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PDB: 1337 results
3N2P
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BU of 3n2p by Molmil
Crystal structure of human carbonic anhydrase II in complex with a benzenesulfonamide inhibitor
Descriptor: 4-{[(3-nitrophenyl)carbamoyl]amino}benzenesulfonamide, Carbonic anhydrase 2, DIMETHYL SULFOXIDE, ...
Authors:Avvaru, B.S, Wagner, J, Robbins, A.H, McKenna, R.
Deposit date:2010-05-18
Release date:2011-03-09
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.648 Å)
Cite:Selective hydrophobic pocket binding observed within the carbonic anhydrase II active site accommodate different 4-substituted-ureido-benzenesulfonamides and correlate to inhibitor potency.
Chem.Commun.(Camb.), 46, 2010
3MZC
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BU of 3mzc by Molmil
Human carbonic ahydrase II in complex with a benzenesulfonamide inhibitor
Descriptor: 4-[(cyclopentylcarbamoyl)amino]benzenesulfonamide, Carbonic anhydrase 2, GLYCEROL, ...
Authors:Avvaru, B.S, Wagner, J, Robbins, A.H, Mckenna, R.
Deposit date:2010-05-12
Release date:2011-03-09
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.498 Å)
Cite:Selective hydrophobic pocket binding observed within the carbonic anhydrase II active site accommodate different 4-substituted-ureido-benzenesulfonamides and correlate to inhibitor potency.
Chem.Commun.(Camb.), 46, 2010
3N3J
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BU of 3n3j by Molmil
Crystal structure of human carbonic anhydrase II in complex with a benzenesulfonamide inhibitor
Descriptor: 4-({[2-(1-methylethyl)phenyl]carbamoyl}amino)benzenesulfonamide, Carbonic anhydrase 2, GLYCEROL, ...
Authors:Avvaru, B.S, Wagner, J, Robbins, A.H, McKenna, R.
Deposit date:2010-05-20
Release date:2011-03-09
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Selective hydrophobic pocket binding observed within the carbonic anhydrase II active site accommodate different 4-substituted-ureido-benzenesulfonamides and correlate to inhibitor potency.
Chem.Commun.(Camb.), 46, 2010
3MWO
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BU of 3mwo by Molmil
Human carbonic anhydrase II in a doubled monoclinic cell: a re-determination
Descriptor: Carbonic anhydrase 2, ZINC ION
Authors:Robbins, A.H, McKenna, R.
Deposit date:2010-05-06
Release date:2010-06-09
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Emerging from pseudo-symmetry: the redetermination of human carbonic anhydrase II in monoclinic P2(1) with a doubled a axis.
Acta Crystallogr.,Sect.D, 66, 2010
3N4B
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BU of 3n4b by Molmil
Crystal structure of human carbonic anhydrase II in complex with a benzenesulfonamide inhibitor
Descriptor: 4-{[(4-fluorophenyl)carbamoyl]amino}benzenesulfonamide, Carbonic anhydrase 2, GLYCEROL, ...
Authors:Avvaru, B.S, Wagner, J, Robbins, A.H, McKenna, R.
Deposit date:2010-05-21
Release date:2011-03-09
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Selective hydrophobic pocket binding observed within the carbonic anhydrase II active site accommodate different 4-substituted-ureido-benzenesulfonamides and correlate to inhibitor potency.
Chem.Commun.(Camb.), 46, 2010
3N0N
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BU of 3n0n by Molmil
Crystal structure of human carbonic anhydrase II in complex with a benzenesulfonamide inhibitor
Descriptor: 4-{[(pentafluorophenyl)carbamoyl]amino}benzenesulfonamide, Carbonic anhydrase 2, GLYCEROL, ...
Authors:Avvaru, B.S, Wagner, J, Robbins, A.H, McKenna, R.
Deposit date:2010-05-14
Release date:2011-03-16
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Selective hydrophobic pocket binding observed within the carbonic anhydrase II active site accommodate different 4-substituted-ureido-benzenesulfonamides and correlate to inhibitor potency.
