8Z73
 
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6MXV
 | | The crystal structure of a rhodanese-like family protein from Francisella tularensis subsp. tularensis SCHU S4 | | Descriptor: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, DODECAETHYLENE GLYCOL, ... | | Authors: | Tan, K, Skarina, T, Di Leo, R, Savchenko, A, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | | Deposit date: | 2018-10-31 | | Release date: | 2018-11-21 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (1.78 Å) | | Cite: | The crystal structure of a rhodanese-like family protein from Francisella tularensis subsp. tularensis SCHU S4
To Be Published
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4XBB
 | | 1.85A resolution structure of Norovirus 3CL protease complex with a covalently bound dipeptidyl inhibitor diethyl [(1R,2S)-2-[(N-{[(3-chlorobenzyl)oxy]carbonyl}-3-cyclohexyl-L-alanyl)amino]-1-hydroxy-3-(2-oxo-2H-pyrrol-3-yl)propyl]phosphonate | | Descriptor: | 3C-LIKE PROTEASE, SULFATE ION, diethyl [(1R,2S)-2-[(N-{[(3-chlorobenzyl)oxy]carbonyl}-3-cyclohexyl-L-alanyl)amino]-1-hydroxy-3-(2-oxo-2H-pyrrol-3-yl)propyl]phosphonate | | Authors: | Lovell, S, Battaile, K.P, Mehzabeen, N, Kankanamalage, A.C.G, Kim, Y, Weerawarna, P.M, Uy, R.A.Z, Damalanka, V.C, Mandadapu, S.R, Alliston, K.R, Groutas, W.C, Chang, K.-O. | | Deposit date: | 2014-12-16 | | Release date: | 2015-03-25 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Structure-Guided Design and Optimization of Dipeptidyl Inhibitors of Norovirus 3CL Protease. Structure-Activity Relationships and Biochemical, X-ray Crystallographic, Cell-Based, and In Vivo Studies.
J.Med.Chem., 58, 2015
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8TMZ
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6OEW
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7Q7Z
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8ZV9
 | | Complex structure of HLA2402 with recognizing SARS-CoV-2 Y453F epitope NYNYLFRLF | | Descriptor: | 1,2-ETHANEDIOL, Beta-2-microglobulin, MHC class I antigen, ... | | Authors: | Deng, S.S, Jin, T.C, Xu, Z.H, Wang, M.H. | | Deposit date: | 2024-06-11 | | Release date: | 2024-08-21 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structural insights into immune escape at killer T cell epitope by SARS-CoV-2 Spike Y453F variants.
J.Biol.Chem., 300, 2024
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5L9G
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9G4Q
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7CHR
 | | AcrIF9 | | Descriptor: | anti-CRISPR AcrIF9 | | Authors: | Kim, G.E, Park, H.H. | | Deposit date: | 2020-07-06 | | Release date: | 2020-12-23 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (1.21 Å) | | Cite: | A high-resolution (1.2 angstrom ) crystal structure of the anti-CRISPR protein AcrIF9.
Febs Open Bio, 10, 2020
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6PBV
 | | Crystal structure of Fab668 complex | | Descriptor: | 1,2-ETHANEDIOL, Fab668 heavy chain, Fab668 light chain, ... | | Authors: | Oyen, D, Wilson, I.A. | | Deposit date: | 2019-06-14 | | Release date: | 2020-03-04 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (1.566 Å) | | Cite: | Structure and mechanism of monoclonal antibody binding to the junctional epitope of Plasmodium falciparum circumsporozoite protein.
Plos Pathog., 16, 2020
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9NTK
 | | Chimeric Adenosine deaminase growth factor (ADGF) in complex with pentostatin monophosphate | | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Adenosine deaminase AGSA,Adenosine deaminase AGSA,Chimeric Adenosine deaminase growth factor, ... | | Authors: | Kaur, G, Horton, J.R, Cheng, X. | | Deposit date: | 2025-03-18 | | Release date: | 2025-06-18 | | Last modified: | 2025-07-23 | | Method: | X-RAY DIFFRACTION (2.53 Å) | | Cite: | Structural basis for the substrate specificity of Helix pomatia AMP deaminase and a chimeric ADGF adenosine deaminase.
J.Biol.Chem., 301, 2025
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6MYI
 | | Pleurotus ostreatus OstreolysinA | | Descriptor: | 1,2-ETHANEDIOL, Ostreolysin A6, SODIUM ION | | Authors: | Tomchick, D.R, Radhakrishnan, A, Endapally, S. | | Deposit date: | 2018-11-01 | | Release date: | 2019-02-13 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.15 Å) | | Cite: | Molecular Discrimination between Two Conformations of Sphingomyelin in Plasma Membranes.
Cell, 176, 2019
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8YFL
 | | crystal structure of FIP200 claw/TNIP1_FIR_pS122pS123 | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, GLYCEROL, RB1-inducible coiled-coil protein 1, ... | | Authors: | Lv, M.Q, Wu, S.M. | | Deposit date: | 2024-02-24 | | Release date: | 2024-08-14 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Structural basis for TNIP1 binding to FIP200 during mitophagy.
