PDB: 5495 件ウェブページステータス検索Chemie searchBIRD

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3RDD	Human Cyclophilin A Complexed with an Inhibitor 分子名称: Peptidyl-prolyl cis-trans isomerase A, ethyl N-[(4-aminobenzyl)carbamoyl]glycinate 著者 Colliandre, L, Ahmed-Belkacem, H, Bessin, Y, Pawlotsky, J.M, Guichou, J.F. 登録日 2011-04-01 公開日 2012-03-21 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.14 Å) 主引用文献 Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities. Nat Commun, 7, 2016
3L6A	Crystal structure of the C-terminal region of Human p97 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, Eukaryotic translation initiation factor 4 gamma 2, ... 著者 Fan, S. 登録日 2009-12-23 公開日 2010-04-28 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal structure of the C-terminal region of human p97/DAP5. Proteins, 78, 2010
3LAU	Crystal Structure of Aurora2 kinase in complex with a GSK3beta inhibitor 分子名称: N-[6-(4-hydroxyphenyl)-1H-indazol-3-yl]butanamide, Serine/threonine-protein kinase 6 著者 Maignan, S, Guilloteau, J.P, Pouzieux, S. 登録日 2010-01-07 公開日 2010-03-02 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Rational design of potent GSK3beta inhibitors with selectivity for Cdk1 and Cdk2. Bioorg.Med.Chem.Lett., 20, 2010
3RLN	Structural Basis of Cytosolic DNA Recognition by Innate Immune Receptors 分子名称: Gamma-interferon-inducible protein 16 著者 Jin, T.C, Xiao, T. 登録日 2011-04-19 公開日 2012-04-25 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.251 Å) 主引用文献 Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor. Immunity, 36, 2012
3LDO	Crystal structure of human GRP78 (70kDa heat shock protein 5 / BIP) ATPase domain in complex with AMPPNP 分子名称: 78 kDa glucose-regulated protein, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER 著者 Dokurno, P, Surgenor, A.E, Shaw, T, Macias, A.T, Massey, A.J, Williamson, D.S. 登録日 2010-01-13 公開日 2011-01-26 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Adenosine-Derived Inhibitors of 78 kDa Glucose Regulated Protein (Grp78) ATPase: Insights into Isoform Selectivity. J.Med.Chem., 54, 2011
1DXO	Crystal structure of human NAD[P]H-QUINONE oxidoreductase CO with 2,3,5,6,tetramethyl-P-benzoquinone (duroquinone) at 2.5 Angstrom resolution 分子名称: DUROQUINONE, FLAVIN-ADENINE DINUCLEOTIDE, QUINONE REDUCTASE 著者 Faig, M, Bianchet, M.A, Chen, S, Winski, S, Ross, D, Amzel, L.M. 登録日 2000-01-12 公開日 2000-04-23 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structures of Recombinant Mouse and Human Nad(P)H:Quinone Oxidoreductases:Species Comparison and Structural Changes with Substrate Binding and Release Proc.Natl.Acad.Sci.USA, 97, 2000
3THX	Human MutSbeta complexed with an IDL of 3 bases (Loop3) and ADP 分子名称: ADENOSINE-5'-DIPHOSPHATE, DNA Loop3 minus strand, DNA Loop3 plus strand, ... 著者 Yang, W. 登録日 2011-08-19 公開日 2011-12-21 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Mechanism of mismatch recognition revealed by human MutSbeta bound to unpaired DNA loops Nat.Struct.Mol.Biol., 19, 2012
3THY	Human MutSbeta complexed with an IDL of 2 bases (Loop2) and ADP 分子名称: ADENOSINE-5'-DIPHOSPHATE, DNA Loop2 minus strand, DNA Loop2 plus strand, ... 著者 Yang, W. 登録日 2011-08-19 公開日 2011-12-21 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.894 Å) 主引用文献 Mechanism of mismatch repair revealed by human MutSbeta bound to unpaired DNA loops Nat.Struct.Mol.Biol., 19, 2012
1DXQ	CRYSTAL STRUCTURE OF MOUSE NAD[P]H-QUINONE OXIDOREDUCTASE 分子名称: FLAVIN-ADENINE DINUCLEOTIDE, QUINONE REDUCTASE 著者 Faig, M, Bianchet, M.A, Chen, S, Winski, S, Ross, D, Amzel, L.M. 登録日 2000-01-14 公開日 2000-04-17 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structures of Recombinant Mouse and Human Nad(P)H:Quinone Oxidoreductases:Species Comparison and Structural Changes with Substrate Binding and Release Proc.Natl.Acad.Sci.USA, 97, 2000
