PDB: 92869 resultsInfo pagesStatus searchChemie searchBIRD

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7B6Q	Crystal structure of MurE from E.coli in complex with Z57299526 Descriptor: ISOPROPYL ALCOHOL, N-[(furan-2-yl)methyl]-1H-benzimidazol-2-amine, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-2,6-diaminopimelate ligase Authors: Koekemoer, L, Steindel, M, Fairhead, M, Talon, R, Douangamath, A, Arrowsmith, C.H, Edwards, A.M, Bountra, C, von Delft, F, Krojer, T, Structural Genomics Consortium (SGC) Deposit date: 2020-12-08 Release date: 2020-12-23 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.82 Å) Cite: Crystal structure of MurE from E.coli To Be Published
7B68	Crystal structure of MurE from E.coli in complex with Z57299526 Descriptor: 4-[(4-methylphenyl)methyl]-1,4-thiazinane 1,1-dioxide, DIMETHYL SULFOXIDE, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-2,6-diaminopimelate ligase Authors: Koekemoer, L, Steindel, M, Fairhead, M, Talon, R, Douangamath, A, Arrowsmith, C.H, Edwards, A.M, Bountra, C, von Delft, F, Krojer, T, Structural Genomics Consortium (SGC) Deposit date: 2020-12-07 Release date: 2020-12-23 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.89 Å) Cite: Crystal structure of MurE from E.coli To Be Published
6RRJ	GOLGI ALPHA-MANNOSIDASE II in complex with 5-(Adamantan-1yl-methoxy)-pentyl 2,5-dideoxy-2,5-imino-D-talo-hexonamide Descriptor: (2~{S},3~{R},4~{S},5~{R})-~{N}-[5-(1-adamantylmethoxy)pentyl]-5-(hydroxymethyl)-3,4-bis(oxidanyl)pyrrolidine-2-carboxamide, 1,2-ETHANEDIOL, Alpha-mannosidase 2, ... Authors: Armstrong, Z, Lahav, D, Johnson, R, Kuo, C.L, Beenakker, T.J.M, de Boer, C, Wong, C.S, van Rijssel, E.R, Debets, M, Geurink, P.P, Ovaa, H, van der Stelt, M, Codee, J.D.C, Aerts, J.M.F.G, Wu, L, Overkleeft, H.S, Davies, G.J. Deposit date: 2019-05-20 Release date: 2020-07-08 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Manno- epi -cyclophellitols Enable Activity-Based Protein Profiling of Human alpha-Mannosidases and Discovery of New Golgi Mannosidase II Inhibitors. J.Am.Chem.Soc., 142, 2020
6RRU	GOLGI ALPHA-MANNOSIDASE II in complex with (5R,6R,7S,8S)-5,6,7,8-tetrahydro-5-(hydroxymethyl)-3-(3-phenylpropyl)imidazo[1,2-a]pyridine-6,7,8-triol Descriptor: (5~{R},6~{R},7~{S},8~{S})-5-(hydroxymethyl)-2-(3-phenylpropyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine-6,7,8-triol, Alpha-mannosidase 2, ZINC ION Authors: Armstrong, Z, Lahav, D, Johnson, R, Kuo, C.L, Beenakker, T.J.M, de Boer, C, Wong, C.S, van Rijssel, E.R, Debets, M, Geurink, P.P, Ovaa, H, van der Stelt, M, Codee, J.D.C, Aerts, J.M.F.G, Wu, L, Overkleeft, H.S, Davies, G.J. Deposit date: 2019-05-20 Release date: 2020-07-08 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Manno- epi -cyclophellitols Enable Activity-Based Protein Profiling of Human alpha-Mannosidases and Discovery of New Golgi Mannosidase II Inhibitors. J.Am.Chem.Soc., 142, 2020
1W0G	Crystal structure of human cytochrome P450 3A4 Descriptor: CYTOCHROME P450 3A4, METYRAPONE, PROTOPORPHYRIN IX CONTAINING FE Authors: Williams, P.A, Cosme, J, Vinkovic, D.M, Ward, A, Angove, H.C, Day, P.J, Vonrhein, C, Tickle, I.J, Jhoti, H. Deposit date: 2004-06-03 Release date: 2004-07-22 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.73 Å) Cite: Crystal Structures of Human Cytochrome P450 3A4 Bound to Metyrapone and Progesterone Science, 305, 2004
