Loading
PDBj
メニューPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

6OSV
DownloadVisualize
BU of 6osv by Molmil
Potent and Selective Antitumor Antibody Targeting a Membrane-Proximal Epitope of ROR2
分子名称: Antibody heavy chain variable region, Antibody light chain variable region, Tyrosine-protein kinase transmembrane receptor ROR2
著者Park, H, Rader, C.
登録日2019-05-02
公開日2020-04-01
最終更新日2020-05-13
実験手法X-RAY DIFFRACTION (1.34 Å)
主引用文献Affinity maturation, humanization, and co-crystallization of a rabbit anti-human ROR2 monoclonal antibody for therapeutic applications.
J.Biol.Chem., 295, 2020
3KIV
DownloadVisualize
BU of 3kiv by Molmil
RECOMBINANT KRINGLE IV-10/M66 VARIANT OF HUMAN APOLIPOPROTEIN(A)
分子名称: 6-AMINOHEXANOIC ACID, APOLIPOPROTEIN
著者Mochalkin, I, Tulinsky, A, Scanu, A.
登録日1998-09-08
公開日1999-05-18
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Recombinant kringle IV-10 modules of human apolipoprotein(a): structure, ligand binding modes, and biological relevance.
Biochemistry, 38, 1999
7TNG
DownloadVisualize
BU of 7tng by Molmil
Kringle domain of human Receptor Tyrosine Kinase-Like Orphan Receptor 1 (ROR1)
分子名称: Inactive tyrosine-protein kinase transmembrane receptor ROR1
著者Guarino, S.R, Di Bello, A, Palamini, M, Forneris, F.
登録日2022-01-21
公開日2022-05-11
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Crystal structure of the kringle domain of human receptor tyrosine kinase-like orphan receptor 1 (hROR1)
Acta Crystallogr.,Sect.F, 78, 2022
8TCE
DownloadVisualize
BU of 8tce by Molmil
Lipoprotein(a) Kringle IV domain 8 - Lp(a) KIV8 in complex with LY3353871
分子名称: (2S)-3-phenyl-2-[(3R)-pyrrolidin-3-yl]propanoic acid, Apolipoprotein(a)
著者Hendle, J, Weichert, K, Sauder, J.M.
登録日2023-06-30
公開日2024-05-08
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (1.07 Å)
主引用文献Discovery of potent small-molecule inhibitors of lipoprotein(a) formation.
Nature, 629, 2024
5Z55
DownloadVisualize
BU of 5z55 by Molmil
NMR Solution Structure of the Kringle domain of human receptor tyrosine kinase-like orphan receptor 1 (ROR1)
分子名称: Inactive tyrosine-protein kinase transmembrane receptor ROR1
著者Ma, X, Hu, K.F.
登録日2018-01-17
公開日2018-05-16
最終更新日2023-06-14
実験手法SOLUTION NMR
主引用文献Backbone and side-chain chemical shift assignments of the kringle domain of human receptor tyrosine kinase-like orphan receptor 1 (ROR1).
Biomol NMR Assign, 12, 2018
6RX7
DownloadVisualize
BU of 6rx7 by Molmil
Structure of the KIV type 2 (KIV-2) domain of lipoprotein (a)
分子名称: Apolipoprotein(a), GLYCEROL, SULFATE ION
著者Santonastaso, A, Maggi, M, Scotti, C.
登録日2019-06-07
公開日2020-07-08
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.63 Å)
主引用文献High resolution structure of human apolipoprotein (a) kringle IV type 2: beyond the lysine binding site.
J.Lipid Res., 61, 2020
1TPK
DownloadVisualize
BU of 1tpk by Molmil
CRYSTAL STRUCTURE OF THE KRINGLE-2 DOMAIN OF TISSUE PLASMINOGEN ACTIVATOR AT 2.4-ANGSTROMS RESOLUTION
分子名称: CHLORIDE ION, TISSUE PLASMINOGEN ACTIVATOR
著者De vos, A.M, Ultsch, M.H, Kelley, R.F, Padmanabhan, K, Tulinsky, A, Westbrook, M.L, Kossiakoff, A.A.
