PDB: 144 件ウェブページステータス検索Chemie searchBIRD

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8VLS	Structure of VCP in complex with an ATPase activator (D2 domains only, dodecameric form) 分子名称: (3R)-N-[2-(ethylsulfanyl)phenyl]-3-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)butanamide, Transitional endoplasmic reticulum ATPase 著者 Jones, N.H, Urnivicius, L, Kapoor, T.M. 登録日 2024-01-12 公開日 2024-06-19 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Allosteric activation of VCP, an AAA unfoldase, by small molecule mimicry. Proc.Natl.Acad.Sci.USA, 121, 2024
8VOV	Structure of VCP in complex with an ATPase activator and ADP (D2 domains only, hexameric form) 分子名称: (3R)-N-[2-(ethylsulfanyl)phenyl]-3-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)butanamide, ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase 著者 Jones, N.H, Urnivicius, L, Kapoor, T.M. 登録日 2024-01-16 公開日 2024-06-19 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Allosteric activation of VCP, an AAA unfoldase, by small molecule mimicry. Proc.Natl.Acad.Sci.USA, 121, 2024
8VKU	Structure of VCP in complex with an ATPase activator (D2 domains only, hexameric form) 分子名称: (3R)-N-[2-(ethylsulfanyl)phenyl]-3-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)butanamide, Transitional endoplasmic reticulum ATPase 著者 Jones, N.H, Urnivicius, L, Kapoor, T.M. 登録日 2024-01-09 公開日 2024-06-19 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Allosteric activation of VCP, an AAA unfoldase, by small molecule mimicry. Proc.Natl.Acad.Sci.USA, 121, 2024
8KG2	Crystal structure of p97-N/D1 hexamer in complex with FAF1-UBX domain 分子名称: ADENOSINE-5'-DIPHOSPHATE, FAS-associated factor 1, Transitional endoplasmic reticulum ATPase 著者 Kang, W. 登録日 2023-08-17 公開日 2024-05-29 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Crystal Structure of p97-N/D1 Hexamer Complexed with FAF1 UBX Domain J. Korean Chem. Soc., 2024
8RSC	p97 (VCP) mutant - F539A 分子名称: ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase 著者 Arie, M, Matzov, D, Karmona, R, Szenkier, N, Stanhill, A, Navon, A. 登録日 2024-01-24 公開日 2024-05-29 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 p97 (VCP) mutant - F539A To Be Published
8RSB	p97 (VCP) mutant - F539A ADP state 分子名称: ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase 著者 Arie, M, Matzov, D, Karmona, R, Szenkier, N, Stanhill, A, Navon, A. 登録日 2024-01-24 公開日 2024-05-29 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 p97 (VCP) mutant - F539A ADP state To Be Published
8RS9	p97 (VCP) double mutant - F266A F539A 分子名称: Transitional endoplasmic reticulum ATPase 著者 Arie, M, Matzov, D, Karmona, R, Szenkier, N, Stanhill, A, Navon, A. 登録日 2024-01-24 公開日 2024-05-29 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 p97 (VCP) double mutant - F266A F539A To Be Published
8R0E	p97 (VCP) mutant - F266A 分子名称: Transitional endoplasmic reticulum ATPase 著者 Arie, M, Matzov, D, Karmona, R, Szenkier, N, Stanhill, A, Navon, A. 登録日 2023-10-31 公開日 2024-05-29 実験手法 ELECTRON MICROSCOPY (2.7 Å) 主引用文献 p97 (VCP) mutant - F266A To Be Published
8PQX	p97 (VCP) mutant - F539A state III 分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Transitional endoplasmic reticulum ATPase 著者 Arie, M, Matzov, D, Karmona, R, Szenkier, N, Stanhill, A, Navon, A. 登録日 2023-07-12 公開日 2024-05-29 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 p97 (VCP) mutant - F539A state III To Be Published
