PDB: 42250 件ウェブページステータス検索Chemie searchBIRD

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1ZFQ	carbonic anhydrase II in complex with ethoxzolamidphenole as sulfonamide inhibitor 分子名称: (4-CARBOXYPHENYL)(CHLORO)MERCURY, 6-HYDROXY-1,3-BENZOTHIAZOLE-2-SULFONAMIDE, Carbonic anhydrase II, ... 著者 Honndorf, V.S, Heine, A, Klebe, G, Supuran, C.T. 登録日 2005-04-20 公開日 2006-05-23 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 carbonic anhydrase II in complex with ethoxzolamidphenole as sulfonamide inhibitor To be Published
8CQE	pVHL:EloB:EloC in complex with (2S,4R)-1-((S)-2-(1-Fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(2-methyl-4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide (Compound 37) 分子名称: (2~{S},4~{R})-1-[(2~{S})-2-[(1-fluoranylcyclopropyl)carbonylamino]-3,3-dimethyl-butanoyl]-~{N}-[(1~{S})-7-fluoranyl-6-(4-methyl-1,3-thiazol-5-yl)-1,2,3,4-tetrahydronaphthalen-1-yl]-4-oxidanyl-pyrrolidine-2-carboxamide, Elongin-B, Elongin-C, ... 著者 Casement, R, Phuong Vu, L, Ciulli, A, Gutschow, M. 登録日 2023-03-06 公開日 2023-09-27 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Expanding the Structural Diversity at the Phenylene Core of Ligands for the von Hippel-Lindau E3 Ubiquitin Ligase: Development of Highly Potent Hypoxia-Inducible Factor-1 alpha Stabilizers. J.Med.Chem., 66, 2023
2FSA	Crystal structure of PHD finger-linker-bromodomain fragment of human BPTF in the H3(1-15)K4ME2 bound state 分子名称: Histone H3(1-15)K4me2 peptide, ZINC ION, bromodomain PHD finger transcription factor 著者 Li, H, Patel, D.J. 登録日 2006-01-21 公開日 2006-07-11 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Molecular basis for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF. Nature, 442, 2006
3MNA	The crystal structure of human carbonic anhydrase Ii in complex with a 1,3,5-triazine-substituted benzenesulfonamide inhibitor 分子名称: Carbonic anhydrase 2, GLYCEROL, ZINC ION, ... 著者 Avvaru, B.S, Wagner, J, Robbins, A.H, Mckenna, R. 登録日 2010-04-21 公開日 2011-04-20 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Sulfonamides incorporating 1,3,5-triazine moieties selectively and potently inhibit carbonic anhydrase transmembrane isoforms IX, XII and XIV over cytosolic isoforms I and II: Solution and X-ray crystallographic studies. Bioorg.Med.Chem., 19, 2011
4HGD	Structural insights into yeast Nit2: C169S mutant of yeast Nit2 in complex with an endogenous peptide-like ligand 分子名称: CACODYLATE ION, GLYCEROL, N-(4-carboxy-4-oxobutanoyl)-L-cysteinylglycine, ... 著者 Liu, H, Qiu, X, Zhang, M, Gao, Y, Niu, L, Teng, M. 登録日 2012-10-08 公開日 2013-07-31 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.04 Å) 主引用文献 Structures of enzyme-intermediate complexes of yeast Nit2: insights into its catalytic mechanism and different substrate specificity compared with mammalian Nit2 Acta Crystallogr.,Sect.D, 69, 2013
1ZHZ	Structure of yeast oxysterol binding protein Osh4 in complex with ergosterol 分子名称: ERGOSTEROL, KES1 protein, LEAD (II) ION 著者 Im, Y.J, Raychaudhuri, S, Prinz, W.A, Hurley, J.H. 登録日 2005-04-26 公開日 2005-09-06 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural mechanism for sterol sensing and transport by OSBP-related proteins Nature, 437, 2005
3MFV	Crystal structure of human arginase I in complex with 2-aminohomohistidine 分子名称: (2S)-2-amino-4-(2-amino-1H-imidazol-5-yl)butanoic acid, Arginase-1, MANGANESE (II) ION 著者 Di Costanzo, L, Christianson, D.W. 登録日 2010-04-04 公開日 2010-05-05 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 2-aminoimidazole amino acids as inhibitors of the binuclear manganese metalloenzyme human arginase I. J.Med.Chem., 53, 2010
