2ZOQ
 
 | | Structural dissection of human mitogen-activated kinase ERK1 | | 分子名称: | (2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL, Mitogen-activated protein kinase 3, SODIUM ION, ... | | 著者 | Kinoshita, T, Tada, T, Nakae, S, Yoshida, I. | | 登録日 | 2008-06-01 | | 公開日 | 2009-04-07 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | | 主引用文献 | Crystal structure of human mono-phosphorylated ERK1 at Tyr204
Biochem.Biophys.Res.Commun., 377, 2008
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7UCK
 | | 80S translation initiation complex with ac4c(-1) mRNA and Harringtonine | | 分子名称: | 18S rRNA, 28s rRNA, 40S ribosomal protein S10, ... | | 著者 | Yang, R, Arango, D, Sturgill, D, Oberdoerffer, S. | | 登録日 | 2022-03-16 | | 公開日 | 2022-06-01 | | 最終更新日 | 2022-08-17 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Direct epitranscriptomic regulation of mammalian translation initiation through N4-acetylcytidine.
Mol.Cell, 82, 2022
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6YLG
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8H6T
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8H6P
 | | Complex structure of CDK2/Cyclin E1 and a potent, selective macrocyclic inhibitor | | 分子名称: | (7S,10R)-11-oxa-2,4,5,13,17,23-hexaazatetracyclo[17.3.1.1~3,6~.1~7,10~]pentacosa-1(23),3(25),5,19,21-pentaene-12,18-dione, Cyclin-dependent kinase 2, G1/S-specific cyclin-E1 | | 著者 | Ren, X. | | 登録日 | 2022-10-18 | | 公開日 | 2023-02-22 | | 最終更新日 | 2023-03-29 | | 実験手法 | X-RAY DIFFRACTION (2.44 Å) | | 主引用文献 | Accelerated Discovery of Macrocyclic CDK2 Inhibitor QR-6401 by Generative Models and Structure-Based Drug Design.
Acs Med.Chem.Lett., 14, 2023
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4ABZ
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7TOR
 | | Mammalian 80S ribosome bound with the ALS/FTD-associated dipeptide repeat protein GR20 | | 分子名称: | 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ... | | 著者 | Loveland, A.B, Svidritskiy, E, Susorov, D, Lee, S, Park, A, Zvornicanin, S, Demo, G, Gao, F.B, Korostelev, A.A. | | 登録日 | 2022-01-24 | | 公開日 | 2022-05-25 | | 最終更新日 | 2022-06-01 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and poly-GR proteins revealed by cryo-EM.
Nat Commun, 13, 2022
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5UQ1
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7UCJ
 | | Mammalian 80S translation initiation complex with mRNA and Harringtonine | | 分子名称: | 18S rRNA, 28s rRNA, 40S ribosomal protein S10, ... | | 著者 | Yang, R, Arango, D, Sturgill, D, Oberdoerffer, S. | | 登録日 | 2022-03-16 | | 公開日 | 2022-06-01 | | 最終更新日 | 2022-08-17 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Direct epitranscriptomic regulation of mammalian translation initiation through N4-acetylcytidine.
Mol.Cell, 82, 2022
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7TOQ
 | | Mammalian 80S ribosome bound with the ALS/FTD-associated dipeptide repeat protein poly-PR | | 分子名称: | 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ... | | 著者 | Loveland, A.B, Svidritskiy, E, Susorov, D, Lee, S, Park, A, Zvornicanin, S, Demo, G, Gao, F.B, Korostelev, A.A. | | 登録日 | 2022-01-24 | | 公開日 | 2022-05-25 | | 最終更新日 | 2024-02-21 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and poly-GR proteins revealed by cryo-EM.
Nat Commun, 13, 2022
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3J9Y
 | | Cryo-EM structure of tetracycline resistance protein TetM bound to a translating E.coli ribosome | | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | 著者 | Arenz, S, Nguyen, F, Beckmann, R, Wilson, D.N. | | 登録日 | 2015-03-23 | | 公開日 | 2015-04-15 | | 最終更新日 | 2022-12-21 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Cryo-EM structure of the tetracycline resistance protein TetM in complex with a translating ribosome at 3.9- angstrom resolution.
