Mol. Biol., 17, 2010
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6NYC
| Munc13-1 C2B-domain, calcium free | Descriptor: | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, Munc13-1 | Authors: | Tomchick, D.R, Rizo, J, Machius, M, Lu, J. | Deposit date: | 2019-02-11 | Release date: | 2019-02-20 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.893 Å) | Cite: | Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis. Nat. Struct. Mol. Biol., 17, 2010
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7JOF
| Calcium-bound C2A Domain from Human Dysferlin | Descriptor: | CALCIUM ION, Isoform 6 of Dysferlin | Authors: | Tadayon, R, Wang, Y, Santamaria, L, Mercier, P, Forristal, C, Shaw, G.S. | Deposit date: | 2020-08-06 | Release date: | 2021-06-16 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Calcium binds and rigidifies the dysferlin C2A domain in a tightly coupled manner. Biochem.J., 478, 2021
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3HN8
| Crystal structure of synaptotagmin | Descriptor: | CALCIUM ION, Synaptotagmin-3, ZINC ION | Authors: | Strop, P, Vrljic, M, Ernst, J, Brunger, A.T. | Deposit date: | 2009-05-30 | Release date: | 2010-02-23 | Last modified: | 2017-11-01 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Molecular mechanism of the synaptotagmin-SNARE interaction in Ca2+-triggered vesicle fusion. Nat.Struct.Mol.Biol., 17, 2010
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5LOB
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5LOW
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3RPB
| THE C2B-DOMAIN OF RABPHILIN: STRUCTURAL VARIATIONS IN A JANUS-FACED DOMAIN | Descriptor: | RABPHILIN 3-A | Authors: | Ubach, J, Garcia, J, Nittler, M.P, Sudhof, T.C, Rizo, J. | Deposit date: | 1999-04-19 | Release date: | 1999-12-23 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Structure of the Janus-faced C2B domain of rabphilin. Nat.Cell Biol., 1, 1999
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3L9B
| Crystal Structure of Rat Otoferlin C2A | Descriptor: | MAGNESIUM ION, Otoferlin | Authors: | Helfmann, S, Neumann, P. | Deposit date: | 2010-01-04 | Release date: | 2011-01-19 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | The crystal structure of the C2A domain of otoferlin reveals an unconventional top loop region. J.Mol.Biol., 406, 2011
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2B3R
| Crystal structure of the C2 domain of class II phosphatidylinositide 3-kinase C2 | Descriptor: | Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide, SULFATE ION | Authors: | Liu, L, Song, X, He, D, Komma, C, Kita, A, Verbasius, J.V, Bellamy, H, Miki, K, Czech, M.P, Zhou, G.W. | Deposit date: | 2005-09-20 | Release date: | 2005-12-13 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structure of the C2 domain of class II phosphatidylinositide 3-kinase C2alpha. J.Biol.Chem., 281, 2006
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3TWY
| RAT PKC C2 DOMAIN BOUND TO PB | Descriptor: | LEAD (II) ION, Protein kinase C alpha type, SULFATE ION | Authors: | Li, P. | Deposit date: | 2011-09-22 | Release date: | 2011-11-02 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Pb2+ as Modulator of Protein-Membrane Interactions. J.Am.Chem.Soc., 133, 2011
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6IEJ
| The C2 domain of cytosolic phospholipase A2 alpha bound to phosphatidylcholine | Descriptor: | 1,2-dihexanoyl-sn-glycero-3-phosphocholine, CALCIUM ION, Cytosolic phospholipase A2, ... | Authors: | Hirano, Y, Gao, Y.G, Stephenson, D.J, Vu, N.T, Malinina, L, Chalfant, C.E, Patel, D.J, Brown, R.E. | Deposit date: | 2018-09-14 | Release date: | 2019-05-22 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.206 Å) | Cite: | Structural basis of phosphatidylcholine recognition by the C2-domain of cytosolic phospholipase A2alpha. Elife, 8, 2019
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4ICW
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4IQH
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6TZ3
| Crystal Structure of Human Synaptotagmin 1 C2B without Ca2+ | Descriptor: | SULFATE ION, Synaptotagmin-1 | Authors: | Dominguez, M.J, Karmakar, S, Meyer, A.G, Sutton, R.B. | Deposit date: | 2019-08-09 | Release date: | 2020-05-13 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.17 Å) | Cite: | Molecular Basis for Synaptotagmin-1-Associated Neurodevelopmental Disorder. Neuron, 107, 2020
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