Chem.Commun.(Camb.), 46, 2010
1BIC
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BU of 1bic by Molmil
CRYSTALLOGRAPHIC ANALYSIS OF THR-200-> HIS HUMAN CARBONIC ANHYDRASE II AND ITS COMPLEX WITH THE SUBSTRATE, HCO3-
Descriptor: BICARBONATE ION, CARBONIC ANHYDRASE II, METHYL MERCURY ION, ...
Authors:Xue, Y, Vidgren, J, Svensson, L.A, Liljas, A, Jonsson, B.-H, Lindskog, S.
Deposit date:1992-09-01
Release date:1993-10-31
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystallographic analysis of Thr-200-->His human carbonic anhydrase II and its complex with the substrate, HCO3-.
Proteins, 15, 1993
1CNC
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BU of 1cnc by Molmil
COMPENSATORY PLASTIC EFFECTS IN THE REDESIGN OF PROTEIN-ZINC BINDING SITES
Descriptor: CARBONIC ANHYDRASE II, ZINC ION
Authors:Ippolito, J.A, Christianson, D.W.
Deposit date:1994-06-13
Release date:1994-10-15
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural consequences of redesigning a protein-zinc binding site.
Biochemistry, 33, 1994
1DMX
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BU of 1dmx by Molmil
MURINE MITOCHONDRIAL CARBONIC ANYHDRASE V AT 2.45 ANGSTROMS RESOLUTION
Descriptor: MURINE CARBONIC ANHYDRASE V, ZINC ION
Authors:Boriack-Sjodin, P.A, Christianson, D.W.
Deposit date:1995-10-04
Release date:1996-04-03
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Structure determination of murine mitochondrial carbonic anhydrase V at 2.45-A resolution: implications for catalytic proton transfer and inhibitor design.
Proc.Natl.Acad.Sci.USA, 92, 1995
1CAJ
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BU of 1caj by Molmil
STRUCTURAL ANALYSIS OF THE ZINC HYDROXIDE-THR 199-GLU 106 HYDROGEN BONDING NETWORK IN HUMAN CARBONIC ANHYDRASE II
Descriptor: CARBONIC ANHYDRASE II, SULFATE ION, ZINC ION
Authors:Xue, Y, Liljas, A, Jonsson, B.-H, Lindskog, S.
Deposit date:1992-09-17
Release date:1993-10-31
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural analysis of the zinc hydroxide-Thr-199-Glu-106 hydrogen-bond network in human carbonic anhydrase II.
Proteins, 17, 1993
1CAH
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BU of 1cah by Molmil
STRUCTURE OF COBALT CARBONIC ANHYDRASE COMPLEXED WITH BICARBONATE
Descriptor: BICARBONATE ION, CARBONIC ANHYDRASE II, COBALT (II) ION
Authors:Hakansson, K, Wehnert, A.
Deposit date:1992-06-25
Release date:1993-10-31
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Structure of cobalt carbonic anhydrase complexed with bicarbonate.
J.Mol.Biol., 228, 1992
1CAO
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BU of 1cao by Molmil
CRYSTALLOGRAPHIC STUDIES OF THE BINDING OF PROTONATED AND UNPROTONATED INHIBITORS TO CARBONIC ANHYDRASE USING HYDROGEN SULPHIDE AND NITRATE ANIONS
Descriptor: CARBONIC ANHYDRASE II, HYDROSULFURIC ACID, ZINC ION
Authors:Mangani, S, Hakansson, K.
Deposit date:1992-07-02
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystallographic studies of the binding of protonated and unprotonated inhibitors to carbonic anhydrase using hydrogen sulphide and nitrate anions.
Eur.J.Biochem., 210, 1992
1CCU
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BU of 1ccu by Molmil
STRUCTURE-ASSISTED REDESIGN OF A PROTEIN-ZINC BINDING SITE WITH FEMTOMOLAR AFFINITY
Descriptor: CARBONIC ANHYDRASE II, SULFATE ION, ZINC ION
Authors:Ippolito, J.A, Christianson, D.W.