5U3C	CryoEM structure of the CTP synthase filament at 4.6 Angstrom resolution Descriptor: ADENOSINE-5'-DIPHOSPHATE, CTP synthase, CYTIDINE-5'-TRIPHOSPHATE Authors: Kollman, J.M, Lynch, E.M. Deposit date: 2016-12-01 Release date: 2017-04-26 Last modified: 2017-06-21 Method: ELECTRON MICROSCOPY (4.6 Å) Cite: Human CTP synthase filament structure reveals the active enzyme conformation. Nat. Struct. Mol. Biol., 24, 2017
7B53	Crystal structure of MurE from E.coli Descriptor: 1,2-ETHANEDIOL, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase Authors: Koekemoer, L, Steindel, M, Fairhead, M, Talon, R, Douangamath, A, Arrowsmith, C.H, Edwards, A.M, Bountra, C, von Delft, F, Krojer, T, Structural Genomics Consortium (SGC) Deposit date: 2020-12-03 Release date: 2020-12-16 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Crystal structure of MurE from E.coli To Be Published
7QYR	Crystal structure of RimK from Pseudomonas aeruginosa PAO1 Descriptor: ADENOSINE-5'-DIPHOSPHATE, Probable alpha-L-glutamate ligase, poly-glutamate Authors: Thompson, C.M.A, Little, R.H, Stevenson, C.E.M, Lawson, D.M, Malone, J.G. Deposit date: 2022-01-29 Release date: 2022-10-05 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structural insights into the mechanism of adaptive ribosomal modification by Pseudomonas RimK. Proteins, 91, 2023
7B60	Crystal structure of MurE from E.coli in complex with Z1269139261 Descriptor: 4-[(furan-2-yl)methyl]-1lambda~6~,4-thiazinane-1,1-dione, DIMETHYL SULFOXIDE, ISOPROPYL ALCOHOL, ... Authors: Koekemoer, L, Steindel, M, Fairhead, M, Talon, R, Douangamath, A, Arrowsmith, C.H, Edwards, A.M, Bountra, C, von Delft, F, Krojer, T, Structural Genomics Consortium (SGC) Deposit date: 2020-12-07 Release date: 2020-12-23 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.91 Å) Cite: Crystal structure of MurE from E.coli To Be Published
7B6M	Crystal structure of MurE from E.coli in complex with Z1198948504 Descriptor: 1,2-ETHANEDIOL, N-[2-(2,5-Dioxopyrrolidin-1-yl)ethyl]-3-methylbenzamide, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-2,6-diaminopimelate ligase Authors: Koekemoer, L, Steindel, M, Fairhead, M, Arrowsmith, C.H, Edwards, A.M, Bountra, C, von Delft, F, Krojer, T, Structural Genomics Consortium (SGC), Structural Genomics Consortium for Research on Gene Expression (SGCGES) Deposit date: 2020-12-07 Release date: 2020-12-23 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.67 Å) Cite: Crystal structure of MurE from E.coli To Be Published
7QYS	Crystal structure of RimK from Pseudomonas syringae DC3000 Descriptor: ADENOSINE-5'-DIPHOSPHATE, Probable alpha-L-glutamate ligase Authors: Thompson, C.M.A, Little, R.H, Stevenson, C.E.M, Lawson, D.M, Malone, J.G. Deposit date: 2022-01-29 Release date: 2022-10-05 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Structural insights into the mechanism of adaptive ribosomal modification by Pseudomonas RimK. Proteins, 91, 2023
