PDB: 5470 resultsInfo pagesStatus searchChemie searchBIRD

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5PO9	PanDDA analysis group deposition -- Crystal Structure of BRD1 in complex with N07950b Descriptor: 1,2-ETHANEDIOL, 1-methyl-4-phenyl-3-(trifluoromethyl)-1H-pyrazol-5-amine, Bromodomain-containing protein 1, ... Authors: Pearce, N.M, Krojer, T, Talon, R, Bradley, A.R, Fairhead, M, Sethi, R, Wright, N, MacLean, E, Collins, P, Brandao-Neto, J, Douangamath, A, Renjie, Z, Dias, A, Ng, J, Brennan, P.E, Cox, O, Bountra, C, Arrowsmith, C.H, Edwards, A, von Delft, F. Deposit date: 2017-02-07 Release date: 2017-03-15 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.116 Å) Cite: A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density. Nat Commun, 8, 2017
5PON	PanDDA analysis group deposition -- Crystal Structure of BRD1 in complex with N10980a Descriptor: 1,2-ETHANEDIOL, 1-[4-(pyridin-2-yl)piperazin-1-yl]ethan-1-one, Bromodomain-containing protein 1, ... Authors: Pearce, N.M, Krojer, T, Talon, R, Bradley, A.R, Fairhead, M, Sethi, R, Wright, N, MacLean, E, Collins, P, Brandao-Neto, J, Douangamath, A, Renjie, Z, Dias, A, Ng, J, Brennan, P.E, Cox, O, Bountra, C, Arrowsmith, C.H, Edwards, A, von Delft, F. Deposit date: 2017-02-07 Release date: 2017-03-15 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.519 Å) Cite: A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density. Nat Commun, 8, 2017
8TPY	Structure of human hypoxanthine guanine phosphoribzosyltransferase in complex with [2S,4R] 4-Guanin-9-yl-2-hydroxymethyl-1-N-(3-phosphonopropionyl)pyrrolidine Descriptor: Hypoxanthine-guanine phosphoribosyltransferase, MAGNESIUM ION, {3-[(2S,4R)-4-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-(hydroxymethyl)pyrrolidin-1-yl]-3-oxopropyl}phosphonic acid Authors: Guddat, L.W. Deposit date: 2023-08-06 Release date: 2024-05-08 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Development of Prolinol Containing Inhibitors of Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase: Rational Structure-Based Drug Design. J.Med.Chem., 67, 2024
5POZ	PanDDA analysis group deposition -- Crystal Structure of BRD1 in complex with N11039a Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 1, N-{[(3R)-1-cyclopentyl-5-oxopyrrolidin-3-yl]methyl}methanesulfonamide, ... Authors: Pearce, N.M, Krojer, T, Talon, R, Bradley, A.R, Fairhead, M, Sethi, R, Wright, N, MacLean, E, Collins, P, Brandao-Neto, J, Douangamath, A, Renjie, Z, Dias, A, Ng, J, Brennan, P.E, Cox, O, Bountra, C, Arrowsmith, C.H, Edwards, A, von Delft, F. Deposit date: 2017-02-07 Release date: 2017-03-15 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.5 Å) Cite: A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density. Nat Commun, 8, 2017
8TPV	Structure of human hypoxanthine guanine phosphoribzosyltransferase in complex with [2S,4R]-4-Guanin-9-yl-2-(2-phosphonoethoxymethyl)-1-N-(3-phosphonopropionyl)pyrrolidine Descriptor: (3-{(2S,4R)-4-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-[(2-phosphonoethoxy)methyl]pyrrolidin-1-yl}-3-oxopropyl)phosphonic acid, Hypoxanthine-guanine phosphoribosyltransferase, MAGNESIUM ION Authors: Guddat, L.W. Deposit date: 2023-08-05 Release date: 2024-05-08 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.27 Å) Cite: Development of Prolinol Containing Inhibitors of Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase: Rational Structure-Based Drug Design. J.Med.Chem., 67, 2024
5PPF	PanDDA analysis group deposition -- Crystal Structure of BRD1 after initial refinement with no ligand modelled (structure 16) Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 1, SODIUM ION Authors: Pearce, N.M, Krojer, T, Talon, R, Bradley, A.R, Fairhead, M, Sethi, R, Wright, N, MacLean, E, Collins, P, Brandao-Neto, J, Douangamath, A, Renjie, Z, Dias, A, Ng, J, Brennan, P.E, Cox, O, Bountra, C, Arrowsmith, C.H, Edwards, A, von Delft, F. Deposit date: 2017-02-07 Release date: 2017-03-29 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.64 Å) Cite: A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density. Nat Commun, 8, 2017