Deposit date:1994-12-09
Release date:1995-02-07
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structure-assisted redesign of a protein-zinc-binding site with femtomolar affinity.
Proc.Natl.Acad.Sci.USA, 92, 1995
1CAN
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BU of 1can by Molmil
CRYSTALLOGRAPHIC STUDIES OF THE BINDING OF PROTONATED AND UNPROTONATED INHIBITORS TO CARBONIC ANHYDRASE USING HYDROGEN SULPHIDE AND NITRATE ANIONS
Descriptor: CARBONIC ANHYDRASE II, MERCURY (II) ION, NITRATE ION
Authors:Mangani, S, Hakansson, K.
Deposit date:1992-07-02
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystallographic studies of the binding of protonated and unprotonated inhibitors to carbonic anhydrase using hydrogen sulphide and nitrate anions.
Eur.J.Biochem., 210, 1992
1CAM
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BU of 1cam by Molmil
STRUCTURAL ANALYSIS OF THE ZINC HYDROXIDE-THR 199-GLU 106 HYDROGEN BONDING NETWORK IN HUMAN CARBONIC ANHYDRASE II
Descriptor: BICARBONATE ION, CARBONIC ANHYDRASE II, ZINC ION
Authors:Xue, Y, Liljas, A, Jonsson, B.-H, Lindskog, S.
Deposit date:1992-09-17
Release date:1993-10-31
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural analysis of the zinc hydroxide-Thr-199-Glu-106 hydrogen-bond network in human carbonic anhydrase II.
Proteins, 17, 1993
1CAZ
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BU of 1caz by Molmil
WILD-TYPE AND E106Q MUTANT CARBONIC ANHYDRASE COMPLEXED WITH ACETATE
Descriptor: ACETIC ACID, CARBONIC ANHYDRASE II, ZINC ION
Authors:Hakansson, K, Briand, C, Zaitsev, V, Xue, Y, Liljas, A.
Deposit date:1993-02-26
Release date:1993-10-31
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Wild-type and E106Q mutant carbonic anhydrase complexed with acetate.
Acta Crystallogr.,Sect.D, 50, 1994
1CAY
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BU of 1cay by Molmil
WILD-TYPE AND E106Q MUTANT CARBONIC ANHYDRASE COMPLEXED WITH ACETATE
Descriptor: ACETIC ACID, CARBONIC ANHYDRASE II, ZINC ION
Authors:Hakansson, K, Briand, C, Zaitsev, V, Xue, Y, Liljas, A.
Deposit date:1993-02-26
Release date:1993-10-31
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Wild-type and E106Q mutant carbonic anhydrase complexed with acetate.
Acta Crystallogr.,Sect.D, 50, 1994
1CCT
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BU of 1cct by Molmil
STRUCTURE-ASSISTED REDESIGN OF A PROTEIN-ZINC BINDING SITE WITH FEMTOMOLAR AFFINITY
Descriptor: CARBONIC ANHYDRASE II, ZINC ION
Authors:Ippolito, J.A, Christianson, D.W.
Deposit date:1994-12-09
Release date:1995-02-07
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure-assisted redesign of a protein-zinc-binding site with femtomolar affinity.
Proc.Natl.Acad.Sci.USA, 92, 1995
1CA2
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BU of 1ca2 by Molmil
REFINED STRUCTURE OF HUMAN CARBONIC ANHYDRASE II AT 2.0 ANGSTROMS RESOLUTION
Descriptor: CARBONIC ANHYDRASE II, ZINC ION
Authors:Eriksson, A.E, Jones, T.A, Liljas, A.
Deposit date:1989-02-06
Release date:1990-01-15
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Refined structure of human carbonic anhydrase II at 2.0 A resolution.
Proteins, 4, 1988
1CAL
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BU of 1cal by Molmil
STRUCTURAL ANALYSIS OF THE ZINC HYDROXIDE-THR 199-GLU 106 HYDROGEN BONDING NETWORK IN HUMAN CARBONIC ANHYDRASE II
Descriptor: CARBONIC ANHYDRASE II, ZINC ION
Authors:Xue, Y, Liljas, A, Jonsson, B.-H, Lindskog, S.
