8F0A
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![BU of 8f0a by Molmil](/molmil-images/mine/8f0a) | Client-bound structure of a DegP trimer within a 12mer cage | Descriptor: | Periplasmic serine endoprotease DegP, Telomeric repeat-binding factor 1 | Authors: | Harkness, R.W, Ripstein, Z.A, Di Trani, J.M, Kay, L.E. | Deposit date: | 2022-11-02 | Release date: | 2022-11-23 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Flexible Client-Dependent Cages in the Assembly Landscape of the Periplasmic Protease-Chaperone DegP. J.Am.Chem.Soc., 145, 2023
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1KY9
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![BU of 1ky9 by Molmil](/molmil-images/mine/1ky9) | Crystal Structure of DegP (HtrA) | Descriptor: | PROTEASE DO | Authors: | Krojer, T, Garrido-Franco, M, Huber, R, Ehrmann, M, Clausen, T. | Deposit date: | 2002-02-04 | Release date: | 2002-04-03 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal structure of DegP (HtrA) reveals a new protease-chaperone machine. Nature, 416, 2002
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3MH7
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![BU of 3mh7 by Molmil](/molmil-images/mine/3mh7) | HtrA proteases are activated by a conserved mechanism that can be triggered by distinct molecular cues | Descriptor: | 5-mer peptide, Protease do | Authors: | Krojer, T, Sawa, J, Huber, R, Clausen, T. | Deposit date: | 2010-04-07 | Release date: | 2010-06-30 | Last modified: | 2014-03-05 | Method: | X-RAY DIFFRACTION (2.961 Å) | Cite: | HtrA proteases have a conserved activation mechanism that can be triggered by distinct molecular cues Nat.Struct.Mol.Biol., 17, 2010
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3MH5
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![BU of 3mh5 by Molmil](/molmil-images/mine/3mh5) | HtrA proteases are activated by a conserved mechanism that can be triggered by distinct molecular cues | Descriptor: | DIISOPROPYL PHOSPHONATE, Protease do | Authors: | Krojer, T, Sawa, J, Huber, R, Clausen, T. | Deposit date: | 2010-04-07 | Release date: | 2010-06-30 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | HtrA proteases have a conserved activation mechanism that can be triggered by distinct molecular cues Nat.Struct.Mol.Biol., 17, 2010
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3OU0
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![BU of 3ou0 by Molmil](/molmil-images/mine/3ou0) | re-refined 3CS0 | Descriptor: | Periplasmic serine endoprotease DegP, heptapeptide, pentapeptide | Authors: | Sauer, R.T, Grant, R.A, Kim, S. | Deposit date: | 2010-09-14 | Release date: | 2011-01-19 | Last modified: | 2012-02-22 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Covalent Linkage of Distinct Substrate Degrons Controls Assembly and Disassembly of DegP Proteolytic Cages. Cell(Cambridge,Mass.), 145, 2011
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3CS0
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![BU of 3cs0 by Molmil](/molmil-images/mine/3cs0) | Crystal structure of DegP24 | Descriptor: | Periplasmic serine endoprotease DegP, pentapeptide | Authors: | Krojer, T, Sawa, J, Schaefer, E, Saibil, H.R, Ehrmann, M, Clausen, T. | Deposit date: | 2008-04-08 | Release date: | 2008-05-27 | Last modified: | 2019-11-13 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural basis for the regulated protease and chaperone function of DegP Nature, 453, 2008
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8F0U
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![BU of 8f0u by Molmil](/molmil-images/mine/8f0u) | Structure of a 12mer DegP cage bound to the client protein hTRF1 | Descriptor: | Periplasmic serine endoprotease DegP, Telomeric repeat-binding factor 1 | Authors: | Harkness, R.W, Ripstein, Z.A, Di Trani, J.M, Kay, L.E. | Deposit date: | 2022-11-04 | Release date: | 2022-11-23 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Flexible Client-Dependent Cages in the Assembly Landscape of the Periplasmic Protease-Chaperone DegP. J.Am.Chem.Soc., 145, 2023
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3MH4
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![BU of 3mh4 by Molmil](/molmil-images/mine/3mh4) | |
3MH6
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![BU of 3mh6 by Molmil](/molmil-images/mine/3mh6) | HtrA proteases are activated by a conserved mechanism that can be triggered by distinct molecular cues | Descriptor: | DIISOPROPYL PHOSPHONATE, Protease do | Authors: | Krojer, T, Sawa, J, Huber, R, Clausen, T. | Deposit date: | 2010-04-07 | Release date: | 2010-06-30 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | HtrA proteases have a conserved activation mechanism that can be triggered by distinct molecular cues Nat.Struct.Mol.Biol., 17, 2010
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6JJK
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![BU of 6jjk by Molmil](/molmil-images/mine/6jjk) | Crystal structure of the DegP dodecamer with a modulator | Descriptor: | CYS-TYR-TYR-LYS-ILE, Periplasmic serine endoprotease DegP | Authors: | Cho, H, Choi, Y, Lee, H.H, Kim, S. | Deposit date: | 2019-02-26 | Release date: | 2020-09-02 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | Over-activation of a nonessential bacterial protease DegP as an antibiotic strategy Commun Biol, 3, 2020