5PPH	PanDDA analysis group deposition -- Crystal Structure of BRD1 after initial refinement with no ligand modelled (structure 18) Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 1, SODIUM ION Authors: Pearce, N.M, Krojer, T, Talon, R, Bradley, A.R, Fairhead, M, Sethi, R, Wright, N, MacLean, E, Collins, P, Brandao-Neto, J, Douangamath, A, Renjie, Z, Dias, A, Ng, J, Brennan, P.E, Cox, O, Bountra, C, Arrowsmith, C.H, Edwards, A, von Delft, F. Deposit date: 2017-02-07 Release date: 2017-03-29 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.89 Å) Cite: A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density. Nat Commun, 8, 2017
5PPV	PanDDA analysis group deposition -- Crystal Structure of BRD1 after initial refinement with no ligand modelled (structure 32) Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 1, SODIUM ION Authors: Pearce, N.M, Krojer, T, Talon, R, Bradley, A.R, Fairhead, M, Sethi, R, Wright, N, MacLean, E, Collins, P, Brandao-Neto, J, Douangamath, A, Renjie, Z, Dias, A, Ng, J, Brennan, P.E, Cox, O, Bountra, C, Arrowsmith, C.H, Edwards, A, von Delft, F. Deposit date: 2017-02-07 Release date: 2017-03-29 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.7 Å) Cite: A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density. Nat Commun, 8, 2017
5PQ1	PanDDA analysis group deposition -- Crystal Structure of BRD1 after initial refinement with no ligand modelled (structure 38) Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 1, SODIUM ION Authors: Pearce, N.M, Krojer, T, Talon, R, Bradley, A.R, Fairhead, M, Sethi, R, Wright, N, MacLean, E, Collins, P, Brandao-Neto, J, Douangamath, A, Renjie, Z, Dias, A, Ng, J, Brennan, P.E, Cox, O, Bountra, C, Arrowsmith, C.H, Edwards, A, von Delft, F. Deposit date: 2017-02-07 Release date: 2017-03-29 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.55 Å) Cite: A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density. Nat Commun, 8, 2017
5PQH	PanDDA analysis group deposition -- Crystal Structure of BRD1 after initial refinement with no ligand modelled (structure 54) Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 1, SODIUM ION Authors: Pearce, N.M, Krojer, T, Talon, R, Bradley, A.R, Fairhead, M, Sethi, R, Wright, N, MacLean, E, Collins, P, Brandao-Neto, J, Douangamath, A, Renjie, Z, Dias, A, Ng, J, Brennan, P.E, Cox, O, Bountra, C, Arrowsmith, C.H, Edwards, A, von Delft, F. Deposit date: 2017-02-07 Release date: 2017-03-29 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.52 Å) Cite: A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density. Nat Commun, 8, 2017
5PQX	PanDDA analysis group deposition -- Crystal Structure of BRD1 after initial refinement with no ligand modelled (structure 70) Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 1, SODIUM ION Authors: Pearce, N.M, Krojer, T, Talon, R, Bradley, A.R, Fairhead, M, Sethi, R, Wright, N, MacLean, E, Collins, P, Brandao-Neto, J, Douangamath, A, Renjie, Z, Dias, A, Ng, J, Brennan, P.E, Cox, O, Bountra, C, Arrowsmith, C.H, Edwards, A, von Delft, F. Deposit date: 2017-02-07 Release date: 2017-03-29 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.95 Å) Cite: A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density. Nat Commun, 8, 2017
5PSK	PanDDA analysis group deposition -- Crystal Structure of BRD1 after initial refinement with no ligand modelled (structure 128) Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 1, SODIUM ION Authors: Pearce, N.M, Krojer, T, Talon, R, Bradley, A.R, Fairhead, M, Sethi, R, Wright, N, MacLean, E, Collins, P, Brandao-Neto, J, Douangamath, A, Renjie, Z, Dias, A, Ng, J, Brennan, P.E, Cox, O, Bountra, C, Arrowsmith, C.H, Edwards, A, von Delft, F. Deposit date: 2017-02-07 Release date: 2017-03-29 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.38 Å) Cite: A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density. Nat Commun, 8, 2017