Deposit date:1992-09-17
Release date:1993-10-31
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural analysis of the zinc hydroxide-Thr-199-Glu-106 hydrogen-bond network in human carbonic anhydrase II.
Proteins, 17, 1993
1CNX
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BU of 1cnx by Molmil
SECONDARY INTERACTIONS SIGNIFICANTLY REMOVED FROM THE SULFONAMIDE BINDING POCKET OF CARBONIC ANHYDRASE II INFLUENCE BINDING CONSTANTS
Descriptor: AMINODI(ETHYLOXY)ETHYLAMINOCARBONYLBENZENESULFONAMIDE, CARBONIC ANHYDRASE II, MERCURY (II) ION, ...
Authors:Boriack, P.A, Christianson, D.W.
Deposit date:1995-07-21
Release date:1995-11-14
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Secondary interactions significantly removed from the sulfonamide binding pocket of carbonic anhydrase II influence inhibitor binding constants.
J.Med.Chem., 38, 1995
1CVC
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BU of 1cvc by Molmil
REDESIGNING THE ZINC BINDING SITE OF HUMAN CARBONIC ANHYDRASE II: STRUCTURE OF A HIS2ASP-ZN2+ METAL COORDINATION POLYHEDRON
Descriptor: CARBONIC ANHYDRASE II, ZINC ION
Authors:Ippolito, J.A, Christianson, D.W.
Deposit date:1993-09-22
Release date:1994-01-31
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:REDESIGNING THE ZINC-BINDING SITE OF HUMAN CARBONIC ANHYDRASE-II - STRUCTURE OF A HIS2ASP-ZN2+ METAL COORDINATION POLYHEDRON.
J.Am.Chem.Soc., 115, 1993
1CZM
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BU of 1czm by Molmil
DRUG-PROTEIN INTERACTIONS: STRUCTURE OF SULFONAMIDE DRUG COMPLEXED WITH HUMAN CARBONIC ANHYDRASE I
Descriptor: 3-ACTOXYMERCURI-4-AMINOBENZENESULFONAMIDE, CARBONIC ANHYDRASE I, MERCURY (II) ION, ...
Authors:Chakravarty, S, Kannan, K.K.
Deposit date:1993-11-28
Release date:1994-04-30
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Drug-protein interactions. Refined structures of three sulfonamide drug complexes of human carbonic anhydrase I enzyme.
J.Mol.Biol., 243, 1994
1CIN
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BU of 1cin by Molmil
THE POSITIONS OF HIS-64 AND A BOUND WATER IN HUMAN CARBONIC ANHYDRASE II UPON BINDING THREE STRUCTURALLY RELATED INHIBITORS
Descriptor: (4S-TRANS)-4-(METHYLAMINO)-5,6-DIHYDRO-6-METHYL-4H-THIENO(2,3-B)THIOPYRAN-2-SULFONAMIDE-7,7-DIOXIDE, CARBONIC ANHYDRASE II, METHYL MERCURY ION, ...
Authors:Smith, G.M, Alexander, R.S, Christianson, D.W, Mckeever, B.M, Ponticello, G.S, Springer, J.P, Randall, W.C, Baldwin, J.J, Habecker, C.N.
Deposit date:1993-10-20
Release date:1994-01-31
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Positions of His-64 and a bound water in human carbonic anhydrase II upon binding three structurally related inhibitors.
Protein Sci., 3, 1994
1CVB
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BU of 1cvb by Molmil
STRUCTURAL AND FUNCTIONAL IMPORTANCE OF A CONSERVED HYDROGEN BOND NETWORK IN HUMAN CARBONIC ANHYDRASE II
Descriptor: CARBONIC ANHYDRASE II, SULFATE ION, ZINC ION
Authors:Ippolito, J.A, Christianson, D.W.
Deposit date:1993-02-04
Release date:1993-10-31
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural and functional importance of a conserved hydrogen bond network in human carbonic anhydrase II.
J.Biol.Chem., 268, 1993

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