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3OTP
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![BU of 3otp by Molmil](/molmil-images/mine/3otp) | |
6JJO
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![BU of 6jjo by Molmil](/molmil-images/mine/6jjo) | Crystal structure of the DegP dodecamer with a modulator | Descriptor: | Periplasmic serine endoprotease DegP, TMB-CYRKL modulator | Authors: | Cho, H, Choi, Y, Lee, H.H, Kim, S. | Deposit date: | 2019-02-26 | Release date: | 2020-09-02 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (4.157 Å) | Cite: | Over-activation of a nonessential bacterial protease DegP as an antibiotic strategy Commun Biol, 3, 2020
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6JJL
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![BU of 6jjl by Molmil](/molmil-images/mine/6jjl) | Crystal structure of the DegP dodecamer with a modulator | Descriptor: | CYS-TYR-ARG-LYS-LEU, Periplasmic serine endoprotease DegP | Authors: | Cho, H, Choi, Y, Lee, H.H, Kim, S. | Deposit date: | 2019-02-26 | Release date: | 2020-09-02 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (4.2 Å) | Cite: | Over-activation of a nonessential bacterial protease DegP as an antibiotic strategy. Commun Biol, 3, 2020
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8F26
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![BU of 8f26 by Molmil](/molmil-images/mine/8f26) | Structure of a 60mer DegP cage bound to the client protein hTRF1 | Descriptor: | Periplasmic serine endoprotease DegP, Telomeric repeat-binding factor 1 | Authors: | Harkness, R.W, Ripstein, Z.A, Di Trani, J.M, Kay, L.E. | Deposit date: | 2022-11-07 | Release date: | 2022-11-23 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (9.7 Å) | Cite: | Flexible Client-Dependent Cages in the Assembly Landscape of the Periplasmic Protease-Chaperone DegP. J.Am.Chem.Soc., 145, 2023
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8F1T
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![BU of 8f1t by Molmil](/molmil-images/mine/8f1t) | Structure of an 18mer DegP cage bound to the client protein hTRF1 | Descriptor: | Periplasmic serine endoprotease DegP, Telomeric repeat-binding factor 1 | Authors: | Harkness, R.W, Ripstein, Z.A, Di Trani, J.M, Kay, L.E. | Deposit date: | 2022-11-06 | Release date: | 2022-11-23 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (12.1 Å) | Cite: | Flexible Client-Dependent Cages in the Assembly Landscape of the Periplasmic Protease-Chaperone DegP. J.Am.Chem.Soc., 145, 2023
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8F1U
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![BU of 8f1u by Molmil](/molmil-images/mine/8f1u) | Structure of a 24mer DegP cage bound to the client protein hTRF1 | Descriptor: | Periplasmic serine endoprotease DegP, Telomeric repeat-binding factor 1 | Authors: | Harkness, R.W, Ripstein, Z.A, Di Trani, J.M, Kay, L.E. | Deposit date: | 2022-11-06 | Release date: | 2022-11-23 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (13.8 Å) | Cite: | Flexible Client-Dependent Cages in the Assembly Landscape of the Periplasmic Protease-Chaperone DegP. J.Am.Chem.Soc., 145, 2023
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8F21
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![BU of 8f21 by Molmil](/molmil-images/mine/8f21) | Structure of a 30mer DegP cage bound to the client protein hTRF1 | Descriptor: | Periplasmic serine endoprotease DegP, Telomeric repeat-binding factor 1 | Authors: | Harkness, R.W, Ripstein, Z.A, Di Trani, J.M, Kay, L.E. | Deposit date: | 2022-11-06 | Release date: | 2022-11-23 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (14.1 Å) | Cite: | Flexible Client-Dependent Cages in the Assembly Landscape of the Periplasmic Protease-Chaperone DegP. J.Am.Chem.Soc., 145, 2023
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2ZLE
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![BU of 2zle by Molmil](/molmil-images/mine/2zle) | Cryo-EM structure of DegP12/OMP | Descriptor: | Outer membrane protein C, Protease do | Authors: | Schaefer, E, Saibil, H.R. | Deposit date: | 2008-04-09 | Release date: | 2008-06-03 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (28 Å) | Cite: | Structural basis for the regulated protease and chaperone function of DegP Nature, 453, 2008
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4A8D
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![BU of 4a8d by Molmil](/molmil-images/mine/4a8d) | DegP dodecamer with bound OMP | Descriptor: | OUTER MEMBRANE PROTEIN C, PERIPLASMIC SERINE ENDOPROTEASE DEGP | Authors: | Malet, H, Krojer, T, Sawa, J, Schafer, E, Saibil, H.R, Ehrmann, M, Clausen, T. | Deposit date: | 2011-11-20 | Release date: | 2012-01-11 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (28 Å) | Cite: | Newly Folded Substrates Inside the Molecular Cage of the Htra Chaperone Degq Nat.Struct.Mol.Biol., 19, 2012
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