登録日1991-09-24
公開日1992-07-15
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal structure of the kringle 2 domain of tissue plasminogen activator at 2.4-A resolution.
Biochemistry, 31, 1992
1URK
DownloadVisualize
BU of 1urk by Molmil
SOLUTION STRUCTURE OF THE AMINO TERMINAL FRAGMENT OF UROKINASE-TYPE PLASMINOGEN ACTIVATOR
分子名称: PLASMINOGEN ACTIVATOR, alpha-L-fucopyranose
著者Hansen, A.P, Petros, A.M, Meadows, R.P, Nettesheim, D.G, Mazar, A.P, Olejniczak, E.T, Xu, R.X, Pederson, T.M, Henkin, J, Fesik, S.W.
登録日1994-01-10
公開日1995-05-08
最終更新日2020-07-29
実験手法SOLUTION NMR
主引用文献Solution structure of the amino-terminal fragment of urokinase-type plasminogen activator.
Biochemistry, 33, 1994
8V9B
DownloadVisualize
BU of 8v9b by Molmil
Lipoprotein(a) Kringle IV domain 7 - Lp(a) KIV7 in complex with LY3441732
分子名称: (2S,2'S)-3,3'-[carbonylbis(azanediyl-3,1-phenylene)]bis{2-[(3R)-pyrrolidin-1-ium-3-yl]propanoate}, Apolipoprotein(a), MAGNESIUM ION, ...
著者Hendle, J, Weichert, K, Sauder, J.M.
登録日2023-12-07
公開日2024-05-08
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (1.19 Å)
主引用文献Discovery of potent small-molecule inhibitors of lipoprotein(a) formation.
Nature, 629, 2024
8V8Z
DownloadVisualize
BU of 8v8z by Molmil
Lipoprotein(a) Kringle IV domain 8 - Lp(a) KIV8 in complex with LY3473329
分子名称: Apolipoprotein(a), muvalaplin
著者Hendle, J, Weichert, K, Sauder, J.M.
登録日2023-12-06
公開日2024-05-08
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (2.01 Å)
主引用文献Discovery of potent small-molecule inhibitors of lipoprotein(a) formation.
Nature, 629, 2024
6BA5
DownloadVisualize
BU of 6ba5 by Molmil
Potent and Selective Antitumor Activity of a T-Cell Engaging Bispecific Antibody Targeting a Membrane-Proximal Epitope of ROR1
分子名称: Inactive tyrosine-protein kinase transmembrane receptor ROR1, Variable domain Heavy chain, antibody R11, ...
著者Park, H, Rader, C.
登録日2017-10-12
公開日2018-06-13
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.62 Å)
主引用文献Potent and selective antitumor activity of a T cell-engaging bispecific antibody targeting a membrane-proximal epitope of ROR1.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6BAN
DownloadVisualize
BU of 6ban by Molmil
Potent and Selective Antitumor Activity of a T-Cell Engaging Bispecific Antibody Targeting a Membrane-Proximal Epitope of ROR1
分子名称: Inactive tyrosine-protein kinase transmembrane receptor ROR1, Variable domain R11 Heavy chain, Variable domain of R11 Light Chain
著者Park, H, Rader, C.
登録日2017-10-14
公開日2018-06-13
最終更新日2019-12-04
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Potent and selective antitumor activity of a T cell-engaging bispecific antibody targeting a membrane-proximal epitope of ROR1.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
4KIV
DownloadVisualize
BU of 4kiv by Molmil
RECOMBINANT KRINGLE IV-10/W72R MUTANT OF HUMAN APOLIPOPROTEIN(A)
分子名称: APOLIPOPROTEIN
著者Mochalkin, I, Tulinsky, A, Scanu, A.