8OOI	Full composite cryo-EM map of p97/VCP in ADP.Pi state 分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Cheng, T.C, Sakata, E, Schuetz, A.K. 登録日 2023-04-05 公開日 2024-01-31 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (2.61 Å) 主引用文献 Characterizing ATP processing by the AAA+ protein p97 at the atomic level. Nat.Chem., 16, 2024
8HRZ	Crystal structure of the p97-N/D1 hexamer in complex with six p47-UBX domains 分子名称: ADENOSINE-5'-DIPHOSPHATE, NSFL1 cofactor p47, Transitional endoplasmic reticulum ATPase 著者 Nguyen, T.Q, Kang, W. 登録日 2022-12-16 公開日 2023-12-20 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Crystal structure of the p97-N/D1 hexmaer in complex with six p47-UBX domains J. Korean Chem. Soc., 68, 2024
7Y53	The cryo-EM structure of human ERAD retro-translocation complex 分子名称: ADENOSINE-5'-DIPHOSPHATE, Derlin-1, Transitional endoplasmic reticulum ATPase 著者 Cao, Y, Rao, B, Wang, Q, Yao, D, Xia, Y, Li, W, Li, S, Shen, Y. 登録日 2022-06-16 公開日 2023-10-18 最終更新日 2024-04-03 実験手法 ELECTRON MICROSCOPY (3.61 Å) 主引用文献 The cryo-EM structure of the human ERAD retrotranslocation complex. Sci Adv, 9, 2023
7Y59	The cryo-EM structure of human ERAD retro-translocation complex 分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Derlin-1, ... 著者 Cao, Y, Rao, B, Wang, Q, Yao, D, Xia, Y, Li, W, Li, S, Shen, Y. 登録日 2022-06-16 公開日 2023-10-18 最終更新日 2024-04-03 実験手法 ELECTRON MICROSCOPY (4.51 Å) 主引用文献 The cryo-EM structure of the human ERAD retrotranslocation complex. Sci Adv, 9, 2023
7Y4W	The cryo-EM structure of human ERAD retro-translocation complex 分子名称: ADENOSINE-5'-DIPHOSPHATE, Derlin-1, Transitional endoplasmic reticulum ATPase 著者 Cao, Y, Rao, B, Wang, Q, Yao, D, Xia, Y, Li, W, Li, S, Shen, Y. 登録日 2022-06-16 公開日 2023-10-18 最終更新日 2024-04-03 実験手法 ELECTRON MICROSCOPY (3.67 Å) 主引用文献 The cryo-EM structure of the human ERAD retrotranslocation complex. Sci Adv, 9, 2023
8HL7	Crystal structure of p97 N/D1 in complex with a valosin-containing protein methyltransferase 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ACETATE ION, ADENOSINE-5'-DIPHOSPHATE, ... 著者 Kang, W, Yang, J.K. 登録日 2022-11-29 公開日 2023-07-12 最終更新日 2023-08-02 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structural basis for recognition and methylation of p97 by METTL21D, a valosin-containing protein lysine methyltransferase. Iscience, 26, 2023
8FCT	Cryo-EM structure of p97:UBXD1 lariat mutant 分子名称: ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase, UBX domain-containing protein 6 著者 Braxton, J.R, Tucker, M.R, Tse, E, Southworth, D.R. 登録日 2022-12-01 公開日 2023-06-21 最終更新日 2023-12-20 実験手法 ELECTRON MICROSCOPY (3.42 Å) 主引用文献 The p97/VCP adaptor UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions. Nat.Struct.Mol.Biol., 30, 2023
8FCP	Cryo-EM structure of p97:UBXD1 para state 分子名称: ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase, UBX domain-containing protein 6 著者 Braxton, J.R, Tucker, M.R, Tse, E, Southworth, D.R. 登録日 2022-12-01 公開日 2023-06-21 最終更新日 2023-12-20 実験手法 ELECTRON MICROSCOPY (3.52 Å) 主引用文献 The p97/VCP adaptor UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions. Nat.Struct.Mol.Biol., 30, 2023