6ILQ	Crystal structure of PPARgamma with compound BR101549 Descriptor: Nuclear receptor coactivator 1, Peroxisome proliferator-activated receptor gamma, ethyl [2-butyl-6-oxo-1-{[2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl}-4-(propan-2-yl)-1,6-dihydropyrimidin-5-yl]acetate Authors: Hong, E, Jang, T.H, Chin, J, Kim, K.H, Jung, W, Kim, S.H. Deposit date: 2018-10-19 Release date: 2019-09-11 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.408 Å) Cite: Identification of BR101549 as a lead candidate of non-TZD PPAR gamma agonist for the treatment of type 2 diabetes: Proof-of-concept evaluation and SAR. Bioorg.Med.Chem.Lett., 29, 2019
7B6N	Crystal structure of MurE from E.coli in complex with Z757284952 Descriptor: 1,2-ETHANEDIOL, N-(2-(2,4-dioxothiazolidin-3-yl)ethyl)-3-methylbenzamide, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase Authors: Koekemoer, L, Steindel, M, Fairhead, M, Arrowsmith, C.H, Edwards, A.M, Bountra, C, von Delft, F, Krojer, T, Structural Genomics Consortium (SGC) Deposit date: 2020-12-07 Release date: 2020-12-23 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.79 Å) Cite: Crystal structure of MurE from E.coli To Be Published
3T4L	Arabidopsis histidine kinase 4 sensor domain in complex with trans-zeatin Descriptor: (2E)-2-methyl-4-(9H-purin-6-ylamino)but-2-en-1-ol, Histidine kinase 4, MALONATE ION Authors: Hothorn, M. Deposit date: 2011-07-26 Release date: 2011-10-05 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.53 Å) Cite: Structural basis for cytokinin recognition by Arabidopsis thaliana histidine kinase 4. Nat.Chem.Biol., 7, 2011
5GUX	Cytochrome c-dependent nitric oxide reductase (cNOR) from Pseudomonas aeruginosa in complex with xenon Descriptor: Antibody fab fragment heavy chain, Antibody fab fragment light chain, CALCIUM ION, ... Authors: Ishii, S, Terasaka, E, Sugimoto, H, Shiro, Y, Tosha, T. Deposit date: 2016-08-31 Release date: 2017-08-16 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (3.3 Å) Cite: Dynamics of nitric oxide controlled by protein complex in bacterial system. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
3T4J	Arabidopsis histidine kinase 4 sensor domain in complex with N-isopentenyl adenine Descriptor: Histidine kinase 4, MALONATE ION, N-(3-METHYLBUT-2-EN-1-YL)-9H-PURIN-6-AMINE Authors: Hothorn, M. Deposit date: 2011-07-26 Release date: 2011-10-05 Last modified: 2011-12-14 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Structural basis for cytokinin recognition by Arabidopsis thaliana histidine kinase 4. Nat.Chem.Biol., 7, 2011
7B6K	Crystal structure of MurE from E.coli in complex with Z57715447 Descriptor: 5-cyclohexyl-3-(pyridin-4-yl)-1,2,4-oxadiazole, CITRIC ACID, DIMETHYL SULFOXIDE, ... Authors: Koekemoer, L, Steindel, M, Fairhead, M, Talon, R, Douangamath, A, Arrowsmith, C.H, Edwards, A.M, Bountra, C, von Delft, F, Krojer, T, Structural Genomics Consortium (SGC) Deposit date: 2020-12-07 Release date: 2020-12-23 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.838 Å) Cite: Crystal structure of MurE from E.coli To Be Published
7B61	Crystal structure of MurE from E.coli in complex with Z57299526 Descriptor: (R)-N-(1-cyclopropylethyl)-6-methylpicolinamide, (S)-N-(1-cyclopropylethyl)-6-methylpicolinamide, CITRIC ACID, ... Authors: Koekemoer, L, Steindel, M, Fairhead, M, Talon, R, Douangamath, A, Arrowsmith, C.H, Edwards, A.M, Bountra, C, von Delft, F, Krojer, T, Structural Genomics Consortium (SGC) Deposit date: 2020-12-07 Release date: 2021-01-13 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Crystal structure of MurE from E.coli To Be Published