登録日1998-08-26
公開日1999-05-18
最終更新日2018-03-14
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Recombinant kringle IV-10 modules of human apolipoprotein(a): structure, ligand binding modes, and biological relevance.
Biochemistry, 38, 1999
2PK4
DownloadVisualize
BU of 2pk4 by Molmil
THE REFINED STRUCTURE OF THE EPSILON-AMINOCAPROIC ACID COMPLEX OF HUMAN PLASMINOGEN KRINGLE
分子名称: 6-AMINOHEXANOIC ACID, HUMAN PLASMINOGEN KRINGLE 4
著者Tulinsky, A, Wu, T.-P.
登録日1991-07-18
公開日1993-10-31
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献The refined structure of the epsilon-aminocaproic acid complex of human plasminogen kringle 4.
Biochemistry, 30, 1991
2L0S
DownloadVisualize
BU of 2l0s by Molmil
Solution Structure of Human Plasminogen Kringle 3
分子名称: Plasminogen
著者Christen, M.T, Frank, P, Schaller, J, Llinas, M.
登録日2010-07-15
公開日2010-08-04
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Human plasminogen kringle 3: solution structure, functional insights, phylogenetic landscape.
Biochemistry, 49, 2010
2FEB
DownloadVisualize
BU of 2feb by Molmil
NMR Solution Structure, Dynamics and Binding Properties of the Kringle IV Type 8 module of apolipoprotein(a)
分子名称: Apolipoprotein(a)
著者Chitayat, S, Kanelis, V, Koschinsky, M.L, Smith, S.P.
登録日2005-12-15
公開日2006-12-26
最終更新日2022-03-09
実験手法SOLUTION NMR
主引用文献Nuclear magnetic resonance (NMR) solution structure, dynamics, and binding properties of the kringle IV type 8 module of apolipoprotein(a).
Biochemistry, 46, 2007
1B2I
DownloadVisualize
BU of 1b2i by Molmil
KRINGLE 2 DOMAIN OF HUMAN PLASMINOGEN: NMR SOLUTION STRUCTURE OF TRANS-4-AMINOMETHYLCYCLOHEXANE-1-CARBOXYLIC ACID (AMCHA) COMPLEX
分子名称: PROTEIN (PLASMINOGEN), TRANS-4-AMINOMETHYLCYCLOHEXANE-1-CARBOXYLIC ACID
著者Marti, D.N, Schaller, J, Llinas, M.
登録日1999-09-24
公開日1999-11-19
最終更新日2023-12-27
実験手法SOLUTION NMR
主引用文献Solution structure and dynamics of the plasminogen kringle 2-AMCHA complex: 3(1)-helix in homologous domains.
Biochemistry, 38, 1999
1CEA
DownloadVisualize
BU of 1cea by Molmil
THE STRUCTURE OF THE NON-COVALENT COMPLEX OF RECOMBINANT KRINGLE 1 DOMAIN OF HUMAN PLASMINOGEN WITH EACA (EPSILON-AMINOCAPROIC ACID)
分子名称: 6-AMINOHEXANOIC ACID, PLASMINOGEN
著者Tulinsky, A, Mathews, I.I.
登録日1995-12-03
公開日1996-04-03
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.06 Å)
主引用文献Crystal structures of the recombinant kringle 1 domain of human plasminogen in complexes with the ligands epsilon-aminocaproic acid and trans-4-(aminomethyl)cyclohexane-1-carboxylic Acid.
Biochemistry, 35, 1996
1CEB
DownloadVisualize
BU of 1ceb by Molmil
THE STRUCTURE OF THE NON-COVALENT COMPLEX OF RECOMBINANT KRINGLE 1 DOMAIN OF HUMAN PLASMINOGEN WITH AMCHA (TRANS-4-AMINOMETHYLCYCLOHEXANE-1-CARBOXYLIC ACID)
分子名称: PLASMINOGEN, TRANS-4-AMINOMETHYLCYCLOHEXANE-1-CARBOXYLIC ACID
著者Tulinsky, A, Mathews, I.I.