3MNI	Human Carbonic Anhydrase II Mutant K170D 分子名称: Carbonic anhydrase 2, SODIUM ION, ZINC ION 著者 Domsic, J.F, McKenna, R. 登録日 2010-04-21 公開日 2010-07-14 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Structural and kinetic study of the extended active site for proton transfer in human carbonic anhydrase II. Biochemistry, 49, 2010
1GUW	STRUCTURE OF THE CHROMODOMAIN FROM MOUSE HP1beta IN COMPLEX WITH THE LYSINE 9-METHYL HISTONE H3 N-TERMINAL PEPTIDE, NMR, 25 STRUCTURES 分子名称: CHROMOBOX PROTEIN HOMOLOG 1, HISTONE H3.1 著者 Nielsen, P.R, Nietlispach, D, Mott, H.R, Callaghan, J.M, Bannister, A, Kouzarides, T, Murzin, A.G, Murzina, N.V, Laue, E.D. 登録日 2002-02-01 公開日 2002-03-12 最終更新日 2025-04-09 実験手法 SOLUTION NMR 主引用文献 Structure of the Hp1 Chromodomain Bound to Histone H3 Methylated at Lysine 9 Nature, 416, 2002
6JZW	Crystal structure of SufU from Bacillus subtilis with Cys persulfurated 分子名称: ZINC ION, Zinc-dependent sulfurtransferase SufU 著者 Fujishiro, T, Takahashi, Y. 登録日 2019-05-04 公開日 2020-05-06 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (2.64 Å) 主引用文献 Cysteine-Persulfide Sulfane Sulfur-Ligated Zn Complex of Sulfur-Carrying SufU in the SufCDSUB System for Fe-S Cluster Biosynthesis. Inorg.Chem., 2024
3QDN	Putative thioredoxin protein from Salmonella typhimurium 分子名称: CALCIUM ION, Putative thioredoxin protein 著者 Osipiuk, J, Zhou, M, Kwon, K, Anderson, W.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) 登録日 2011-01-18 公開日 2011-02-09 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (2.09 Å) 主引用文献 Putative thioredoxin protein from Salmonella typhimurium. To be Published
8CKU	Translocation intermediate 1 (TI-1*) of 80S S. cerevisiae ribosome with ligands and eEF2 in the absence of sordarin 分子名称: 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... 著者 Milicevic, N, Jenner, L, Myasnikov, A, Yusupov, M, Yusupova, G. 登録日 2023-02-16 公開日 2023-09-20 最終更新日 2024-04-24 実験手法 ELECTRON MICROSCOPY (3.11 Å) 主引用文献 mRNA reading frame maintenance during eukaryotic ribosome translocation. Nature, 625, 2024
2FQL	Crystal structure of trimeric frataxin from the yeast Saccharomyces cerevisiae 分子名称: Frataxin homolog, mitochondrial 著者 Al-Karadaghi, S, Karlberg, T. 登録日 2006-01-18 公開日 2006-11-07 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (3.01 Å) 主引用文献 The structures of frataxin oligomers reveal the mechanism for the delivery and detoxification of iron. Structure, 14, 2006
3V2J	Effect of Sucrose and Glycerol as Cryoprotectans, on the Inhibition of Human Carbonic Anhydrase II 分子名称: 5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE, Carbonic anhydrase 2, ZINC ION 著者 Aggarwal, M, McKenna, A. 登録日 2011-12-12 公開日 2012-12-26 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.699 Å) 主引用文献 Effect of Sucrose and Glycerol as Cryoprotectans, on the Inhibition of Human Carbonic Anhydrase II To be Published
2FR0	The first ketoreductase of the erythromycin synthase (crystal form 1) 分子名称: Erythromycin synthase, EryAI, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Keatinge-Clay, A.T, Stroud, R.M. 登録日 2006-01-18 公開日 2006-04-04 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.81 Å) 主引用文献 The Structure of a Ketoreductase Determines the Organization of the beta-Carbon Processing Enzymes of Modular Polyketide Synthases Structure, 14, 2006
3MH5	HtrA proteases are activated by a conserved mechanism that can be triggered by distinct molecular cues 分子名称: DIISOPROPYL PHOSPHONATE, Protease do 著者 Krojer, T, Sawa, J, Huber, R, Clausen, T. 登録日 2010-04-07 公開日 2010-06-30 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 HtrA proteases have a conserved activation mechanism that can be triggered by distinct molecular cues Nat.Struct.Mol.Biol., 17, 2010
3V3G	Kinetic and structural studies of thermostabilized mutants of HCA II. 分子名称: CHLORIDE ION, Carbonic anhydrase 2, ZINC ION 著者 Boone, C.D, Fisher, S.Z, McKenna, R. 登録日 2011-12-13 公開日 2012-06-20 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.5581 Å) 主引用文献 Kinetic and structural characterization of thermostabilized mutants of human carbonic anhydrase II. Protein Eng.Des.Sel., 25, 2012