Proc.Natl.Acad.Sci.USA, 112, 2015
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3JBU
 | | Mechanisms of Ribosome Stalling by SecM at Multiple Elongation Steps | | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | | 著者 | Zhang, J, Pan, X.J, Yan, K.G, Sun, S, Gao, N, Sui, S.F. | | 登録日 | 2015-10-16 | | 公開日 | 2016-01-27 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (3.64 Å) | | 主引用文献 | Mechanisms of ribosome stalling by SecM at multiple elongation steps
Elife, 4, 2015
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4B1R
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6I0Y
 | | TnaC-stalled ribosome complex with the titin I27 domain folding close to the ribosomal exit tunnel | | 分子名称: | 23S ribosomal RNA, 50S ribosomal protein L10, 50S ribosomal protein L11, ... | | 著者 | Su, T, Kudva, R, von Heijne, G, Beckmann, R. | | 登録日 | 2018-10-26 | | 公開日 | 2018-12-05 | | 最終更新日 | 2019-01-23 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Folding pathway of an Ig domain is conserved on and off the ribosome.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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7UXK
 | | Structure of CDK2 in complex with FP24322, a Helicon Polypeptide | | 分子名称: | 1,2-ETHANEDIOL, Cyclin-dependent kinase 2, FP24322, ... | | 著者 | Li, K, Agarwal, S, Tokareva, O, Thomson, T, Wahl, S, Verdine, G, McGee, J. | | 登録日 | 2022-05-05 | | 公開日 | 2022-12-28 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.63 Å) | | 主引用文献 | De novo mapping of alpha-helix recognition sites on protein surfaces using unbiased libraries.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7UXI
 | | Structure of CDK2 in complex with FP19711, a Helicon Polypeptide | | 分子名称: | AMINO GROUP, Cyclin-dependent kinase 2, FP19711, ... | | 著者 | Li, K, Agarwal, S, Tokareva, O, Thomson, T, Wahl, S, Verdine, G, McGee, J. | | 登録日 | 2022-05-05 | | 公開日 | 2022-12-28 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | | 主引用文献 | De novo mapping of alpha-helix recognition sites on protein surfaces using unbiased libraries.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7NWG
 | | Mammalian pre-termination 80S ribosome with Hybrid P/E- and A/P-site tRNA's bound by Blasticidin S. | | 分子名称: | 18S Ribosomal RNA, 28S Ribosomal RNA, 40S ribosomal protein S10, ... | | 著者 | Powers, K.T, Yadav, S.K.N, Bufton, J.C, Schaffitzel, C. | | 登録日 | 2021-03-16 | | 公開日 | 2021-07-07 | | 最終更新日 | 2023-01-11 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Blasticidin S inhibits mammalian translation and enhances production of protein encoded by nonsense mRNA.
Nucleic Acids Res., 49, 2021
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7NWI
 | | Mammalian pre-termination 80S ribosome with Empty-A site bound by Blasticidin S | | 分子名称: | 18S ribosomal RNA, 28S ribosomal RNA+BlaS, 40S ribosomal protein S11, ... | | 著者 | Powers, K.T, Yadav, S.K.N, Bufton, J.C, Schaffitzel, C. | | 登録日 | 2021-03-16 | | 公開日 | 2021-07-07 | | 最終更新日 | 2023-01-11 | | 実験手法 | ELECTRON MICROSCOPY (3.13 Å) | | 主引用文献 | Blasticidin S inhibits mammalian translation and enhances production of protein encoded by nonsense mRNA.
Nucleic Acids Res., 49, 2021
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3JCE
 | | Structure of Escherichia coli EF4 in pretranslocational ribosomes (Pre EF4) | | 分子名称: | 16S ribosomal RNA, 23 ribosomal RNA, 30S ribosomal protein S10, ... | | 著者 | Zhang, D, Yan, K, Liu, G, Song, G, Luo, J, Shi, Y, Cheng, E, Wu, S, Jiang, T, Low, J, Gao, N, Qin, Y. | | 登録日 | 2015-12-01 | | 公開日 | 2016-01-13 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | EF4 disengages the peptidyl-tRNA CCA end and facilitates back-translocation on the 70S ribosome
Nat. Struct. Mol. Biol., 23, 2016
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4TYH
 | | Ternary complex of P38 and MK2 with a P38 inhibitor | | 分子名称: | MAP kinase-activated protein kinase 2, Mitogen-activated protein kinase 14, N-[5-(dimethylsulfamoyl)-2-methylphenyl]-1-phenyl-5-propyl-1H-pyrazole-4-carboxamide | | 著者 | Cumming, J.G, Debreczeni, J.E, Edfeldt, F, Evertsson, F, Harrison, M, Holdgate, G, James, M, Lamont, S, Oldham, K, Sullivan, J.E, Wells, S. | | 登録日 | 2014-07-08 | | 公開日 | 2015-07-22 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Discovery of substrate selective, ATP-competitive P38 alpha MAP kinase inhibitors
To Be Published
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7BY2
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7BY3
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7MDZ
 | | 80S rabbit ribosome stalled with benzamide-CHX | | 分子名称: | 18S rRNA, 28S rRNA, 40S ribosomal protein S21, ... | | 著者 | Koga, Y, Hoang, E.M, Park, Y, Keszei, A.F.A, Murray, J, Shao, S, Liau, B.B. | | 登録日 | 2021-04-06 | | 公開日 | 2021-09-01 | | 最終更新日 | 2021-09-15 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Discovery of C13-Aminobenzoyl Cycloheximide Derivatives that Potently Inhibit Translation Elongation.
J.Am.Chem.Soc., 143, 2021
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3J9Z
 | | Activation of GTP Hydrolysis in mRNA-tRNA Translocation by Elongation Factor G | | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | 著者 | Li, W, Liu, Z, Koripella, R.K, Langlois, R, Sanyal, S, Frank, J. | | 登録日 | 2015-03-27 | | 公開日 | 2015-07-01 | | 最終更新日 | 2024-02-21 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Activation of GTP hydrolysis in mRNA-tRNA translocation by elongation factor G.
Sci Adv, 1, 2015
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3JCD
 | | Structure of Escherichia coli EF4 in posttranslocational ribosomes (Post EF4) | | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | 著者 | Zhang, D, Yan, K, Liu, G, Song, G, Luo, J, Shi, Y, Cheng, E, Wu, S, Jiang, T, Low, J, Gao, N, Qin, Y. | | 登録日 | 2015-12-01 | | 公開日 | 2016-01-13 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | EF4 disengages the peptidyl-tRNA CCA end and facilitates back-translocation on the 70S ribosome
Nat. Struct. Mol. Biol., 23, 2016
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