登録日1995-12-03
公開日1996-04-03
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (2.07 Å)
主引用文献Crystal structures of the recombinant kringle 1 domain of human plasminogen in complexes with the ligands epsilon-aminocaproic acid and trans-4-(aminomethyl)cyclohexane-1-carboxylic Acid.
Biochemistry, 35, 1996
2I9A
DownloadVisualize
BU of 2i9a by Molmil
Crystal structure of the free aminoterminal fragment of urokinase type plasminogen activator (ATF)
分子名称: PHOSPHATE ION, Urokinase-type plasminogen activator
著者Lubkowski, J, Barinka, C.
登録日2006-09-05
公開日2006-11-28
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural basis of interaction between urokinase-type plasminogen activator and its receptor.
J.Mol.Biol., 363, 2006
2KNF
DownloadVisualize
BU of 2knf by Molmil
Solution structure and functional characterization of human plasminogen kringle 5
分子名称: Plasminogen
著者Battistel, M.D, Grishaev, A, An, S.A, Castellino, F.J, Llinas, M.
登録日2009-08-21
公開日2009-10-27
最終更新日2021-10-13
実験手法SOLUTION NMR
主引用文献Solution structure and functional characterization of human plasminogen kringle 5.
Biochemistry, 48, 2009
5HPG
DownloadVisualize
BU of 5hpg by Molmil
STRUCTURE AND LIGAND DETERMINANTS OF THE RECOMBINANT KRINGLE 5 DOMAIN OF HUMAN PLASMINOGEN
分子名称: PLASMINOGEN
著者Tulinsky, A, Mochalkin, I, Castellino, F.J.
登録日1997-09-19
公開日1998-03-25
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (1.66 Å)
主引用文献Structure and ligand binding determinants of the recombinant kringle 5 domain of human plasminogen.
Biochemistry, 37, 1998
6OSN
DownloadVisualize
BU of 6osn by Molmil
Potent and Selective Antitumor Antibody Targeting a Membrane-Proximal Epitope of ROR2
分子名称: ACETATE ION, Tyrosine-protein kinase transmembrane receptor ROR2
著者Park, H, Rader, C.
登録日2019-05-01
公開日2020-04-01
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.083 Å)
主引用文献Affinity maturation, humanization, and co-crystallization of a rabbit anti-human ROR2 monoclonal antibody for therapeutic applications.
J.Biol.Chem., 295, 2020
6OSH
DownloadVisualize
BU of 6osh by Molmil
Potent and Selective Antitumor Antibody Targeting a Membrane-Proximal Epitope of ROR2
分子名称: Antibody Light chain variable region, Antibody heavy chain variable region, Tyrosine-protein kinase transmembrane receptor ROR2
著者Park, H, Rader, C.
登録日2019-05-01
公開日2020-04-01
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.117 Å)
主引用文献Affinity maturation, humanization, and co-crystallization of a rabbit anti-human ROR2 monoclonal antibody for therapeutic applications.
J.Biol.Chem., 295, 2020
1PK4
DownloadVisualize
BU of 1pk4 by Molmil
CRYSTAL AND MOLECULAR STRUCTURE OF HUMAN PLASMINOGEN KRINGLE 4 REFINED AT 1.9-ANGSTROMS RESOLUTION
分子名称: PLASMINOGEN KRINGLE 4, SULFATE ION
著者Tulinsky, A, Mulichak, A.M.
登録日1991-07-18
公開日1993-10-31
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal and molecular structure of human plasminogen kringle 4 refined at 1.9-A resolution.
Biochemistry, 30, 1991

225946

件を2024-10-09に公開中

PDB statisticsPDBj update infoContact PDBjnumon