5PSZ	PanDDA analysis group deposition -- Crystal Structure of BRD1 after initial refinement with no ligand modelled (structure 143) Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 1, SODIUM ION Authors: Pearce, N.M, Krojer, T, Talon, R, Bradley, A.R, Fairhead, M, Sethi, R, Wright, N, MacLean, E, Collins, P, Brandao-Neto, J, Douangamath, A, Renjie, Z, Dias, A, Ng, J, Brennan, P.E, Cox, O, Bountra, C, Arrowsmith, C.H, Edwards, A, von Delft, F. Deposit date: 2017-02-07 Release date: 2017-03-29 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.53 Å) Cite: A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density. Nat Commun, 8, 2017
5PTF	PanDDA analysis group deposition -- Crystal Structure of BRD1 after initial refinement with no ligand modelled (structure 158) Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 1, SODIUM ION Authors: Pearce, N.M, Krojer, T, Talon, R, Bradley, A.R, Fairhead, M, Sethi, R, Wright, N, MacLean, E, Collins, P, Brandao-Neto, J, Douangamath, A, Renjie, Z, Dias, A, Ng, J, Brennan, P.E, Cox, O, Bountra, C, Arrowsmith, C.H, Edwards, A, von Delft, F. Deposit date: 2017-02-07 Release date: 2017-03-29 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.49 Å) Cite: A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density. Nat Commun, 8, 2017
5PTV	PanDDA analysis group deposition -- Crystal Structure of BRD1 after initial refinement with no ligand modelled (structure 173) Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 1, SODIUM ION Authors: Pearce, N.M, Krojer, T, Talon, R, Bradley, A.R, Fairhead, M, Sethi, R, Wright, N, MacLean, E, Collins, P, Brandao-Neto, J, Douangamath, A, Renjie, Z, Dias, A, Ng, J, Brennan, P.E, Cox, O, Bountra, C, Arrowsmith, C.H, Edwards, A, von Delft, F. Deposit date: 2017-02-07 Release date: 2017-03-29 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.7 Å) Cite: A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density. Nat Commun, 8, 2017
5PUB	PanDDA analysis group deposition -- Crystal Structure of BRD1 after initial refinement with no ligand modelled (structure 189) Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 1, SODIUM ION Authors: Pearce, N.M, Krojer, T, Talon, R, Bradley, A.R, Fairhead, M, Sethi, R, Wright, N, MacLean, E, Collins, P, Brandao-Neto, J, Douangamath, A, Renjie, Z, Dias, A, Ng, J, Brennan, P.E, Cox, O, Bountra, C, Arrowsmith, C.H, Edwards, A, von Delft, F. Deposit date: 2017-02-07 Release date: 2017-03-29 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.23 Å) Cite: A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density. Nat Commun, 8, 2017
5PUO	PanDDA analysis group deposition -- Crystal Structure of BRD1 after initial refinement with no ligand modelled (structure 202) Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 1, SODIUM ION Authors: Pearce, N.M, Krojer, T, Talon, R, Bradley, A.R, Fairhead, M, Sethi, R, Wright, N, MacLean, E, Collins, P, Brandao-Neto, J, Douangamath, A, Renjie, Z, Dias, A, Ng, J, Brennan, P.E, Cox, O, Bountra, C, Arrowsmith, C.H, Edwards, A, von Delft, F. Deposit date: 2017-02-07 Release date: 2017-03-29 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.06 Å) Cite: A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density. Nat Commun, 8, 2017
5PV1	PanDDA analysis group deposition -- Crystal Structure of BRD1 after initial refinement with no ligand modelled (structure 215) Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 1, SODIUM ION Authors: Pearce, N.M, Krojer, T, Talon, R, Bradley, A.R, Fairhead, M, Sethi, R, Wright, N, MacLean, E, Collins, P, Brandao-Neto, J, Douangamath, A, Renjie, Z, Dias, A, Ng, J, Brennan, P.E, Cox, O, Bountra, C, Arrowsmith, C.H, Edwards, A, von Delft, F. Deposit date: 2017-02-07 Release date: 2017-03-29 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.73 Å) Cite: A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density. Nat Commun, 8, 2017
5PVO	PanDDA analysis group deposition -- Crystal Structure of BRD1 after initial refinement with no ligand modelled (structure 239) Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 1, SODIUM ION Authors: Pearce, N.M, Krojer, T, Talon, R, Bradley, A.R, Fairhead, M, Sethi, R, Wright, N, MacLean, E, Collins, P, Brandao-Neto, J, Douangamath, A, Renjie, Z, Dias, A, Ng, J, Brennan, P.E, Cox, O, Bountra, C, Arrowsmith, C.H, Edwards, A, von Delft, F. Deposit date: 2017-02-07 Release date: 2017-03-29 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.96 Å) Cite: A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density. Nat Commun, 8, 2017