7B6O	Crystal structure of E.coli MurE mutant - C269S C340S C450S Descriptor: ISOPROPYL ALCOHOL, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-2,6-diaminopimelate ligase Authors: Koekemoer, L, Steindel, M, Fairhead, M, Arrowsmith, C.H, Edwards, A.M, Bountra, C, von Delft, F, Krojer, T, Structural Genomics Consortium (SGC) Deposit date: 2020-12-08 Release date: 2020-12-23 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.86 Å) Cite: Crystal structure of MurE from E.coli To Be Published
7B6L	Crystal structure of MurE from E.coli in complex with Z57299368 Descriptor: (1-ethyl-1H-benzoimidazol-2-yl)-furan-2-ylmethyl-aminee, ISOPROPYL ALCOHOL, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-2,6-diaminopimelate ligase Authors: Koekemoer, L, Steindel, M, Fairhead, M, Arrowsmith, C.H, Edwards, A.M, Bountra, C, von Delft, F, Krojer, T, Structural Genomics Consortium (SGC) Deposit date: 2020-12-07 Release date: 2020-12-23 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.08 Å) Cite: Crystal structure of MurE from E.coli To Be Published
2B90	Crystal structure of the interleukin-4 variant T13DR85A Descriptor: Interleukin-4, SULFATE ION Authors: Kraich, M, Klein, M, Patino, E, Harrer, H, Sebald, W, Mueller, T.D. Deposit date: 2005-10-10 Release date: 2006-05-30 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.1 Å) Cite: A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor Bmc Biol., 4, 2006
5U6R	E. coli CTP synthase CC mutant filament (product-bound) Descriptor: ADENOSINE-5'-DIPHOSPHATE, CTP synthase, CYTIDINE-5'-TRIPHOSPHATE Authors: Kollman, J.M, Lynch, E.M. Deposit date: 2016-12-08 Release date: 2017-04-26 Last modified: 2018-07-18 Method: ELECTRON MICROSCOPY (5.7 Å) Cite: Human CTP synthase filament structure reveals the active enzyme conformation. Nat. Struct. Mol. Biol., 24, 2017
7B6I	Crystal structure of MurE from E.coli in complex with Z1373445602 Descriptor: 4-(3-fluoranylpyridin-2-yl)-1-methyl-piperazin-2-one, CITRIC ACID, ISOPROPYL ALCOHOL, ... Authors: Koekemoer, L, Steindel, M, Fairhead, M, Talon, R, Douangamath, A, Arrowsmith, C.H, Edwards, A.M, Bountra, C, von Delft, F, Krojer, T, Structural Genomics Consortium (SGC) Deposit date: 2020-12-07 Release date: 2020-12-23 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.069 Å) Cite: Crystal structure of MurE from E.coli To Be Published
6X9F	Pseudomonas aeruginosa MurC with AZ8074 Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, DIMETHYL SULFOXIDE, ... Authors: Horanyi, P.S, Mayclin, S.J, Durand-Reville, T.F, Lorimer, D.D, Edwards, T.E, Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2020-06-02 Release date: 2020-09-02 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Pseudomonas aeruginosa MurC with AZ8074 To Be Published
7B6P	Crystal structure of E.coli MurE - C269S C340S C450S in complex with Ellman's reagent Descriptor: 1,2-ETHANEDIOL, CITRIC ACID, ISOPROPYL ALCOHOL, ... Authors: Koekemoer, L, Steindel, M, Fairhead, M, Arrowsmith, C.H, Edwards, A.M, Bountra, C, von Delft, F, Krojer, T, Structural Genomics Consortium (SGC) Deposit date: 2020-12-08 Release date: 2020-12-23 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.68 Å) Cite: Crystal structure of MurE from E.coli To Be Published

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