3V3F	Kinetic and structural studies of thermostabilized mutants of HCA II. 分子名称: CHLORIDE ION, Carbonic anhydrase 2, ZINC ION 著者 Boone, C.D, Fisher, S.Z, McKenna, R. 登録日 2011-12-13 公開日 2012-06-20 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Kinetic and structural characterization of thermostabilized mutants of human carbonic anhydrase II. Protein Eng.Des.Sel., 25, 2012
3V43	Crystal structure of MOZ 分子名称: ACETATE ION, Histone H3.1, Histone acetyltransferase KAT6A, ... 著者 Qiu, Y, Li, F. 登録日 2011-12-14 公開日 2012-06-27 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (1.47 Å) 主引用文献 Combinatorial readout of unmodified H3R2 and acetylated H3K14 by the tandem PHD finger of MOZ reveals a regulatory mechanism for HOXA9 transcription Genes Dev., 26, 2012
6SAC	N-terminal expression tag remainder of human Carbonic Anhydrase II covalently modified by fragment 分子名称: (4-CARBOXYPHENYL)(CHLORO)MERCURY, 1-(1,3-dimethyl-1H-pyrazol-5-yl)methanamine, Carbonic anhydrase 2, ... 著者 Gloeckner, S, Heine, A, Klebe, G. 登録日 2019-07-16 公開日 2020-04-15 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (1.02 Å) 主引用文献 A Proof-of-Concept Fragment Screening of a Hit-Validated 96-Compounds Library against Human Carbonic Anhydrase II. Biomolecules, 10, 2020
2FTY	Crystal structure of dihydropyrimidinase from Saccharomyces kluyveri 分子名称: ZINC ION, dihydropyrimidinase 著者 Dobritzsch, D, Lohkamp, B. 登録日 2006-01-25 公開日 2006-03-14 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 The Crystal Structures of Dihydropyrimidinases Reaffirm the Close Relationship between Cyclic Amidohydrolases and Explain Their Substrate Specificity. J.Biol.Chem., 281, 2006
6SB0	cryo-EM structure of mTORC1 bound to PRAS40-fused active RagA/C GTPases 分子名称: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Proline-rich AKT1 substrate 1, ... 著者 Anandapadamanaban, M, Berndt, A, Masson, G.R, Perisic, O, Williams, R.L. 登録日 2019-07-18 公開日 2019-10-16 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (5.5 Å) 主引用文献 Architecture of human Rag GTPase heterodimers and their complex with mTORC1. Science, 366, 2019
2BU8	crystal structures of human pyruvate dehydrogenase kinase 2 containing physiological and synthetic ligands 分子名称: ADENOSINE-5'-DIPHOSPHATE, DICHLORO-ACETIC ACID, MAGNESIUM ION, ... 著者 Knoechel, T.R, Tucker, A.D, Robinson, C.M, Phillips, C, Taylor, W, Bungay, P.J, Kasten, S.A, Roche, T.E, Brown, D.G. 登録日 2005-06-08 公開日 2006-02-02 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Regulatory Roles of the N-Terminal Domain Based on Crystal Structures of Human Pyruvate Dehydrogenase Kinase 2 Containing Physiological and Synthetic Ligands. Biochemistry, 45, 2006
4H4F	Crystal structure of human chymotrypsin C (CTRC) bound to inhibitor eglin c from Hirudo medicinalis 分子名称: Chymotrypsin-C, Eglin C, PHOSPHATE ION 著者 Batra, J, Soares, A.S, Radisky, E.S. 登録日 2012-09-17 公開日 2013-02-27 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Long-range Electrostatic Complementarity Governs Substrate Recognition by Human Chymotrypsin C, a Key Regulator of Digestive Enzyme Activation. J.Biol.Chem., 288, 2013
3V72	Crystal Structure of Rat DNA polymerase beta Mutator E295K: Enzyme-dsDNA 分子名称: CHLORIDE ION, DNA 5'-D(P*AP*AP*AP*CP*TP*CP*AP*CP*AP*T)-3', DNA 5'-D(P*AP*TP*GP*TP*GP*AP*GP*T)-3', ... 著者 Gridley, C.L, Jaeger, J. 登録日 2011-12-20 公開日 2012-07-04 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.49 Å) 主引用文献 Unfavorable Electrostatic and Steric Interactions in DNA Polymerase beta E295K Mutant Interfere with the Enzyme s Pathway J.Am.Chem.Soc., 134, 2012

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