3TYT	Crystal structure of a Heterogeneous nuclear ribonucleoprotein L (Hnrpl) from Mus musculus at 1.60 A resolution 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, Heterogeneous nuclear ribonucleoprotein L 著者 Joint Center for Structural Genomics (JCSG), Partnership for Stem Cell Biology (STEMCELL), Partnership for T-Cell Biology (TCELL) 登録日 2011-09-26 公開日 2011-11-16 最終更新日 2023-02-01 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Crystal structure of a Heterogeneous nuclear ribonucleoprotein L (Hnrpl) from Mus musculus at 1.60 A resolution To be published
1DZ1	Mouse HP1 (M31) C terminal (shadow chromo) domain 分子名称: MODIFIER 1 PROTEIN 著者 Brasher, S.V, Smith, B.O, Fogh, R.H, Nietlispach, D, Thiru, A, Nielsen, P.R, Broadhurst, R.W, Ball, L.J, Murzina, N, Laue, E.D. 登録日 2000-02-11 公開日 2000-04-09 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 The Structure of Mouse Hp1 Suggests a Unique Mode of Single Peptide Recognition by the Shadow Chromo Domain Dimer Embo J., 19, 2000
3QBY	Crystal structure of the PWWP domain of human Hepatoma-derived growth factor 2 分子名称: H4K20me3 Histone H4 Peptide, Hepatoma-derived growth factor-related protein 2, SULFATE ION, ... 著者 Zeng, H, Tempel, W, Amaya, M.F, Adams-Cioaba, M.A, Mackenzie, F, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Min, J, Wu, H, Structural Genomics Consortium (SGC) 登録日 2011-01-14 公開日 2011-02-09 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Structural and Histone Binding Ability Characterizations of Human PWWP Domains. Plos One, 6, 2011
1CJY	HUMAN CYTOSOLIC PHOSPHOLIPASE A2 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, PROTEIN (CYTOSOLIC PHOSPHOLIPASE A2) 著者 Dessen, A, Tang, J, Schmidt, H, Stahl, M, Clark, J.D, Seehra, J, Somers, W.S. 登録日 1999-04-20 公開日 2000-04-20 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal structure of human cytosolic phospholipase A2 reveals a novel topology and catalytic mechanism. Cell(Cambridge,Mass.), 97, 1999
3TO8	Crystal structure of the two C-terminal RRM domains of heterogeneous nuclear ribonucleoprotein L (hnRNP L) 分子名称: DI(HYDROXYETHYL)ETHER, GLYCEROL, Heterogeneous nuclear ribonucleoprotein L, ... 著者 Zhang, W.J, Zeng, F.X, Liu, Y.W, Zhao, Y, Niu, L.W, Teng, M.K, Li, X. 登録日 2011-09-04 公開日 2012-03-07 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.82 Å) 主引用文献 Crystal structure of the two C-terminal RRM domains of heterogeneous nuclear ribonucleoprotein L (hnRNP L) To be Published
3TU9	Crystal structure of rabbit muscle aldolase bound with 5-O-methyl mannitol 1,6-phosphate 分子名称: 2-O-methyl-1,6-di-O-phosphono-D-mannitol, Fructose-bisphosphate aldolase A 著者 Arthus-Cartier, G, Sygusch, J. 登録日 2011-09-16 公開日 2011-10-12 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.09 Å) 主引用文献 Mannitol Bis-phosphate Based Inhibitors of Fructose 1,6-Bisphosphate Aldolases. ACS Med Chem Lett, 2, 2011
1EJF	CRYSTAL STRUCTURE OF THE HUMAN CO-CHAPERONE P23 分子名称: Prostaglandin E synthase 3, SULFATE ION 著者 Weaver, A.J, Sullivan, W.P, Felts, S.J, Owen, B.A.L, Toft, D.O. 登録日 2000-03-02 公開日 2000-06-19 最終更新日 2020-10-28 実験手法 X-RAY DIFFRACTION (2.49 Å) 主引用文献 Crystal structure and activity of human p23, a heat shock protein 90 co-chaperone. J.Biol.Chem., 275, 2000
3UCD	Asymmetric complex of human neuron specific enolase-2-PGA/PEP 分子名称: 2-PHOSPHOGLYCERIC ACID, Gamma-enolase, MAGNESIUM ION, ... 著者 Qin, J, Chai, G, Brewer, J, Lovelace, L, Lebioda, L. 登録日 2011-10-26 公開日 2012-08-22 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.41 Å) 主引用文献 Structures of asymmetric complexes of human neuron specific enolase with resolved substrate and product and an analogous complex with two inhibitors indicate subunit interaction and inhibitor cooperativity. J.Inorg.Biochem., 111, 2012