8FCL	Cryo-EM structure of p97:UBXD1 closed state 分子名称: ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase, UBX domain-containing protein 6 著者 Braxton, J.R, Tucker, M.R, Tse, E, Southworth, D.R. 登録日 2022-12-01 公開日 2023-06-21 最終更新日 2023-12-20 実験手法 ELECTRON MICROSCOPY (3.51 Å) 主引用文献 The p97/VCP adaptor UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions. Nat.Struct.Mol.Biol., 30, 2023
8FCQ	Cryo-EM structure of p97:UBXD1 PUB-in state 分子名称: ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase, UBX domain-containing protein 6 著者 Braxton, J.R, Tucker, M.R, Tse, E, Southworth, D.R. 登録日 2022-12-01 公開日 2023-06-21 最終更新日 2023-12-20 実験手法 ELECTRON MICROSCOPY (3.93 Å) 主引用文献 The p97/VCP adaptor UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions. Nat.Struct.Mol.Biol., 30, 2023
8FCR	Cryo-EM structure of p97:UBXD1 H4-bound state 分子名称: ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase, UBX domain-containing protein 6 著者 Braxton, J.R, Tucker, M.R, Tse, E, Southworth, D.R. 登録日 2022-12-01 公開日 2023-06-21 最終更新日 2023-12-20 実験手法 ELECTRON MICROSCOPY (4.12 Å) 主引用文献 The p97/VCP adaptor UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions. Nat.Struct.Mol.Biol., 30, 2023
8FCM	Cryo-EM structure of p97:UBXD1 open state 分子名称: ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase, UBX domain-containing protein 6 著者 Braxton, J.R, Tucker, M.R, Tse, E, Southworth, D.R. 登録日 2022-12-01 公開日 2023-06-21 最終更新日 2023-12-20 実験手法 ELECTRON MICROSCOPY (3.27 Å) 主引用文献 The p97/VCP adaptor UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions. Nat.Struct.Mol.Biol., 30, 2023
8FCO	Cryo-EM structure of p97:UBXD1 meta state 分子名称: ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase, UBX domain-containing protein 6 著者 Braxton, J.R, Tucker, M.R, Tse, E, Southworth, D.R. 登録日 2022-12-01 公開日 2023-06-21 最終更新日 2023-12-20 実験手法 ELECTRON MICROSCOPY (3.31 Å) 主引用文献 The p97/VCP adaptor UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions. Nat.Struct.Mol.Biol., 30, 2023
8FCN	Cryo-EM structure of p97:UBXD1 VIM-only state 分子名称: ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase, UBX domain-containing protein 6 著者 Braxton, J.R, Tucker, M.R, Tse, E, Southworth, D.R. 登録日 2022-12-01 公開日 2023-06-21 最終更新日 2023-12-20 実験手法 ELECTRON MICROSCOPY (2.95 Å) 主引用文献 The p97/VCP adaptor UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions. Nat.Struct.Mol.Biol., 30, 2023
8B5R	p97-p37-SPI substrate complex 分子名称: I3 sequence being threaded through the p97 channel, Protein phosphatase 1 regulatory subunit 7, Serine/threonine-protein phosphatase PP1-gamma catalytic subunit, ... 著者 van den Boom, J, Marini, G, Meyer, H, Saibil, H. 登録日 2022-09-24 公開日 2023-06-07 最終更新日 2023-07-26 実験手法 ELECTRON MICROSCOPY (6.1 Å) 主引用文献 Structural basis of ubiquitin-independent PP1 complex disassembly by p97. Embo J., 42, 2023
7PUX	Structure of p97 N-D1(L198W) in complex with Fragment TROLL2 分子名称: (1S)-2-amino-1-(4-bromophenyl)ethan-1-ol, ADENOSINE-5'-DIPHOSPHATE, DI(HYDROXYETHYL)ETHER, ... 著者 Bothe, S, Schindelin, H. 登録日 2021-10-01 公開日 2022-12-14 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.73 Å) 主引用文献 Fragment screening using biolayer interferometry reveals ligands targeting the SHP-motif binding site of the AAA+ ATPase p97 Commun Chem, 5, 2022

 

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