8RYS
| Human IL-1beta, unliganded | 分子名称: | Interleukin-1 beta, SULFATE ION | 著者 | Rondeau, J.-M, Lehmann, S. | 登録日 | 2024-02-09 | 公開日 | 2024-03-06 | 最終更新日 | 2024-06-05 | 実験手法 | X-RAY DIFFRACTION (1.16 Å) | 主引用文献 | Ligandability Assessment of IL-1 beta by Integrated Hit Identification Approaches. J.Med.Chem., 67, 2024
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5R8Q
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5R7W
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5BOW
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5R8E
| PanDDA analysis group deposition INTERLEUKIN-1 BETA -- Fragment Z57475877 in complex with INTERLEUKIN-1 BETA | 分子名称: | Interleukin-1 beta, SULFATE ION, ~{N}-(2-ethyl-1,2,3,4-tetrazol-5-yl)butanamide | 著者 | De Nicola, G.F, Nichols, C.E. | 登録日 | 2020-03-03 | 公開日 | 2020-04-22 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1 beta-IL1R and p38 alpha-TAB1 Complexes. J.Med.Chem., 63, 2020
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5R8M
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5R8F
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5R8O
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5R8G
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5R85
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6Y8I
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5R8K
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5R87
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5R8D
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5R8I
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5R8A
| PanDDA analysis group deposition INTERLEUKIN-1 BETA -- Fragment Z1492796719 in complex with INTERLEUKIN-1 BETA | 分子名称: | Interleukin-1 beta, SULFATE ION, ~{N}-[(3~{R})-1,2,3,4-tetrahydroquinolin-3-yl]ethanamide | 著者 | De Nicola, G.F, Nichols, C.E. | 登録日 | 2020-03-03 | 公開日 | 2020-04-22 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.47 Å) | 主引用文献 | Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1 beta-IL1R and p38 alpha-TAB1 Complexes. J.Med.Chem., 63, 2020
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5R88
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5R8N
| PanDDA analysis group deposition INTERLEUKIN-1 BETA -- Fragment Z57292400 in complex with INTERLEUKIN-1 BETA | 分子名称: | 3-ethoxy-~{N}-(2-methyl-1,2,3,4-tetrazol-5-yl)benzamide, Interleukin-1 beta, SULFATE ION | 著者 | De Nicola, G.F, Nichols, C.E. | 登録日 | 2020-03-03 | 公開日 | 2020-04-22 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | 主引用文献 | Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1 beta-IL1R and p38 alpha-TAB1 Complexes. J.Med.Chem., 63, 2020
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4GAI
| Crystal structure of EBI-005, a chimera of human IL-1beta and IL-1Ra | 分子名称: | EBI-005 | 著者 | Hou, J, Townson, S.A, Kovalchin, J.T, Masci, A, Kiner, O, Shu, Y, King, B, Thomas, C, Garcia, K.C, Furfine, E.S, Barnes, T.M. | 登録日 | 2012-07-25 | 公開日 | 2013-02-20 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.49 Å) | 主引用文献 | Design of a superior cytokine antagonist for topical ophthalmic use. Proc.Natl.Acad.Sci.USA, 110, 2013
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2VXT
| Crystal structure of human IL-18 complexed to murine reference antibody 125-2H Fab | 分子名称: | CHLORIDE ION, INTERLEUKIN-18, MAGNESIUM ION, ... | 著者 | Argiriadi, M.A, Xiang, T, Wu, C, Ghayur, T, Borhani, D.W. | 登録日 | 2008-07-10 | 公開日 | 2009-06-23 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.49 Å) | 主引用文献 | Unusual Water-Mediated Antigenic Recognition of the Proinflammatory Cytokine Interleukin-18. J.Biol.Chem., 284, 2009
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5R8B
| PanDDA analysis group deposition INTERLEUKIN-1 BETA -- Fragment Z2027049478 in complex with INTERLEUKIN-1 BETA | 分子名称: | 5-(1,3-thiazol-2-yl)-1H-1,2,4-triazole, Interleukin-1 beta, SULFATE ION | 著者 | De Nicola, G.F, Nichols, C.E. | 登録日 | 2020-03-03 | 公開日 | 2020-04-22 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.49 Å) | 主引用文献 | Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1 beta-IL1R and p38 alpha-TAB1 Complexes. J.Med.Chem., 63, 2020
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5R86
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5R8H
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2NVH
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5R8P
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