8W23
 
 | | Cryo-EM structure of human tankyrase 2 SAM-PARP filament bound to compound, TDI-2804 (consensus map). | | Descriptor: | Maltose/maltodextrin-binding periplasmic protein,Poly [ADP-ribose] polymerase tankyrase-2, N-{2-[4-(2-hydroxypropan-2-yl)phenyl]-4-oxo-1,4-dihydroquinazolin-7-yl}-4-methoxy-6-phenylpyridine-3-carboxamide, ZINC ION | | Authors: | Malone, B.F, Zimmerman, J.L, Dow, L.E, Hite, R.K. | | Deposit date: | 2024-02-19 | | Release date: | 2025-07-09 | | Method: | ELECTRON MICROSCOPY (2.28 Å) | | Cite: | A potent and selective TNKS2 inhibitor for tumor-selective WNT suppression.
Biorxiv, 2025
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8W25
 | | Cryo-EM structure of human tankyrase 2 SAM-PARP filament bound to compound, TDI-2804 (focused refinement map). | | Descriptor: | Maltose/maltodextrin-binding periplasmic protein,Poly [ADP-ribose] polymerase tankyrase-2, N-{2-[4-(2-hydroxypropan-2-yl)phenyl]-4-oxo-1,4-dihydroquinazolin-7-yl}-4-methoxy-6-phenylpyridine-3-carboxamide, ZINC ION | | Authors: | Malone, B.F, Zimmerman, J.L, Dow, L.E, Hite, R.K. | | Deposit date: | 2024-02-20 | | Release date: | 2025-07-09 | | Method: | ELECTRON MICROSCOPY (2.42 Å) | | Cite: | A potent and selective TNKS2 inhibitor for tumor-selective WNT suppression.
Biorxiv, 2025
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8W2T
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8W28
 | | Cryo-EM structure of human tankyrase 2 SAM-PARP filament bound to compound, XAV (focused refinement map). | | Descriptor: | 2-[4-(trifluoromethyl)phenyl]-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-4-ol, Maltose/maltodextrin-binding periplasmic protein,Poly [ADP-ribose] polymerase tankyrase-2, ZINC ION | | Authors: | Malone, B.F, Zimmerman, J.L, Dow, L.E, Hite, R.K. | | Deposit date: | 2024-02-20 | | Release date: | 2025-07-09 | | Method: | ELECTRON MICROSCOPY (2.19 Å) | | Cite: | A potent and selective TNKS2 inhibitor for tumor-selective WNT suppression.
Biorxiv, 2025
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8W2U
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8W27
 | | Cryo-EM structure of human tankyrase 2 SAM-PARP filament bound to compound, XAV (consensus map). | | Descriptor: | 2-[4-(trifluoromethyl)phenyl]-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-4-ol, Maltose/maltodextrin-binding periplasmic protein,Poly [ADP-ribose] polymerase tankyrase-2, ZINC ION | | Authors: | Malone, B.F, Zimmerman, J.L, Dow, L.E, Hite, R.K. | | Deposit date: | 2024-02-20 | | Release date: | 2025-07-09 | | Method: | ELECTRON MICROSCOPY (2.21 Å) | | Cite: | A potent and selective TNKS2 inhibitor for tumor-selective WNT suppression.
Biorxiv, 2025
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