J.Biol.Chem., 300, 2024
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9QAP
 | | Human angiotensin-1 converting enzyme C-domain in complex with quinaprilat | | Descriptor: | 1,2-ETHANEDIOL, Angiotensin-converting enzyme, soluble form, ... | | Authors: | Gregory, K.S, Acharya, K.R. | | Deposit date: | 2025-02-28 | | Release date: | 2025-09-03 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Molecular basis of domain-specific angiotensin I-converting enzyme inhibition by the antihypertensive drugs enalaprilat, ramiprilat, trandolaprilat, quinaprilat and perindoprilat.
Febs J., 2025
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8YHZ
 | | The co-crystal structure of the Fab fragment of Ab-1080 with NaV1.7 VSDII peptide | | Descriptor: | Heavy chain of 1080 Fab, Light chain of 1080 Fab, Sodium channel protein type 9 subunit alpha | | Authors: | Du, J, Zhang, Y, Zhu, R, Ding, Y. | | Deposit date: | 2024-02-28 | | Release date: | 2024-10-23 | | Last modified: | 2024-12-04 | | Method: | X-RAY DIFFRACTION (1.62 Å) | | Cite: | Intra-channel bi-epitopic crosslinking unleashes ultrapotent antibodies targeting Na V 1.7 for pain alleviation.
Cell Rep Med, 5, 2024
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6NOE
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6NOH
 | | Crystal structure of FBF-2 repeat 5 mutant (C363S, R364Y, Q367S) in complex with 8-nt RNA | | Descriptor: | 1,2-ETHANEDIOL, Fem-3 mRNA-binding factor 2, RNA (5'-R(*UP*GP*UP*AP*AP*AP*UP*A)-3') | | Authors: | McCann, K.L, Wang, Y, Qiu, C, Hall, T.M.T. | | Deposit date: | 2019-01-16 | | Release date: | 2019-01-30 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (2.249 Å) | | Cite: | Engineering a conserved RNA regulatory protein repurposes its biological function in vivo .
Elife, 8, 2019
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6NE2
 | | Designed repeat protein in complex with Fz7 | | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, ... | | Authors: | Miao, Y, Jude, K.M, Garcia, K.C. | | Deposit date: | 2018-12-15 | | Release date: | 2019-05-15 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (1.299 Å) | | Cite: | Receptor subtype discrimination using extensive shape complementary designed interfaces.
Nat.Struct.Mol.Biol., 26, 2019
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6VLX
 | | Crystal structure of FabI from Alistipes finegoldii | | Descriptor: | Enoyl-[acyl-carrier-protein] reductase [NADH], GLYCEROL | | Authors: | Radka, C.D, Seetharaman, J, Rock, C.O. | | Deposit date: | 2020-01-27 | | Release date: | 2020-04-29 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.72 Å) | | Cite: | The genome of a Bacteroidetes inhabitant of the human gut encodes a structurally distinct enoyl-acyl carrier protein reductase (FabI).
J.Biol.Chem., 295, 2020
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6NHU
 | | Crystal Structure of the Beta Lactamase Class D YbxI from Agrobacterium fabrum | | Descriptor: | 1,2-ETHANEDIOL, Beta-lactamase, GLYCEROL, ... | | Authors: | Kim, Y, Welk, L, Endres, M, Babnigg, G, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | | Deposit date: | 2018-12-23 | | Release date: | 2019-01-16 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal Structure of the Beta Lactamase Class D YbxI from Agrobacterium fabrum
To Be Published
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8CMS
 | | OTUB2 in covalent complex with LN5P45 | | Descriptor: | (1~{S},2~{S})-~{N}'-ethanoyl-2-(3-methylphenyl)cyclopropane-1-carbohydrazide, Ubiquitin thioesterase OTUB2 | | Authors: | Gan, J, de Vries, J. | | Deposit date: | 2023-02-21 | | Release date: | 2023-11-15 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (1.77 Å) | | Cite: | Cellular Validation of a Chemically Improved Inhibitor Identifies Monoubiquitination on OTUB2.
Acs Chem.Biol., 18, 2023
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6NTR
 | | Crystal Structure of Beta-barrel-like Protein of Domain of Unknown Function DUF1849 from Brucella abortus | | Descriptor: | 1,2-ETHANEDIOL, ATP/GTP-binding site-containing protein A, GLYCEROL | | Authors: | Kim, Y, Bigelow, L, Endres, M, Babnigg, G, Crosson, S, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | | Deposit date: | 2019-01-30 | | Release date: | 2019-02-13 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.101 Å) | | Cite: | BrucellaPeriplasmic Protein EipB Is a Molecular Determinant of Cell Envelope Integrity and Virulence.
J.Bacteriol., 201, 2019
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6NNX
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6NPM
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