3UF1	Crystal Structure of Vimentin (fragment 144-251) from Homo sapiens, Northeast Structural Genomics Consortium Target HR4796B 分子名称: Vimentin 著者 Kuzin, A, Abashidze, M, Vorobiev, S.M, Patel, P, Xiao, R, Ciccosanti, C, Shastry, R, Everett, J.K, Nair, R, Acton, T.B, Rost, B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) 登録日 2011-10-31 公開日 2011-11-30 最終更新日 2013-04-24 実験手法 X-RAY DIFFRACTION (2.81 Å) 主引用文献 The structure of vimentin linker 1 and rod 1B domains characterized by site-directed spin-labeling electron paramagnetic resonance (SDSL-EPR) and X-ray crystallography. J.Biol.Chem., 287, 2012
1EWE	Fructose 1,6-Bisphosphate Aldolase from Rabbit Muscle 分子名称: FRUCTOSE 1,6-BISPHOSPHATE ALDOLASE, SULFATE ION 著者 Maurady, A, Sygusch, J. 登録日 2000-04-25 公開日 2001-01-24 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 A conserved glutamate residue exhibits multifunctional catalytic roles in D-fructose-1,6-bisphosphate aldolases. J.Biol.Chem., 277, 2002
9BBI	Co-crystal structure of human DDB1 bound to fragment UB028669 分子名称: 3-([1,3]oxazolo[4,5-b]pyridin-2-yl)aniline, DNA damage-binding protein 1, L(+)-TARTARIC ACID, ... 著者 Zeng, H, Dong, A, Frommlet, A, Seitova, A, Loppnau, P, Ackloo, S, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) 登録日 2024-04-05 公開日 2024-06-12 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Co-crystal structure of human DDB1 bound to fragment UB028669 To be published
9FPZ	Human NatA-MAP2 80S ribosome complex 分子名称: 28S rRNA (300-MER, fragments), 5.8S rRNA (58-MER), ... 著者 Klein, M.A, Wild, K, Sinning, I. 登録日 2024-06-14 公開日 2024-07-03 実験手法 ELECTRON MICROSCOPY (2.69 Å) 主引用文献 Multi-protein assemblies orchestrate enzymatic processing of the nascent chain on the 80S ribosome To Be Published
5LZU	Structure of the mammalian ribosomal termination complex with accommodated eRF1 分子名称: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S12, ... 著者 Shao, S, Murray, J, Brown, A, Taunton, J, Ramakrishnan, V, Hegde, R.S. 登録日 2016-10-02 公開日 2016-11-30 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (3.75 Å) 主引用文献 Decoding Mammalian Ribosome-mRNA States by Translational GTPase Complexes. Cell, 167, 2016
5M25	Modulation of MLL1 Methyltransferase Activity 分子名称: (2~{S})-2-[[(2~{S})-2-[[(2~{S})-2-azanyl-3-oxidanyl-propanoyl]amino]propanoyl]amino]-5-carbamimidamido-~{N}-[(2~{S})-1-[[4-[(~{E})-[4-(hydroxymethyl)phenyl]diazenyl]phenyl]methylamino]-1-oxidanylidene-propan-2-yl]pentanamide, WD repeat-containing protein 5 著者 Srinivasan, V. 登録日 2016-10-11 公開日 2017-06-28 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.43 Å) 主引用文献 Controlled inhibition of methyltransferases using photoswitchable peptidomimetics: towards an epigenetic regulation of leukemia. Chem Sci, 8, 2017
6X7B	BRD4 Bromodomain 1 in complex with multi-action inhibitor SRX3212P 分子名称: 7-[7-oxo-5-(piperazin-1-yl)-7H-thieno[3,2-b]pyran-3-yl]-N-[(pyridin-3-yl)methyl]-2,3-dihydro-1,4-benzodioxine-5-carboxamide, Bromodomain-containing protein 4 著者 Vann, K.R, Kutateladze, T.G. 登録日 2020-05-29 公開日 2020-08-05 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.951 Å) 主引用文献 Design of thienopyranone-based BET inhibitors that bind multiple synthetic lethality targets. Sci Rep, 10, 2020
9LDT	DESIGN AND SYNTHESIS OF NEW ENZYMES BASED ON THE LACTATE DEHYDROGENASE FRAMEWORK 分子名称: LACTATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, OXAMIC ACID, ... 著者 Dunn, C.R, Holbrook, J.J, Muirhead, H. 登録日 1991-11-26 公開日 1993-10-31 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Design and synthesis of new enzymes based on the lactate dehydrogenase framework. Philos.Trans.R.Soc.London,Ser.B, 332, 1991

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