5PVZ	PanDDA analysis group deposition -- Crystal Structure of BRD1 after initial refinement with no ligand modelled (structure 250) Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 1, SODIUM ION Authors: Pearce, N.M, Krojer, T, Talon, R, Bradley, A.R, Fairhead, M, Sethi, R, Wright, N, MacLean, E, Collins, P, Brandao-Neto, J, Douangamath, A, Renjie, Z, Dias, A, Ng, J, Brennan, P.E, Cox, O, Bountra, C, Arrowsmith, C.H, Edwards, A, von Delft, F. Deposit date: 2017-02-07 Release date: 2017-03-29 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.64 Å) Cite: A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density. Nat Commun, 8, 2017
5PO2	PanDDA analysis group deposition -- Crystal Structure of BRD1 in complex with N10132a Descriptor: 1,2-ETHANEDIOL, 5-hydroxy-1,3-dihydro-2H-indol-2-one, Bromodomain-containing protein 1, ... Authors: Pearce, N.M, Krojer, T, Talon, R, Bradley, A.R, Fairhead, M, Sethi, R, Wright, N, MacLean, E, Collins, P, Brandao-Neto, J, Douangamath, A, Renjie, Z, Dias, A, Ng, J, Brennan, P.E, Cox, O, Bountra, C, Arrowsmith, C.H, Edwards, A, von Delft, F. Deposit date: 2017-02-07 Release date: 2017-03-15 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.67 Å) Cite: A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density. Nat Commun, 8, 2017
5POI	PanDDA analysis group deposition -- Crystal Structure of BRD1 in complex with N11016a Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 1, N-methylpyrimidine-2-carboxamide, ... Authors: Pearce, N.M, Krojer, T, Talon, R, Bradley, A.R, Fairhead, M, Sethi, R, Wright, N, MacLean, E, Collins, P, Brandao-Neto, J, Douangamath, A, Renjie, Z, Dias, A, Ng, J, Brennan, P.E, Cox, O, Bountra, C, Arrowsmith, C.H, Edwards, A, von Delft, F. Deposit date: 2017-02-07 Release date: 2017-03-15 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.365 Å) Cite: A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density. Nat Commun, 8, 2017
5PP8	PanDDA analysis group deposition -- Crystal Structure of BRD1 after initial refinement with no ligand modelled (structure 8) Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 1, SODIUM ION Authors: Pearce, N.M, Krojer, T, Talon, R, Bradley, A.R, Fairhead, M, Sethi, R, Wright, N, MacLean, E, Collins, P, Brandao-Neto, J, Douangamath, A, Renjie, Z, Dias, A, Ng, J, Brennan, P.E, Cox, O, Bountra, C, Arrowsmith, C.H, Edwards, A, von Delft, F. Deposit date: 2017-02-07 Release date: 2017-03-29 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.74 Å) Cite: A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density. Nat Commun, 8, 2017
5PQD	PanDDA analysis group deposition -- Crystal Structure of BRD1 after initial refinement with no ligand modelled (structure 50) Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 1, SODIUM ION Authors: Pearce, N.M, Krojer, T, Talon, R, Bradley, A.R, Fairhead, M, Sethi, R, Wright, N, MacLean, E, Collins, P, Brandao-Neto, J, Douangamath, A, Renjie, Z, Dias, A, Ng, J, Brennan, P.E, Cox, O, Bountra, C, Arrowsmith, C.H, Edwards, A, von Delft, F. Deposit date: 2017-02-07 Release date: 2017-03-29 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.65 Å) Cite: A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density. Nat Commun, 8, 2017
5PQR	PanDDA analysis group deposition -- Crystal Structure of BRD1 after initial refinement with no ligand modelled (structure 64) Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 1, SODIUM ION Authors: Pearce, N.M, Krojer, T, Talon, R, Bradley, A.R, Fairhead, M, Sethi, R, Wright, N, MacLean, E, Collins, P, Brandao-Neto, J, Douangamath, A, Renjie, Z, Dias, A, Ng, J, Brennan, P.E, Cox, O, Bountra, C, Arrowsmith, C.H, Edwards, A, von Delft, F. Deposit date: 2017-02-07 Release date: 2017-03-29 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.43 Å) Cite: A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density. Nat Commun, 8, 2017

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